Flemoxin solutab or ceftriaxone

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Review: Astellas Pharma antibiotic Flemoxin Solutab is one of the most effective antibiotics for children. (Advantages and disadvantages)

An effective antibiotic at an affordable price. No injections! Can be used by babies, during pregnancy and breastfeeding!

Table of contents:

Not the most pleasant taste, there are contraindications.

— I was treated with it myself for the second time (with an adult dosage, of course). The temperature quickly subsided, and all other symptoms almost completely disappeared within 3 days. I then had a sore throat, which I had previously treated for probably 6-7 days to no avail. I had a fever, a sore throat, etc. Everything went away quickly!

— the last time I treated the child again. The temperature lasted for three days, there was gingivitis (inflammation of the gums), a red throat, a slight cough and snot flowing in a stream. After starting to take Flemoxin, the very next (.) day the temperature subsided on its own, without antipyretic drugs. The maximum reached 37.3 and did not rise again. The cough also disappeared completely. The only thing we struggled with for longer was a runny nose, but that’s understandable. We had him for a week, as expected));

General impression: One of the most effective antibiotics for children. (Advantages and disadvantages)

But there is such an interesting and ambiguous story here. We can attribute something other than that to the antibiotic. Perhaps it was the child’s immune system that defeated the bacterium itself. My daughter is 2.3 months old. I have never taken antibiotics. At the same time, she suffered from tracheitis and laryngitis.

Source: http://otzovik.com/review_863624.html

Severe sore throat, injecting ceftriaxone, which antibiotic should I switch to next?

If the antibiotic does not bring any improvement in 4-5 days, then you need to change it to an antibiotic of a different group. In this case, ceftriaxone is a cephalosporin antibiotic; cephalosporins probably do not act on the pathogen that caused your sore throat (as I understand, the type of pathogen in your case is unknown). As is known, the cause of tonsillitis (tonsillitis) can be viruses, mycoplasmas and pyogenic microbes (staphylococcus, streptococcus). So, if tonsillitis is caused by viruses or mycoplasmas, then ceftriaxone is ineffective against these microorganisms. This may seem strange to you, but I would advise you to try the usual (and undeservedly forgotten) erythromycin. During my childhood, it was often prescribed, and in relation to tonsillitis, it was quite effective. When my son (then 7 years old) had a severe sore throat, and the amoxicillin prescribed by the pediatrician did not help at all, I, at my own peril and risk, bought ordinary erythromycin. Improvement occurred within two days. Apparently, the cause of my son’s sore throat was not staphylococcus or streptococcus. If, in addition to tonsillitis, there are herpetic rashes on the lips or on the oral mucosa, then it makes sense to also take acyclovir. And of course, an ENT consultation is necessary. doctor Sore throat is dangerous due to its complications, so in this case, I would not recommend self-medication.

The amygdala is terribly enclosed (about 1 cm wide and several in length), it goes all the way down into the throat.

Last time it was prescribed for 5 days. On the second day, literally everything went away, but there was no fever. And this time. I didn’t have time to recover from bronchitis (I was also injected with ceftriaxone), I had to go to work, I won’t be able to take sick leave.

How to take Erythromycin? - 2 years ago

Should I drink erythromycin for another 5 days? - 2 years ago

The sore throat was severe, and besides, this dirty trick happened just during the New Year holidays, when everyone is resting and nothing is working, including the clinics. I know about ceftriaxone from the previous time I had a sore throat. It is prescribed as injections for 5 days, twice a day, after which you need to switch to another antibiotic. In the case of ENT sore throat, doctors recommend switching to the antibiotic clatrimycin, for example Klabaix. Klabax is a broad-spectrum and long-acting drug, i.e. It is enough to take it once a day.

Allergic reactions may occur when taking ceftriaxone, so for prevention purposes it is advisable to also take an antihistamine.

And in order not to disturb and maintain the intestinal microflora, it is also good to take Bifiform or Linex, as well as Fluconazole.

There is a rule that if an antibiotic is ineffective in the first three days of treatment, then it is necessary to replace it with an antibiotic of another group; if the effectiveness is good, treatment is continued until recovery, combining antibacterial therapy with local one. For diseases of the oropharynx, semisynthetic penicillins are indicated, one of which is amoxicillin, the more modern flemoxin solutab.

I recommend contacting an ENT doctor, if at home - tea with lemon and honey, lemon juice, garlic, porridge, in any case it will help, but completely, I also recommend citramon + paracetamol to make it easier to walk somewhere, for example to the store or to the kitchen. The likelihood of complications will be less if you have a fever.

Try Amoxil. He was the only one who helped my wife, although I had to persuade the pharmacist at the pharmacy to give it without a prescription.

Source: http://www.bolshoyvopros.ru/questions/silnaja-angina-kolju-ceftriakson-na-kakoj-perejti-antibiotik-posle.html

Which antibiotic is better - Flemoxin solutab or Amoxicillin?

When choosing an antibiotic to treat any ailment, many people ask questions about which one is better, more effective, safer, because there are so many of them and all the remedies are different.

Of course, it is best to entrust the prescription of therapy to an experienced doctor, who will take into account not only the existing indications, but also the characteristics of the patient’s body, however, most people strive to solve this problem on their own, and trust the choice of antibiotic to the employees of the nearest pharmacy.

Pharmacy chains, as a rule, recommend two types of the most popular drugs, these are Amoxicillin and Flemoxin, but it is important to know how they differ from each other, and which one is better, because they have almost the same effect.

Difference and Similarity

Both of these semisynthetic drugs are representatives of the same group of antibiotics (penicillin), and have a very wide spectrum of action. They also have a common active ingredient - amoxicillin trihydrate, which is active against many types of bacteria, not only against gram-negative, but also against gram-positive.

It would seem that the products are almost the same and have a similar effect, but, nevertheless, many experts claim that the best of them is Flemoxin Solutab, and the difference is very noticeable. Amoxicillin, familiar to everyone, is a kind of predecessor of many modern antibiotic drugs of the penicillin group, but it itself has many shortcomings, which are corrected in the new generation of drugs created on its basis.

Flemoxin Solutab differs from its well-known predecessor in that it is devoid of the main disadvantages and disadvantages of Amoxicillin, but at the same time fully retains the effectiveness of the main substance against a variety of bacteria.

An important difference between Flemoxin Solutab is, for example, that:

  1. It has a unique property, expressed in the drug’s resistance to the influence of gastric acids, which allows you not to worry about the condition of the stomach and the entire tract when treated with such an antibiotic, because it does not corrode the walls of the gastrointestinal tract.
  2. It can be taken as you wish - as a whole tablet, divided into parts (if necessary), it can be chewed with water.
  3. It can be crushed and simply dissolved in water, resulting in a kind of syrup that smells like lemon, vanilla or tangerine.

At the same time, Flemoxin Solutab fully retains all its medicinal qualities, regardless of the form in which it is taken. An important point is that the drug has virtually no side effects, unlike Amoxicillin, due to the fact that Flemoxin Solutab contains the active ingredient in a very special, soluble form.

At the same time, the main substance (amoxicillin) is here in purified form, which has reduced the risk of possible negative reactions to a minimum. The bioavailability of this drug is about 93%, so it is used with great success to eliminate various infectious diseases even in children, since it practically does not cause dysbiosis and other digestive problems.

Indications and contraindications, side effects

Amoxicillin, like all its derivatives, as well as drugs based on it, is intended to eliminate a variety of diseases caused by bacterial infections, in particular, the drug is prescribed for:

  • pneumonia;
  • bronchitis of varying complexity;
  • acute otitis media;
  • tonsillitis;
  • pharyngitis and sinusitis;
  • pyelonephritis;
  • urethritis and pyelitis;
  • cervicitis and endometritis;
  • cystitis, etc.

Amoxicillin preparations should not be taken by people who are intolerant to the main substance or any of the additional components of the drug. Amoxicillin is also prohibited for infectious mononucleosis and the presence of lymphatic leukemoid reactions.

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Many amoxicillin preparations (including Flemoxin) have restrictions and special instructions for the use of drugs, for example, in the presence of bronchial asthma, lymphocytic leukemia, renal failure, allergic diathesis, hay fever, as well as colitis that occurred due to previous use of any antibiotics , and other gastrointestinal ailments, the use of drugs is possible only with caution.

During pregnancy, such drugs can be used only in cases where the necessary benefits for the expectant mother significantly outweigh the possible risks of a negative impact on the developing baby, since studies under the strict supervision of specialists have not been conducted in this direction.

During lactation, it is important to take into account that the substance quickly penetrates into milk and can harm the baby through it, therefore, if such treatment is necessary, a temporary cessation of breastfeeding is recommended.

If there is an individual sensitivity to the components of the product, various allergic reactions may occur, for example:

  • anaphylactic shock;
  • erythema multiforme exudative;
  • hives;
  • rhinitis;
  • Stevens-Johnson syndrome;
  • conjunctivitis;
  • various forms of rashes;
  • exfoliative dermatitis;
  • Quincke's edema;
  • as well as reactions similar to serum sickness.

Of course, all such reactions are absolutely individual, as is their intensity when manifested. Complications may also occur in the gastrointestinal tract, expressed in the form of changes in taste, stomatitis, diarrhea, nausea (and sometimes vomiting), glossitis, as well as pain and discomfort in the anus. Complications from the sensory organs and nervous system include the appearance of dizziness, excessive agitation, insomnia, seizures, confusion, headaches, anxiety, and changes in habitual behavior.

In the heart and vascular system, adverse reactions can be considered the occurrence of tachycardia, eosinophilia, agranulocytosis, leukopenia, transient anemia, neutropenia, blood clotting disorders and changes in its composition.

In addition, some patients may experience pain in the joints, difficulty breathing, hemorrhagic colitis, oral candidiasis (in women - vaginal), interstitial nephritis. Almost 10-15% of patients who are treated with such antibiotics develop diarrhea or severe dysbiosis, so such drugs should be taken only when prescribed by a doctor and strictly following the dosage indicated by him.

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  • exacerbation of chronic diseases.

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Source: http://opnevmonii.ru/preparaty/otlichie-amoksicillina-ot-flemoksin-solyutab.html

Flemoxin solutab or amoxicillin - which is better?

When choosing between two drugs, it is better to trust a specialist. To decide which is better – amoxicillin or flemoxin, you should analyze them carefully. They are identical in properties and belong to the semisynthetic antibiotics of the penicillin group. The main component is amoxicillin trihydrate. It has an effect in relatively gram-negative and gram-positive microorganisms.

Although the drugs are identical, one is still better than the other for a number of reasons. To explain this difference, it is necessary to examine in more detail the composition of the drugs and their pharmacological action.

Comparison of two drugs

Amoxicillin is an antibacterial agent. It has a wide range of effects. The effect is noticeable against gram-positive microflora. The mechanism of action is based on the destructive ability of the cell membrane that exists in the microbe. The drug is actively prescribed for the treatment of the following diseases:

  • Genitourinary area
  • Upper and lower respiratory tract
  • In combination with other antibiotics, it is used to combat stomach ulcers.
  • Meningitis
  • Lyme disease
  • Leptospirosis
  • Salmonellosis
  • Endocarditis
  • Sepsis

The drug is sold in different forms - granules and capsules. To obtain a suspension, granules are needed; they are used in childhood. In adults, other types of the drug are used.

Flemoxin solutab is an antibacterial agent and a generic form of amoxicillin. It has a destructive effect on the bacterial cell walls. It has the greatest effect on gram-positive and gram-negative flora. In this respect, Flemoxin Solutab and Amoxicillin are similar. The least result is seen in the fight against staphylococci, proteus, and Helicobacter pylori. This remedy is used to treat the following pathologies:

  • Infections affecting the respiratory tract
  • Infectious diseases in the genitourinary system
  • Skin infections
  • Gastrointestinal disorders

The drug is available as tablets. Can be used in children even at a very young age. The main thing is a clear dosage.

What's the difference?

The main difference between Flemoxin Solutab is that it is a generic of the mentioned predecessor. It has a special structure that allows it to be quickly absorbed into the gastrointestinal tract. Amoxicillin does not have this structure, so it can break down and lose its antibacterial properties.

Another point why one drug may differ from another is price. Flemoxin has a higher cost. It is generally accepted that it is more suitable for children, and its analogue is more suitable for adults.

There is no need to choose any of these drugs on your own. Any medicine must be prescribed by a physician. The medications are almost the same, but one of them is better.

The effect of Flemoxin Solutab is better than that of regular amoxicillin. It is considered an improved version of its predecessor. Manufacturers have eliminated the shortcomings of the antibiotic, but the required effectiveness remains the same. Comparing bioavailability, in the case of flemoxin it is higher. There are fewer side effects and the product is less susceptible to the influence of gastric juice, so it is safe for the mucous membrane.

The drug can be divided into several parts, chewed and washed down with a small amount of water. When dissolved in water, a syrup with a citrus or vanilla aroma is obtained. The therapeutic effect does not disappear.

Taking the drug correctly

For adults and children over ten years of age and weighing over 40 kg, the drug should be taken 0.5 g tablet three times a day. In case of severe infection, the dosage is increased to 0.75 g - 1 g with the same frequency. In order to treat mild gonorrhea, three grams are prescribed for one-time use.

As for the fight against infectious diseases of gynecology and diseases of the gastrointestinal tract, biliary tract, it is necessary to take 1.5-2 g three times a day or 1-1.5 g four times a day. Leptospirosis is treated with a dosage of 0.5-0.75 g with the same frequency. Duration - from six to twelve days.

Carriers of salmonellosis take the drug 1.5-2 g three times a day for two to four weeks. After minor surgical operations and to prevent endocarditis, doctors prescribe 3-4 g to patients an hour before the procedure.

Regarding the use of Flemoxin, the important thing is that it can be taken during meals, before or after - it doesn’t matter. The dosage is selected individually, based on test results and general condition. The duration of administration is determined based on the nature of the bacteria that have infected the body. This usually takes about ten days. A couple of days after the condition improves, you can stop taking the drug. If there are any signs that the drug is not suitable, use should be discontinued.

Overdose

Side effects are limited to intestinal symptoms. For example, nausea and diarrhea. An allergic reaction to the components included in the composition is possible.

Source: http://gaimoritstop.ru/flemoksin-solyutab-ili-amoksicillin.html

Flemoxin Solutab - instructions for use, analogs, reviews and release forms (tablets 125 mg, 250 mg, 500 mg and 1000 mg) of a medicinal product for the treatment of sore throat, sinusitis and other infections in adults, children and pregnancy

In this article you can read the instructions for use of the drug Flemoxin Solutab. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Flemoxin Solutab in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Flemoxin Solutab in the presence of existing structural analogues. Use for the treatment of sore throat, sinusitis and other infections in adults, children, as well as during pregnancy and lactation.

Flemoxin Solutab is a broad-spectrum semi-synthetic penicillin antibiotic. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. Active against aerobic gram-positive and gram-negative bacteria.

Microorganisms that produce penicillinase are resistant to amoxicillin (the active substance of the drug Flemoxin Solutab).

In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

Cross-resistance exists between amoxicillin and ampicillin.

The spectrum of antibacterial action expands with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid. This combination increases the activity of Flemoxin Solutab against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other gram-negative bacteria remain resistant.

When taken orally, Flemoxin Solutab is quickly and completely absorbed from the gastrointestinal tract and is not destroyed in the acidic environment of the stomach. When the dose is doubled, the concentration also doubles. In the presence of food in the stomach does not reduce total absorption. Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported (therefore, concomitant use of ethanol (alcohol) has a negative effect on this organ with the possibility of developing liver failure).

About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion. A certain amount of amoxicillin is detected in feces.

In small quantities, amoxicillin penetrates the BBB during inflammation of the pia mater.

  • infectious and inflammatory diseases (respiratory organs, genitourinary system, skin) caused by sensitive microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea;
  • For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Dispersible tablets 125 mg, 250 mg, 500 mg and 1000 mg.

Instructions for use and dosage

The drug is taken orally. The drug is prescribed before, during or after meals. The tablet can be swallowed whole, divided into pieces or chewed with a glass of water, and can also be diluted in water to form a syrup (20 ml) or suspension (100 ml), which has a pleasant fruity taste.

The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

In the case of infectious and inflammatory diseases of mild to moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years of age are prescribed pomg 2 times a day or pomg 3 times a day; children aged 3 to 10 years are prescribed 375 mg 2 times a day or 250 mg 3 times a day; Children aged 1 to 3 years are prescribed 250 mg 2 times a day or 125 mg 3 times a day.

The daily dose of the drug for children (including children under 1 year old) is mg/kg per day, divided into 2-3 doses.

When treating severe infections, as well as for hard-to-reach foci of infection (for example, acute otitis media), a three-time dose is recommended.

For chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times a day; children - 60 mg/kg per day, divided into 3 doses.

For acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.

For patients with impaired renal function with CC≤10 ml/min, the dose of the drug is reduced by 15-50%.

In case of mild to moderate infections, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

The drug must be continued for 48 hours after the symptoms of the disease disappear.

  • change in taste;
  • nausea, vomiting;
  • diarrhea;
  • dysbacteriosis;
  • stomatitis, glossitis;
  • hepatic cholestasis;
  • pseudomembranous and hemorrhagic colitis;
  • leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia;
  • excitement, anxiety;
  • insomnia;
  • ataxia;
  • confusion;
  • behavior change;
  • depression;
  • peripheral neuropathy;
  • headache;
  • dizziness;
  • skin reactions, mainly in the form of a specific maculopapular rash;
  • hives;
  • skin hyperemia;
  • erythematous rash;
  • rhinitis;
  • conjunctivitis;
  • arthralgia;
  • toxic epidermal necrolysis;
  • allergic vasculitis;
  • anaphylactic shock;
  • angioedema;
  • labored breathing;
  • vaginal candidomycosis;
  • superinfection (especially in patients with chronic diseases or reduced body resistance).
  • hypersensitivity to the components of the drug;
  • hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.

Use during pregnancy and breastfeeding

The use of Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

Amoxicillin is excreted in small quantities into breast milk, which can lead to the development of sensitization phenomena in an infant.

It is used in children according to indications according to the dosage regimen (including infants and newborns).

The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of exanthema of non-allergic origin.

A history of erythroderma is not a contraindication for the use of Flemoxin Solutab.

Cross-resistance with penicillin drugs and cephalosporins is possible.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

During a course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibacterial therapy.

When using estrogen-containing oral contraceptives and amoxicillin simultaneously, other or additional methods of contraception should be used, if possible.

Impact on the ability to drive vehicles and operate machinery

There were no reports of adverse effects of the drug on the ability to drive vehicles or operate machines.

Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, and to a lesser extent, acetylsalicylic acid and sulfinpyrazone suppress the tubular secretion of penicillins, which leads to an increase in T1/2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) exhibit synergism when taken simultaneously.

Antagonism is possible when taken with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides).

Simultaneous use of Flemoxin Solutab with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Antacids, glucosamine, laxatives, aminoglycosides, and food reduce absorption. Ascorbic acid increases absorption.

Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); enhances the absorption of digoxin.

Concomitant use of amoxicillin with allopurinol increases the risk of developing skin rash.

Analogues of the drug Flemoxin Solutab

Structural analogues of the active substance:

  • Amoxisar;
  • Amoxicillin;
  • Amoxicillin DS;
  • Amoxicillin sodium sterile;
  • Amoxicillin Sandoz;
  • Amoxicillin-ratiopharm;
  • Amoxicillin trihydrate;
  • Amosin;
  • Gonoform;
  • Grunamox;
  • Danemox;
  • Ospamox;
  • Hiconcil;
  • Ecobol.

Similar medications:

Other medicines:

News edited by: admin015, 16:26

Source: http://instrukciya-otzyvy.ru/118-flemoksin-solutab-po-primeneniyu-analogi-tabletki-angina-gaymorit-i-drugie-infekcii.html

Flemoxin is a well-known antibiotic in an innovative form

Flemoxin is a generic version of one of the most popular antibiotics in the world - Amoxicillin. The original drug was developed by British pharmacists in the 60s of the last century. Amoxicillin appeared on the pharmaceutical market in the early 70s.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to look at this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

Amoxicillin is, without a doubt, one of the safest broad-spectrum antibacterial drugs. According to some reports, this penicillin antibiotic is almost the most prescribed medicine in pediatrics. Almost every reputable pharmaceutical company considers it its duty to release its own Amoxicillin. The Japanese corporation Astellas Pharma also succeeded in this matter by developing Flemoxin.

Flemoxin Solutab stands out from the monotonous background of Amoxicillins due to its release form. After all, the drug is available in the form of dispersible tablets, which have many advantages compared to the pills we are used to.

In this article we will try to understand how Flemoxin differs from its analogues, and also clarify the positive aspects of the drug. And let’s not ignore the negative qualities, which, of course, are also present.

Astellas Pharma: new life for antibiotics

Astellas Pharma is the largest Japanese pharmaceutical concern. It appeared in 2005 thanks to the merger of two well-known Japanese companies: Fujisawa Pharmaceutical Co and Yamanouchi Pharmaceutical Co.

Today, Astellas Pharma works in various areas of medicine, creating both original drugs and analogues of well-known brands. The company also produces several antibiotics, which have become widely known due to their dispersible form.

Each of these medicines has an additional word in the name indicating a special form - solutab. Dispersible drugs include:

  • cephalosporin antibiotic Ceforal solutab;
  • Unidox Solutab, widely known in Russia;
  • Vilprafen solutab;
  • Flemoxin Solutab and Flemoklav Solutab are two related drugs containing Amoxicillin as the active ingredient.

I would like to note that Flemoxin Solutab is registered only in Germany, Iceland, Portugal and the CIS countries.

Flemoxin solutab: composition of the drug

So, Flemoxin contains, as you already understood, the only active component - Amoxicillin - in the form of a stable compound (trihydrate).

Amoxicillin is a semi-synthetic penicillin, which in its chemical structure and spectrum of activity is very similar to Ampicillin.

As additional substances, Flemoxin contains chemical substances, which, in fact, ensure its solubility in a minimum volume of solvent. These include cellulose and MCC - microcrystalline cellulose.

Note that Flemoxin tablets have a pleasant citrus taste due to the addition of tangerine and lemon flavoring.

The color of the tablet can vary from pure white to yellowish or even light yellow. A change in color does not mean that the drug was stored incorrectly. Or, moreover, it is a crude fake. The color variations of Flemoxin are associated with the presence of cellulose compounds in it, in which color changes are allowed.

Forms of release of Flemoxin - for both children and adults

The wide range of Flemoxin includes both children's and adult forms of release, which differ only in dosage.

Unlike conventional oral antibiotics, Flemoxin is not presented in powder form for the preparation of a children's suspension. Therefore, parents of young patients are practically deprived of the opportunity to show their hidden pharmaceutical abilities, calculating the volume of water and diluting the white powder with trembling hands.

So, let’s list the release forms of Flemoxin Solutab.

Children's release forms:

  • Flemoxin solutab dosage 125 mg;
  • Flemoxin solutab at a dose of 250 mg.

Adult release forms:

  • Flemoxin solutab 500 mg;
  • Flemoxin solutab at a dose of 1000 mg.

Why can’t you split a Flemoxin tablet?

The oblong tablet of Flemoxin has a cross mark. Most patients believe that the score is needed in order to split the tablet in half. And get a dosage exactly half the original one.

I would like to explain to readers why experts persistently warn patients against such a division.

There may be two reasons why you should not divide the tablet into two parts. Firstly, many tablets are coated with a protective coating that protects them from the destructive properties of hydrochloric acid. However, this does not apply to Flemoxin - it is not coated, so we can go further.

The second and main reason is that when dividing a tablet, it is technically impossible to find out the dosage of the resulting parts. Even if you have a pharmacy scale at hand, and you were able to absolutely accurately divide a 1000 milligram tablet of Flemoxin into two equal parts, the amount of the active substance remains unknown. Why do you think?

Take another look at the drug packaging or instructions for Flemoxin. The composition of any tablet drug (as, by the way, most others) often contains many other substances in addition to the main active component. Using the example of Flemoxin Solutab at a dosage of 125 mg, we see that the content of cellulose, microcellulose (or MCC), as well as flavorings and saccharin is about 17% of the share of Amoxicillin. In this case, the active substance is distributed unevenly, and therefore the left half of the tablet may contain N percent more active substance than the right half. Or vice versa.

Accordingly, the effectiveness of different parts of the Flemoxin tablet may, to put it mildly, be different. And side effects too.

Now let’s remember that we are not dealing with ascorbic acid vitamins, but with a drug, the dose of which is carefully selected depending on age and the severity of the infection. And let’s remember the unshakable rule of pharmaceuticals: dividing a tablet in order to reduce the dosage is simply prohibited!

Exceptions may include some cardiac medications. In such cases, the manufacturers themselves take into account all the nuances and technologically achieve uniform distribution of all the components of the tablet.

Dispersible tablet: what is it?

Many patients, when they first encounter the name “dispersible tablet,” have difficulty imagining what it is. Meanwhile, more and more pharmaceutical companies are trying to put older drugs into dispersible form. Dispersible vitamins, antibiotics, and even erectile dysfunction drugs are appearing on the market.

Dispersible tablets were originally created for patients who had difficulty swallowing. This condition, which is medically called dysphagia, occurs in 35% of the general population and in 60% of older people.

The first dispersible tablets dissolved in the mouth to produce gas. Subsequently, new forms were developed, which included cellulose and its compounds. We have already mentioned that Flemoxin solutab is one of these drugs.

Advantages of dispersible form

So, let's figure out how Flemoxin dispersible tablets differ from regular Amoxicillin and what their advantage is.

So, the dispersible form of Flemoxin:

Flemoxin dispersible tablets are absorbed in the oral cavity directly into the blood, bypassing the gastrointestinal tract. Due to this, the bioavailability of orally soluble tablets is an order of magnitude higher than that of oral tablets;

  • quickly reaches peak concentration.

Oral tablets begin to be absorbed into the blood within 15–20 minutes after administration, at best. Dispersible dosage forms (including Flemoxin) are absorbed within 5 minutes after dissolving in the mouth;

  • more convenient for pharmaceutical substances that are unstable in water.

An excellent example is children's Flemoxin Solutab 125 mg, which is much more convenient in the form of soluble tablets than Amoxicillin suspension;

  • can be used for newborns and infants;
  • does not require additional manipulations before use, unlike, for example, a suspension that needs to be prepared;
  • may be dissolved in breast milk;
  • Requires very little water to dissolve.

Every parent knows how important it is that the medicine is not only effective, but also tasty. A mother who is trying to pour the hated bitter medicine into a sick child while the father is holding the child by the arms and legs is a very sad picture. And not that rare.

Astellas Pharma pharmacists masked the traditionally bitter taste of Amoxicillin with citrus flavors and saccharin. Therefore, Flemoxin Solutab is a tasty medicine for children.

Flemoxin pharmacokinetic data provide convincing evidence of its benefits

The pharmacokinetic properties of drugs largely determine their effectiveness. This is an axiom that does not require proof.

For example, one of the most negative aspects of Flemoxin’s predecessor, Ampicillin, is low absorption and short half-life. Imagine that two-thirds of the antibiotic is not absorbed at all. That is, you drink one gram of a drug that is not the safest, but only 300 mg enters the blood. The remaining part is excreted from the body, simultaneously “working” in the intestines on your previously quite viable microflora. Not the most pleasant prospect, is it?

Therefore, one of the main tasks of modern pharmaceuticals is the search for new drugs and forms that have a high level of bioavailability. And Flemoxin Solutab, without any doubt, can be called one of these drugs.

Flemoxin is absorbed into the blood very quickly - within 5-10 minutes - and almost completely. The bioavailability of dispersible Amoxicillin is close to 93%. Note that for oral dosage forms such figures are practically record-breaking. In comparison with oral Amoxicillin, Flemoxin also clearly wins in this indicator. Thus, the bioavailability of conventional tablet forms of Amoxicillin rarely exceeds 75-80%.

Flemoxin packaging: tightness is a condition of preservation

Flemoxin dispersible tablets are extremely sensitive to moisture. To protect the tablet from moisture in the air, it is necessary to ensure that the packaging is completely sealed. Flemoxin is packaged in aluminum blisters, which guarantee protection of the antibiotic from premature decomposition.

If you accidentally squeezed a Flemoxin tablet out of the cell, it is better to either take it immediately or dispose of it, that is, mercilessly throw it in the trash.

It should be remembered that due to the high cellulose content, there is a possibility of gradual dissolution of the tablet in air moisture. And we know that any antibiotic, including Flemoxin, is unstable in a dissolved state.

Therefore, a Flemoxin tablet that was stored in damaged packaging or, even worse, without it, may turn out to be, at best, a harmless dummy.

Flemoxin solutab: spectrum of pharmacological activity

Amoxicillin, the active ingredient in Flemoxin, is active against many gram-positive and gram-negative bacteria. Among them:

  • streptococci - Streptococcus pyogenes and Streptococcus pneumonia;
  • staphylococci, including Staphylococcus aureus;
  • clostridia;
  • gonorrhea pathogens Neisseria gonorrhoeae;
  • listeria;
  • causative agent of peptic ulcer Helicobacter pylori.

Low activity of Flemoxin is recorded against most pathogens of intestinal infections:

And finally, Proteus, Enterobacteriaceae, and microorganisms that produce beta-lactamases are absolutely insensitive to the action of Flemoxin.

Beta-lactamases and Flemoxin: a fight for life

In the instructions for Flemoxin and other penicillin, as well as cephalosporin antibiotics, the term “beta-lactamase” is often used. Usually, patients who carefully study the annotations intuitively understand that lactamase is probably something very bad. But it is not always possible to clearly understand what it is and what, exactly, the harm of beta-lacatmaz is.

Let's try to find out who or what this beta-lactamase is. Let's start by remembering when the first penicillins began to be used.

The history of antibiotics goes back more than 70 years. During this period, many microorganisms learned to recognize the destructive antibacterial substance. Modern strains of bacteria already synthesize antidotes for at least two groups of antibiotics—penicillins and cephalosporins. The role of “antidote” is played by special enzymes from the group of beta-lactamases (penicillinases), which destroy the beta-lactam ring of the antibiotic. As a result, the drug is completely inactivated and has no antibacterial effect.

The first bacteria that learned to produce penicillinase were staphylococci. And, if in 1944 only 5% of Staphylococcus aureus strains produced the enzyme, now this figure has increased many times and is almost 90%!

In addition, bacteria that produce beta-lactamase include streptococci, as well as many gram-negative microorganisms, including Klebsiella, Enterobacteriaceae, Pseudomonas and other pathogens.

So, when infected with microorganisms that produce beta-lactamases, neither Flemoxin, nor other analogues of Amoxicillin, nor Ampicillin are absolutely effective.

Therefore, a correct assessment by a doctor when prescribing unprotected penicillins is so important. The specialist’s task is to differentiate the pathogen and “not to miss” in choosing an antibiotic.

Flemoxin or Flemoklav, which is better?

The Astellas Pharma company produces another antibiotic containing Amoxicillin, Flemoclav. Both the name and packaging of the drug are very similar to Flemoxin, however, there is a significant difference between these drugs. Let's figure out how these seemingly similar antibiotics differ.

We have already found out that some strains of microorganisms produce beta-lactamase, which inactivates Flemoxin. Therefore, for many infectious diseases, Amoxicillin, the active ingredient in Flemoxin, is absolutely ineffective.

Researchers from the British company Beecham, which developed Amoxicillin, have managed to find a substance that blocks beta-lactamases. This substance turned out to be clavulanic acid. Scientists have proven that the combination of clavulanic acid and penicillin antibiotics is effective against strains of bacteria that produce beta-lactamase.

This is how a new antibacterial drug with an extended spectrum of action appeared. The original antibiotic was released by Glaxo under the name Augmentin. By the way, thanks to the protective effect of clavulanates, complex antibiotics began to be called protected. After all, clavulanic acid really serves as a real protection for the lactam penicillin ring from destruction!

The Japanese corporation Astellas Pharma has developed a dispersible form of protected Amoxicillin - Flemoklav.

Patients often wonder: which antibiotic is preferable - Flemoxin or Flemoklav? Only a specialist who relies not only on theoretical, but also on practical knowledge can resolve this dilemma.

When deciding on the selection of a particular antibiotic, the doctor evaluates the history of the current disease, as well as experience in treating previous infections. The most important stage in selecting an antibiotic is differentiation of the pathogen. An error leads to incorrect prescription of the drug, and, therefore, to ineffective treatment.

Making a decision is complicated by the fact that in the vast majority of cases the pathogen is calculated empirically, that is, based on the symptoms of the disease. A qualified doctor will undoubtedly be able to do this. But a medical amateur is definitely not able to do this. Therefore, patients should remember: the decision to prescribe antibiotics and the choice of a specific drug should be entrusted to the doctor or clinical pharmacist. And no one else!

Flemoxin solutab: when to take?

Indications for the use of Flemoxin are primarily related to the spectrum of pharmacological activity of the drug. Note that Amoxicillin is included in the treatment protocols for many infectious diseases.

Modern semi-synthetic penicillin - Flemoxin solutab - is the drug of choice for uncomplicated pathologies of the respiratory tract of bacterial origin. I would like to place special emphasis on the word “uncomplicated”. In case of a moderately severe disease or a severe, complicated course of infection, protected penicillins or antibiotics of other groups are preferred to Flemoxin.

So, let's list the main diseases for which Flemoxin Solutab is indicated:

- acute otitis media - inflammation of the middle ear.

In the initial treatment of acute otitis media, Flemoxin is the first-line drug, that is, the preferred antibiotic. However, if the disease is aggravated by severe otalgia (ear pain), a temperature above 39 degrees, then the doctor may suspect infection with beta-lactamase producing strains of Haemophilus influenzae and Moraxella catarrhalis. In such cases, the drug of choice is Flemoclav, that is, protected Amoxicillin.

- pharyngitis and tonsillitis - inflammation of the mucous membrane of the pharynx and tonsils.

As a rule, these diseases are caused by Streptococcus pyogenes, which are highly sensitive to Amoxicillin. Standard treatment protocols indicate that for bacterial tonsillitis Flemoxin solutab is the drug of choice. However, if the disease is recurrent in nature, that is, it recurs periodically over, for example, one year, then preference is given to a combination with clavulanates, as well as macrolides or cephalosporins.

- lower respiratory tract infections.

The main causative agents of pneumonia and bacterial bronchitis - alpha and beta hemolytic streptococci, Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae - are sensitive to Flemoxin. Therefore, for uncomplicated bronchitis and pneumonia, Flemoxin Solutab can be used.

- skin infections caused by sensitive streptococci, Staphylococcus aureus and Escherichia coli.

- urinary tract infections.

Flemoxin is effective for inflammatory diseases of the kidneys and bladder if they are caused by sensitive enterococci Enterococcus faecalis, Escherichia coli or Proteus. For the treatment of uncomplicated urinary tract infections caused by enterococcus, Flemoxin is the drug of choice.

However, it is worth considering that some strains of E. coli are resistant, that is, completely insensitive to Amoxicillin. Meanwhile, cystitis - inflammation of the bladder - in most cases is caused by E. coli. Therefore, Flemoxin is prescribed with caution for urological infections.

- typhoid fever and salmonellosis.

Flemoxin is considered an alternative antibiotic for these infections and is used when first-line drugs are contraindicated. Note that the drugs of choice are fluoroquinolone antibiotics and third-generation cephalosporins.

Flemoxin is used in cases of early localized Lyme disease.

Treatment of peptic ulcer with Flemoxin

Long gone are the days when peptic ulcer disease was considered an incurable chronic disease that truly aggravated the patient’s life. Ulcer sufferers no longer need to be teetotalers, drink potato juice on an empty stomach, or poison themselves with vinylin. And especially to lie down on the operating table.

Thanks to the discovery of the role of a banal infection in the formation of ulcers in the wall of the stomach or duodenum, quick and effective therapy for these diseases has become possible. Helicobacter pylori infection, the causative agent of which is the microorganism Helicobacter pylori, is the cause of peptic ulcer disease in almost 90% of cases. In addition, Helicobacter provokes the development of atrophic gastritis, a dangerous inflammatory disease of the stomach wall, which is a risk factor for ulcers and even stomach cancer.

For a long time, scientists could not even imagine that anything living could survive in a highly hydrochloric acid environment. It turned out that Helicobacter pylori not only survives, but also actively reproduces. The bacterium synthesizes a special enzyme that neutralizes the hydrochloric acid of the stomach - that’s the whole secret of survival.

Meanwhile, Helicobacter responds well to therapy. The complex treatment regimen for the infection includes two antibacterial drugs (one of which is Flemoxin), as well as a proton load inhibitor. The last medicine is necessary in order to completely neutralize hydrochloric acid in the stomach. Otherwise, healing of the inflamed area is simply impossible.

So, one of the most effective treatment regimens for peptic ulcer disease includes Amoxicillin (Flemoxin Solutab), Clarithromycin and a proton pump inhibitor (for example, Omeprazole, Lanzaprozole and other drugs). If you are intolerant to Clarithromycin, use a two-component regimen or add Metronidazole as an antimicrobial agent.

STD treatment

The abbreviation STD hides not the most pleasant diseases - diseases that are sexually transmitted.

Flemoxin is used only for two infections, and only in special cases. Let's look at them in more detail:

Amoxicillin was previously widely used to treat uncomplicated cases of gonorrhea. But recently, penicillin-resistant strains of Neisseria gonorrhoeae have emerged, so Flemoxin is often replaced with another antibiotic.

Flemoxin is a first-line treatment for uncomplicated urethritis (inflammation of the urethra) and cervicitis (inflammation of the cervical canal) during pregnancy. Note that in most cases of chlamydia in pregnant women, instead of Flemoxin or other Amoxicillin, Sumamed is still used, which is considered the drug of choice.

Flemoxin is usually prescribed in case of individual intolerance to macrolides.

Standard dosages of Flemoxin according to the instructions for use

Let us immediately emphasize that any antibacterial drug is dosed individually. And Flemoxin is no exception to the rule. In each specific case, the doctor assesses the severity of the disease, medical history, that is, medical history, as well as concomitant diseases. And based on this information, he selects the correct dosage.

However, there are still standard dosages of Flemoxin - something like the average body temperature in the ward. We emphasize that they are necessary for the doctor, not for the patient. And even more so, you should not rely on this information in order to prescribe the most correct treatment regimen for yourself.

So, according to the instructions for use of Flemoxin, the following dosages are recommended:

  • For children from 1 to 3 years old, Flemoxin 250 mg tablets are used twice a day. An alternative prescription may be 125 mg of Flemoxin three times a day at regular intervals;
  • The maximum dose of Flemoxin for a child is 60 mg per kilogram of weight per day. This dosage is indicated for severe infectious processes;
  • for children from 3 to 10 years old, 375 mg of Flemoxin is prescribed twice or 250 mg three times a day;
  • for children over 10 years of age and adults, the average dosage of Flemoxin is 500–750 mg twice or 375–500 mg three times a day.

For severe infections, Flemoxin can be used up to 3 grams per day, certainly divided into three doses.

The duration of treatment, as well as the dosage of Flemoxin, is selected individually. Please note that the minimum course of therapy should not be less than five days. The standard treatment regimen consists of a weekly course of antibiotics. If the infection is caused by the streptococcus Streptococcus pyogenes, Flemoxin is used for at least 10 days.

It is worth emphasizing that antibiotic treatment should not be stopped immediately after the symptoms of the disease disappear. This haste is fraught with the formation of resistant strains from among selected and strong bacteria, on which Flemoxin simply does not have time to act.

In order to avoid complications, it is necessary to continue treatment with Flemoxin for two days after the manifestations of the infection stop. At the same time, we must not forget that the minimum course should not be less than five days.

Chew, swallow, dissolve, or what is the best way to take Flemoxin?

When encountering dispersible tablets for the first time, many patients wonder what is the best way to take Flemoxin. We will try to answer this question and clarify whether there is a difference between the methods of taking this drug.

So, one of the most significant advantages of Flemoxin Solutab is the ability to choose a method of use that is convenient for the patient.

Depending on the individual characteristics and personal preferences of each Flemoxin tablet, you can:

  • chew in the mouth;
  • suck like a lollipop;
  • dissolve in a small amount of cool boiled or simply purified water;
  • dissolve in breast milk - for infants;
  • dissolve in any juice, compote, tea and other drink. The only condition is that the drink should not be hot.

Let us immediately note that there is no fundamental difference in the methods of application. The rate of absorption, bioavailability and metabolism of Flemoxin do not depend on how long you chewed the tablet or how much juice you diluted in.

In addition, the pharmacokinetic properties of Flemoxin are not affected by food intake. You can take the tablet before meals, during lunch or after dinner, and in all cases the bioavailability of the antibiotic will be the same.

Contraindications to taking Flemoxin

Do not forget that Flemoxin is an antibacterial drug that has side effects and contraindications. However, in fairness, it is worth noting that Amoxicillin is one of the safest antibiotics.

So, we list the absolute contraindications to taking Flemoxin:

- individual sensitivity to penicillin antibiotics.

The likelihood of an allergic reaction to Flemoxin is low. However, if you are allergic to medications, especially antibiotics, do not forget to warn your doctor about this. A specialist will be able to assess the risk and choose the right antibacterial agent.

In addition, do not forget about cross-sensitivity between penicillins and cephalosporins. If you have had an allergic reaction, for example, to ceftriaxone or any other antibiotic from the cephalosporin group, then it is also better to replace Flemoxin.

Erroneous prescription of Flemoxin and other penicillins for this disease leads to the appearance of an erythematous rash. Note that the symptoms of infectious mononucleosis are similar to those of bacterial pharyngitis and tonsillitis. However, mononucleosis is caused by a virus and does not require antibiotic treatment. Only a doctor can make the correct diagnosis and prescribe the correct medication.

Flemoxin during pregnancy: risks and benefits

Flemoxin is one of the antibiotics conditionally approved for use during pregnancy. The instructions for Flemoxin indicate that the drug can be used in cases where the risk to the child is less than the expected benefit to the mother.

Don't be afraid of this wording. It is caused solely by the fact that clinical trials of Flemoxin on pregnant women have not been carried out, and it is unlikely that they will ever be carried out for obvious reasons.

Nevertheless, Flemoxin is considered one of the safest antibiotics that can be used during pregnancy. And quite a long experience of using it is excellent proof of this. But let us emphasize once again that any antibiotic, including Flemoxin, can only be prescribed by a doctor. Think about your health and the health of your unborn child.

Side effects associated with treatment with Flemoxin

Flemoxin is one of the antibiotics that is well tolerated. However, there is a possibility of adverse events during or after treatment with the drug. Among them:

in 1-10% of cases the following are registered:

  • development of vulvovaginal fungal infection (in 2% of patients). In such situations, during treatment with Flemoxin, parallel use of antifungal drugs, for example, Fluconazole, is recommended;
  • diarrhea (in 1.7% of patients). As a rule, this symptom does not require discontinuation of Flemoxin and goes away on its own;
  • nausea (in 1.3% of patients);
  • headache (in 1% of cases).

in less than 1% of cases the following are possible:

In less than 1% of cases treated with Flemoxin, a rather serious side effect may develop - pseudomembranous colitis. The cause of this condition is a change in the composition of the intestinal flora and the proliferation of opportunistic microorganisms Clostridium difficile. Clinically, pseudomembranous colitis is manifested by severe diarrhea, which is fraught with general dehydration of the body.

When such symptoms appear, the first thing the patient should do is to immediately notify the attending physician. Usually in such cases, the only possible solution is to discontinue Flemoxin and prescribe another antibiotic or antimicrobial drug to which clostridia are sensitive. In addition, restoring the water-salt balance in the body plays an important role.

Flemoxin solutab - analogues

The pharmaceutical market is replete with generics of Amoxicillin from a variety of manufacturers. Let's try to list those Flemoxin analogues that have earned positive reviews from doctors:

  • Amoxicillin produced by the Serbian company Hemofarm;
  • Amoxicillin Sandoz, which is produced by the French corporation Sandoz;
  • Hiconcil, a drug from the Slovak company KRKA;
  • Ospamox produced by the Austrian pharmaceutical concern Biochemi;
  • Amosin, Russian pharmaceutical company Synthesis.

Despite the abundance of analogues of Flemoxin Solutab, very few drugs have the same dispersible form. These include the Austrian Ospamox DT.

And the last thing I would like to note. Despite the wide selection of Flemoxin analogues, one should not forget that the prerogative of both prescribing an antibiotic and selecting a generic belongs exclusively to the doctor.

The article above and comments written by readers are for informational purposes only and do not encourage self-medication. Consult a specialist regarding your own symptoms and illnesses. When taking any medicine, you should always use the instructions that come with the medicine and your doctor's advice as a guide.

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It is also worth paying attention to other medications:

I didn’t notice any side effects: we didn’t have diarrhea, although we didn’t take Linex. The doctor said that Flemoxin does not cause dysbacteriosis, and he was right.

Be careful! Especially with children!

By the way, having exceeded the dose of the drug (it happened (((, severe cough with vomiting, I thought that the drug was not absorbed and repeated taking the medicine again.) we were covered with a rash, recalculated the dose for that day and that’s it, the rash went away and we were treated for 5 days.

Mother of two sons (2.5 and 5 years old).

Repeated use caused anaphylactic shock. Pale face, blue lips, leg and arm cramps, respiratory arrest and loss of consciousness. Unfortunately, there are doctors who “earn their living” in front of drug companies, without thinking about the life and safety of young patients.

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