Flemoklav or flemoksin

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Flemoxin and Flemoklav - is there a difference between the two drugs?

It is important to treat diseases of bacterial etiology efficiently and in a timely manner. Antibacterial drugs based on amoxicillin are excellent for this purpose.

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They not only help in a short time to stop the adverse effects of microflora on the body, but also completely destroy it.

Today, the antibiotic market is filled with a huge number of drugs that differ in potency and other characteristics. In today's material, our resource decided to take a closer look at such popular medications as Flemoxin and Flemoklav, and also highlight the most significant differences between them.

Flemoxin Solutab - composition, properties and release form

Flemoxin Solutab is a broad-spectrum antibacterial agent

Before analyzing the effects of drugs on the human body and highlighting the differences between them, it would be a good idea to consider each antibiotic separately. Let's start looking at medications with Flemoxin.

So, the trade name of this antibiotic looks like “Flemoxin Solutab”. The drug belongs to the group of antibacterials based on the active substance “amoxicillin” (the pharmacological group of the drug is penicillin, semi-synthetic antibiotics). Flemoxin is produced in white or slightly yellow tablets, which have an oval shape and an image of the manufacturer’s logo, as well as a digital designation. The latter is identification and indicates how much active substance the tablet contains.

Digital identification has the following grouping:

The tablets are sorted into rectangular packages and similar blisters, which contain 5 tablets each and are presented in 2 or 4 copies.

The active ingredient in the drug "Flemoxin Solutab" is represented by amoxicillin, which is contained in the drug in the dosages mentioned above.

In addition, the drug contains dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, saccharin, magnesium stearate and some flavorings.

The properties of Flemoxin Solutab are standard for its pharmacological group. In simple terms, this drug stops the development of the bacterial microflora that caused the disease, and over time reduces its adverse effects on the patient’s body to a minimum. Thanks to this, the antibiotic is accepted for its excellent bactericidal properties all over the world.

More information about the drug Flemoxin Solutab can be found in the video:

You can take Flemoxin Solutab for pathologies of bacterial etiology in such human organs as:

  • respiratory system organs
  • genitourinary system organs
  • organs of the gastrointestinal tract
  • leather and other soft tissues

It is important to take the drug taking into account the recommendations of the treating specialist and the background information provided in the instructions for the antibiotic. It is in the latter that you can learn in more detail about contraindications, dosages and other things related to Flemoxin Solutab.

Flemoklav Solutab - composition, properties and release form

Flemoxin Solutab effectively treats respiratory diseases caused by bacterial infection

Flemoklav Solutab, in turn, is not much different from its opponent in terms of release form. This antibiotic is also available in tablets similar in size to Flemoxin. However, the tablets are divided into 4 per blister, which can be from 4 to 8 in one package. At the same time, Flemoklav contains slightly less active substance (the same amoxicillin) than in the previously considered drug.

Depending on the form of release, the antibiotic may contain from 125 to 875 mg of active substance, supplemented by an appropriate dose of a special substance - clavulanic acid.

The composition of Flemoklav Solutab includes:

  • active substance – amoxicillin trihydrate
  • clavulanic acid
  • microcrystalline cellulose
  • vanillin
  • saccharin
  • magnesium stearate
  • flavorings

Similar to Flemoxin, Flemoklav has antibacterial properties with a wide spectrum of effects, since both drugs belong to the same pharmacological group - penicillin, semi-synthetic antibiotics.

Despite this similarity, the medication is taken in fewer situations.

Thus, Flemoklav is widely used in the treatment of the following pathologies:

  • respiratory diseases
  • diseases of the genitourinary system
  • lesions of the skin and soft tissues
  • rarely – gastrointestinal pathologies

The dosage for use is determined solely by the doctor based on the severity of the disease and the age of the patient. It is worth understanding that correct use is a fundamental factor in successful therapy, therefore it is necessary to take Flemoklav taking into account the recommendations of the treating specialist and the manufacturer of the drug. You can find out about contraindications, expiration dates and similar things about a medication by carefully reading the instructions for it.

Flemoxin and Flemoklav - what is the difference?

It would seem that after receiving general information about both Flemoxin and Flemoklav, it is extremely difficult to identify any differences between the drugs. However, this is a rather erroneous judgment, since, delving into the study of antibiotics more deeply, a number of differences can be identified between them. Our resource has carried out this procedure and is ready to present you with its results.

First of all, we note that Flemoclav Solutab contains clavulanic acid, but its opponent does not. This difference makes the first antibiotic more resistant in the fight against bacterial microflora, since it is clavulanic acid that binds to bacterial beta-lactamases, which helps protect the antibiotic from the adverse effects of particularly strong microorganisms and their enzymes that can destroy the drug and neutralize its effects. Such a minor nuance puts Flemoklav Solutab in a more honorable position relative to his today's opponent.

In addition, the combined use of clavulanic acid and amoxicillin allows Flemoclav to provide additional benefits:

  • increase the versatility of the drug, that is, this antibiotic is able to fight a larger list of bacteria than its opponent - Flemoxin
  • reduce the dose of the antibiotic taken, since amoxicillin is supplemented with an appropriate dose of clavulanic acid (for example, 250 + 62.5 Mg or 875 + 125 Mg)

Despite the smaller list of pathologies for the treatment of which Flemoklav is used, it is more universal, especially in the treatment of respiratory tract pathologies. It is worth noting that both drugs we are considering are produced by the same pharmacological company from Holland. In fact, they are close analogues with slight differences in composition, which modify the method and effect of the drugs.

Comparing the statistical data collected by specialists regarding treatment with Flemoxin and Flemoclav, the following can be highlighted:

  • When using the first antibiotic, about 50% of people notice a noticeable effect from the drug
  • when using a medication containing clavulanic acid, this effect is noted by more than 60% of patients

There are no other differences between the drugs, except for their cost. On average, Flemoklav costs % more than its opponent when used in similar situations.

Do not forget that both antibiotics are quite potent and should not be prescribed for self-medication by the patient himself or his relatives.

Which of them is most optimal for use in a particular case can only be determined by the attending physician who has the necessary information about the pathology and clinical picture of the patient’s illness. Improper organization of antibacterial therapy is a dangerous practice that can cause some complications in the patient, remember this.

Summarizing today's material, we note that Flemoxin and Flemoklav are highly soluble and very similar antibiotics, but they still have differences between themselves. The most significant of these is the general principle of influencing unfavorable microflora. It can be stated that Flemoclav is a more universal antibiotic that will perform slightly better than its opponent. Despite this, the final choice between two drugs should be made only by the treating specialist, taking into account all the characteristics of the patient’s disease. We hope that the previously presented material was useful to you. Good luck in treating your illnesses!

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The medical information published on this page is strictly not recommended for self-medication. If you feel negative changes in your health, immediately contact an ENT specialist. All articles published on our resource are for informational purposes only. If you use this material or a fragment of it on your website, an active link to the source is required.

Source: http://tvojlor.com/lekarstva/flemoksin-i-flemoklav-otlichie.html

Flemoxin Solutab: features of the antibiotic

Flemoxin is an antibacterial drug with a wide spectrum of antimicrobial action, belonging to the group of semisynthetic penicillins.

The international name of the active ingredient is amoxicillin.

Various pharmaceutical manufacturers produce analogues of amoxicillin under the names: Flemoxin, Flemoxin Solutab, Flemoklav, Amoxicar, Amoxil, Amoxiclav, Ospamox, Hiconcil and others.

Despite the emergence of new modern highly active antibacterial agents in recent years, changes in the sensitivity of microbial flora to antibiotics, amoxicillin remains the most popular drug in the treatment of acute and exacerbation of chronic uncomplicated respiratory infections, ENT diseases, kidney diseases, urogenital tract, and surgical infections. It is actively used in pediatric practice, convenient and effective during outpatient treatment of patients.

Mechanism of action

Amoxicillin and its analogs have a bactericidal effect, destroying the cell membrane of microorganisms sensitive to it, thereby contributing to the destruction and death of the pathogenic agent.

  1. Since Flemoxin belongs to the group of semi-synthetic penicillins, it is effective against many both gram-positive and negative microorganisms.
  2. Those sensitive to it are Escherichia coli, Proteus, Salmonella, Shigella, Leptospira, and some types of chlamydia.
  3. When used in combination with metronidazole, it is prescribed to eliminate Helicobacter pylori lesions of the stomach and duodenum.
  4. Penetrates the placental barrier and is excreted in breast milk.

Features of interaction

Once ingested, it quite easily penetrates all organs and tissues, reaching maximum concentration in the blood after 1.5-2 hours; up to 70% of the drug is excreted by the kidneys. Duration of action is about 8 hours.

Flemoxin is the drug of choice, widely used in pediatric practice, in the treatment of most infectious diseases of the respiratory tract and ENT pathologies.

The current problem of using antibacterial therapy at the present stage is the following issues:

  • How to prevent the emergence of therapy-resistant strains of microorganisms.
  • How to increase the duration and effectiveness of the biological action of a drug without increasing its dosage.

To potentiate the antibacterial effect of amoxicillin, reduce the formation of antibiotic-resistant pathogenic microflora, in order to increase the bioavailability of the drug, various pharmaceutical companies are currently producing:

  • Combination drugs containing two components: amoxicillin and clavulanic acid.
  • Release of the drug in the form of Solutab.

Clavulanic acid

Clavulanic acid is an active substance that is a lactamase inhibitor. Its structure is similar to the core of the penicillin molecule.

  • It is able to block penicillin-binding proteins contained in the microbial cell, thereby promoting the antimicrobial effect of the antibiotic and destroying the pathogen.
  • Thanks to clavulanic acid, the bactericidal effect of the antibacterial agent increases, while the dose of the drug does not change, and the spectrum of the antimicrobial action of amoxicillin is significantly expanded.

Tablets of clavulanic acid are also produced separately, however, in recent decades, combination drugs including amoxicillin and clavulanic acid have been successful: flemoclav, amoxiclav, augmentin, etc.

Solutab form

The release form of the antibacterial drug Solutab was patented by a Japanese pharmaceutical manufacturer several decades ago. The essence of the innovation is that the antibacterial drug is produced in the most convenient form - in the form of microspheres with an active ingredient contained inside.

The fundamental difference between the Solutab form and others is that:

  • The destruction of microspheres occurs precisely in the area of ​​the absorption window, making it possible to increase the useful concentration of the antibacterial agent and prevent premature destruction of the drug.
  • Thanks to this form, an increase in the concentration of the drug in the blood is achieved without increasing the dosage, and the biological activity of the drug increases.
  • The risk of common side effects from the ventricle and intestines is reduced.
  • Placing the active substance in microspheres not only helps to reduce the size of the tablet, which makes taking the drug more convenient for the patient, but also frees it from excipients: sugar and gluten, which is fundamentally important for patients suffering from diabetes and gluten intolerance.
  • The tablet is quite easy to swallow whole due to its small size, or pre-dissolve with water, which does not affect the therapeutic effect of the drug.

Using this type of placement of the medicinal component, today the company produces antibacterial drugs: Flemoxin Solutab, Flemoklav Solutab, Unidox Solutab.

Indications

All drugs whose main active ingredient is amoxicillin: Flemoxin and Flemoclav, Flemoxin Solutab and others, despite their structural features, shape and composition, have similar indications for use:

  1. Almost all uncomplicated respiratory infections and ENT diseases.
  2. Infections of the genitourinary tract - inflammation of the bladder, urethra, infectious kidney diseases.
  3. Infectious peritonitis, colitis, enteritis, inflammatory processes of the biliary tract.
  4. Infectious lesions of the skin and soft tissues.
  5. Prevention of postoperative infectious complications.
  6. Treatment of peptic ulcer in combination with metronidazole.
  7. Can be used as part of a combination treatment of various septic conditions.

Contraindications

Contraindications for taking medications whose main active ingredient is amoxicillin are:

  • The presence of intolerance to penicillin antibiotics.
  • History of colitis caused by taking antibacterial agents.
  • Manifestations of allergic diathesis, bronchial asthma.
  • Severe blood diseases.
  • Severe renal failure.

For pregnant and breastfeeding patients, flemoklav and flemoxin are prescribed only after assessing all the risks of possible undesirable effects. The active ingredient, amoxicillin, passes into breast milk quite easily and can cause unwanted side reactions in the baby.

Side effects

All antibiotics in this group can cause the following adverse reactions:

  • Allergic manifestations: urticaria, erythematous changes on the skin and mucous membranes, anaphylaxis.
  • From the digestive tract: nausea, vomiting, stool disorders, increased levels of liver enzymes, intestinal dysbiosis, colitis.
  • Neurological disorders: insomnia, psychomotor agitation or depression, seizures.
  • Headache, dizziness.
  • Changes in the level of platelets, eosinophils, leukocytes in peripheral blood.
  • Shortness of breath, tachycardia, joint pain.

Admission rules

During treatment, it is fundamentally important:

  • Maintain equal intervals of time between taking the drug.
  • Compliance with prescribed dosages and duration of treatment.
  • The drug can be taken regardless of meals; as a rule, it is well tolerated by patients. In order to reduce the likelihood of possible undesirable reactions from the digestive system, it is better to do this during or immediately after eating.
  • With long-term use, it is necessary to monitor biochemical and general blood parameters.

Which drug should I choose?

We examined the main mechanisms of action, indications, and contraindications of antibacterial drugs, the main active ingredient of which is amoxicillin. Patients may well have a question: what is the difference between Flemoxin Solutab and Flemoklav Solutab, what is the difference between Flemoxin and Flemoxin Solutab, what is the difference between the drugs, which one is better?

  1. The main component of Flemoxin, Flemoclav, Flemoxin Solutab is the same active ingredient - amoxicillin. These are drugs of the same group, the therapeutic effect of which is mainly due to amoxicillin, they differ in composition and release form.
  2. Flemoxin, Flemoxin Solutab are monopreparations containing only one main antibacterial substance - amoxicillin.
  3. Flemoklav, Flemoklav Solutab - in addition to amoxicillin, they contain clavulanic acid and are combined. On the one hand, such a composition provides a more complete therapeutic effect of the drugs, however, it should be understood that the incoming clavulanic acid can have independent side effects, causing undesirable reactions of the body.
  4. The word “Solyutab” in the name of the drugs characterizes the special form of packaging of the active substance of the drug in the form of microspheres, which helps to increase the biological activity of the drug, reducing the destruction of its active components.

It is impossible to give a definite answer when choosing what is better to take. Each drug has its own characteristics of action, rules of administration, special indications and contraindications.

The choice of a drug is a medical responsibility, and it is carried out taking into account the clinical picture of the disease, age, severity of concomitant diseases, and the individual characteristics of the patient.

Source: http://elaxsir.ru/lekarstva/antibiotiki/chem-otlichaetsya-flemoksin-ot-flemoksin-solyutab.html

Which is better Flemoxin or Flemoklav

The modern medicine market includes many drugs, which often have names similar to each other. Although drugs may have the same antimicrobial properties, they may differ in their mechanism of action. To understand which is better – Flemoxin or Flemoclav, you need to study their composition, pharmacological properties and contraindications. But we must not forget that antimicrobial agents should only be prescribed by the attending physician.

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Composition of drugs

Flemoxin is often presented as an analogue of Flemoklav, but pharmacists make a mistake, even though such a regimen is possible in accordance with pharmaceutical data. If you are unable to purchase one of these medications prescribed by your doctor, you do not need to purchase its equivalent, since the drugs have important differences.

Amoxicillin is the main active ingredient in both drugs, which is an antimicrobial substance from the penicillin series. It has a wide spectrum of action and destroys most known bacteria. However, Flemoklav contains clavulanic acid - this compound increases the activity of amoxicillin, since it is also an antibacterial substance and also protects the active substance from the effects of bacterial defense mechanisms.

The difference between antibiotics, Flemoxin and Flemoklav, is expressed in belonging to pharmacological groups. Flemoxin is a penicillin antibiotic, Flemoklav is a combination antibiotic (penicillin and beta-lactamase inhibitors).

Difference in Action

The chemical structure of amoxicillin is similar to that of ampicillin. Also, the spectrum of action of both substances is approximately the same, but amoxicillin is absorbed almost one and a half times better by the intestines, so that a high content of the active component in the blood is ensured in a short period of time.

Amoxicillin, ampicillin and some other antibiotics are classified as beta-lactams, since one of the constituent parts of the molecule is a compound called the “beta-lactam ring”. For this reason, they work almost identically. The effect is expressed in binding to the central part of the enzyme, which provokes the production of peptidoglycan.

For bacteria, peptidoglycan is an essential element for function. It is contained in the cell walls of the microorganism and is responsible for division. If its production fails, the cell is unable to divide. The bottom line is this: fission is a mechanism for the reproduction of bacteria, in which one cell “breaks up” into two daughter cells, and when the production of peptidoglycan is suppressed, the resulting cell does not bud off. Two cells do not live in one, so they die without ever separating.

It would seem - why create combination drugs and work to increase the effectiveness of active substances, if the mechanism is good in its simplicity. The problem is the evolution of bacteria - they have their own natural defenses and have developed resistance to drugs. They synthesize beta-lactamase enzymes, which neutralize beta-lactamase-based drugs during a hydrolysis reaction, so there is no therapeutic effect from amoxicillin in this case.

For this reason, Flemoklav contains clavulanic acid. This compound binds to beta-lactamases and neutralizes them, while the effect of the acid is irreversible. As a result, the main active ingredient of the antibiotic is not damaged by the bacterial enzyme and can act according to the standard scheme.

Which product to choose

Obviously, with differences in composition, the therapeutic effect will also differ. For example, there is no point in using Flemoxin to fight bacteria that synthesize beta-lactamase, since the action of the antibiotic will be blocked.

This can be solved with Flemoklav, which contains clavulanic acid. Taking this medicine provides important benefits:

  • expansion of indications for use and the list of bacteria that can be combated;
  • reducing the daily dose of the drug;
  • increasing the effectiveness of the drug in a lower dosage.

It can be concluded that a combined antibiotic is necessary for diseases caused by bacteria that synthesize beta-lactamases:

  • sinusitis;
  • bronchitis;
  • otitis;
  • skin and urinary tract infections;
  • inflammation in the oral cavity and subsequent suppuration (abscess).

Some research was carried out to select the proportions of the two active ingredients of Flemoclav in order to achieve good treatment effectiveness. At the moment, there are several ratios, but the Flemoklav packaging usually indicates the ratio of antibiotic to acid in a ratio of 4:1 or 7:1.

Statistics have established that therapy for childhood reactive arthritis, which included a combination of amoxicillin and clavulanic acid, gave results after a month of stable use. At the same time, the proportion of patients who took a combination antibiotic were cured faster than those who took only amoxicillin. Also, observations by dentists showed the effectiveness of Flemoklav in the postoperative period: swelling and pain subside much faster. Therapy for peptic ulcer disease also requires a combination medication to achieve rapid recovery and reduce the risk of relapse.

It is important to note that the differences lie not only in the therapeutic effect, but also in safety. The fact is that the use of clavulanic acid is fraught with adverse reactions. Thus, there are more contraindications for taking Flemoklav than for Flemoxin. Adverse reactions include stomach upset, nausea and vomiting, the risk of liver disease also increases significantly, and damage to the kidneys occurs.

Features of taking medications

Both remedies are good in that even a child can use them, but the medication should only be prescribed by a pediatrician, after conducting a preliminary examination of the small patient. The instructions state that Flemoklav can be given to children over 3 months old, and the dosage is no more than 30 mg per 1 kg of body weight once a day. The dosage of Flemoxin can be 2 times higher - a maximum of 60 mg per 1 kg of body weight per day. Since young children sometimes cannot or do not want to swallow tablets, the manufacturer has released a special powder form of antibiotics for ease of use.

Antibiotics are suitable for women during pregnancy at any stage of fetal development. Studies have shown that the combination of amoxicillin and clavulanic acid has no effect on intrauterine development and does not cause congenital anomalies. Despite this, doctors are reluctant to prescribe Flemoclav, preferring Flemoxin, which does not contain clavulanic acid. The doctor has the right to prescribe an antibiotic only after a thorough assessment of the possible risk to the unborn child and mother. Large doses (1000 mg tablets) are not prescribed to pregnant women, limiting themselves to lower concentrations.

If a woman is breastfeeding and has been prescribed a course of antibiotic therapy, then it is worth stopping breastfeeding and switching the baby to formula milk. The bottom line is that amoxicillin easily passes through the placental barrier and is mixed with breast milk, which may well cause sensitization in a small child and the appearance of diarrhea or candidiasis. Although your baby may not experience side effects, it’s not worth the risk.

For adults and children over 12 years of age, the doctor prescribes a dose according to the instructions. If the case of the disease is severe, then the attending physician doubles the dosage, but you should not take more than 1000 mg of amoxicillin in 8 hours. The duration of therapy is determined by the doctor depending on the severity of the disease, the tendency to recovery and other factors.

The regimen for taking the drugs is simple - the tablets are dissolved in 1/3 glass of cool water or swallowed and washed down with liquid. In addition, the tablets can be crushed and made into syrup with sugar (a good option for children). You should take the antibiotic before meals because it causes irritation to the digestive tract if you take the medicine on an empty stomach.

Can it be taken together?

Antibiotics reduce the effectiveness of birth control pills and medications that stimulate the synthesis of vitamins B10 and H1 due to the effects of amoxicillin.

If you take medications simultaneously with bactericidal antibiotics, the drugs will increase their effectiveness, but if you use bacteriostatic agents, the effectiveness will decrease.

Amoxicillin should not be taken together with laxatives, antacids and glucosamine, since the medicinal effect of antibiotics will be significantly reduced due to poor absorption in the intestine. However, ascorbic acid, on the contrary, improves the absorption of amoxicillin.

Diuretics and other drugs that block tubular secretion increase the amount of amoxicillin in the body. Amoxicillin increases the effectiveness of indirect coagulants, but it is necessary to regularly monitor blood clotting parameters when using drugs together.

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What is the difference between Flemoklav and Flemoxin?

Often, with the beginning of the cold season, people need to take antibacterial drugs that suppress the activity of pathogens. The most common medications are considered to be the group of penicillins, prominent representatives of which are Flemoklav with Flemoxin. This article will help you understand the difference between Flemoxin and Flemoklav.

Indications for use

Both Flemoklav Solutab and Flemoxin Solutab have fairly high effectiveness against pathogens, against which Amoxicillin is effective.

These medications are effective in eliminating the following pathologies:

  • infectious pathologies of the respiratory system;
  • genitourinary system infections;
  • inflammatory processes of the skin;
  • diseases of bone tissue;
  • ENT diseases.

Flemoxin Solutab differs from Flemoklav Solutab in the absence of a broad composition, due to which Flemoklav has an increased ability to eliminate bacteria from the lactamase environment.

This is the best drug to combat the following microorganisms:

  • staphylococcus;
  • Pseudomonas aeruginosa;
  • hydrophilic aeromonas.

Important! Taking medications together is strictly prohibited.

In addition, Flemoklav is distinguished by its effectiveness in treating gastrointestinal diseases; it is effective against the Helicobacter bacterium. This advantage is achieved by the drug due to the presence of clavulanic acid, which does not allow pathogens to resist drug exposure. If a patient takes Flemoxin Solutab and it turns out that the disease is caused by the above representatives, then the drug should be replaced with another, stronger drug.

Active substance

Based on pharmaceutical data, Flemoxin is an analogue of the drug Flemoklav. Sometimes in the pharmacy, if the original has run out, they offer this particular substitute. In fact, this alternative is not always correct. The active ingredient of both drugs is amoxicillin. It belongs to the penicillin series, which has a fairly wide spectrum of action and is effective against a large number of pathogens.

However, Flemoklav has a wider composition. Along with amoxicillin, it contains clavulanic acid, known as a blocker of enzymes of the causative agent of the disease, which also has antibacterial activity. This intensity further expands the range of antimicrobial actions. Due to this, Flemoklav is able to block the enzymes of pathogenic bacteria that destroy amoxicillin.

Important! Clavulanic acid, which is part of Flemoklav, enhances the effect of amoxicillin.

When describing comparisons between Flemoxin and Flemoclav, it should be noted that they are similar in their active component. Based on this, the principle of influencing pathogenic microorganisms is approximately similar. However, Flemoklav is a combination drug, and Flemoxin is a single drug. This is the main difference between these medications.

Compound

Flemoklav and Flemoxin were released in the Netherlands. On the pharmaceutical market they are presented as dispersed tablets that easily dissolve in water. The tablets are in a blister of 4 pieces. in everyone. Moreover, 1 package can contain 4-8 blisters. These medications have different dosages. For example, Flemoxin is issued in the following dose, which is indicated in mg:

Moreover, the amount of mg. shows the content of the active ingredient in 1 tablet form. Each tablet is engraved with the exact amount of active ingredient indicated. The exact content of clavulanic acid is added to the dosage of amoxicillin in Flemoclav. The tablets are also labeled with the amount of active ingredients listed in mg.

Advice: when the patient cannot take the medicine in tablets, it can be prepared in the form of a suspension, which will have a rather pleasant taste.

When is Flemoklav prescribed?

Many people cannot decide which is better, between Flemoxin or Flemoklav, or how to make a choice in favor of one drug or another. First of all, the combination drug is prescribed when pathogenic bacteria have developed resistance to amoxicillin. This often happens when using Flemoxin Solutab on your own or stopping the drug too early. Most often this situation occurs with the following diseases:

In medicine, an experiment was carried out in which children were treated for reactive arthritis for 30 days with Flemoxin and Flemoclav. In the group taking Flemoxin, complete cure occurred in 48% of cases. Those who were treated with the combination drug were cured in 58%. The same results were observed in the treatment of gastric ulcers caused by the Helicobacter bacterium. Therapy with Flemoklav gave complete recovery in 92%, and with a single dose of amoxicillin, a positive result occurred in 85% of cases.

In addition, operative surgery notes that the combination of amoxicillin with clavulanic acid leads to a reduction in the period of complete recovery. Typically, during recovery, patients taking this drug experience faster relief from swelling and less pain than those treated with Flemoxin.

Advantages of Flemoclav

Having considered the effect of both drugs, we can say that you can take both drugs if you have an infectious disease. Flemoxin can successfully cope with a number of pathogenic microorganisms. If the causative agent of the disease is not known in the patient, then it would be good to opt for Flemoklav. Since it gives a better chance of a speedy recovery due to the presence of clavulanic acid. Its introduction gives the combination drug the following advantages:

  • Expanded number of drug-sensitive microorganisms;
  • Reduced antibiotic dosage;
  • Increased effectiveness of the product.

Side effects

Mentioning the difference between Flemoxin and Flemoclav, it should be said that the single drug is safer to use. Everyone knows about adverse reactions of antibiotics. However, clavulanic acid, which is part of the combined product, also has a number of side effects. It turns out that while taking Flemoclav, a number of undesirable effects increase significantly and, accordingly, the number of contraindications increases.

Based on reviews of people who have taken this drug, it can be argued that the combination of clavulanic acid with an antibiotic increases complaints from the gastrointestinal tract several times. When taken regularly, the risk of liver pathologies increases 6 times.

Treatment of children

Both of these drugs can be prescribed in pediatrics for the treatment of bacterial infections. Moreover, the instructions say that they can be given to a child from 3 months of age. There is a difference in dosage between Flemoxin and Flemoklav for the treatment of children. When treating with the first drug, the calculation is made using the following formula: per 1 kg. The child’s weight is taken from 40 to 60 mg. amoxicillin. In severe cases of the disease, a large dosage of antibiotic is prescribed.

The daily dosage of Flemoclav should not exceed mg. per 1 kg. child's weight. A more precise recommendation for admission is given by the attending physician, based on the condition of the baby and his individual characteristics. When selecting a drug and its quantity, the child’s weight, type of pathogen, and the presence of chronic diseases are taken into account.

Cost of medicines

In addition, you should indicate the difference in price between Flemoxin and Flemoklav. Doctors usually prescribe treating the infection for a week, taking an antibiotic twice or three times a day. Since a standard package usually contains 20 tablets, you will need to purchase one package to complete the full course.

The cost of Flemoxin Solutab in pharmacies varies from 230 to 470 rubles. This difference in price depends on the dosage of the drug. Flemoklav Solutab can be purchased in exchange. per package. It follows from this that a combination antibiotic usually costs 20% more than a single drug.

Flemoxin and Flemoklav are quite serious drugs, treatment of which should be started only after a doctor’s prescription.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

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Flemoxin and Flemoklav - what is the difference?

When the cold season begins, every person thinks about choosing an effective medicine.

The complex of treatment for colds always includes an antibacterial drug. Some of the most common drugs in this group are Flemoklav solutab and Flemoxin solutab. These drugs are in great demand in medicine; you can buy them at any pharmacy and the packaging is very similar in appearance. Now he’ll try to figure out whether Flemoxin Solutab or Flemoklav - which is better?

To make a choice in someone’s favor, let’s consider how Flemoxin Solutab differs from Flemoklav Solutab.

Flemoklav Solutab

The drug is aimed at treating the respiratory system, which is caused by a bacterial infection. Flemoxin comes in the form of tablets. The active substance is amoxicillin. The dosage of the active ingredient depends on the form of release. The antibacterial agent may contain from 125 to 875 mg of the active component. The active substance is supplemented with a special component. It's called clavulanic acid.

Flemoklav is an antibiotic with a broad spectrum of action. Like Flemoxin, Flemoklav is part of the same pharmacological group - penicillin, semi-synthetic antibiotics.

Flemoklav is prescribed for:

  • respiratory tract diseases;
  • ailments of the genitourinary system;
  • lesions of the gastrointestinal tract.

Only the doctor who is seeing the patient can determine the required dosage, based on the severity of the disease and age.

Amoxicillin and clavulanic acid can develop a number of adverse reactions. Often, patients complain of stomach pain, vomiting, diarrhea, dyspepsia, flatulence and dryness of the oral mucosa. This drug can be prescribed to pregnant women. Clavulanic acid and Amoxicillin do not adversely affect intrauterine development. But in any case, in the first months, doctors try to replace Flemoklav with a more gentle drug. If, according to indications, a woman needs to undergo a course of treatment during breastfeeding, then it would be good to temporarily transfer the child to artificial feeding.

If you take Flemoklav according to all the rules, you can achieve quick positive results. To do this, you need to listen to all the doctor’s recommendations and carefully study the description of use.

Flemoxin contains amoxicillin. It is the active ingredient and exhibits resistance to trihydrate compounds. Amoxicillin is part of the group of semisynthetic penicillins. Their chemical spectrum and active structure are similar to Ampicillin.

Flemoxin consists of additional components, namely a chemical substance that ensures solubility in minimal volumes. Chemical substances include cellulose and microcrystalline cellulose.

To remove the bitterness in the tablets, pharmacists added special flavorings. Thanks to them, the tablets became pleasant in taste, reminiscent of the taste of tangerine and lemon.

This drug is also available in tablet form. Their color can be white or light yellow. Color may vary due to cellulose dosage.

Doctors can prescribe Flemoxin for children. Therefore, pharmacists have created special children's tablets with a lower dosage of the active substance. But it is very difficult to give a tablet to a small child, and Flemoxin is not available in powder form. Although, all oral antibiotics are produced in this form.

The attending physician can prescribe a drug to a woman during pregnancy, but only if the positive results outweigh the risk of adverse reactions.

The active substance flemoxin easily penetrates the placental barrier and is excreted in breast milk during lactation. This may cause sensitization in the newborn.

Side effects may include nausea, vomiting, and loss of taste buds. Also, due to individual intolerance to the active substance, the patient begins to experience allergic reactions in the form of skin rashes.

Release form of Flemoxin:

  • Flemoxin Solutab - dosage 125 mg;
  • Flemoxin Solutab - dosage 250 mg;
  • Flemoxin Solutab - dosage 500 mg;
  • Flemoxin Solutab - dosage 1000 mg.

What is the difference between Flemoxin and Flemoklav?

The chemical structure of amoxicillin is almost the same as ampicillin. It has the same spectrum of antibacterial actions. But there is one main difference - amoxicillin is more easily absorbed, thereby ensuring a higher level of the active component in the blood.

Penicillins, ampicillins, oxacillins, amoxicillins are beta-lactam antibiotics, that is, the structure of their molecules contains a beta-lactam ring. Because of this, they act identically on bacterial cells. The mechanism of action lies in the chemical structure: the antibiotic binds to the active center of the enzyme. A kind of catalytic exchange of peptidoglycan occurs. Peptidoglycan is an important component of bacterial cell walls. If the body produces it, then the division process is completed. When bacteria reproduce, one parent cell divides into two daughter cells. But, if peptidoglycan synthesis is inhibited, then the new cell does not receive its own separate place and is not separated from the parent. Because of this, two cells die.

Why then invent a combination drug if everything is so easy? Every pathogenic microorganism has a natural protective barrier. The process of evolution has developed special enzyme substances in them, these are beta lactamases.

So, what is the difference between these two drugs? Flemoclav contains not only amoxicillin, but also clavulanic acid. Beta-lactamases bind to clavulanic acid and inactivation begins. Therefore, the active component is not damaged by enzymes and exerts its antibacterial effect.

What is better Flemoxin or Flemoklav?

Above, we examined the compositions of these two drugs and determined that Flemoklav better fights pathogenic microorganisms that produce beta-lactamases. Meanwhile, Flemoxin does not resist these bacteria. But, more often, Flemoxin copes with infectious diseases.

If doctors have not diagnosed the disease, namely its causative agent, then it is better to take Flemoklav. The drug has a great chance of coping with infectious diseases of an inflammatory nature. In addition, clavulanic acid in some situations reduces the concentration of the antibiotic and increases effectiveness.

Although antibiotics have become popular, they have one negative effect - they negatively affect the microflora of the human body.

Therefore, doctors do not recommend taking antibiotics on your own. It is better to leave the choice to your doctor.

Also, the doctor will help you choose one of the two medications under consideration.

What is the difference between Flemoklav Solutab and Flemoxin Solutab?

Flemoxin Solutab contains one active ingredient - amoxicillin, and Flemoklav consists of two active ingredients - amoxicillin and clavulanic acid.

Due to the fact that Flemoklav contains clavulanic acid, the drug is considered more active.

If you compare the price, then Flemoklav is two times cheaper than Flemoxin.

If you decide to choose one of the medications that are not particularly different from each other, then first consult with your doctor. Self-medication can negatively affect your health.

Source: http://wmedik.ru/zabolevaniya/urologiya/flemoksin-i-flemoklav-v-chem-raznica.html

Flemoxin and Flemoklav - what is the difference?

Thanks to the discovery of antibiotics, many diseases have ceased to be deadly. Over the last century, many antibacterial agents have been synthesized, but amoxicillin, first introduced into clinical practice in the 70s, is still one of the widely used antibiotics. Its importance is so great that the drug has been listed by the WHO as an essential medicinal substance needed in the basic health care system of all countries. Let's compare modern antibiotics based on amoxicillin, which can be found in our pharmacies.

What is the difference between Flemoklav and Flemoxin?

There are contraindications, use only after consulting a doctor

The antibiotics contain the same active ingredient - amoxicillin . However, Flemoklav contains an additional active agent - clavulanic acid . Therefore, the pharmacological groups to which the drugs belong are different. Thus, the usual one belongs to the pharmaceutical group of penicillins, and Flemoklav belongs to penicillins in combination with beta-lactamase inhibitors.

Both drugs are products of Astellas Pharma Inc. (Netherlands) and are available in the form of easily dissolving tablets, as emphasized in their name (“Solutab”). But, if you compare other characteristics of the drugs, there is a difference in the dosage of amoxicillin.

Flemo xin is produced in the following dosages:

  • 125 mg;
  • 250 mg;
  • 500 mg;
  • 1000 mg.

Flemo Clav has the following dosages of amoxicillin plus a proportional amount of clavulanic acid (indicated in parentheses):

  • 125 + (31.25) mg;
  • 250 + (62.5) mg;
  • 500 + (125) mg;
  • 875 + (125) mg.

Difference in Action

In terms of its chemical structure, amoxicillin is closest to ampicillin. It has the same spectrum of antibacterial action, but unlike ampicillin, it is 40-60% better absorbed when taken per os (orally) and thus provides a higher concentration of the active substance in the blood.

Antibiotics of this series (penicillin, ampicillin, oxacillin, amoxicillin, etc.) are also called beta-lactams, because in the structure of their molecule they contain the so-called beta-lactam ring. Therefore, their mechanism of action on a bacterial cell is similar. It lies in the fact that, thanks to this chemical structure, the antibiotic binds to the active center of the enzyme that catalyzes the synthesis of peptidoglycan.

Peptidoglycan is a vital component of the bacterial cell wall. If it is not produced, the bacteria cannot complete the division process. When bacteria multiply, two daughter cells arise from one parent cell. However, when peptidoglycan synthesis is inhibited, the new cell will never receive its own “separate apartment” and will not bud off from the parent. As a result, both cells die.

If the mechanism is so simple and reliable, why come up with combination drugs? This is necessary because bacteria have natural protection. During evolution, they developed beta-lactamase enzymes that hydrolyze beta-lactam antibiotics.

So, Flemoklav, in addition to amoxicillin, contains clavulanic acid. This substance irreversibly binds to beta-lactamases and inactivates them. As a result, the antibiotic is saved from the damaging effects of the enzyme and can achieve its antibacterial effect.

"Solyutab" - packages of 250, 500 and 875 mg

What's better?

According to the differences in composition, the difference will also be observed in their therapeutic effect. Flemoxin cannot effectively fight bacteria that can produce beta-lactamases.

But the introduction of clavulanic acid into the composition of Flemoklav allows you to achieve the following advantages:

  1. expand the list of sensitive microorganisms (and therefore expand the indications for use);
  2. reduce the dose of antibiotic;
  3. increase the clinical effectiveness of the drug.

Thus, a combined antibiotic is the drug of choice in cases where the pathogenesis of the disease is due to the presence of microorganisms that produce beta-lactamases, namely when:

Many studies have been conducted to find the optimal combinations of amoxicillin and clavulanate. Nowadays, the ratios most often used in pharmaceuticals are 14:1, 7:1, 4:1, 2:1. In the drug Flemoklav, the ratio is 4 or 7 parts of antibiotic to 1 part of inhibitor.

A comparative evaluation of the effectiveness made it possible to establish that in the treatment of reactive arthritis in children, after only a month of taking amoxicillin in combination with clavulanate, an improvement was observed in 58% of patients compared to 48% of patients in the group taking only amoxicillin.

Observations in operative dentistry have shown that taking a combination of amoxicillin + clavulanate shortens the recovery period after surgery, relieves swelling faster and reduces the subjective feeling of pain compared to a single antibiotic.

The use of amoxicillin in combination with clavulanate as part of combination therapy for peptic ulcer disease associated with Helicobacter pylori resulted in recovery in 92% of patients, while the rate in the group taking only amoxicillin was 85%.

However, simple and combined antibiotics differ not only in their therapeutic properties, but also in their safety profile. The fact is that clavulanate can cause adverse reactions on its own, regardless of amoxicillin. This increases the list of contraindications and increases the risk of side effects when taking Flemoklav.

Clinical trial data indicate a higher incidence of gastrointestinal symptoms (diarrhea, vomiting, nausea) after taking the combination drug. Retrospective studies show that liver disease is 6 times more common in patients taking clavulanate-based drugs. Therefore, you should not make a decision on your choice without consulting a doctor and testing. Otherwise, you can cause harm to your health, and you will never be cured of pathogenic bacteria.

Can these antibiotics be used for children?

With a doctor's prescription, of course, yes. According to the instructions, Flemoklav Solutab can be prescribed to children starting from 3 months of age. The daily dose for them is 20–30 mg amoxicillin/kg body weight.

The daily dose of Flemoxin for children under 1 year of age is 30–60 mg amoxicillin/kg body weight.

Cost difference

When treating mild/moderate infections, an adult needs to take 1–1.5 g of the drug per day, the duration of use is 7 days. The dose is divided into 2-3 doses. Let's calculate how much a course of treatment with tablets with a dosage of amoxicillin of 500 mg will cost.

The daily dose will be 3 tablets, 21 will be needed per week. 20 tablets of Flemoxin costs from 335 to 380 rubles. The same package of Flemoclav will cost approximately 15% more.

Source: http://www.kliwi.ru/2016/12/flemoksin-i-flemoklav-v-chem-raznica.html