Saline storage conditions

Posted on by admin

How and how long is saline solution for inhalation stored?

The procedures are carried out for diseases of the nasopharynx and upper respiratory tract and are a recognized medicinal method that can significantly speed up recovery.

Table of contents:

Characteristics of the drug

Saline solution is a dosage form consisting of a mixture of water and table salt. A product is prepared with a certain concentration, in accordance with pharmacological standards. Carrying out an inhalation procedure makes it possible to spray the solution and deliver it directly to those areas of the mucous membrane that are affected by infection or virus.

At the same time, the patient’s condition improves - the nasopharynx is cleared of excess secretions, inflammation and swelling are relieved.

For bronchitis

If inhalations are indicated for bronchitis, saline solution helps to quickly and effectively liquefy mucus and remove it from problem organs. Like any other medication, saline solution is used in treatment only as prescribed by a specialist. In addition, for inhalations, some doctors recommend adding medicinal herbs or essential oils to it.

From the pharmacy

Saline solution is sold in the public domain, without a prescription. The cost of the drug is affordable. The product is prepared in the relevant pharmaceutical laboratories, taking into account the norms and requirements for medications of this group and is released for use for various purposes. Saline solution is often used not only for inhalation, but also for intravenous and intramuscular injections when the body is dehydrated.

How to cook it yourself

You can prepare a saline solution at home, but you must remember that this product is stored in the refrigerator in a glass container. The concentration of the solution is maintained based on the ratio - take 1 tablespoon of table salt per liter of warm boiled water. The mixture is thoroughly stirred and filtered before use. The shelf life of homemade saline solution should not exceed 24 hours, but you need to remember that no matter what conditions you prepare the product, it will not be sterile.

The doctor must determine how much solution is needed. He also prescribes a treatment regimen, which depends on the nature and nature of the disease, the degree of its development, what goals are being pursued (relieving inflammatory processes, eliminating swelling, dilating the bronchi for free breathing). In addition, the frequency of use and amount of saline solution depends on the age of the patient.

How to use and store

Doctors today recommend carrying out inhalation procedures only using special devices - nebulizers. The device ensures that the drug is split into particles of the required size and aerated directly into the infected areas of the mucous membrane.

Whether you buy a solution at a pharmacy or prepare it yourself, before filling it into the nebulizer, it must be warmed to room temperature. Steam inhalers are also used for procedures. They are good in cases where the upper respiratory tract is being treated and targeted drug delivery is not required.

In ampoules

For inhalation, it is better to buy the drug in small glass bottles or ampoules. Ampoules of 5 or 10 ml are ideal for the procedure. Considering the short shelf life after opening, purchase as many ampoules at once as you need for the full course of treatment. If the solution is in a container with a tight-fitting lid, the remaining product after the procedure can be stored in the refrigerator for another day. If the ampoule is broken and it is not possible to seal it tightly after opening, the product can be stored for hours. After this, saline solution will not only do no good, but may also cause harm.

Storage

You can often hear that for inhalations the expiration date of a saline solution does not matter, and even an opened solution can be stored in the refrigerator for up to 3-5 days and then used. This is argued by the fact that saline solution is not used for injections, and simply plugging a broken ampoule with cotton wool soaked in alcohol can preserve the drug. This is not entirely true. The solution is stored exactly as long as written in the instructions for use.

Research has proven that such widespread use of this drug is due to the fact that germs and infections do not live in it. However, the fresh drug acts more quickly on the inflamed problem areas of the mucous membrane, being absorbed and immediately giving an effective result.

Maintaining tightness

If you have a large bottle of saline solution (200 or 400 ml) at home, you can extract as much as necessary for the procedure using a syringe. By inserting a needle into the rubber cap of the container, remove as much solution as you need for the nebulizer. The seal of the container will not be compromised, and the shelf life of the remaining drug placed in the refrigerator will not be in doubt the next time it is used.

However, we should not forget that this only applies to the use of saline solution for inhalation. If you are using the drug for intravenous infusion or intramuscular injection, the remaining liquid after using the required amount is immediately discarded. No matter how much and how correctly the saline solution is stored, it will no longer bring any benefit.

Despite the fact that this medicine belongs to the group of medicines of natural origin, you must be careful about its safety. Do not put bottles and ampoules with the drug in the freezer, do not reuse the drug, even if there is a sufficient amount left in the nebulizer. Be sure to follow all instructions for use and storage of the solution, and only in this case will it give the desired result and speed up the healing process.

Source: http://nasmorklechit.ru/procedury/kak-hranit-fizrastvor.html

Sodium chloride - characteristics, properties, instructions for use, side effects, interactions with other drugs

Compound

1. Isotonic (physiological) 0.9% solution containing sodium chloride – 9 g, distilled water – up to 1 liter.

2. Hypertonic 10% solution containing sodium chloride - 100 g, distilled water - up to 1 liter.

Release form

  • To dissolve medicinal substances for intramuscular and subcutaneous injections, a 0.9% sodium chloride solution is produced in ampoules of 5, 10, 20 ml.
  • For dissolving medications, intravenous drips, enemas and external use: 0.9% sodium chloride solution in bottles of 100, 200, 400 and 1000 ml.
  • For intravenous injection and external use: 10% sodium chloride solution in bottles of 200 and 400 ml.
  • For oral (inside) administration: tablets 0.9 g. To use, the tablet must be dissolved in 100 ml of boiled warm water.
  • For treating the nasal cavity: nasal spray – 10 ml.

pharmachologic effect

Indications for use

  • Restoring water balance in case of body dehydration caused by various reasons.
  • Maintaining plasma volume during surgery and after.
  • Detoxification of the body (food poisoning, dysentery, cholera, etc.).
  • Maintaining plasma volume in case of extensive burns, diarrhea, blood loss, diabetic coma.
  • Eye rinsing for inflammatory and allergic irritations of the cornea.
  • Rinsing the nasal mucosa for allergic rhinitis, nasopharyngitis, prevention of sinusitis, acute respiratory infections, after removal of polyps and adenoids.
  • Inhalation of the respiratory tract (using special devices - inhalers).

It is used to treat wounds, moisturize bandages and fabric dressings. The neutral environment of saline is well suited for dissolving drugs and co-infusion with other drugs.

1. Deficiency of the elements sodium and chlorine.

2. Dehydration due to various reasons: pulmonary, gastric and intestinal bleeding, burns, vomiting, diarrhea.

Sodium chloride - instructions for use

With long-term use of large doses of sodium chloride, it is necessary to analyze the content of electrolytes in plasma and urine.

Sodium chloride 10 - instructions for use

Sodium chloride 9 - instructions for use

Contraindications

  • increased content of sodium ions in the body;
  • increased content of chlorine ions in the body;
  • lack of potassium;
  • circulatory fluid disorders, with the possibility of cerebral and pulmonary edema;
  • cerebral edema, pulmonary edema;
  • acute heart failure;
  • intracellular dehydration;
  • extracellular excess fluid;
  • treatment with significant doses of corticosteroids.

Used with great caution in patients with changes in renal excretory function, as well as in children and the elderly.

Side effects

  • discomfort in the digestive system: nausea, vomiting, stomach cramps, diarrhea;
  • disorders of the nervous system: lacrimation, constant thirst, anxiety, sweating, dizziness, headache, weakness;
  • arterial hypertension, rapid heartbeat and pulse;
  • dermatitis;
  • menstrual irregularities;
  • anemia;
  • excess fluid content in the body or its parts (edema), which indicates a pathological shift in water-salt metabolism;
  • acidosis – a shift in the body’s acid-base balance towards increased acidity;
  • hypokalemia – a decrease in potassium content in the body’s blood.

If side effects occur, the drug should be stopped. It is necessary to assess the patient’s well-being, provide adequate assistance and save the bottle with the remaining solution for analysis.

Sodium chloride during pregnancy

1. Preeclampsia (increased concentration of sodium in the blood plasma) with severe swelling.

2. Moderate and severe stages of toxicosis.

Interaction with other drugs

Synonymous drugs for sodium chloride

  • Sodium chloride 0.9% for intravenous infusion - sterile solution in bottles.
  • Sodium chloride 1.6% for intravenous infusion.
  • Sodium chloride 12% for intravenous infusion.
  • Sodium chloride Brown (Germany) - powder for the preparation of solution for injection, solution for infusion, solution for injection, solvent for the preparation of dosage forms for injection, nasal spray.
  • Sodium chloride bufus – powder for the preparation of solution for injection, solution for infusion, solution for injection, solvent for the preparation of dosage forms for injection, nasal spray.
  • Sodium chloride-Cinco – isotonic solution for infusion, hypertonic solution, eye drops and eye ointment.
  • Sodium chloride – 0.9% solution for infusion (Bulgaria).
  • Salorid – 0.9% solution for infusion (Bangladesh).
  • Rizosin – 0.65% nasal spray with and without menthol.
  • Salin – 0.65% nasal spray (India).
  • No-salt – 0.65% nasal spray.
  • Physiodose – 0.9% solution for topical use.

Additional Information

1. Remove container from outer packaging immediately before use. It protects and maintains the sterility of the drug.

2. Squeeze the container tightly and check for integrity. If damage is found, discard the container, as the solution in it is dangerous.

3. Check the solution visually: for transparency, absence of impurities and inclusions. If present, discard the container.

4. Hang the container on a tripod, remove the plastic fuse and unscrew the lid.

5. Add medications into the solution following aseptic rules. Move the clamp that regulates the movement of the solution to the “closed” position. Disinfect the area of ​​the injection container, make a puncture in it with a syringe and inject the drug. Mix well. Move the clamp to the “open” position.

Storage conditions and expiration dates

  • powder and tablets - without restrictions;
  • 0.9% solution in ampoules – 5 years;
  • 0.9% solution in bottles – 12 months;
  • 10% solution in bottles – 2 years.

Do not use after expiration date. Before using any drug containing sodium chloride, you should consult your doctor.

Read more:
Leave feedback

You can add your comments and feedback to this article, subject to the Discussion Rules.

Source: http://www.tiensmed.ru/news/natriahlorid-ec7.html

How long should saline solution be stored?

Comments

there was no need to open the bottle. Puncture the cap with a syringe and take out as much as you need. Store in a dark place. As the sediment appeared, it is no good. and so it costs me 2 months

Thank you very much, I'm already doing that)

you're welcome. I do this now - I buy sea salt - 1 tsp per glass of water and rinse my nose)

I did this a couple of times too, but for some reason my daughter starts crying, maybe she’s getting the pickles. In general, we went back to regular saline solution, it costs 20 rubles, so you won’t go broke)

I do inhalations with saline solution. I keep it on a shelf in a closet. In the dark.

If you do inhalations, your solution must be sterile.

as soon as I open it, it is no longer sterile(((((((((((. Only if you buy/open a new bottle for each inhalation

In a good way, yes. Because you are injecting liquid, bypassing all the body's natural protective barriers. It is very easy to get infected. This is especially true for a nebulizer, which is used to treat the lower respiratory tract.

We have a dolphin. I took it, I thought it would help treat a runny nose. It helps, but not from the runny nose itself, but helps to blow your nose. Those. After inhalation with saline solution, it is easier for my daughter to blow her nose.

What kind of inhaler do you have?

Once upon a time I also had this question))), you can store it for exactly as long as it lasts until the expiration date expires. for example, you have it until 2014, so you can store it until 2014. The main thing was opened, poured as much as needed, closed and put in the refrigerator and that’s it!

draw it up with a syringe...and store it as long as you want...you’re not dripping it into your veins. if it’s in the veins, then there’s probably some kind of expiration date... but for our nose, it’s definitely been in the refrigerator for 2 months. what will happen to him..

Do you store it in the refrigerator? It says on it to store at a temperature no higher than 25*C

Well. not higher means lower! just convenient in the refrigerator..

Don't open the plug, just draw it in with a syringe.

Thanks, I already did that.

We use a syringe to draw as much as we need through the stopper. and we store it for a long time, we didn’t even think about it

see also

Good day! Mommies, tell me how often you can rinse your nose with saline and is it harmful to the mucous membrane?

Please tell me, from how many months can a child’s nose be washed with saline? At the pharmacy they said from the age of two, but I’ve been using mine almost since birth.

Not so long ago I wrote that we had a runny nose (We washed our nose with aquamaris, but it ran out, I ran to the pharmacy, but it wasn’t there. I read before that you can replace it with saline solution (they say.

Girls. Probably everyone already knows and understands that in case of viral infections or simply dry air, you need to rinse your nose. So .. what is called - Aquamaris, water from the sea. and in general all washes are an ordinary saline solution that has been spilled.

The doctor said to put saline solution in a syringe and rinse the nose. but considering that we had purulent otitis media and the eardrum was ruptured, I’m kind of scared to wash it. because there will be pressure, etc. What does it have to do with the procedure calmly?

Girls, how long can you store opened Anauran drops? There is no word about this in the instructions, except for the storage temperature and the general shelf life. But if you think logically, then the bottle is clearly not designed for course use, it is quite voluminous, which means we can assume that it can be stored for a period of time.

Dear girls, please advise what to do, how to treat it, I have been persistently rinsing my nose with saline solution for the third week now, no effect, dripping derinat for the third week, no effect, Nazivan SNUP and the like for a course of 5 days, no more! I drip intermittently, but even...

She opened it and put it into a glass jar. How long can you store in the refrigerator so that you can give it to your child? A day, two? I’m on the third or in the soup or on my own, I’m already afraid of the child. Are there any storage standards? I don't.

Parents have a huge responsibility for the life and well-being of their baby, so it is incredibly important to protect your little one from the threat of drug poisoning. Child safety: how to store medicines in the house There are many chilling stories when children.

Good day everyone! Who rinses children’s noses with something when they have a runny nose and just periodically? When we had a runny nose, we used to wash it with aquamaris, then we switched to Aqualor Baby (cheaper than aquamaris). Recently, in the pharmacy, due to the lack of Aqualor, they tried to sniff it.

Source: http://www.babyblog.ru/community/post/diseases/

Sodium chloride

Sodium chloride (formula NaCL) is a substance known to every person. We all use it as a seasoning for cooking and call it salt. But today we will talk about how sodium chloride solution is used in medicine, and the range of its use in this industry is quite wide.

In its pure form, NaCL is a transparent white crystal with a salty taste. They dissolve well in water and are ideal for preparing a solution. In medicine, a sodium chloride solution, depending on the concentration of the active ingredient, is either a saline solution (physiological or isotonic) or a hypertonic solution, with a NaCL content of 0.9% and 10%, respectively.

Compound

  1. Physiological (isotonic) 0.9% solution contains 9 grams of NaCL and distilled water up to 1 liter
  2. Hypertonic 10% solution is more concentrated - 100 grams of NaCL per liter of distilled water

Release form

Saline solution

  1. Sodium chloride for infusions, dissolution of medications, enemas and external use is available in bottles of 100, 200, 400 and 100 ml
  2. Saline solution for diluting drugs, which will subsequently be used for intramuscular and subcutaneous injections, is available in ampoules of 5, 10 and 20 ml
  3. There are also tablets for oral administration. One tablet contains 0.9 mg of the active substance, and before use it must be dissolved in 100 ml of warm boiled water

Hypertonic solution

  1. 10% sodium chloride for intravenous injection and external use is available in 200 and 400 ml bottles
  2. For treating the nasal cavity, the medicine is available in the form of a spray, usually 10 ml in volume (depending on the manufacturer)

pharmachologic effect

Pharmacodynamics

  1. The substance NaCL itself in the body is responsible for maintaining constant pressure in the plasma and extracellular fluid. Usually the required amount enters the body with food.
  2. However, sometimes various kinds of pathological conditions may occur (for example, diarrhea, vomiting, high-degree burns), which are characterized by a large loss of fluid and salts by the body, and as a result - a deficiency of sodium and chlorine ions
  3. The above leads to thickening of the blood, convulsions, spasms of smooth muscles, and the functions of the nervous system and circulatory system may be disrupted
  4. Why is sodium chloride given intravenously when dehydrated? Its timely use will quickly restore fluid deficiency and water-salt balance.
  5. In addition, the drug has a plasma-replacing and detoxification effect, which is why sodium chloride solution is used for infusion for minor blood loss
  6. As for the hypertonic solution, when administered intravenously, it quickly replenishes the deficiency of sodium and chloride ions and enhances diuresis. This allows the drug to be used as an emergency aid for dehydration. Sodium chloride 10% is especially often needed for children, in whom dehydration occurs very quickly and can have the most serious consequences, including death.

Pharmacokinetics

  1. A NaCl solution, when administered intravenously, is very quickly removed from the vascular bed; after an hour, less than half of this substance remains in the vessels. Because of this property, saline solution is ineffective in cases of large blood loss.
  2. So, the half-life is approximately one hour, after which sodium, chloride ions and water begin to be eliminated by the kidneys, increasing the overall production of urine

Indications

As we have already said, the use of sodium chloride in medicine is quite widespread. Let's see how solutions of this substance of different concentrations are used:

NaCL 0.9%

    1. Restores the water-salt balance of the body in case of dehydration that occurs for any reason
    2. Intravenous administration of sodium chloride maintains the necessary plasma balance both during and after surgery
  1. This drug is an ambulance for detoxifying the body (for food poisoning, dysentery and other intestinal infections)
  2. This is why a dropper with sodium chloride is also needed: due to its plasma-replacing properties, this drug is used to maintain plasma volume in cases of severe diarrhea, burns, diabetic coma, and blood loss
  3. For inflammatory and allergic irritations of the cornea, saline solution is used to wash the eyes
  4. Sodium chloride is used to rinse the nasal cavity for allergic rhinitis, rhinopharyngitis, for the prevention of sinusitis, after removal of adenoids or polyps, for acute respiratory diseases
  5. Also, sodium chloride, both in combination with other drugs and without excipients, is used for inhalation of the respiratory tract.
  6. For treating wounds, moistening bandages and gauze dressings
  7. The neutral environment of saline is ideal for dissolving other drugs in it and subsequent infusions and injections

NaCL 10%

    1. Hypertonic solution is used primarily for acute deficiency of sodium and chlorine in the body
    2. To quickly restore water-salt balance in case of dehydration caused by gastric, pulmonary, intestinal bleeding, burns, severe vomiting and diarrhea
    3. The drug is an ambulance for poisoning due to silver nitrate
    4. Used to rinse the nasal cavity for sinusitis
  • Used externally to treat wounds
  • As an osmotic remedy for constipation - through an enema
  • As an aid to quickly increase the total volume of urine

Contraindications

Physiological (isotonic) solution

  1. Increased content of sodium or chlorine ions in the body
  2. Potassium deficiency
  3. Impaired fluid circulation, and, as a result, a tendency to pulmonary or cerebral edema
  4. Directly, cerebral edema or pulmonary edema
  5. Acute heart failure
  6. Intracellular dehydration
  7. Excess fluid in the extracellular space
  8. Taking corticosteroids
  9. Disorders and changes in renal excretory function
  10. With caution in children and the elderly

Hypertonic solution

Important! The use of the drug for subcutaneous and intramuscular injections is prohibited (this can lead to tissue necrosis)

Otherwise, all the contraindications listed for saline are relevant for hypertonic solution

Side effects

    1. When administered intravenously, local reactions are possible (burning sensation and hyperemia)
  1. Long-term use may result in symptoms of body intoxication.
  2. Nausea, vomiting, diarrhea, stomach cramps
  3. Nervous system disorders: dizziness, headache, weakness, sweating, anxiety, lacrimation, severe persistent thirst
  4. Increased heart rate and pulse, increased blood pressure
  5. Dermatitis
  6. Anemia
  7. Menstrual irregularities in women
  8. Edema (this may indicate a chronic imbalance of water-salt balance)
  9. Increased acidity
  10. Decreased potassium levels in the blood

Instructions for use

Instructions for using sodium chloride look like this:

  • Saline solution is administered to the patient both intravenously and subcutaneously, but most often - intravenously.
  • Before administration, the drug is warmed to body temperature.
  • The volume of medication is calculated based on the patient’s condition, as well as the amount of fluid he has lost; body weight and age are also taken into account
  • The average daily dose of the solution is 500 ml. This amount completely covers the body’s daily need for the substance. However, in case of severe intoxication and a high degree of dehydration, the volume of administered saline solution can be increased to 3000 ml
  • The average rate of drug administration is 540 ml per hour
  • Again, in case of urgent need, the rate of administration increases to 70 drops per minute
  • For children, the dosage is calculated based on age and body weight, and ranges, on average, from 20 to 100 ml. With long-term use, urine and plasma analysis is required for electrolyte content.
  • If the solution is used as an adjuvant for other medications when preparing a dropper, its volume varies from 50 to 250 ml
  • The hypertonic solution is administered only intravenously, in a stream (very slowly), volume - from 10 to 30 ml
  • When immediate replenishment of sodium and chlorine ions is required, a 100 ml dropper is used
  • Enemas with a hypertonic solution are used not only for constipation, they help with intracranial pressure, cardiac and renal edema, hypertension, inflammation and erosion of the colon
  • Compresses with a hypertonic solution are used to treat purulent wounds, abscesses, boils
  • Hypertonic and isotonic solutions are used to treat the nasal cavity in order to clear it of mucus or pus. For this, the drug is available in the form of a spray, but you can use a regular pipette, instilling 2 drops into each nostril for adults, and one drop for children
  • For the treatment of colds and diseases of the upper respiratory tract, inhalations with saline solution are very effective.

Already in itself, it is an excellent remedy for facilitating the discharge of sputum. In difficult cases, additional medications are added to the solution (Lazolvan, Ambroxol, Hydelix). To relieve the symptoms of bronchial asthma, bronchial dilators (for example, Berodual) are added to the saline solution.

During pregnancy

Why is sodium chloride administered intravenously during pregnancy? There are two indications for this treatment:

  • Too much sodium concentration in the blood plasma, a condition that leads to severe swelling
  • Medium and severe stage of toxicosis

In addition, saline solution is often used as a “placebo”, because a woman expecting a baby is subject to quite strong emotional stress.

Sodium chloride is a drug that solves many medical problems; its scope of application is very wide. That is why it takes its very important place among pharmaceuticals.

Questions on the topic

Ask a question Cancel

Types of anesthesia

Types of anesthesia

Additionally

Various types of artificial pulmonary ventilation (ALV) make it possible to provide gas exchange to the patient both during surgery and in critical conditions of dangerous...

Anesthesia during operations depends on the anesthesiologist. Anesthesia is the deprivation of pain sensitivity in the body or areas for surgical...

Statistics show that the number of complications when tracheal extubation is performed has not decreased recently, unlike complications associated ...

Diet table 13 according to Pevzner is prescribed for acute infectious diseases, because at this moment the body especially needs support. In addition to the general...

In modern dentistry, doctors have not been able to do without anesthesia for quite some time. Far behind were the painful procedures that caused utter horror. ...

Often anesthesia scares people, sometimes even more than surgery. The biggest fear is the unknown and possible discomfort when falling asleep and...

Source: http://vnarkoze.ru/natriya-chlorid.html

Saline solution: requirements and shelf life

What is saline solution

The basis of the medicinal liquid is sodium chloride, or more precisely, table or sea salt. The liquid is obtained after dissolving 9 g of sodium chloride in 1 liter. For home use, you can prepare the drug yourself, but for treatment you need to use a special pharmaceutical product. This drug is produced using a special technology, purified from harmful impurities, and can be used for injections and other medical procedures where sterility is required.

In terms of its properties, saline solution is identical to the substances present in the cellular space that maintain pressure in the plasma and inside cells. Due to this, the saline solution is used to quickly replenish the deficiency of elements that is formed as a result of dehydration, poisoning, and inflammatory and infectious diseases. The drug is capable of increasing the volume of fluid circulating in the body for a certain time, which helps restore the most important internal processes.

In addition, sodium chloride solution is used:

  • To detoxify the body when damaged by harmful substances of various origins
  • As a base solution for diluting drugs for intravenous infusions, infusions or intramuscular administration
  • In some cases - as a blood substitute during operations
  • For the treatment of colds
  • In enemas to improve bowel movements
  • For cleansing and disinfecting wound, purulent surfaces and tissues
  • For washing eyes and nasal passages
  • In inhalations as an independent means - for cleansing, softening and moisturizing tissues, together with other drugs - for transporting the smallest particles of the drug to the affected area.

The solution must be used according to its intended purpose. The pharmacy network has many drugs from various manufacturers that are produced for a specific purpose: infusions, dilution of drugs or for inhalation. Therefore, it is better for the patient to consult a doctor before purchasing and ask him which solution is best and how important it is to maintain sterility. And after that you can focus on storage rules and expiration dates.

Features of storing saline solution for injection

Despite the wide range of applications of sodium chloride solution, it is most often used in injections and infusions to cleanse the body and restore normal processes.

When carrying out detoxification, the solution is injected into the body, so particularly strict requirements are imposed on the drug. According to medical standards, the shelf life of the drug after uncorking the container in which it was stored is hours.

But at the same time, you need to take into account how the bottle is actually opened: has the cap been removed or just freed from the aluminum crimping rim? In the first case, the shelf life of the product will be predictably shorter, since the smallest particles of dust, dirt, toxic substances, etc. will fall into an open container with a sodium chloride solution. Therefore, there is no need to talk about maintaining any sterility.

If sodium chloride solution is prescribed for infusion, then it must be used within 12 hours after opening, and only if during this time it has been stored under appropriate conditions - in a cool place.

If the cap was removed from the bottle, but the solution was not used, then even in this case the drug has lost its sterility, and it is better to use it topically. This product is no longer suitable for injection, even if less than 12 hours have passed since opening.

How to store the product for inhalation or nasal rinsing

Saline solution for inhalation is a popular and safe remedy that is well suited for treating very young children and expectant mothers. The drug is used as an independent remedy or together with other medications in a nebulizer. The solution is not used for steam inhalers.

When used in a nebulizer, a tiny suspension is created that penetrates very deeply into the respiratory system. Therefore, only a sterile solution must be used, otherwise an infection or foreign particles will get in with the medicine, which will cause a new round of complications.

In addition, it is necessary to take into account the amount of medicine that will be consumed. If very little is required for one procedure, then it is more advisable to purchase the drug in ampoules so as not to throw away an almost full bottle. In this case, you can take an unopened container each time and not worry about the sterility of the drug.

When using a solution for rinsing the nose, sterility requirements may not be observed. But to protect yourself, just in case, you can remove the solution each time with a sterile syringe through a rubber cap.

If you used the product in ampoules, then the remaining product can be saved until next time by plugging the hole with a sterile cotton ball. In the case of rinsing the nose with a saline solution prepared at home, it should be taken into account that it is better to prepare it immediately before the procedure, and if a large volume of the solution is diluted, then it should be used during the day. It is not recommended to store longer.

General storage rules

It is recommended to keep the unopened drug at room temperature - no higher than 25 °C. The expiration date is usually indicated on the packaging and, depending on the manufacturers, is 2-3 years.

If you use a product from the Spanish manufacturer Bieffe Medital, the shelf life is different, depending on the volume of the drug:

  • (50 ml) – 1.5 years
  • (100 ml) sodium chloride solution can be stored for 2 years
  • Packaging of 200 ml sodium chloride – 3 years
  • Bottles 500 ml and 1 l – 3 years.

Source: http://lekhar.ru/lekarstva/preparaty-dlya-krovi/hranenie-fizrastvora/

Sodium chloride

Description current as of 08/03/2015

  • Latin name: Natrii chloridum
  • ATX code: B05XA03
  • Active ingredient: Sodium chloride
  • Manufacturer: Medpolymer, Sintez OJSC, Alium Pharmaceutical Manufacturing Company (Russia), Pharmland JV (Republic of Belarus)

Compound

The active ingredient of this product is sodium chloride. The formula for sodium chloride is NaCl, these are white crystals that quickly dissolve in water. Molar mass 58.44 g/mol. OKPD code - 14.40.1.

Saline solution (isotonic) is a 0.9% solution, it contains 9 g of sodium chloride, up to 1 liter of distilled water.

Hypertonic sodium chloride solution is a 10% solution, it contains 100 g of sodium chloride, up to 1 liter of distilled water.

Release form

A 0.9% sodium chloride solution is produced, which can be contained in ampoules of 5 ml, 10 ml, 20 ml. Ampoules are used to dissolve medications for injection.

A solution of sodium chloride 0.9% is also produced in bottles of 100, 200, 400 and 1000 ml. Their use in medicine is practiced for external use, intravenous drips, and enemas.

Sodium chloride solution 10% is contained in bottles of 200 and 400 ml.

For oral administration, tablets of 0.9 g are available.

A nasal spray is also produced in 10 ml bottles.

pharmachologic effect

Sodium chloride is a drug that acts as a rehydrating and detoxifying agent. The medicine is able to compensate for the lack of sodium in the body, subject to the development of various pathologies. Sodium chloride also increases the amount of fluid that circulates in the vessels.

Such properties of the solution are manifested due to the presence of chloride ions and sodium ions in it. They are able to penetrate the cell membrane using various transport mechanisms, in particular the sodium-potassium pump. Sodium plays an important role in the process of signal transmission in neurons; it is also involved in the metabolic process in the kidneys and in the electrophysiological processes of the human heart.

Pharmacopoeia indicates that sodium chloride maintains constant pressure in the extracellular fluid and blood plasma. In the normal state of the body, a sufficient amount of this compound enters the body with food. But in pathological conditions, in particular, with vomiting, diarrhea, and serious burns, there is an increased release of these elements from the body. As a result, the body experiences a deficiency of chlorine and sodium ions, as a result of which the blood becomes thicker, the functions of the nervous system, blood flow, convulsions, and spasms of smooth muscles are disrupted.

If an isotonic sodium chloride solution is promptly introduced into the blood, its use helps restore the water-salt balance. But since the osmotic pressure of the solution is similar to the pressure of blood plasma, it does not stay in the vascular bed for a long time. After administration, it is quickly eliminated from the body. As a result, after 1 hour, no more than half of the injected amount of solution is retained in the vessels. Therefore, in case of blood loss, the solution is not effective enough.

The product also has plasma-substituting and detoxifying properties.

When a hypertonic solution is administered intravenously, there is an increase in diuresis, replenishing the deficiency of chlorine and sodium in the body.

Pharmacokinetics and pharmacodynamics

Excretion from the body occurs mainly through the kidneys. Some sodium is excreted in sweat and feces.

Indications for use

Sodium chloride is a saline solution that is used when the body loses extracellular fluid. Indicated for conditions that lead to limited fluid intake:

Considering what sodium chloride is, it is used externally to wash wounds, eyes, and nose. The drug is used to moisturize dressings, for inhalation, and for the face.

The use of NaCl is indicated for forced diuresis in cases of constipation, poisoning, and internal bleeding (pulmonary, intestinal, gastric).

It is also indicated in the indications for use of sodium chloride that this is a drug that is used for diluting and dissolving drugs that are administered parenterally.

Contraindications

The use of the solution is contraindicated for the following diseases and conditions:

The solution is prescribed with caution to people who suffer from arterial hypertension, peripheral edema, decompensated chronic heart failure, chronic renal failure, preeclampsia, as well as those diagnosed with other conditions in which sodium retention occurs in the body.

If the solution is used as a diluent for other medications, existing contraindications should be taken into account.

Side effects

The following conditions may develop when using sodium chloride:

If the drug is used correctly, the development of side effects is unlikely.

If a 0.9% NaCl solution is used as a base solvent, then side effects are determined by the properties of the drugs that are diluted with the solution.

If any negative effects occur, you should immediately report it to a specialist.

Instructions for use of Sodium Chloride (Method and dosage)

The instructions for saline solution (isotonic solution) provide for its administration intravenously and subcutaneously.

In most cases, intravenous drip administration is practiced, for which the Sodium Chloride dropper is heated to a temperature of degrees. The volume that is administered to the patient depends on the condition of the patient, as well as the amount of fluid that has been lost by the body. It is important to take into account the person’s age and weight.

The average daily dose of the drug is ml, the solution is administered at an average speed of 540 ml/h. If there is a severe degree of intoxication, then the maximum volume of medication per day can be 3000 ml. If there is such a need, a volume of 500 ml can be administered at a speed of 70 drops per minute.

Children are given a dose of 20 to 100 ml per day per 1 kg of weight. The dosage depends on body weight and the age of the child. It should be borne in mind that with prolonged use of this medicine it is necessary to monitor the level of electrolytes in plasma and urine.

To dilute drugs that need to be administered by drip, use 50 to 250 ml of sodium chloride per dose of the drug. The characteristics of administration are determined based on the main drug.

The hypertonic solution is administered intravenously.

If the solution is used to immediately compensate for the deficiency of sodium and chlorine ions, 100 ml of the solution is injected dropwise.

To perform a rectal enema to induce defecation, 100 ml of a 5% solution is administered; 3000 ml of an isotonic solution can also be administered throughout the day.

The use of a hypertensive enema is slowly indicated for renal and cardiac edema, increased intracranial pressure and for hypertension it is carried out slowly, ml is administered. Such an enema cannot be performed in case of colon erosion and inflammatory processes.

Purulent wounds are treated with a solution according to the regimen prescribed by the doctor. Compresses with NaCl are applied directly to a wound or other lesion on the skin. Such a compress promotes the separation of pus and the death of pathogenic microorganisms.

The nasal spray is instilled into the nasal cavity after it has been cleansed. For adult patients, two drops are instilled into each nostril, for children - 1 drop. It is used for both treatment and prevention, for which the solution is dripped for about 20 days.

Sodium chloride for inhalation is used for colds. To do this, the solution is mixed with bronchodilators. Inhalation is carried out for ten minutes three times a day.

If absolutely necessary, saline solution can be prepared at home. To do this, mix a full teaspoon of table salt in one liter of boiled water. If it is necessary to prepare a certain amount of solution, for example, with salt weighing 50 g, appropriate measurements should be taken. This solution can be applied topically, used for enemas, rinses, and inhalations. However, under no circumstances should such a solution be administered intravenously or used to treat open wounds or eyes.

Overdose

In case of overdose, the patient may feel nausea, suffer from vomiting and diarrhea, he may develop abdominal pain, fever, and rapid heartbeat. Also, in case of an overdose, blood pressure may increase, pulmonary edema and peripheral edema, renal failure, muscle cramps, weakness, dizziness, generalized convulsions, and coma may develop. If the solution is administered excessively, hypernatremia may develop.

With excessive intake into the body, hyperchlorimic acidosis may develop.

If sodium chloride is used to dissolve drugs, then the overdose is mainly associated with the properties of those drugs that are diluted.

If NaCl is inadvertently overadministered, it is important to stop this process and assess whether the patient has any more negative symptoms. Symptomatic treatment is practiced.

Interaction

NaCl is compatible with most medications. It is this property that determines the use of the solution for diluting and dissolving a number of drugs.

When diluting and dissolving, it is necessary to monitor the compatibility of drugs visually, determining whether a precipitate appears during the process, whether the color changes, etc.

When concomitantly prescribing the drug with corticosteroids, it is important to constantly monitor the levels of electrolytes in the blood.

When taken in parallel, the hypotensive effect of Enalapril and Spirapril decreases.

Sodium Chloride is incompatible with the leukopoiesis stimulator Filgrastim, as well as with the polypeptide antibiotic Polymyxin B.

There is evidence that isotonic solution increases the bioavailability of drugs.

When diluted with a solution of powdered antibiotics, they are completely absorbed by the body.

Terms of sale

Sold in pharmacies by prescription. If necessary, use the drug to dilute other medications, etc. write out a prescription in Latin.

Storage conditions

The powder, tablets and solution should be stored in a dry place, in a well-closed container, and the temperature should not exceed 25 degrees Celsius. It is important to keep the drug away from children. If the packaging is sealed, freezing does not affect the properties of the drug.

Best before date

There are no restrictions on storing powder and tablets. The solution in 0.9% ampoules can be stored for 5 years; solution in bottles 0.9% - one year, solution in bottles 10% - 2 years. Cannot be used after the shelf life has expired.

special instructions

If an infusion is given, the patient's condition should be carefully monitored, in particular plasma electrolytes. It should be taken into account that in children, due to immature renal function, sodium excretion may slow down. It is important to determine its plasma concentration before repeated infusions.

It is important to monitor the condition of the solution before administering it. The solution must be transparent and the packaging undamaged. Only a qualified specialist can use the solution for intravenous administration.

Any preparations with Sodium Chloride should only be dissolved by a specialist who can qualifiedly assess whether the resulting solution is suitable for administration. It is important to strictly adhere to all antiseptic rules. Any solution should be administered immediately after its preparation.

The result of a series of chemical reactions involving sodium chloride is the formation of chlorine. Electrolysis of molten Sodium Chloride in industry is a method of producing chlorine. If you carry out electrolysis of a solution of Sodium Chloride, you also end up with chlorine. If crystalline Sodium Chloride is treated with concentrated sulfuric acid, the result is hydrogen chloride. Sodium sulfate and sodium hydroxide can be produced through a chain of chemical reactions. A qualitative reaction to chloride ion is a reaction with silver nitrate.

Analogs

Different drug manufacturers may produce the solution under a separate name. These are the drugs Sodium chloride Brown, Sodium chloride Bufus, Rizosin, Salin Sodium chloride Sinco, etc.

Preparations containing sodium chloride are also produced. These are combined salt solutions of sodium acetate + sodium chloride, etc.

For children

It is used in accordance with the instructions and under the careful supervision of specialists. The immaturity of renal function in children should be taken into account, so repeated administration is carried out only after an accurate determination of plasma sodium levels.

During pregnancy and lactation

During pregnancy, a sodium chloride dropper can only be used in pathological conditions. This is toxicosis in the moderate or severe stage, as well as gestosis. Healthy women receive sodium chloride from food, and its excess can lead to the development of edema.

Reviews

Most reviews are positive, as users write about this product as a useful drug. There are especially many reviews about the nasal spray, which, according to patients, is a good remedy for both the prevention and treatment of a runny nose. The product effectively moisturizes the nasal mucosa and promotes healing.

Sodium Chloride price, where to buy

The price of saline solution in ampoules of 5 ml is on average 30 rubles per 10 pcs. Buying sodium chloride 0.9% in a 200 ml bottle costs an average of rubles for 1 bottle.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

WER.RU

ZdravZone

Pharmacy IFC

Pharmacy24

PaniPharmacy

BIOSPHERE

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Work experience: From 2003 to 2013 – worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

Please tell me how much sodium chloride 0.9% 200 ml should be taken for gargling?

Thank you! Well done for explaining the drug!

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/natriya-chlorid