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Bacteriophage Staphylococcal

Description current as of 02/20/2015

  • Latin name: Bacteriophagum Staphylococcum
  • ATX code: J01XX
  • Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)
  • Manufacturer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)

Compound

The active component of the drug Staphylococcal Bacteriophage is an anti-staphylococcal bacteriophage in liquid form, in the form of suppositories, ointments or tablets.

Table of contents:

Release form

  • 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
  • 20 ml of this solution in a bottle - four bottles in a cardboard box.
  • 25 ml of such a solution in an aerosol package - one package in a cardboard box.
  • 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
  • 10 candles per package, one package in a cardboard box.
  • 10, 25 and 50 tablets per package, one package in a cardboard box.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

What is a Bacteriophage?

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

Structure of Bacteriophages

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with an inactive transcriptase, surrounded by a shell of protein or lipoprotein called the capsid.

Reproduction of Bacteriophages

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is broken down by lysozyme enzymes. At the same time, calcium ions are released, activating ATPase - this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out the phage’s reproductive cycle.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA (DNA polymerase, thymidylate synthetase, kinase) occurs. It takes 5-7 minutes from the moment of infection. The cell's RNA polymerase converts viral DNA into mitochondrial RNA, which is translated by ribosomes into early proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit the expression of bacterial genes. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity of synthesized DNA polymerases of the virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes a plasmid. As a result, the viral genome replicates along with the host DNA.

Types of Bacteriophages

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

  • bacteriophages for the treatment of intestinal infections: dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
  • bacteriophages for the treatment of purulent-septic lesions: Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation are possible.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

It is advisable to carry out therapy of purulent-inflammatory limited lesions both locally and orally for 1-4 weeks.

For purulent-inflammatory lesions of the throat, ear or nose, the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

For carbuncles and boils, liquid bacteriophage is injected directly into or around the lesion, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment of chronic osteomyelitis is carried out by infusion of the drug into the wound immediately after surgical treatment.

In case of abscesses, the bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis is carried out by making intradermal injections of the drug into one place of 0.1-0.5 ml or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For administration into the abdominal, pleural, and articular cavities, capillary drainage is used, and up to 100 ml of bacteriophage is injected every other day. There are only 3-4 such introductions.

For cystitis, the drug is injected into the bladder using a catheter.

For purulent bursitis, pleurisy or arthritis, the drug is administered into a cavity previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Also, Staphylococcal bacteriophage is used orally in the form of tablets in the treatment of urogenital infections (cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions and intestinal dysbiosis: the drug is used orally on an empty stomach three times a day, 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

For sepsis or enterocolitis in newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

When treating pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with bandages of 5-20 grams up to two times a day.

For the prevention of enterocolitis and sepsis in newborns, when there is a risk of developing a hospital infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal Bacteriophage is used to irrigate affected mucous membranes and skin for purulent-inflammatory lesions, burns, septic wounds and sore throat.

The most justified use of this remedy is in cases of infection with antibiotic-resistant strains.

Overdose

Such cases have not been studied.

Interaction

If antiseptic solutions (not including furatsilin) ​​were used before local application of the product, the affected area should be washed with saline solution or 3% sodium bicarbonate solution.

Terms of sale

Dispensing of the drug is permitted without a prescription.

Storage conditions

Store at a temperature of 2-10 degrees in a dark place. Keep away from children.

Best before date

special instructions

Treatment with the drug should be started as early as possible.

The drug must be shaken before use; a cloudy solution should not be used.

When opening the bottle, storing and sampling the product, the following rules should be observed:

  • hands must be washed thoroughly;
  • Before removing, the cap must be treated with an alcohol solution;
  • the cap should be removed without removing the stopper;
  • the drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  • If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  • It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Analogs

For children

The drug is approved for use in newborns and children of all ages.

With antibiotics

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

Reviews of Staphylococcal Bacteriophage

Despite many cases of cure, the therapeutic effect of taking the drug is not guaranteed in all cases. This is evidenced by reviews of Staphylococcal Bacteriophage. This feature is more often detected when the product is used for newborns and young children.

The effectiveness of the drug may vary depending on the sensitivity of the particular strain to the phage and other factors that should be determined before starting treatment.

In some situations, parents prematurely stop the course of treatment for their infant, frightened by the supposedly worsening symptoms of the disease, and then report that the drug did not work on the child. In any case, before deciding to undergo therapy with this medicine, and during treatment, you should be observed by your doctor and clarify all unclear questions with him.

Staphylococcal Bacteriophage price, where to buy

In Ukraine, the price of the drug Staphylococcal Bacteriophage liquid 100 ml produced by the Biopharma company (Kiev) averages 318 hryvnia.

In Russia, the price of staphylococcal and polyvalent Pyobacteriophage liquid bacteriophage in standard packaging of 20 ml No. 4 is almost the same and amounts to rubles.

Buying a staphylococcal bacteriophage in Moscow (manufactured by NPO Microgen, Nizhny Novgorod) will cost rubles per 100 ml bottle.

Such drugs are almost never found in tablet or suppository forms in pharmacies.

  • Online pharmacies in Russia Russia

WER.RU

ZdravZone

Pharmacy IFC

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/bakteriofag-stafilokokkovyiy

Staphylococcal bacteriophage: instructions for use

Staphylococcal bacteriophage is an immunobiological drug that contains specific viruses that can infect bacterial cells that are sensitive to them. This drug is used only in the presence of an infectious process in the body caused by bacteria of the genus Staphylococcus (staphylococci).

Release form and composition

There are several dosage forms of staphylococcal bacteriophage. The solution is available in glass bottles of 20, 50 and 100 ml. It contains lyophilisate (cell components) of staphylococcus bacteria, live bacteriophages and a preservative (quinosol). The solution is a dark yellow transparent liquid without impurities or sediment.

pharmachologic effect

The staphylococcal bacteriophage solution contains specific viruses (bacteriophages) that are able to penetrate only susceptible bacterial cells. They are integrated into the genome of the bacterial cell, changing its metabolism, which leads to the synthesis of new bacteriophages. This in turn leads to damage (lysis) and death of the bacterium, the release of new bacteriophages that penetrate new sensitive bacterial cells. The staphylococcal bacteriophage does not infect human cells and other bacteria. The spectrum of effectiveness of this bacteriophage extends only to bacteria of the genus Staphylococcus (staphylococci), which cause pathological infectious processes of various localizations in the human body, in particular Staphylococcus aureus. The presence of lysate (components of staphylococcal bacterial cells) in the solution has a stimulating effect on the development of a specific antibacterial immune response.

After local injection of a solution of staphylococcal bacteriophage directly into the area of ​​the focus of the inflammatory infectious process, the bacteriophage practically does not penetrate into the systemic bloodstream; it directly affects staphylococcal bacterial cells that are localized in the focus of inflammation. The bacteriophage exists only if there is a staphylococcal infection. After the destruction of all bacterial cells, the number of bacteriophage particles decreases, and it is gradually eliminated (removed) from human tissues (for the most part, the remnants of these specific viral particles are absorbed and inactivated by cells of the immune system by macrophages).

Indications for use

A solution of staphylococcal bacteriophage is used to treat infectious processes in the body of various localizations caused by strains of bacteria of the genus Staphylococcus that are sensitive to it. Most often these bacteria cause the following diseases:

  • Purulent and infiltrative lesions of the skin and subcutaneous tissue - furuncle (purulent inflammation of one hair follicle), carbuncle (purulent process in which several hair follicles are involved), abscess (limited cavity filled with pus) of subcutaneous tissue and soft tissues, phlegmon (leakage of intercellular substance pus) and hidradenitis (bacterial infection of the sweat glands of the skin).
  • Infectious process in the upper respiratory tract - staphylococcal rhinitis (inflammation of the nasal mucosa), sinusitis (pathological process in the paranasal sinuses), otitis (inflammation of the ear), pharyngitis (inflammation of the pharynx), laryngitis (parasitism of staphylococci in the larynx), staphylococcal tonsillitis (purulent inflammation of the tonsils).
  • Infectious pathological process in the lower respiratory tract - tracheitis (localization of infection in the tracheal mucosa), bronchitis (pathological process in the bronchi) or pneumonia (pneumonia).
  • Urogenital infectious process - characterized by bacterial damage to the organs of the urinary system (kidneys, ureters, bladder and urethra) and genitals.
  • Staphylococcal damage to the digestive system - enterocolitis (inflammatory process of the small and large intestines), cholecystitis (pathological process in the gallbladder), inflammation of the tissue around the liver with the development of phlegmon or an abscess in it. Also, staphylococcal bacteriophage is used for intestinal dysbiosis (disturbance in the ratio of normal and conditionally pathogenic intestinal flora), in which the number of staphylococcal bacteria increases.
  • Purulent inflammatory processes in the body of a newborn of any localization, caused by parasitism of staphylococci.
  • A purulent-inflammatory process in the organs of the musculoskeletal system - infectious arthritis (joint damage), periarthritis (inflammation of periarticular tissues).
  • Prophylactic use to prevent purulent bacterial complications after various injuries associated with violation of the integrity of the skin or mucous membranes.
  • Generalized staphylococcal infection - sepsis (blood poisoning), in which bacteria spread throughout the body, their deposition in various tissues and organs with the development of secondary purulent processes.

An important condition for the use of staphylococcal bacteriophage is the presence of sensitivity of bacterial cells to it.

Contraindications for use

There are no absolute contraindications to the use of staphylococcal bacteriophage solution. Relative contraindications that require delaying the use of this immunobiological drug are determined by the doctor on an individual basis. Staphylococcal bacteriophage is not used if the causative agent of the infectious pathological process is not sensitive to it.

Directions for use and doses

The method of introducing or applying a solution of staphylococcal bacteriophage depends on the localization of the infectious process in the human body:

  • In case of pathology of the female genital organs, the solution is used in the form of irrigation or application to the mucous membrane.
  • If the skin, subcutaneous tissue, or soft tissues are affected, the solution is used in the form of washing the area of ​​inflammatory or purulent process. It is also possible to administer the solution intradermally or subcutaneously.
  • If the infectious process is localized in the digestive tract, the solution is administered into the rectum (rectal administration) or taken orally (through the mouth).
  • In case of disease of the upper or lower respiratory tract, irrigation of the mucous membranes or inhalation of the aerosol is carried out.
  • If the outer or middle ear or nasal mucosa is affected, the solution is instilled.

Recommended dosages of the drug depend on the age of the person, the method of administration and the severity of the pathological infectious process. When administered orally and rectally, the drug can be used by children from birth. The duration of treatment also depends on the severity of the staphylococcal infection, on average it is 7-20 days. In case of relapse (exacerbation), the drug can be reused up to several times during the year.

Side effects

After using a solution of staphylococcal bacteriophage, no cases of side effects were recorded.

special instructions

The use of a solution of staphylococcal bacteriophage should be carried out taking into account special instructions:

  • Before using a solution of staphylococcal bacteriophage, a mandatory bacteriological study is required to isolate staphylococcus and determine its sensitivity to the drug.
  • If solutions of local chemical antiseptics (chemical compounds that destroy various types of infection) are used the day before, the area treated with staphylococcal bacteriophage must be thoroughly rinsed with water, since antiseptic residues can lead to the death of bacteriophages.
  • The drug can be used during pregnancy or breastfeeding only after a doctor's prescription.
  • The solution does not affect the speed of psychomotor reactions and a person’s ability to concentrate.
  • Staphylococcal solution can be used in combination with antibiotics, since they do not have a negative effect on the viability of bacteriophages.
  • It is not allowed to use a cloudy solution if it contains sediment or flakes.

In the pharmacy chain, the drug is dispensed only with a doctor's prescription. Its use will be effective only after appropriate examination and doctor's prescription.

Overdose

Cases and symptoms of overdose of staphylococcal bacteriophage solution have not been described.

Analogs

There are dosage forms of staphylococcal bacteriophage in the form of aerosols, suppositories and tablets.

Terms and conditions of storage

An unopened solution of staphylococcal bacteriophage can be stored for 3 years from the date of its manufacture. Storage is possible only at temperatures from +2 to +8° C (temperatures up to +30° C are allowed during transportation of the drug, the duration should not exceed 30 days). The solution must be stored out of the reach of children.

Staphylococcal bacteriophage price

Staphylococcal bacteriophage, 100 ml - from 782 rub.

Source: http://bezboleznej.ru/bakteriofag-stafilokokkovyj

Krasnoyarsk medical portal Krasgmu.net

Bacteriophages or phages (from ancient Greek φᾰγω - “I devour”) are viruses that selectively infect bacterial cells. Most often, bacteriophages multiply inside bacteria and cause their lysis. As a rule, a bacteriophage consists of a protein shell and genetic material

Bacteriophages are highly effective immunobiological drugs with antibacterial action. Staphylococcal bacteriophage - the drug is intended to combat staphylococcal infections. Instructions for use of the drug Staphylococcal Bacteriophage describe that the bacteriophage is injected into the site of infection.

Staphylococcal bacteriophage is capable of lysing staphylococci, i.e. has the ability to specifically dissolve staphylococcal bacteria isolated during purulent infections.

INSTRUCTIONS for the use of the medicinal product for medical use Staphylococcal bacteriophage

Staphylococcal bacteriophage liquid - instructions for use. Indications for use, composition, pharmacological properties, reviews.

Name of the drug: Staphylococcal bacteriophage.

Dosage form: Solution for oral, local and external use.

Average price for staphylococcal bacteriophage in Russia (2014):

Average price: 880 rub.

Maximum price: 1868 rub.

Compound

Composition of the drug Staphylococcal bacteriophage: 1 ml of the drug contains the active substance of the sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

Excipients: Preservative 8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate - 0.0001 g/ml (in terms of 8-hydroxyquinoline sulfate, calculated content).

Description: The drug Staphylococcal Bacteriophage is a transparent yellow liquid of varying intensity.

Pharmacotherapeutic group of the drug: MIBP-bacteriophage.

Biological properties: The drug Staphylococcal Bacteriophage causes specific lysis of Staphylococcus bacteria.

Indications

Indications for use of the drug Staphylococcal Bacteriophage:

  • Treatment and prevention of purulent-inflammatory and enteric diseases caused by bacteria of the genus Staphylococcus in adults and children.
  • diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
  • surgical infections (wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);
  • urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);
  • enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis;
  • generalized septic diseases;
  • purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);
  • other diseases caused by staphylococci.

In case of severe manifestations of staphylococcal infection, the drug is prescribed as part of complex therapy.

For prophylactic purposes, the drug Staphylococcal Bacteriophage is used for the treatment of postoperative and newly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug Staphylococcal Bacteriophage;

Contraindications to the drug Staphylococcal Bacteriophage:

Individual intolerance or sensitivity to any of the components of the drug.

Use of the drug Staphylococcal Bacteriophage during pregnancy and breastfeeding:

It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Method of administration and dosage of the drug Staphylococcal bacteriophage:

The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities. Before use, the vial with the bacteriophage must be shaken and inspected. The Staphylococcal Bacteriophage preparation should be transparent and not contain sediment.

Recommended dosages of the drug Staphylococcal Bacteriophage:

Dose per 1 dose (ml)

from 1 year to 3 years

from 8 years and older

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug Staphylococcal Bacteriophage orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the source of infection, Staphylococcal bacteriophage is used:

1. In the form of irrigation, lotions and tamponing in a volume of up to 200 ml, depending on the size of the affected area. In case of an abscess, after removing the purulent contents using a puncture, the drug Staphylococcal Bacteriophage is administered in an amount less than the volume of the removed pus. In case of osteomyelitis, after appropriate surgical treatment, the bacteriophage is infused into the wound.

2. When administered into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which the staphylococcal bacteriophage is administered for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, staphylococcal bacteriophage is administered through a cystostomy or nephrostomy 1-2 times a day, poured into the bladder and 5-7 ml into the renal pelvis.

4. For purulent-inflammatory gynecological diseases, the drug Staphylococcal Bacteriophage is administered into the cavity of the vagina, uterus in a dose of 5-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.

5. For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Staphylococcal bacteriophage is used for rinsing, washing, instilling, and introducing moistened turundas (leaving them for 1 hour).

6. For enteral infections and intestinal dysbiosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

Use of Staphylococcal bacteriophage in children (up to 6 months)

For sepsis, enterocolitis of newborns, including premature babies

The bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5-15 days. In case of recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, and infected wounds, the drug Staphylococcal Bacteriophage is used in the form of applications twice daily (a gauze cloth is moistened with the bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).

Side effects of the drug Staphylococcal bacteriophage

Overdose

Interaction with other drugs.

The use of the drug Staphylococcal Bacteriophage is possible in combination with other drugs, including antibiotics.

Special instructions.

Staphylococcal bacteriophage is not suitable for use in bottles with damaged integrity or labeling, if the expiration date has expired, or if they are cloudy.

Due to the presence of a nutrient medium in the preparation Bacteriophage staphylococcus, in which bacteria from the environment can develop, causing clouding of the preparation, it is necessary to observe the following rules when opening the bottle:

  • wash your hands thoroughly;
  • treat the cap with an alcohol-containing solution; remove the cap without opening the cap;
  • do not place the cork with the inner surface on a table or other objects;
  • do not leave the bottle open
  • Store opened bottle only in the refrigerator

Opening the bottle of Staphylococcal Bacteriophage and extracting the required volume of the drug can be done with a sterile syringe by piercing the stopper. The drug Staphylococcal Bacteriophage from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the shelf life.

Impact on the ability to drive vehicles and machinery

Release form of the drug Bacteriophage staphylococcal

Solution for oral, local and external use in bottles of 20 ml or 100 ml. 4 or 8 bottles of 20 ml or 1 bottle of 100 ml in a cardboard pack with instructions for use.

Storage and transportation conditions

Storage in accordance with SP 3.3.2. at a temperature of 2 to 8 ° C in a dry place, protected from light and out of reach of children.

Transportation in accordance with SP 3.3.2. at temperatures from 2 to 8°C, transportation is allowed at temperatures from 9 to 25°C for no more than 1 month.

Shelf life of the drug Bacteriophage staphylococcal.

Shelf life: 2 years. The drug Staphylococcal Bacteriophage with an expired shelf life cannot be used.

Vacation conditions.

Staphylococcal bacteriophage is sold without a prescription.

Source: http://krasgmu.net/publ/zdorove/lekarstva/bakteriofag_stafilokokkovyj_instrukcija_cena_otzyvy/

FAGIO (Phagyo) - for the treatment and prevention of purulent-inflammatory diseases

Bacteriophagum Pseudomonas aeruginosa,

each of them in quantity - not less than 105;

Specific antibacterial drug

— In Surgery: purulent wound, burn, abscess, phlegmon, boil, carbuncle, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis;

— In Urology: urogenital infections: urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis;

— Gastroenterology: enterocolitis, cholecystitis, irritable bowel syndrome (IBS) (dysbacteriosis);

— Generalized septic diseases;

— Purulent-inflammatory diseases of newborns: omphalitis, pyoderma, conjunctivitis, sepsis;

— Other diseases caused by the above-mentioned bacteria.

For prophylactic purposes, the drug is used:

— for the treatment of fresh wounds, both in domestic and medical institutions;

— to prevent purulent complications during surgical procedures and operations;

— to prevent bacterial complications in Acute Respiratory Viral Diseases;

— for the prevention of bacterial contamination and nosocomial infections in medical institutions.

Special instructions: Special precautions when using bacteriophage preparations: not suggested. It is recommended to remove the contents of the bottle with a sterile syringe. The contents of the bottle can be used within 24 hours after opening, when stored under appropriate conditions.

Interaction with other drugs of bacteriophage preparations:

Pregnancy and lactation: Bacteriophage preparations can be used during pregnancy and lactation.

Ability to drive a car and operate machinery

Keep out of the reach of children!

FAGIO is prescribed for oral administration (orally, in the form of enemas), locally (in the form of rinses, irrigations, lotions), for introduction into the cavity (wound, abscess, abdominal, pleural cavities, phlegmon, nose, sinuses, middle ear, urinary bladder, uterus, vagina).

For the treatment of purulent-inflammatory diseases with local lesions, FAGIO is prescribed simultaneously: both locally and for oral administration. The duration of treatment with the drug is from 5 to 10 days.

In the following days, the drug is injected into the infected cavity using drainage.

The procedure is carried out once a day, for 3-5 days.

  • For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected 2 times a day into the bladder and 5-10 ml into the pelvis;
  • For purulent-inflammatory gynecological diseases, the drug is administered into the cavity of the vagina, uterus, in a dose of 5-10 ml daily, once.
  • For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instilling, introducing moistened turundas (leaving them for 1 hour). For the treatment of purulent tonsillitis, the drug is used as a rinse and is also prescribed at the same time.
  • In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of rinses in the mouth 3-4 times a day in the morning, and also injected into the periodontal pockets of turunda, impregnated with pyobacteriophage, for 5-10 minutes.
  • For intestinal forms of the disease, diseases of internal organs, IBS (dysbacteriosis), FAGIO is used orally and in an enema. The drug is given on an empty stomach, 1 hour before meals.

In the form of enemas, it is prescribed once a day, in the evening, before bedtime, after bowel movements.

Recommended dosages of the drug:

The dose of the drug for prophylactic use is determined by the condition of the patients.

Bacteriophage preparations are non-toxic. There were no undesirable effects or reactions associated with the use of FAGIO.

FAGIO is available in 20 ml bottles made of medical glass. There are 4 bottles of the drug in a cardboard box along with instructions for use.

The drug is stored at a temperature of 2oC - 15oC in a dry place protected from light. Transportation is allowed at temperatures from 2 to 25oC by all types of covered transport, providing a stable temperature regime in ZAJQ21 X during the entire transportation period, with a transportation period of no more than 2 weeks.

Do not use after the expiration date indicated on the package.

Conditions for dispensing from pharmacies: without a doctor's prescription.

Manufacturer: JSC "Biochimpharm"

Address: st. Gotua 3, Tbilisi 0160, Georgia,

Source: http://ge.all.biz/ru/fagio-phagyo-dlya-lecheniya-i-profilaktiki-gnojno-g27520

Fagio instructions

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Fagio spray (20 ml)

FAGIO is used for the treatment and prevention of purulent diseases caused by bacteria (Streptococcus, Staphylococcus, E.Coli, Pseudomonas aeruginosa, Proteus).

For the treatment of pharyngitis, laryngitis and tonsillitis; For inflammation of the oral mucosa: for the treatment and prevention of glossitis, gingivitis and stomatitis.

For the treatment of purulent wounds, burns, abscesses, phlegmons, boils, carbuncles, felons.

For purulent-inflammatory diseases of newborns (omphalitis, pyoderma);

Other diseases caused by bacteria Streptococcus, Staphylococcus, E.Coli, Pseudomonas aeruginosa, Proteus.

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Pregnancy and lactation

Can be used during

Instructions for Use

International nonproprietary name

Pio Bacteriophage Spray

Pyo Bacteriophagum Spray

A transparent yellow liquid of varying intensity with a specific taste.

1 ml of liquid preparation contains bacteria: Streptococcus, Staphylococcus, E. Coli, Pseudomonas aeruginosa, Proteus, a mixture of sterile phagolysate filtrates, the titer of each phage is at least 1X10 5;

Spray, 20 ml sterile solution for local and external use.

Pharmacotherapeutic group: Specific antibacterial drug.

Pharmacological action: A bacteriophage is a specific bacterial virus that is adsorbed on the cell membrane of a homologous bacterium, disrupts its integrity, penetrates the cell, multiplies and lyses it.

The composition of FAGIO ® spray includes selective, only virulent bacterial phages - Streptococcus, Staphylococcus, E.Coli, Pseudomonas aeruginosa, Proteus, which ensures high activity and effectiveness of the drug. Regardless of the method of administration, bacteriophage preparations quickly penetrate the blood and lymph and reach the site of the disease. The main part of the drug is excreted by the kidneys, providing a sanitizing effect on the urinary tract, and the rest through the gastrointestinal tract.

Therapeutic indications (during complex therapy):

FAGIO ® spray is used for the treatment and prevention of purulent diseases caused by bacteria (Streptococcus, Staphylococcus, E.Coli, Pseudomonas aeruginosa, Proteus) in all age groups, as well as in high-risk groups.

For the treatment of pharyngitis, laryngitis and tonsillitis; For inflammation of the oral mucosa: for the treatment and prevention of glossitis, gingivitis and stomatitis.

For the treatment of purulent wounds, burns, abscesses, phlegmons, boils, carbuncles, felons.

For purulent-inflammatory diseases of newborns (omphalitis, pyoderma);

Other diseases caused by bacteria Streptococcus, Staphylococcus, E.Coli, Pseudomonas aeruginosa, Proteus.

For prophylactic purposes, the drug is used:

After various manipulations in the oral cavity, after surgery (periodontal procedures, tooth extraction, etc.).

For the treatment of fresh wounds, both in domestic and medical institutions;

To prevent purulent complications during surgical procedures and operations;

To prevent bacterial complications in acute respiratory viral diseases;

Contraindications: Hypersensitivity to any component of the contents of the drug bottle.

Special instructions: Special precautions when using bacteriophage preparations: not suggested.

It is necessary to shake the bottle with the drug before use. The contents of the bottle should be transparent, without sediment.

Do not use the drug if there is turbidity!

After using the drug, store the bottle with the remaining liquid in the refrigerator.

Do not allow the drug to become frozen!

After opening the drug (after the first spray), the drug must be stored for 20 days at a temperature of 2 ° C - 8 ° C. Ingestion of the drug when treating the oral mucosa is allowed.

Interaction with other drugs of bacteriophage preparations

not installed. Bacteriophage preparations can be used with other drugs in complex therapy, including antibacterial drugs (antibiotics).

Pregnancy and lactation: Bacteriophage preparations can be used during pregnancy and lactation.

Ability to drive a car and operate machinery: Bacteriophage preparations do not affect the ability to drive a car or perform work requiring a motor response.

Method of administration and dosage: An important condition for the successful use of bacteriophage preparations is the determination of the phage sensitivity of the pathogen. The drug is especially effective in the initial stage of the disease and when applied directly to the lesion.

FAGIO ® spray is prescribed by a doctor.

When administered orally (oral cavity and throat), the drug should be taken half an hour before or after meals to achieve a therapeutic effect.

Among children under 6 years of age - 5 sprays, with an interval of 2-4 hours, 4-5 times a day.

From 6 to 12 years - 8 sprays, with an interval of 2-4 hours, 4-5 times a day.

Among adults and elderly patients, spray at intervals of 2-4 hours, 4-5 times a day.

The duration of treatment is 5-10 days.

In case of external use, the dose of the drug (amount sprayed) is determined by the doctor depending on the size of the damaged area.

Note: If chemical antiseptics were used before using the drug to treat wounds and/or cavities, then 3 hours must pass before using the drug, or the areas must be thoroughly treated with a sterile 0.9% saline solution.

Overdose: Symptoms of overdose of bacteriophage drugs are unknown.

Side effects: The drug is non-toxic. Data on side effects or harmful effects on the human body after using the drug have not been identified.

Release form and packaging: FAGIO ® spray is available in 20 ml glass bottles, closed with a sealed mechanical sprayer with a transparent cap. The cardboard box contains 1 bottle of the drug, 20 ml each, along with instructions for use.

Storage and transportation conditions: The drug is stored at a temperature of 2 o C - 25 o C in a dry place protected from light.

Transportation by all types of covered transport is allowed, providing stable thermal conditions during the entire transportation time.

Shelf life: When stored under appropriate conditions, 2 years from the production date indicated on the package.

Do not use the drug after the expiration date.

Conditions for dispensing from pharmacies: Product of pharmaceutical group III, dispensed without a doctor's prescription.

Source: http://biochimpharm.ge/ru/product/phagyo-spray/

Fagio instructions

A bacteriophage is a specific bacterial virus that is adsorbed on the cell membrane of a homologous bacterium, penetrates the cell and lyses it. FAGIO contains selective, only virulent bacterial phages: Streptococcus, Staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, which ensures high activity and effectiveness of the drug. Regardless of the method of administration, bacteriophage preparations penetrate the blood and lymph and reach the site of inflammation. The main part of the drug is excreted by the kidneys, providing a sanitizing effect on the urinary tract, and the rest through the gastrointestinal tract.

FAGIO is used for the treatment and prevention of purulent-inflammatory diseases caused by the bacteria Streptococcus, Staphylococcus, E. Coli, Pseudomonas aeruginosa, Proteus, in all age and high-risk groups of patients:

— In Surgery: purulent wound, burn, abscess, phlegmon, boil, carbuncle, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis;

— In Urology: urogenital infections: urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis;

— Gastroenterology: enterocolitis, cholecystitis, irritable bowel syndrome (IBS) (dysbacteriosis);

— Generalized septic diseases;

— Purulent-inflammatory diseases of newborns: omphalitis, pyoderma, conjunctivitis, sepsis;

— Other diseases caused by the above-mentioned bacteria.

For prophylactic purposes, the drug is used:

— for the treatment of fresh wounds, both in domestic and medical institutions;

— to prevent purulent complications during surgical procedures and operations;

— to prevent bacterial complications in Acute Respiratory Viral Diseases;

— for the prevention of bacterial contamination and nosocomial infections in medical institutions.

Hypersensitivity to any component of the contents of the drug bottle.

Special instructions: Special precautions when using bacteriophage preparations: not suggested. It is recommended to remove the contents of the bottle with a sterile syringe. The contents of the bottle can be used within 24 hours after opening, when stored under appropriate conditions.

Interaction with other drugs of bacteriophage preparations:

not installed. Bacteriophage preparations can be used with other drugs, including antibacterial drugs.

Pregnancy and lactation: Bacteriophage preparations can be used during pregnancy and lactation.

Ability to drive a car and operate machinery

Bacteriophage preparations do not affect the ability to drive a car or perform work that requires increased concentration and motor response.

Keep out of the reach of children!

An important condition for the successful use of bacteriophage drugs is the determination of the phage sensitivity of the pathogen and the previous use of the drug. The drug is especially effective in the initial stage of the disease and when applied directly to the lesion.

FAGIO is prescribed for oral administration (orally, in the form of enemas), locally (in the form of rinses, irrigations, lotions), for introduction into the cavity (wound, abscess, abdominal, pleural cavities, phlegmon, nose, sinuses, middle ear, urinary bladder, uterus, vagina).

For the treatment of purulent-inflammatory diseases with local lesions, FAGIO is prescribed simultaneously: both locally and for oral administration (per os). The duration of treatment with the drug is from 5 to 10 days.

In the following days, the drug is injected into the infected cavity using drainage.

The procedure is carried out once a day, for 3-5 days.

  • For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected 2 times a day into the bladder and 5-10 ml into the renal pelvis;
  • For purulent-inflammatory gynecological diseases, the drug is administered into the cavity of the vagina, uterus, in a dose of 5-10 ml daily, once.
  • For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instilling, introducing moistened turundas (leaving them for 1 hour). For the treatment of purulent tonsillitis, the drug is used as a rinse and is also prescribed, per so, at the same time.
  • In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of rinses in the mouth 3-4 times a day in the morning, and also injected into the periodontal pockets of turunda, impregnated with pyobacteriophage, for 5-10 minutes.
  • For intestinal forms of the disease, diseases of internal organs, IBS (dysbacteriosis), FAGIO is used orally and in an enema. The drug is given on an empty stomach, 1 hour before meals.

In the form of enemas, it is prescribed once a day, in the evening, before bedtime, after bowel movements.

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Source: http://lekar.kg/goods/full/id/1603