What is fusafungine

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Fusafungin*

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

Description of the active substance Fusafungine.

Formula: C29H51N2O8, chemical name: no data.

Pharmacological group: antimicrobial, antiparasitic and anthelmintic agents/antibiotics/other antibiotics.

Pharmacological action: local anti-inflammatory, antibacterial.

Pharmacological properties

Fusafungin remains on the surface of the mucous membrane of the respiratory tract when used locally in the form of inhalation, without being detected in the blood serum. Fusafungin in the form of microparticles (aerosol form) completely covers the respiratory tract, penetrates the bronchioles and sinuses. With 4-fold inhalations through each nasal passage and/or through the mouth, the content in the bronchi and trachea is 40 mcg/ml, in the lungs it is 80 mcg/ml, in the nasal cavity it reaches 60 mcg/ml. Fusafungin is active against gram-negative microorganisms (Moraxella catarrhalis, some strains of Neisseria spp., Legionella pneumophila, Haemophilus influenzae), gram-positive microorganisms (Streptococcus pneumoniae, Streptococcus spp. (group A), Staphylococcus spp.), Mycoplasma pneumoniae, some anaerobes, fungi (Candida albicans and others). Fusafungine does not reduce the effectiveness of systemic antimicrobial treatment. There are no reports of cross-resistance or acquired resistance. Fusafungin improves nasal breathing, reduces exudation, swelling and inflammation of the mucous membrane of the respiratory tract. It has been established that the effectiveness of fusafungin is higher if treatment is started early.

Indications

Local therapy of inflammatory and infectious pathology of the respiratory tract (rhinitis, sinusitis, nasopharyngitis, tracheitis, pharyngitis, bronchitis, laryngitis, sinusitis, tonsillitis); condition after tonsillectomy.

Method of administration of fusafungine and dose

Fusafungin is used by inhalation, every 4 hours (for adults) or every 6 hours (for children), 4 inhalations into each nasal passage or/and through the mouth. The duration of the usual course of therapy should be no more than 10 days. It is necessary to reconsider the treatment regimen if longer treatment is necessary. If patients have general symptoms of a bacterial infection, a course of treatment with systemic antibiotics should be considered.

It is not recommended to discontinue therapy when the first signs of improvement appear, because there is a risk of relapse of the disease. Do not use for a long time, as this may cause disruption of the normal microflora with further spread of infection. Local phenomena from the mucous membrane of the upper respiratory tract are usually temporary. Patients with a predisposition to allergies are most likely to develop attacks of allergic reactions and bronchospasm. Do not allow the aerosol to get into your eyes.

Contraindications for use

Hypersensitivity, age up to 2.5 years (due to the risk of developing laryngospasm).

Restrictions on use

Predisposition to allergic reactions and bronchospasm.

Use during pregnancy and breastfeeding

It is possible to use fusafungine during pregnancy and breastfeeding when prescribed by a doctor according to indications.

Side effects of fusafungine

Attacks of sneezing, coughing, irritation of the nasopharynx, local reactions in the mucous membranes and skin (rash, swelling), allergic reactions, bronchospasm, superinfection, dryness of the nasal pharynx and cavity, unpleasant taste in the mouth, congestion in the eyes, allergic skin reactions, urticaria , attacks of bronchial asthma, vomiting.

Interaction of fusafungine with other substances

Overdose

An overdose of fusafungine may cause circulatory problems, dizziness, numbness in the mouth, burning in the throat, and increased sore throat. Required: symptomatic treatment with further monitoring of the patient.

Source: http://xn——8kceunaflgjrqyoqfbei8dxl.xn--p1ai/%D1%84%D1%83%D0%B7%D0%B0%D1%84%D1%83%D0%BD%D0%B3%D0 %B8%D0%BD

Bioparox (Fuzafungin)

There are contraindications. Before starting use, consult your doctor.

Trade names abroad (abroad) - Locabiotal, Locabiosol.

Currently, analogues (generics) of the drug are NOT FOR SALE in Moscow pharmacies!

Other drugs for the treatment of throat diseases are here.

All drugs used in ENT practice are here.

You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the drug in the text of the message) here.

Preparations containing Fusafungine (ATC code R02AB03):

Bioparox - doctor's review:

Unfortunately, I have a clear understanding that at least some of the products of the pharmaceutical company Servier do not have a real therapeutic effect (for example, the cardiac Preductal).

I will give facts about Bioparox.

Fact one. Many years ago, when the drug first appeared on the Russian market, bronchitis was included in the indications for use.

(Excerpts of old instructions can still be found on the Internet at the request Bioparox bronchitis, for example: Indications - acute inflammatory diseases of the respiratory tract caused by microorganisms sensitive to the action of fusafungine (tracheitis, BRONCHITIS). Method of application - for inflammatory diseases of the mucous membrane of the throat and upper respiratory tract (pharyngitis, laryngitis, tonsillitis, BRONCHITIS, tracheitis), as well as after surgical interventions (tonsillectomy), the drug is administered orally.)

And I, as a law-abiding doctor, prescribed this drug for bronchitis. It seemed to me then that the effect was not particularly good.

And now, twenty years later, bronchitis has disappeared from the indications (that is, it has officially turned out that Bioparox is absolutely useless in this case).

It turns out that the Servier company deceived doctors by presenting wishful thinking in the instructions for the drug.

Fact two. The instructions for the drug say: In vitro (translation from Latin - in glass, that is, in laboratory studies) Bioparox® is active against: (the following is a list of killed bacteria).

A little further in the same instructions: Fusafungin is SUPPOSED to have similar activity in vivo (translation from Latin - in the living, that is, in the body).

It turns out that over the twenty years of the drug’s existence, the manufacturer only speculates, but did not bother to test the effect in clinical studies.

Therefore, I cannot judge whether Bioparox helps with ENT pathologies.

Draw your own conclusions.

Sincerely, the author of the site.

Bioparox (Fuzafungin) - official instructions for use:

Clinical and pharmacological group:

Antibacterial drug for local use in ENT practice

pharmachologic effect

Antibiotic for local use. Has antibacterial and anti-inflammatory activity.

In vitro Bioparox® is active against: Streptococcus spp. group A, Streptococcus pneumoniae (old name - Pneumococcus), Staphylococcus spp., some strains of Neisseria spp., some anaerobes, as well as Mycoplasma spp., fungi of the genus Candida. Fusafungin is believed to have similar activity in vivo.

Fusafungin has a pronounced anti-inflammatory effect by reducing the concentration of tumor necrosis factor (TNF-a) and suppressing the synthesis of free radicals by macrophages while maintaining phagocytosis.

Pharmacokinetics

After inhalation use of the drug Bioparox®, fusafungin is mainly distributed on the surface of the mucous membrane of the oropharynx and nasal cavity. Fusafungin can be detected in blood plasma in very low concentrations (no more than 1 ng/ml), which does not affect the safety of the drug.

Indications for use of the drug BIOPAROX®

  • treatment of infectious and inflammatory diseases of the respiratory tract (rhinitis, nasopharyngitis, pharyngitis, laryngitis, tracheitis, tonsillitis, conditions after tonsillectomy, sinusitis).

Dosage regimen

The drug is used in the form of inhalation (through the mouth and/or nose).

Adults are prescribed 4 inhalations through the mouth and/or 2 inhalations into each nasal passage 4 times a day.

Children over 2.5 years old are prescribed 2-4 inhalations through the mouth and/or 1-2 inhalations into each nasal passage 4 times a day.

To make maximum use of the activity of the Bioparox® drug, it is necessary to follow the prescribed doses and follow the rules for using the attached attachments.

To obtain a lasting therapeutic effect, it is necessary to observe the duration of the prescribed treatment: it is not recommended to stop treatment when the first signs of improvement appear, because premature cessation of therapy may lead to relapse.

You should always have the drug with you, placing it in the attached portable carrying case.

The duration of treatment, as a rule, does not exceed 7 days.

After completing the 7-day course of treatment, the patient should consult a doctor to assess the effectiveness of therapy.

If symptoms of the disease and/or elevated temperature persist during therapy with Bioparox®, the patient should inform the attending physician.

In the case of pronounced clinical manifestations of a bacterial infection, treatment with Bioparox® in combination with systemic antibiotics is possible.

Rules for using the drug

Before using the canister for the first time, press its base 4 times to activate it.

Inhalations through the nose should be carried out for rhinitis, nasopharyngitis, and sinusitis. Before inhalation, you should clean your nose. The container with the drug must be held vertically with the nozzle upward, holding it between the thumb and forefinger. To carry out inhalation through the nose, attach the nozzle to the balloon (yellow for adults or transparent for children) and insert it into the nasal passage (while holding the opposite nasal passage and closing the mouth). While inhaling deeply through your nose, press the base of the balloon vigorously and all the way.

Inhalation through the mouth. Place the white nozzle on the balloon, insert it into your mouth, pressing it tightly with your lips, while holding the balloon vertically and slightly tilted.

For pharyngitis, tonsillitis, conditions after tonsillectomy, laryngitis, you should press firmly and for a long time on the bottom of the balloon and take a deep breath to completely irrigate the tonsils and pharynx.

For tracheitis, before inhalation it is necessary to cough, then deeply inhale the aerosol mixture and hold your breath for a few seconds to completely irrigate the trachea.

The attachments should be disinfected every other day using a cotton swab soaked in ethanol (90%).

Side effect

Local reactions: possible dryness of the mucous membranes of the nose or oropharynx, tingling sensation in the nasal cavity, mouth and throat, sneezing, coughing, nausea, unpleasant taste in the mouth, swelling of the eyes. These reactions pass quickly and, as a rule, cessation of treatment is not required.

Allergic reactions from the skin and mucous membranes: in some cases - rash, itching, urticaria, Quincke's edema, mainly in patients predisposed to allergies. Asthmatic attacks, bronchospasm attacks, shortness of breath, laryngeal spasm, angioedema, and anaphylactic shock may occur.

Contraindications to the use of the drug BIOPAROX®

  • children under 2.5 years of age (risk of developing laryngospasm);
  • hypersensitivity to the components of the drug.

Bioparox® should be used with caution in patients predisposed to allergic reactions.

Use of the drug BIOPAROX® during pregnancy and breastfeeding

There are no clinical data on the use of the drug during pregnancy. The drug should be prescribed with caution during pregnancy.

Due to the lack of data on excretion in breast milk, the use of Bioparox® in nursing women is not recommended.

Long-term studies on laboratory animals did not reveal embryo-, genotoxic effects or teratogenic effects on the fetus.

special instructions

It is not recommended to exceed the duration of the standard 7-day course of treatment in accordance with the general rules for the use of antibiotics.

At the end of the 7-day course of treatment, the patient should consult a doctor to assess the effectiveness of therapy.

Do not spray the drug into the eyes.

Do not store the drug near strong heat sources. Do not expose to temperatures above 50°C.

Avoid breaking the seal of the canister body and burning it, even after the drug has been completely used.

Impact on the ability to drive vehicles and operate machinery

Bioparox® does not affect the ability to drive vehicles or the speed of psychomotor reactions.

Overdose

Overdose symptoms are not described.

Drug interactions

Data on drug interactions of Bioparox with other drugs, incl. and with other antibiotics is not available.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

List B. No special storage conditions are required. Shelf life: 2 years. Do not use after the expiration date stated on the package.

Source: http://xn—-7sbabkdpwufdsp9apq.xn--p1ai/bioparox

Fusafungin: complete information

Spray Fusafungin instructions

Instructions for using the antibiotic Fusafungin for topical use contain all the necessary information about it. Here you can read about its pharmacological action, learn about indications and contraindications, as well as how the drug should be used and what its side effects are.

Also, each patient can get acquainted with additional instructions regarding its use, analogues of the drug, cost and reviews of those people who have already used the drug.

Form, composition, packaging

The drug Fusafungin spray is a medicine in the form of a metered aerosol for inhalation. It is produced in the form of a solution, which has a yellow color and a specific odor.

The active substance of the drug is fusafungin, 50 milligrams of which are contained in an aerosol can and 125 micrograms per single inhalation.

In the form of auxiliary components, aromatic additives, anhydrous ethanol, saccharin, isopropyl myristate, propellant, tetrafluoroethane in the required quantity were used.

The drug is supplied to pharmacies in cardboard packs with a contoured cell packaging and a case to make the drug convenient to carry. The cylinder is made of aluminum and has a metering valve. It comes complete with a spray nozzle and an activator cap. Each cylinder has a volume of 10 milliliters, which is enough to perform four hundred inhalations.

Pharmacology

Being an antibacterial, anti-inflammatory agent of local action, the drug Fusafungin can be used in the form of inhalation, where it will completely remain in the respiratory tract on the surface of their mucosa.

The drug can be considered active against:

  • Group A gram-positive bacteria;
  • Some strains of gram-negative organisms;
  • Some are anaerobes;
  • Mushrooms.

Systemic antimicrobial therapy with fusafungin does not decrease and does not develop acquired or cross-resistance. Its use helps reduce exudation, as well as reduce inflammation and swelling of the respiratory mucosa. When treatment is started at an early stage of the disease, its effectiveness is higher.

Indications for use Fusafungin

The use of the drug is indicated for those patients who need local treatment of diseases in the respiratory tract of an infectious and inflammatory nature.

Contraindications

The use of the drug Fusafungin is not advisable if the patient has hypersensitivity, as well as for children under two and a half years old. Because for this category of patients, the use of the drug is fraught with the development of laryngospasm.

Fusafungin instructions for use

The drug is used by inhalation.

For adults, four inhalations into each of the nasal passages or into the oral cavity every four hours;

For children, four inhalations into each of the nasal passages or into the oral cavity after six hours;

The duration of the course of treatment is no more than ten days. Longer therapy will require a revision of the treatment regimen. When a patient exhibits general clinical manifestations of a bacterial infection, the possibility of conducting a course of treatment using antibiotics with a pronounced systemic effect should be considered.

How to use Fusafungin spray correctly

To activate the balloon and start using it, you need to press its base four times.

Inhalation through the nasal passages

Clean your nose first. Place the balloon vertically between your index finger and thumb so that the nozzle is at the top. When the nozzle is inserted into one of the nostrils, the second should be closed, like the mouth. Inhaling deeply through your nose, vigorously press the base of the balloon until it stops.

Inhalation through the oral cavity

The balloon must be equipped with a nozzle for inhalation through the mouth. The nozzle is inserted into the oral cavity and tightly covered by the lips. The cylinder is located in a vertical position with a slight tilt. In order to irrigate the tonsils and pharynx, it is enough to inhale deeply by pressing firmly and for a long time on the bottom of the container with the drug. In order to irrigate the trachea after a deep inhalation of the aerosol mixture, the patient must hold his breath as much as possible.

Nozzles for inhalation must be disinfected. This can be done with ethanol by wiping with a gauze swab.

Fusafungin during pregnancy

If there is a need to take a medicine for a pregnant or lactating woman, then its use for treatment according to the doctor’s indications is quite acceptable.

Side effects

A side effect of the drug may manifest itself in the form of superinfection and allergic reactions. Local reaction on the skin and mucous membranes, expressed by swelling or rash. In addition, you can expect irritation in the nasopharynx and sneezing attacks.

Additional instructions

Patients with a predisposition to allergies can expect the development of allergic reactions or bronchospasms during treatment with the drug. Each of the local reactions in the mucosal area goes away quite quickly.

Treatment should not be considered complete with the first signs of improvement and should be stopped to avoid relapse. However, long-term use is not advisable, since this may disrupt the normal microflora with a risk of further spread of infection.

Fusafungin analogues

Fusafungin can be replaced during treatment with drugs with a similar effect. Not all of them come in spray form and have a weaker antiseptic effect. For example:

  • The drug Grammidin in the form of capsules for resorption;
  • The drug Hexoral;
  • The drug Chlorophyllipt in the form of tablets and solution;
  • The drug Isofra;
  • The drug Tantum Verde;
  • The drug Faringosept in the form of lozenges.

Each of these drugs is distinguished by the absence of an antibiotic in its composition, which explains its more affordable cost.

Fusafungin price

The drug has a fairly high cost, which ranges from 515 to 530 rubles.

Fusafungin reviews

Almost every review of the drug Fusafungin is positive. It is called an effective medicine that can not only cure, but also do it quickly. The only thing that patients are dissatisfied with is its not very pleasant taste and specific smell. Many people are not satisfied with its price. However, otherwise patients are satisfied with Fusafungin and recommend its use to their friends.

There are a lot of reviews about the drug. Here are some of those that have arrived quite recently.

Antonina: My throat hurt and the disease developed into a severe sore throat. It got to the point where it became almost impossible to talk. Fusafungin helped and not only with the throat, but also the nose was cured. I don’t regret at all that I purchased this particular drug. It is used sparingly; I use the remaining drug for preventive purposes.

Luda: I didn’t cure my runny nose in time and got sinusitis. There were concerns that I could not avoid surgical intervention. However, everything worked out. As prescribed by the doctor, I began taking Fusafungin in combination with other drugs. In the end, there was no surgery.

Victoria: I bought Fusafungin on the advice of a doctor to treat a sore throat. At first I was confused by its cost, but my throat required urgent help. I liked the drug because of its good therapeutic effect and ease of use. I used it for a week as recommended by the doctor, although significant relief came already on the third day.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/401-fuzafungin-fusafungin-polnaya-informatsiya

Fusafungine

Content

Russian name

The Latin name of the substance is Fusafungin

Gross formula

Pharmacological group of the substance Fusafungin

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Fusafungin

Antibiotic for local use. Isolated from a culture of the fungus Fusarium lateritium (strain 437). Practically insoluble in water, soluble in glycols and fats.

Pharmacology

When applied topically in the form of inhalations, it remains on the surface of the mucous membrane of the respiratory tract and is not detected in the blood plasma. The aerosol form (in the form of microparticles) provides complete coverage of the respiratory tract, penetration into the sinuses and bronchioles. After 4 times inhalation through the mouth and/or through each nasal passage, the concentration in the lungs reaches 80 mcg/ml, in the trachea and bronchi - 40 mcg/ml, in the nasal cavity - 60 mcg/ml.

Active against gram-positive bacteria (Streptococcus spp. (group A), Streptococcus pneumoniae, Staphylococcus spp.), gram-negative microorganisms (some strains of Neisseria spp., Moraxella catarrhalis, Haemophilus influenzae, Legionella pneumophila), some anaerobes, Mycoplasma pneumoniae, fungi (Candida albicans , etc.).

Does not reduce the effectiveness of systemic antimicrobial therapy. There are no reports of the development of acquired or cross-resistance. Reduces exudation, inflammation and swelling of the mucous membrane of the respiratory tract, improves nasal breathing. It has been shown that the effectiveness of therapy is higher when treatment is started early.

Use of the substance Fusafungin

Local treatment of infectious and inflammatory diseases of the respiratory tract (sinusitis, rhinitis, nasopharyngitis, pharyngitis, tracheitis, laryngitis, tonsillitis, sinusitis, bronchitis), condition after tonsillectomy.

Contraindications

Hypersensitivity, children under 2.5 years of age (risk of developing laryngospasm).

Use during pregnancy and breastfeeding

Can be used during pregnancy and breastfeeding (according to indications).

Side effects of the substance Fusafungin

Irritation of the nasopharynx, sneezing attacks, local reactions in the skin and mucous membranes (swelling and rash), bronchospasm, allergic reactions, superinfection.

Routes of administration

Precautions for the substance Fusafungin

It is not recommended to stop treatment when the first signs of improvement appear, because relapse is possible. Should not be used for a long time, because this can lead to disruption of normal microflora with the risk of spreading infection.

Local reactions from the mucous membrane of the upper respiratory tract are usually transient. The development of bronchospasm attacks and allergic reactions is more likely in patients with a predisposition to allergies.

Interactions with other active ingredients

Trade names

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Fusafungin

Description current as of 01/21/2016

  • Latin name: Fusafunginum
  • ATX code: R02AB03
  • Chemical formula: C 2 9 H 5 1 N 2 O 8
  • CAS code:

Chemical properties

Fusafungin is a polypeptide antibiotic; it is used mainly topically. The substance was isolated from strain 437 of the fungus Fusarium lateritium. The product is practically insoluble in water, but mixes well with fats and glycols. The medicine is produced in the form of metered aerosols for local use (inhalation).

The drug Fusafungin, a group of topical antibiotics, effectiveness

According to the results of studies conducted in 2015 by the international non-profit organization Cochrane, this substance has a significantly pronounced effect in the treatment of inflammatory and infectious diseases of the throat within 5 days. On days 8 and 28 of treatment, the drug did not have any positive effects. The researchers also noted the low quality of previously conducted studies of Fusafungin and the lack of materials showing reliable effectiveness of the drug in the treatment of laryngitis. At the moment, new studies on the safety and effectiveness of drugs based on this component have been launched (at the request of AIFA).

pharmachologic effect

Pharmacodynamics and pharmacokinetics

A local antibiotic has anti-inflammatory and antibacterial properties. The substance is active against gram-positive (Streptococcus spp., Staphylococcus spp., Streptococcus pneumoniae) and gram-negative microorganisms (strains of Moraxella catarrhalis, Haemophilus influenzae, Neisseria spp., Legionella pneumophila), some anaerobes, fungi, including the genus Candida, Mycoplasma pneumoniae .

Fusafungin, when applied topically, does not penetrate into the systemic circulation. The substance settles on the surface of the mucous membrane of the respiratory tract, and microparticles of the drug completely cover them. Aerosolized drugs penetrate the bronchioles and sinuses.

The medicine combines well with systemic antimicrobial therapy. Cross or acquired resistance does not occur. With systematic use of the drug, exudation decreases, swelling and inflammation of the mucous membrane of the respiratory tract subsides. The patient can breathe normally through the nose. It has been proven that the effectiveness of the drug is higher in the initial stages of the disease.

Indications for use

Contraindications

The medicine should not be used to treat children under two and a half years of age due to the increased likelihood of laryngospasm. Also, the drug is not prescribed to patients with hypersensitivity to this antibiotic.

Side effects

The medicine is usually well tolerated. However, you may develop:

  • dry mucous membranes, coughing and sneezing;
  • unpleasant taste in the mouth and distortion of the perception of tastes in general;
  • congestion in the eyes, irritation of the mucous membrane.

Fusafungin, instructions for use (Method and dosage)

The substance is used in the form of inhalations.

Adults are most often prescribed 4 injections into the mouth or into each nasal passage. The procedure is repeated every 4 hours.

For children, it is necessary to adjust the dosage of the drug. Therefore, under the age of 18, it is recommended to use the drug no more than once every 6 hours.

The duration of treatment is from 5 to 10 days, depending on the disease, its severity and the recommendations of the attending physician.

When carrying out inhalations, it is recommended to follow the instructions for use of the inhaler, which are included with the medicine.

Overdose

The likelihood of overdose is low. The drug is not subject to systemic absorption.

Interaction

If the patient shows signs of developing a widespread bacterial infection, it is recommended to additionally prescribe systemic antibiotics.

Terms of sale

No prescription required.

Best before date

special instructions

During treatment, caution should be exercised in patients with a predisposition to developing allergic reactions. If the patient is allergic to the drug, therapy with the drug is stopped.

When treatment lasts more than 10 days, superinfections may develop.

It is necessary to avoid contact of the antibiotic with the eyes.

Vials of medicine that are under pressure should not be stored near sources of fire or heat, and should not be heated to more than 50 degrees Celsius.

For children

The medicine can be prescribed to children from 2 and a half years of age. In this case, it is necessary to adjust the dosage.

During pregnancy and lactation

Experience with the use of this antibiotic in pregnant women is somewhat limited. During pregnancy, the medicine is used with extreme caution.

The drug is not recommended for nursing mothers.

Drugs containing (Fuzafungin analogues)

Reviews

Reviews of the medicine are generally good. A local antibiotic when used systemically, according to the instructions, copes well with infectious and inflammatory diseases of the throat. However, there are reports of cases of ineffective therapy with the drug, high cost and unpleasant taste and smell of the drug.

Fusafungin price, where to buy

You can buy the medicine at any pharmacy or online store. The price of Fusafungin in the form of a Bioparox aerosol is approximately 500 rubles per 10 ml can, with a dosage of 0.125 mg of the active substance.

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All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/fuzafungin

Fusafungin

Fusafungin has often been criticized as a drug promoted as a replacement for systemic antibiotic therapy. It is noted that the properties of fusafungine declared by the manufacturers currently appear to be unfounded, since there is no reliable clinical data showing its effectiveness.

Content

pharmachologic effect

Local antibiotic with anti-inflammatory properties. Active against the following microorganisms: Streptococcus spp. group A, Streptococcus pneumoniae, Staphylococcus spp., some strains of Neisseria spp., some anaerobes, as well as Mycoplasma spp., fungi of the genus Candida. [2]

Pharmacokinetics

It is practically not absorbed from the surface of the mucous membrane of the respiratory tract. [2]

Application

Infectious and inflammatory diseases of the respiratory tract: rhinitis, nasopharyngitis, tracheitis, laryngitis, tonsillitis, condition after tonsillectomy, sinusitis and bronchitis.

Hypersensitivity, children's age (up to 2.5 years) - danger of developing laryngospasm.

Dryness of the mucous membranes of the respiratory tract, paresthesia or sneezing.

Local allergic reactions (swelling and hyperemia of the skin and mucous membranes), bronchospasm. [2]

Use during pregnancy and breastfeeding

There are no clinical data on use during pregnancy. There are no data on excretion of the drug into breast milk. The drug is not recommended for use during pregnancy and breastfeeding. [4]

Dosage regimen [2] [3]

Adults: 4 inhalations through the mouth and/or into each nasal passage every 4 hours.

Children: 4 inhalations through the mouth and/or into each nasal passage every 6 hours.

The duration of treatment should not exceed 10 days.

To inhale 1 dose of the drug, you must insert the nozzle of the can into the oral cavity, tightly clasping it with your lips. Then, while taking a deep breath, vigorously and completely press the nozzle of the can. To administer the drug through the nose, you need to close one nostril with your finger, insert the nozzle of the can into the opposite nasal passage and, while taking a deep breath, press it vigorously and completely.

If patients have clinical manifestations of a common bacterial infection, it is necessary to provide for the possibility of systemic administration of antibiotics. [2]

Precautionary measures

It is not recommended to stop treatment when the first signs of improvement appear, as relapse is possible. It should not be used for a long time, as this may lead to disruption of normal microflora with the risk of spreading infection.

Local reactions from the mucous membrane of the upper respiratory tract are usually transient. The development of bronchospasm attacks and allergic reactions is more likely in patients with a predisposition to allergies. [1]

Notes

  1. ↑ 1 2 3 Fuzafyungin. Register of medicines . ReLeS.ru (10/14/2003). Archived from the original on March 11, 2012. Retrieved April 3, 2008.
  2. ↑ 1 2 3 4 5 6 7 Search in the drug database, search options: INN - Fusafungin , flags “Search in the register of registered drugs” , “Search TKFS” , “Show lekforms” . Circulation of medicines . Federal State Institution “Scientific Center for Expertise of Medical Products” of Roszdravnadzor of the Russian Federation (03/27/2008). — A standard clinical and pharmacological article is a by-law and is not protected by copyright in accordance with part four of the Civil Code of the Russian Federation No. 230-FZ of December 18, 2006. Archived from the original on August 22, 2011. Retrieved April 3, 2008.
  3. ↑ 1 2 Fusafungine. Encyclopedia of Medicines . Register of Medicines of Russia (2003). (unavailable link - history ) Retrieved April 3, 2008.
  4. ↑Instructions.

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Source: http://dikc.academic.ru/dic.nsf/ruwiki/491037

Fusafungin is an antibacterial substance in the form of aerosols

The substance fusafungin is a polypeptide antibiotic used in various fields of medicine. The best use is local, since only in this case does it show the greatest effectiveness against pathogenic microflora.

Composition, release form, packaging

The antibiotic was derived from the 437 strain of the fungi Fusarium lateritium. The substance is practically insoluble in water, but combines well with fats and glycols, which explains the main forms of preparations based on it - aerosols like Bioparox.

Manufacturer

Basic data on the study and the characteristics of the action of the substance were provided by the international non-profit organization Cochrane.

Indications

Indications for use: infectious pathologies of the throat and upper and middle respiratory tract:

Diseases that are treated with fusafungine

Contraindications

Contraindications are age under 2.5 years due to the risk of developing laryngospasm, as well as hypersensitivity.

Review of the drug Bioparox (Fuzafungin):

Mechanism of action

Fusafungin is a substance with antibacterial and anti-inflammatory effects. Shows high effectiveness against gram-positive and gram-negative bacteria, as well as some fungi and anaerobes.

When applied topically, it does not penetrate the bloodstream, which is why it is not able to have a systemic effect. The substance settles on the surfaces of the mucous membranes of the respiratory organs, which completely cover the drug particles. The aerosol form of the drug penetrates well into the sinuses and bronchioles.

The drug combines well with systemic antimicrobial therapy. There is no risk of developing acquired or cross-resistance.

Instructions for use

Since preparations based on this substance are produced in aerosol form, application is carried out by injecting the product into the mouth or nasal passages. Adults are usually prescribed a regimen that involves 4 injections every 4 hours.

For children, adjustment of the substance and its dosage is necessary. Therefore, up to 18 years of age, injections are carried out once every 6 hours. The duration of the course is 5-10 days, depending on the pathology, severity of the disease, as well as the doctor’s recommendations.

When using this or that product, it is recommended to strictly follow the instructions for use.

How to take fusafungine during pregnancy:

Side effects

Side effects appear as:

  • Dryness of mucous surfaces;
  • Cough;
  • Sneezing;
  • Unpleasant taste;
  • Distorted perception of tastes;
  • Congestion in the eyes;
  • Irritation of the mucous surfaces of the eye;
  • Bronchial asthma;
  • Allergic reactions of the skin type;
  • Vomit;
  • Hives;
  • Systemic allergic reactions.

In general, the drug is well tolerated, without causing serious side symptoms.

Overdose

Since the drug is not absorbed into the systemic bloodstream, the risk of overdose will be reduced to almost zero.

special instructions

When administering therapy with fusafungine, caution should be exercised in people prone to allergic reactions. If allergy symptoms appear, therapy with the drug is stopped.

How to use Fusafungin spray

Drug interactions

At the first signs of the development or spread of a bacterial infection, it is necessary to additionally use systemic antibacterial drugs.

Reviews about the drug

In general, reviews of drugs based on this substance are positive. What especially stands out is that the drugs do not have a pronounced systemic effect on the body, and also extremely rarely give side effects. If we talk about doctors, not so long ago it was decided to conduct additional studies that should confirm or refute the safety of the drug and, as a result, the drug may be banned.

Fusafungin price

Prices for the substance are not indicated. But if we talk about drugs based on it, then the main representative - Bioparox in a volume of 10 ml can be bought for 500 rubles.

Analogs

Cheap

Cheap analogues are Grammidin, Gramicidin, Isofra.

Drug synonyms

The substance has no synonym.

Conditions for dispensing from pharmacies

Available without a prescription.

How to replace the drug, see our video:

Storage conditions and shelf life

Stored for 2 years at temperatures less than 25 degrees and more than 15 degrees. Avoid heating above 50 degrees.

Source: http://gidmed.com/otorinolarintologija/lekarstva-lor/fuzafungin.html

fusafungine what is it

fusafungine what is it

In the section Diseases, Medicines, to the question What kind of medicine is Bioparox fusafungine? asked by the author Alina_the best answer is an Antibiotic in the form of a spray. PHARMACOLOGICAL PROPERTIES: Bioparox is an antibiotic obtained from the fungal strain Fusarium lateritium WR (strain 437) for topical use with an anti-inflammatory effect. Active against group A streptococci, pneumococci, staphylococci, some strains of Neisseria, some anaerobes, Candida and Mycoplasma pneumoniae. After inhalation, fusafungin is not absorbed from the mucous membrane of the respiratory tract and is not detected in the blood plasma.

INDICATIONS: local treatment for infectious and inflammatory diseases of the upper respiratory tract - sinusitis, rhinitis, nasopharyngitis, pharyngitis, tonsillitis, laryngitis, tracheitis, bronchitis, condition after tonsillectomy.

APPLICATION: during each session, adults receive 4 inhalations of the aerosol through the mouth and/or 4 inhalations through each nasal passage every 4 hours, for children - every 6 hours. The duration of treatment should not exceed 10 days.

The yellow nozzle is intended for nasal inhalations, the white nozzle is intended for oral inhalations.

When performing inhalation through the mouth, the white nozzle is tightly wrapped around the lips and at the moment of a deep inhalation, the nozzle of the can is pressed.

When performing inhalation through the nose, use a yellow nozzle, which is inserted into the nostril, after which the opposite nostril is clamped with a finger and, at the moment of inhalation, the nozzle of the can is pressed.

Antibiotic in the form of a spray. Treats throat and nose.

Fusafungin is a topical antibiotic with anti-inflammatory properties. Determination of the antibacterial activity of fusafungin in vitro allows us to judge its effectiveness in vivo against a number of the following microorganisms: group A streptococci, pneumococci, staphylococci, some strains of Neisseria, a number of anaerobic microorganisms, Candida albicans and Mycoplasma pneumoniae.

I had this inhaler type spray - it seemed to be for the throat, if I'm not mistaken, based on antibiotics and with the addition of lavender, although I'm not sure.

Source: http://2oa.ru/fuzafungin-chto-eto-takoe/

Fusafungin

Russian name

Latin name

Gross formula

Pharmacological group

Nosological classification (ICD-10)

CAS code

Characteristic

Antibiotic for local use. Isolated from a culture of the fungus Fusarium lateritium (strain 437). Practically insoluble in water, soluble in glycols and fats.

Pharmacology

When applied topically in the form of inhalations, it remains on the surface of the mucous membrane of the respiratory tract and is not detected in the blood plasma. The aerosol form (in the form of microparticles) provides complete coverage of the respiratory tract, penetration into the sinuses and bronchioles. After 4 times inhalation through the mouth and/or through each nasal passage, the concentration in the lungs reaches 80 mcg/ml, in the trachea and bronchi - 40 mcg/ml, in the nasal cavity - 60 mcg/ml.

Active against gram-positive bacteria (Streptococcus spp. (group A), Streptococcus pneumoniae, Staphylococcus spp.), gram-negative microorganisms (some strains of Neisseria spp., Moraxella catarrhalis, Haemophilus influenzae, Legionella pneumophila), some anaerobes, Mycoplasma pneumoniae, fungi (Candida albicans, etc.).

Does not reduce the effectiveness of systemic antimicrobial therapy. There are no reports of the development of acquired or cross-resistance. Reduces exudation, inflammation and swelling of the mucous membrane of the respiratory tract, improves nasal breathing. It has been shown that the effectiveness of therapy is higher when treatment is started early.

Application

Local treatment of infectious and inflammatory diseases of the respiratory tract (sinusitis, rhinitis, nasopharyngitis, pharyngitis, tracheitis, laryngitis, tonsillitis, sinusitis, bronchitis), condition after tonsillectomy.

Contraindications

Hypersensitivity, children under 2.5 years of age (risk of developing laryngospasm).

Use during pregnancy and breastfeeding

Can be used during pregnancy and breastfeeding (according to indications).

Side effects

Irritation of the nasopharynx, sneezing attacks, local reactions in the skin and mucous membranes (swelling and rash), bronchospasm, allergic reactions, superinfection.

Directions for use and doses

Inhalation, 4 inhalations through the mouth and/or into each nasal passage every 4 hours (adults) or every 6 hours (children). The duration of the usual course of treatment should not exceed 10 days. If longer treatment is necessary, the regimen must be reconsidered. If patients have general clinical manifestations of a bacterial infection, it is necessary to provide for the possibility of a course of treatment with systemic antibiotics.

Precautionary measures

It is not recommended to stop treatment when the first signs of improvement appear, because relapse is possible. Should not be used for a long time, because this can lead to disruption of normal microflora with the risk of spreading infection.

Local reactions from the mucous membrane of the upper respiratory tract are usually transient. The development of bronchospasm attacks and allergic reactions is more likely in patients with a predisposition to allergies.

Source: http://www.med-09.ru/dv2298.htm

Fusafungin

Fusafungin is an antibiotic produced by Fusarium lateritium. The drug is capable of exhibiting bacteriostatic and anti-inflammatory activity. It acts by reducing swelling and other manifestations of inflammation in the mucous membranes of the oral/nasal cavities and respiratory tract.

The antibiotic is active against:

  • Mycoplasma spp.;
  • fungi of the genus Candida;
  • some strains of Neisseria spp.,
  • Staphylococcus spp.;
  • Streptococcus spp. (including group A Streptococcus and Streptococcus pneumoniae);
  • some anaerobic bacteria.

Instructions for Fusafungin

The active ingredient is Fusafungine.

On the pharmaceutical market, Fusafungin is presented in the form of a spray (400 doses), which has a set of two tips (for the oral/nasal cavities).

Indications for taking Fusafungin

The pharmaceutical product Fusafungin is recommended for use in the local treatment of respiratory tract/nasopharyngeal diseases of an infectious or inflammatory nature, including:

Also, an antibacterial drug is used for conditions after tonsillectomy.

Fusafungin contraindications

The use of Fusafungine is not recommended for persons who have increased personal sensitivity to Fusafungine, the active component of the drug.

You should also not take antibacterial drugs if:

  • under 2.5 years of age;
  • intolerance to the auxiliary components of the drug.

Fusafungin has no other contraindications.

Side effects of Fusafungin

Observations of patients using Fusafungin showed that the antibiotic, as a rule, does not provoke the occurrence of any significant side symptoms.

Occasionally, local irritation reactions may occur, manifested by congestion in the eye area, unpleasant taste in the mouth, dryness of the mucous membranes of the pharynx/nasal cavity, sneezing, coughing.

Extremely rarely (in particular in patients who have a tendency to allergic reactions) the following may occur:

  • Digestive system - vomiting;
  • Dermatological manifestations – urticaria;
  • Respiratory system – paroxysmal phenomena of bronchial asthma;
  • Allergic skin reactions – itching/rash.

Precautions when taking Fusafungin

Caution must be exercised if you have any kind of predisposition (including genetic) to allergic reactions.

Avoid contact of Fusafungin with the eyes.

The use of an antibiotic over a long period of time can provoke suppression of normal microflora, which in turn can lead to the development of superinfection.

If there are general clinical symptoms of a bacterial infection, systemic antibiotic treatment is necessary.

It is not forbidden to use this medicine in old age, pregnancy, breastfeeding.

It is recommended to disinfect aerosol tips daily using cotton swabs moistened with ethyl (90°) alcohol.

From patients who have used the spray, reviews of Fusafungin are mostly positive. The bacteriostatic effect of the drug is noted.

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Source: http://101god.ru/preparaty/respiratornaya-sistema/4037-fuzafungin.html