What is stronger: cefotaxime or ceftriaxone?

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Which drug is more effective: Cefotaxime or Ceftriaxone?

Treatment of many serious diseases requires the use of antibacterial drugs. In many cases, experts recommend the use of Cefotaxime and Ceftriaxone.

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They belong to the group of third generation antibiotics. Their effectiveness has been proven against a wide range of bacteria. But which of these drugs is stronger and what is their difference?

Indications for use and characteristics of drugs

Third generation antibacterial drugs are effective against most bacterial infections. They quickly cope with streptococci, penicillin-resistant pneumococci, meningococci, gonococci and other microorganisms.

Such medications are prescribed to combat the following ailments:

  1. Diseases of the genitourinary system.
  2. Infectious lesions of the respiratory tract.
  3. Infection of the abdominal organs.
  4. Gynecological problems.
  5. Soft tissue damage
  6. Diseases of the musculoskeletal system.

Most often, drugs are prescribed to people suffering from sore throat, flu, sinusitis, pneumonia, bronchitis, cystitis, syphilis and prostatitis. The expected effect is achieved quite quickly.

Cefotaxime and Ceftriaxone work well against bacteria that have developed resistance to penicillin antibiotics. In addition, they are used if the patient has an allergic reaction to penicillin.

Ceftriaxone is often used in cases of severe illness and after surgery. It prevents the active reproduction of pathogenic microflora. The drug is available in powder form. Immediately before use, a solution for injection is prepared from it. Administration can be intramuscular or intravenous.

Long-term therapy with Ceftriaxone can lead to the formation of sand in the kidneys. At the end of the course, it is eliminated from the body on its own. In severe cases, specialized medications may be prescribed to remove it.

Taking any antibiotics can lead to changes in blood composition. Therefore, when using them, it is necessary to regularly conduct laboratory tests.

Cefotaxime prevents the active reproduction of pathogens and also destroys pathogens. It is advisable to use it only for infectious diseases that are severe. The active substance quickly spreads to all organs of the body.

How are the drugs different?

The properties of these drugs are very similar, so the question very often arises, “Which is better, Cefotaxime or Ceftriaxone?” To answer it, you need to determine the differences between medications. They are as follows:

  1. Ceftriaxone interferes with the normal absorption of vitamin K. This substance is involved in the formation and restoration of the skeletal system and prevents the development of osteoporosis.
  2. Long-term use of Ceftriaxone can cause stagnation of bile in the gallbladder. This negatively affects the functioning of the liver.
  3. Taking Ceftriaxone can provoke pseudocholelithiasis. This is pain in the subcostal area, which is caused by the influx of calcium ions into the bile ducts. This phenomenon is often observed when using a high dosage of an antibiotic.
  4. Cefotaxime is devoid of the above-described side effects. In rare cases, it can cause an attack of arrhythmia.
  5. These antibiotics have different half-lives. With Cefotaxime it is slightly less. The drug is eliminated from the body more quickly with urine and bile.

Despite the fact that the effects of the drugs are almost identical, you cannot replace one with the other on your own. The choice of a specific drug should be carried out under the supervision of the attending physician.

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The answer to the question, “Which is stronger, Cefotaxime or Ceftrixon?” depends on the causative agent of the infection. In most cases they demonstrate the same performance. But if we are talking about pneumococci or Haemophilus influenzae, then there is a difference.

Ceftriaxone actively affects microorganisms. One injection per day with a dosage of no more than two grams will be enough. In this case, Cefotaxime will have to be injected up to six grams, since it has a weaker effect on bacteria.

The antibiotic a person needs is determined based on the clinical picture of the disease and the person’s health status. A full medical examination is required.

Contraindications

The use of third-generation cephalosporin antibiotics can be called practically safe. The only contraindication is an allergic reaction to the drug. This phenomenon is quite rare, observed in only 3% of patients. There are a number of cases when taking medication should be taken with extreme caution:

  1. Pregnancy. There are no direct indications of the harm of such antibacterial drugs during pregnancy. But it is worth noting that full-fledged studies of this issue have not been carried out. Therefore, if possible, pregnant women should refrain from such therapy.
  2. Lactation period. Cephalosporins can enter the baby's body through breast milk. This can lead to changes in the child's intestinal microflora, causing candidiasis or skin rashes.
  3. Such antibiotics are not recommended for older people. This is due to age-related changes in kidney function. The removal of the substance from the body is slowed down.
  4. People suffering from impaired liver and kidney function. In these cases, there is a high risk of bleeding or hypoprothrombinemia.

It is worth remembering that taking antibacterial drugs leads to disruption of the natural balance of microflora in the intestines. Therefore, after the main treatment, a course of rehabilitation therapy is necessary.

In addition, long-term use of cephalosporins can provoke the development of oral candidiasis.

These two antibiotics have similar properties and effectiveness. The choice of a specific remedy should be made by the attending physician based on the results of a medical examination of the patient and his state of health.

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Which is better: Ceftriaxone or Cefotaxime?

The choice between Ceftriaxone and Cefotaxine is made by the doctor, but patients are often interested in which is better: Ceftriaxone or Cefotaxime. People especially often ask if Cefotaxime and then Ceftriaxone were prescribed for the treatment of the same disease. To answer the question, it is necessary to consider the similarities and differences of the drugs.

First about the similarities

Both drugs are broad-spectrum antibiotics and are used to destroy pathogenic bacterial microflora.

General characteristics

Ceftriaxone is considered an analogue of Cefotaxime and the medications have similar characteristics:

  • belong to third generation cephalosparin drugs;
  • destroy identical microorganisms;
  • penetrate the hemoplacental barrier and are excreted in breast milk (should be taken with caution during pregnancy and lactation);
  • approved for the treatment of bacterial infections in newborns;
  • solutions for injections are prepared before administration and are not stored for more than 6 hours (the effectiveness of the medication is reduced);
  • the injection is given 1-2 times a day at the same time;
  • Prescribe with caution together with antibacterial drugs of other groups (at least an hour must pass between the use of Cefotaxime or Ceftriaxone and other antibiotics compatible with cephalosparins).

Ceftriaxone and Cefotaxime are well tolerated by patients and rarely cause side effects, but the course of treatment should not exceed 7-10 days.

The price difference between the drugs is small: 1 bottle of Ceftriaxone or Cefotaxime with a single dose for injection costs rubles.

Indications for use

Cefotaxime or Ceftriaxone is prescribed for the following diseases caused by bacterial microflora:

  • tonsillitis;
  • pharyngitis;
  • otitis;
  • sinusitis;
  • pneumonia;
  • acute or chronic kidney disease;
  • urethritis;
  • cystitis;
  • exacerbation of prostatitis in men;
  • inflammatory diseases of the female genital organs (endometritis, adnexitis, etc.);
  • postpartum infections;
  • inflammation after abortion;
  • venereal diseases;
  • meningitis;
  • salmonellosis;
  • intestinal infections;
  • sepsis;
  • purulent-inflammatory processes of the skin.

Also, Cefotaxime or its substitute Ceftriaxone is prescribed to prevent postoperative complications.

Prohibited use

Like Cefotaxime, Ceftriaxone should not be prescribed for the following conditions:

  • intolerance to the active component of the drug;
  • renal failure (the medication is excreted in urine);
  • acute or chronic liver pathologies (drug elimination slows down and overdose may develop);
  • taking blood thinners (antibiotics can cause bleeding);
  • first trimester of pregnancy (in later stages, according to indications, it is possible to use Cefotaxime or Ceftriaxone for the expectant mother);
  • hyperbilirubinemia;
  • recent heart attack;
  • heart failure;
  • alcoholism;
  • epilepsy;
  • increased nervous excitability.

Sometimes Cefotaxime and Ceftriaxone are prescribed to a mother who is breastfeeding, but pharmacological reference books indicate that the compatibility of breastfeeding and antibiotic therapy is impossible. But a small amount of the active ingredients of the drug is released into breast milk, so doctors allow a healthy baby to be breastfed while treating a nursing mother.

Adverse reactions

Cefotaxime and Ceftriaxone have the same effect on the body, so the side effects of antibiotics are the same.

It is recommended to stop taking medications if the following occur:

  • nausea and vomiting;
  • bowel dysfunction (constipation or diarrhea);
  • dysbacteriosis;
  • decreased appetite;
  • stomach ache;
  • itching in the perineum (anus and genitals);
  • addition of a fungal infection (stomatitis, thrush);
  • anxiety and increased nervous excitability;
  • sleep disorder;
  • headache;
  • inflammation of the conjunctiva of the eye.

The most dangerous side reaction is the development of anaphylactic shock, accompanied by loss of consciousness and a sharp decrease in blood pressure. Without medical attention, shock is fatal.

Due to the risk of side effects, treatment with drugs is carried out in a hospital setting. Taking Cefotaxime or Ceftriaxone without a medical prescription is unacceptable.

Possible complications after antibiotic therapy

Cefotaxime and Ceftriaxone penetrate through the bloodstream into all tissues of the body, destroying not only pathogenic bacteria, but also beneficial microorganisms.

The death of beneficial microflora is accompanied by digestive disorders:

  • dyspepsia;
  • epigastric pain;
  • flatulence and bloating;
  • decreased appetite.

To prevent disruption of the digestive tract when taking antibiotics, patients are additionally prescribed drugs to restore intestinal microflora (Bifidumbacterin, Acipol, Hilak Forte).

In case of severe infectious processes, to prevent possible side effects, patients are prescribed to take Cefotaxime simultaneously with Ceftriaxone. Despite the fact that drugs are analogues and have similar effects on the body, they have different compositions. The combined use of Cefotaxime and Ceftriaxone will help to quickly suppress the inflammatory process.

Let's get acquainted with the differences

Despite the fact that antibacterial agents are considered analogues, there are differences between Cefotaxime and Ceftriaxone:

  • Active substance. Cefotaxime contains the active component Cefotaxime, and Ceftriaxone contains the sodium salt of Ceftriaxone. The active ingredients differ in chemical composition;
  • Release form. Cefotaxime is poorly absorbed through the gastric mucosa, so it is available in powder form for intravenous or intramuscular injection; Ceftriaxone is manufactured in tablet form and for parenteral administration.
  • Solution for diluting the powder. Medications with intramuscular injections cause pain to the patient, so anesthetics are used to prepare solutions. Ceftriaxone is diluted with novocaine, and Cefotaxime with lidocaine (when Cefotaxime and novocaine are mixed, the effectiveness of the antibiotic decreases). For intravenous use, both antibiotics are diluted with 0.9% sodium chloride solution and administered slowly;
  • Frequency of side effects. According to statistics, Cefotaxime is more likely to cause adverse reactions, and Ceftriaxone is more easily tolerated by patients with penicillin intolerance;
  • Efficiency. Cefotaxime has a weaker effect, so in case of severe infectious processes it is better to prescribe Ceftriaxone.

After considering how Ceftriaxone differs from Cefotaxime, we can conclude that both medications differ only in composition and release form. If necessary, without compromising the therapy, you can replace Ceftriaxone with Cefotaxime.

What is better to choose

If we compare Ceftriaxone with Cefotaxime in terms of therapeutic effect, then there is no difference in the choice of drug for the treatment of moderate diseases, and sometimes the pharmacist may suggest replacing Cefotaxime with Ceftriaxone if the drug specified in the prescription is not available in the pharmacy. But, despite the fact that replacing the drug does not affect the quality of treatment, you should consult your doctor before use.

The reason for prescribing a specific antibiotic may be the following:

  • Severity of infection. Ceftiaxone, in comparison with Cefotaxime, is more effective in the fight against pathogenic microflora and, in case of severe inflammation, will help to quickly overcome the disease;
  • Portability. Some patients experience allergic reactions to Cefotaxime, but Ceftriaxone is well tolerated and suitable for treatment. If there is a history of an allergic reaction to one of the antibiotics, then substitution is unacceptable;
  • Convenience. If treatment is not carried out in a hospital, then Cefotaxime is inconvenient due to the fact that it is only available in powder for injection. For mild infections, patients undergoing outpatient treatment are recommended to take Ceftriaxone tablets.

It is impossible to say whether Cefotaxime or Ceftriaxone is better. Both antibiotics help to successfully cope with infections caused by bacterial microflora. The use of Cefotaxime is advantageous only in the treatment of severe infections or due to its tablet form, convenient for treatment at home.

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Which is better Ceftriaxone or Cefotaxime

Ceftriaxone and Cefotaxime are antibacterial drugs classified as cephalosporin antibiotics. They effectively help with infectious pathologies caused by pathogenic microorganisms (streptococci, gonococci, pneumococci, meningococci). These medications are prescribed for diseases of the genitourinary, respiratory systems, and musculoskeletal system. Cefotaxime and Ceftriaxone give good results in cases of damage to soft tissues and abdominal organs.

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  • The patient suffers from hypersensitivity to penicillin.
  • The pathogen is resistant to other antibiotics.

Ceftriaxone is often prescribed to prevent infection in the postoperative period. Cefotaxime is indicated only for the treatment of existing pathology. These medications have several similar characteristics.

They can be administered via intramuscular or intravenous injection. Ceftriaxone and Cefotaxime are sold in powder form, which must first be diluted with saline solution, Lidocaine and Novocaine. The last two drugs are anesthetics. This is the name given to substances that have an analgesic effect. They are necessary to relieve the discomfort accompanying the procedure. Both formulations are designed to combat pathogens. Their spectrum of action is almost the same.

What is the difference between Ceftriaxone and Cefotaxime?

Despite the similarities, these drugs are not analogues in composition. They contain different chemical ingredients. Differences between medications can be seen by comparing side effects. The annotation for Ceftriaxone indicates the following disadvantages:

  • The drug prevents the penetration of vitamin K. Its lack leads to weakening of the skeletal system and the occurrence of osteoporosis.
  • With long-term therapy, bile stagnation may form, which causes partial liver dysfunction.
  • Regular use of a high dose of medication is the cause of pseudocholelithiasis. This condition is characterized by pain in the subcostal area. Their development is triggered by the entry of excessive amounts of calcium into the bile ducts.

His opponent's list of adverse reactions is much shorter. People for whom it is prescribed may suffer from arrhythmia.

There are several other differences between Cefotaxime and Ceftriaxone, including:

  • Half life. The first antibiotic is eliminated from the body faster. This happens with the help of bile and urine.
  • Efficiency. Ceftriaxone is stronger than Cefotaxime.
  • Range of action. Haemophilus influenzae and pneumococci are not immediately affected by Cefotaxime.

When selecting drug therapy, the attending physician is guided by the clinical picture of the pathology, its etiology, condition and individual characteristics of the patient. The treatment regimen for a child and an adult differs in several respects. Among them: duration of administration, number of injections, single dose. It is strictly prohibited to replace Ceftriaxone with Cefotaxime on your own. Only a doctor can prescribe these drugs.

How to make the right choice

Ceftriaxone and Cefotaxime are effective antibacterial drugs. Therefore, it should not be said that one is worse and the other is better. Each of them has its own advantages and disadvantages. The attending physician must decide which drug is most suitable for treatment.

Before drawing up a therapeutic regimen, he prescribes a diagnostic examination. During it, the patient’s susceptibility to the chemical ingredients included in Cefotaxime (Ceftriaxone) and the substances with which it will be diluted are checked. Almost all viruses, fungi and bacteria die when using these medications, so they are prescribed for:

  • pneumonia;
  • sore throat, pharyngitis;
  • pyelonephritis;
  • sinusitis and sinusitis;
  • prostatitis;
  • otitis;
  • cystitis, urethritis;
  • sepsis;
  • salmonellosis;
  • gonorrhea, syphilis;
  • dermatitis.

Ceftriaxone and Cefotaxime are also used to prevent infection after surgery, childbirth and abortion.

When choosing between these drugs, you need to consider that:

  • They should not be mixed with other medications belonging to the group of antibiotics.
  • Otherwise, the likelihood of an allergic reaction increases several times.
  • If anesthetics will be used when preparing the medicinal solution, then intravenous injection should not be done.
  • Novocaine cannot be combined with Ceftriaxone. This can lead to anaphylactic shock.
  • It is not recommended to prepare the medicinal composition in advance. It will lose its effectiveness after 6 hours.

Therapy should be carried out under the supervision of a doctor. To avoid serious complications from taking Ceftriaxone and Cefotaxime, the patient must strictly follow all of its recommendations. To self-medicate is to risk your health.

What is best to use for pneumonia?

Antibiotics are a mandatory element of the therapeutic regimen for pneumonia. Injections are given intramuscularly. Ceftriaxone or Cefotaxime are good choices. Both have proven themselves in the treatment of this infectious pathology. The first drug is prescribed more often, since it has a stronger effect on the pathogen and remains in the body longer. In this case, you can hope for a long-lasting effect.

Ease of use is also considered an advantage. The daily dose is not divided into several doses; it is administered into the body through an injection, which is especially important when treating children. If the disease has just begun to develop, Cefotaxime is prescribed. It stops foci of inflammation and prevents the disease from moving to a more severe stage.

Side effects from taking

The prescription of Ceftriaxone and Cefotaxime, like any other third-generation antibiotics, is fraught with an allergic reaction. It is classified as a side effect that rarely occurs. According to statistics, only 3% of patients suffer from hypersensitivity. Pregnant women, nursing mothers, and elderly people are not recommended to receive injections. The consequences of such therapy are unknown. For patients with a history of kidney or liver disease, Cefotaxime and Ceftriaxone are prescribed only when strictly necessary. In this case, medical supervision is strictly required. There is a high risk of hypoprothrombinemia and internal bleeding.

Along with antibiotics, medications that restore intestinal microflora are usually prescribed. This is a necessary measure, since cephalosporins have a negative effect on the mucous membranes of the gastrointestinal tract. The most common clinical manifestation can be considered candidiasis.

The similarity between Ceftriaxone and Cefotaxime is not limited to the release form. They have the same contraindications, including:

  • Hypersensitivity to the components of the drug.
  • Inclusion of anticoagulants in the treatment regimen.
  • Increased level of bilirubin in the blood.
  • Alcohol addiction.
  • Diseases of the cardiovascular system.
  • Pathologies of the kidneys, adrenal glands, liver.
  • Epilepsy.

It is also worth paying attention to possible complications. Most often they develop due to improper use of these drugs. Errors in diluting Ceftriaxone and Cefotaxime lead to pain in the stomach, nausea, vomiting and diarrhea. An overdose can provoke stomatitis, unreasonable anxiety, insomnia, severe pain in the head, anaphylactic shock and drug-induced coma.

When considering the negative consequences of taking Cefotaxime and Ceftriaxone, no significant difference was found between them. Of course, there are no absolutely safe drugs. All of them can cause discomfort and additional health problems. Therefore, they should be taken in accordance with the manufacturer’s instructions (they are listed in the instructions) and the recommendations of the attending physician.

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Ceftriaxone: instructions for use

The proposed material will provide detailed instructions for the use of the drug Ceftriaxone. Feedback from patients and opinions of specialists will be presented. You will also be informed about the composition, release form and cost of the medicine. Your attention will be presented with information about the method of use (how and what to dilute), dosages, the possibility of taking it for children and indications for women during pregnancy.

Indications for use

Ceftriaxone is a broad-spectrum antibiotic of the third generation of the cephalosporin group. Bioavailability of the drug is 100%. The use of the medicine is recommended in full accordance with the instructions and only as prescribed by a doctor.

  • pyelonephritis, cystitis, urethritis, etc.
  • gonorrhea, syphilis, etc.
  • meningitis (bacterial)
  • various infections
  • sepsis
  • endocarditis
  • sinusitis or sore throat
  • burns and wounds (infected), etc.

The specialist makes individual prescriptions according to the indications of each patient (full clinical picture).

Contraindications for use

According to the instructions for use, Ceftriaxone is not indicated for use in case of individual intolerance to one of the components, drugs of the penicillin group or other cephalosporins or carbapenams. In this option, consultation with a doctor and changes in prescriptions are recommended.

Composition - release form

Ceftriaxone is available in a single dosage form - a white powder for injection. Use strictly in accordance with the instructions and only as prescribed by a doctor. If there is a need for a replacement (for example, injections are not acceptable in this particular situation), it makes sense to seek advice from a specialist and find a replacement for Ceftriaxone injections and tablets in analogues.

Ceftriaxone injections: instructions for use

How to dilute Ceftriaxone injections with novocaine according to the instructions for use? The instructions indicate two components that can be used to dilute the powder - distilled water or lidocaine (1 or 2%). It can be diluted with water if the body has an allergic reaction to lidocaine or as an auxiliary component when using 2% lidocaine (diluted in the same dose).

As for novocaine, the instructions for use contain information about a decrease in the activity of Ciftriaxone if the medicine is diluted in this way, and novocaine can cause anaphylactic shock. Therefore, according to the instructions, it is recommended to use novocaine only as a last resort in a dosage of 5 ml of novocaine per 1 g of powder (if diluted with a smaller dosage of novocaine, the powder may not completely dissolve, which will complicate further administration).

Important! Ciftriaxone is not available in tablet form. For this reason, it is recommended to select high-quality analogues in tablet form, but only after agreeing on the prescriptions and dosage with the attending physician.

Dosage and indications during pregnancy and children

Ceftriaxone is prescribed to be taken during pregnancy only if the benefits for the expectant mother outweigh the possible risks for the baby. During the lactation period, it is recommended to stop feeding for the duration of the appointment. The dosage and course of treatment depend on the disease, form and/or severity and are prescribed only by a specialist.

On average, the following dosages are prescribed according to the instructions:

  • adults and children under 12 years of age - 1-2 g of powder in an injection or dropper once a day, or 0.5-1 g twice a day (maximum permissible dose 4 g per day)
  • for infants and children under 12 years of age, the dosage is determined based on body weight – mg per 1 kg of weight
  • for newborns (from 2 weeks) – maximum dosage 20 mg per 1 kg.

Analogs

A replacement of the drug (injections or tablets) can be carried out only after agreeing on the prescription and/or dosage with the attending physician.

Ceftriaxone and Cefotaxime: differences

Ceftriaxone and Cefotaxime are very similar to each other - both belong to the same group of antibiotics, have a similar chemical formula, are used both intravenously and intramuscularly (injections only) and do not have a tablet form. However, there are still differences between them: Ceftriaxone injections can lead to stagnation of bile and reduce the absorption of vitamin K. Cefotaxime injections do not have such side effects, but increase heart rhythms. However, despite all the apparent similarity, the chemical composition of the drugs has differences, and the prescription of one or another drug can only be carried out by the treating specialist.

What is the price?

The price of Ceftriaxone depends on the manufacturer, dosage and pharmacy markup; on average, the cost of the medicine is from 17 rubles per bottle. The drug is a prescription drug.

Reviews about the drug Ceftriaxone

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What is more effective than Cefotaxime or Ceftriaxone: comparative characteristics

Various groups of antibacterial drugs are used to treat diseases of the urinary system.

Among effective third-generation antibiotics, doctors highlight Cefotaxime and Ceftriaxone.

Before prescribing cephalosporin antibacterial drugs, it is necessary to conduct a thorough diagnosis and establish the exact cause of the disease.

What are their main differences and how to apply them correctly in urological practice?

General information about Cefotaxime

The drug belongs to the cephalosporin series of antibacterial agents and has a wide spectrum of action. Available in powder form for the preparation of a suspension solution of 0.5, 1 or 2 or ready-made diluted solutions.

It is prepared under sterile conditions on the basis of saline solution or anesthetic (lidocaine, novocaine, etc.), administered intramuscularly or intravenously. Detailed information about the drug is at the link.

Composition and pharmacological action

The main component is the synthetic substance cefazolin. It has an antimicrobial effect against many groups of pathogenic microorganisms: streptococcus, staphylococcus, E. coli, pneumococcus, etc.

Capable of suppressing bacteria resistant to the group of penicillin antibiotics. Helps quickly cope with pathogenic organisms, destroying their cell wall and preventing reproduction. The therapeutic effect occurs very quickly, so the bacteria do not have time to develop resistance.

Indications for use

Cefotaxime is prescribed for the initial forms of infectious diseases of the genitourinary system (urethritis, pyelonephritis, cystitis, prostatitis, etc.) and the respiratory system.

It is important to remember that when preparing the suspension, it is prohibited to use novocaine (it leads to a decrease in the activity of the antibiotic). The drug has a rapid half-life and is excreted primarily in urine and bile.

Basic information about Ceftriaxone

Belongs to the group of cefazolin antibiotics of the 3rd generation. Available exclusively in powder form for the preparation of injection solutions.

It has a stronger effect on the patient’s body, so it is prescribed in case of emergency. More information on the link.

What is included and which group does it belong to?

The main component is the substance ceftriascone. Mainly used in the form of infusion therapy. Shows its activity against microorganisms resistant to penicillins. Widely used for severe forms of disease or to prevent postoperative infection.

The antibiotic inhibits the growth and reproduction of bacteria. It is worth noting that with long-term use of this drug, the patient may develop sand in the kidneys, and the absorption of vitamin K may also be impaired.

This leads to the development of concomitant pathologies in the form of dysfunction of the musculoskeletal system. Therefore, the dosage and duration of use are prescribed exclusively by the attending physician.

When to use

Ceftriaxone has a wide range of applications compared to Cefotaxime, and is prescribed in cases of severe forms of disease or in the postoperative period:

  • pathologies of the abdominal organs caused by pathogenic microorganisms;
  • bacterial and viral infection of the respiratory system (pneumonia, bronchitis, etc.);
  • infectious lesions of the joints or skin;
  • diseases of the genitourinary system (pyelonephritis, urethritis, gonorrhea, etc.);
  • meningitis, salmonellosis;
  • sepsis;
  • prevention of postpartum or postoperative infection.

The drug is excreted from the body for a long time, so the number of injections per day for the patient is minimal.

Comparative characteristics of medications

It all depends on the purposes for which this or that drug will be used. The first one shows low activity against bacterial flora and is quickly eliminated from the body, so it must be injected in high doses. Ceftriaxone is advisable to use in case of serious complications, as it is considered a very strong antibiotic.

It is important to remember that taking any antibiotics greatly disrupts the balance of the natural intestinal microflora, so it is advisable to simultaneously carry out maintenance therapy with probiotics.

Women very often develop a fungal infection in the vagina (candidiasis) while taking antibacterial drugs, so doctors often prescribe combined use with antifungal drugs.

One of the disadvantages of Ceftriaxone is that it cannot be taken for a long course due to the excretion of vitamin K and increased accumulation of bile. All this has a very negative effect on the functioning of the liver and the formation of bones in humans, causing serious complications.

With high doses of this antibiotic, the patient often experiences severe pain attacks in the hypochondrium area. This is due to the presence of calcium in the biliary tract.

Cefotaxime is considered a safer antibiotic; it very rarely leads to the development of arrhythmia (if the recommended dose is exceeded). During treatment, it is recommended to carefully monitor the composition of the blood, as they can change its rheological properties.

Which is better and more effective?

It is unequivocal to say that this or that drug cannot be better. They both belong to the same group of antibiotics and have similar pharmacological effects. It should be noted that in severe forms of bacterial infection it is more advisable to use Ceftriaxone. It is much more powerful and to relieve acute symptoms, administration once a day is sufficient.

When treating uncomplicated bacterial infections, it is best to use Cefotaxime. It helps get rid of acute cystitis, urethritis or pyelonephritis. In this case, it is necessary to take into account possible contraindications to its use. This antibiotic is prescribed in small doses up to 6 times a day.

For patients who are allergic to penicillin antibiotics, it is best to use Ceftriaxone.

Ceftriaxone and Cefotaxime are quite strong drugs; their improper use can cause serious complications. The dosage and duration of therapy is selected exclusively by the attending physician.

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Source: http://urohelp.guru/lekarstva/chto-luchshe-cefotaksim-ili-ceftriakson.html

What is Ceftriaxone?

I diluted it like this: I took 3 ml of ceftriaxone diluted with water for injection into a 5 ml syringe and then put 2 ml of lidocaine into the syringe! Ceftriaxone is not available in tablets or syrup. I have a sore throat, which I initially treated with amoxiclav, but now I have been prescribed ceftriaxone for physical therapy. solution! I am diluted in 3 ml of novocaine. It is necessary to dilute the composition with one needle and inject it with another. Ceftriaxone was prescribed for bronchitis.

10 seconds they will hit him and that’s it! Go for a walk! And then not only can’t I walk, I can’t even breathe, it feels like it’s in my butt))))) TERRIBLE CEFTRIAXONE! In February I was treated with ceftriaxone (14 days), thrush began, then the hospital diagnosed drug-induced agranulocytosis (my bone marrow stopped producing white blood cells and red blood cells).

As soon as she began to administer the medicine, I immediately screamed and burst into tears! I have never experienced such pain. I was given injections of ceftriaxone, now the temperature has risen, my head is splitting from pain, the injections themselves were not so painful.

I can confirm with both hands that ceftriaxone without lidocaine is terrible. They did it on 08/15/11 at the 67th hospital in Moscow, before the operation. Methicillin-resistant Staphylococcus, many strains of Enterococcus (including Str. faecalis) and group D Streptococcus are resistant to cephalosporin antibiotics (including ceftriaxone).

The annotation states that the indications for the use of Ceftriaxone are infections caused by bacteria sensitive to the drug. The medicine is most effective in cases where the causative agent of the disease is Treponema pallidum, since the distinctive feature of Ceftriaxone is its high treponemocidal activity.

Since T1/2 of Ceftriaxone is approximately 8 hours, the drug can be used equally successfully in both inpatient and outpatient treatment regimens. For children with angina, Ceftriaxone is prescribed in exceptional cases when acute angina is complicated by severe suppuration and inflammation.

For sinusitis, antibacterial agents are first-line drugs. Completely penetrating the blood, Ceftriaxone is retained at the site of inflammation in the required concentrations.

What is Ceftriaxone?

Ceftriaxone is not prescribed in case of known hypersensitivity to cephalosporin antibiotics or auxiliary components of the drug. The injections are easiest to tolerate if you dilute the powder with an anesthetic. The same feature of Ceftriaxone enhances the effect of anticoagulants when used together. In patients who are on hemodialysis, as well as with simultaneous severe hepatic and renal failure, plasma concentrations of Ceftriaxone should be kept under control.

Which is better: Ceftriaxone or Cefotaxime?

Both drugs belong to the “Cephalosporins” group, but Ceftriaxone is a third generation antibiotic, and Cefazolin is a first generation drug. Cefotaxime and Ceftriaxone are the basic antimicrobial agents of the third generation cephalosporin group.

Ceftriaxone - reviews from doctors confirm this fact - is a potent antibiotic that helps cure the disease in a short time and with a minimum number of side effects. In reviews of Ceftriaxone injections for children, to facilitate the procedure, mothers (on the advice of the attending physician) are recommended to use Emla cream, which is a local anesthetic.

The price of Ceftriaxone injections varies depending on which company produces it, as well as the number of ampoules in each package and the concentration of the active substance in the vial. Before using the drug Ceftriaxone, be sure to consult with your doctor.

I'm a nurse in a treatment room. My head is very dizzy, my vision is getting dark, the noise is terrible. I have never suffered from such things. Tomorrow I will go to complain to the doctor)). Although there is pain with the injections, it is tolerable. Well, be patient. And there are only 14 of them. You have to hold a rag between your teeth, even though they inject you with novocaine. Antibiotics cause all this.

God, the injections are already behind us. I’m not a doctor either, my mother worked in the ENT department and injected exactly this way and taught me and I didn’t feel any pain when I injected myself intramuscularly and there were no traces of the injections. It turned out that they were treating me for something that did not exist and did not exist... Right now I am lying in surgery after an operation.

Today my husband gave me my first injection. Mixed with saline solution. My husband injected it for a very long time, about 30 seconds. It didn’t hurt at all, a little later there was a slight tingling inside and that was all. Despite all this, I can’t stand pain at all. I got my first injection today. At first she said that her husband would inject, then the legs themselves were taken to the treatment room. THIS IS HARD! 2 injections are already behind us. Last night I injected myself, it didn’t hurt at all, but I felt dizzy, it felt like I was in prostration, or what?

Indications for use of Ceftriaxone

In general, the doctor said that this was most likely a reaction to lidocaine, by the way it is written there in the side effects. Very good afternoon! I want to cry to you and hear your feedback/opinions... The pain was TERRIBLE (despite the fact that novocaine numbs the pain), even the tips of my toes hurt, it seemed as if the muscles of my entire leg were being squeezed into a tight grip, 5 hours had already passed, and my leg did not subside.

Based on the reviews of the patients themselves, they note that Lidocaine is better than Novocaine in relieving pain when Ceftriaxone is administered. The doctor prescribed ceftriaxone for me to treat sinusitis. The doctor prescribed azithromycin for 3 days and ceftriaxone with lidocaine and water for injection.

Source: http://merotudly.ru/chto-takoe-ceftriakson/

Cefotaxime or ceftriaxone - which is better for injection?

Let's compare two drugs, ceftriaxone and cefotaxime. These medicines not only have common features, but also differ. The drug cannot be used in treatment on its own, as they are available in the form of tablets and capsules. The drugs are intended for injection.

What to choose: cefotaxime or ceftriaxone?

The first drug has a strong active substance; it contains cefazolin. This is the main component; there is 0.5, 1.0 or, for example, 2 g of cefazolin in a bottle. The second drug does not contain cefazolin. But this drug contains ceftriaxone instead of cefazolin. This is a fairly strong antibiotic that belongs to the class of cephalosporins.

Now let's look at the release form. Ceftriaxone is available in powder form, for example 0.25/0.5/1/2 g. A solution is subsequently prepared from it, which can also be used for infusion therapy.

The second medicine is also available in powder form and is prescribed to patients for intramuscular or intravenous injections. The powder itself can be colored yellow or white. Available only in 10 ml volumes.

Indications for use

Cefotaxime is prescribed not only for infectious diseases. It can also be used in the treatment of pathologies in the respiratory system. In addition, this drug has proven itself well in ENT practice, especially in the treatment of sinusitis, otitis or sinusitis.

The first drug, unlike Cefotaxime, has a more extensive list of indications. It can be used for infectious diseases in the abdominal cavity, sepsis, syphilis, abdominal type. However, this antibiotic is also prescribed for the treatment of ENT diseases. Therefore, what to choose, cefotaxime or a second medicine?

Key Features

It is necessary to pay attention to the fact that Ceftriaxone negatively affects the absorption of vitamin K. Therefore, if you have been prescribed vitamins from this group for sinusitis, then you cannot use this antibiotic in treatment. We also note that long-term use of an antibiotic can lead to stagnation of bile in the gallbladder. Thereby causing complications.

As for the drug Cefotaxime, it has no pronounced side effects. But, if the injections with this medicine are carried out incorrectly, the patient may experience arrhythmia.

What's better?

Ceftriaxone has a strong effect on all organs and systems in the human body. Therefore, most often, this antibiotic drug is prescribed for pneumonia or if the patient has Haemophilus influenzae.

The second drug has less activity, directly on bacteria. In addition, it should be noted that this medicine can be injected only once a day, but Cefotaxime can be used up to 6 grams per day.

From this we can conclude that these are two strong antibiotics. But, if the patient has sinusitis, then it is best, in the absence of contraindications, to use Cefotaxime.

In any case, a person tolerates each medicine differently. Therefore, before prescribing, doctors collect anamnesis and conduct diagnostics, including laboratory tests, to determine the body’s susceptibility to the composition of the drug. You should not use antibiotics in treatment yourself, otherwise serious health complications may occur.

Source: http://gaimoritstop.ru/cefotaksim-ili-ceftriakson-chto-luchshe.html

Cefotaxime or Ceftriaxone – which is better?

During various serious illnesses, injections of drugs related to third-generation cephalosporin antibiotics are often prescribed. Cefotaxime or Ceftriaxone is usually used for treatment, but not everyone understands which is better? Both products have similar structures. The list of microorganisms affected by these drugs is almost the same. The drugs are not available in tablets and enter the body only through injections.

What is the difference between Ceftriaxone and Cefotaxime?

Although these products are very similar, they still have some differences. For example, Ceftriaxone negatively affects the absorption of vitamin K. In addition, its long-term use can lead to stagnation of bile in the gallbladder.

In turn, cefotaxime does not have such side effects. However, if administered quickly, it can lead to arrhythmia. Despite the fact that both drugs are similar, they are not identical in chemical composition. This means that you cannot replace medications yourself - only after consultation with a specialist.

What is better and how to use it for pneumonia – Cefotaxime or Ceftriaxone?

When tests indicate complications with pneumonia, antibiotic injections are often prescribed in addition to taking pills. They are administered intramuscularly. Ceftriaxone and Cefotaxime are considered the most effective. They are clearly superior to other drugs in this group in their effect on most pathogens and streptococci.

Ceftriaxone has high activity against pneumococci and Haemophilus influenzae. This drug is used more often than others because it has a long half-life. It can be injected only once a day. In this case, the dose does not exceed two grams.

In turn, Cefotaxime has a less active effect on bacteria. It is administered from three to six grams per day.

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Source: http://womanadvice.ru/cefotaksim-ili-ceftriakson-chto-luchshe

Ceftriaxone or Cefotaxime: which is better?

The drug Ceftriaxone is a broad-spectrum antibiotic that belongs to the type of cephalosporin drugs of the third generation.

This medicine is intended to fight infectious diseases in the body. The purpose of the drug is to destroy pathogenic microorganisms. The medicine Ceftriaxone is very painful both intramuscularly and intravenously. To solve this problem, it was decided to dilute Ceftriaxone powder with anesthetics, which significantly reduce pain.

Cefotaxime also belongs to the type of third generation cephalosporin drugs, its spectrum of action is the same as that of the drug ceftriaxone. Cefotaxime is poorly absorbed from the stomach, so this drug is used only by injection.

For what diseases is Ceftriaxone and Cefotaxime used?

What does Ceftriaxone and Cefotaxime help with? All inflammatory diseases in the human body are caused by microorganisms: viruses, bacteria, fungi. Bacteria that cause infections are quite sensitive to the antibiotic Ceftriaxone and the antibiotic Cefotaxime. These drugs are used for the following diseases:

  • infectious pneumonia;
  • diseases pyelonephritis in acute and chronic form;
  • prostatitis in the male body;
  • bacterial cystitis;
  • acute and latent form of urethritis;
  • acute and chronic form of cystitis;
  • endometritis disease;
  • gynecological diseases;
  • gonorrhea, syphilis, chancroid;
  • diseases caused by E. coli;
  • salmonellosis;
  • purulent meningitis;
  • purulent sepsis;
  • purulent skin diseases;
  • infections after abortions;
  • postpartum infections;
  • for the prevention of postoperative sepsis;
  • otitis of ENT organs;
  • inflammation of the nasopharynx (sinusitis, sinusitis);
  • infectious sore throat, pharyngitis, tonsillitis;

Ceftriaxone has high activity in all organs of the human body, so it is prescribed for complicated forms of the disease or the presence of Haemophilus influenzae in the body.

Cefotaxime exhibits less activity on human organs and systems, so it is often used for simple forms of the disease at the initial stage of development.

Ceftriaxone can be administered into the body once a day, Cefotaxime - a maximum daily dose of 6 grams.

Release form for these antibacterial drugs

A fairly large number of manufactured antibacterial drugs used for injection are produced in bottles with lyophilized powder. Before use, this powder must be dissolved in saline or anesthetics (lidocaine, novocaine).

Ceftriaxone is available only in powder form; this product is not available in the form of ready-made solutions or suspensions.

Cefotaxime is also available only in powder form; this product is not available in the form of ready-made solutions or suspensions

But when using antibiotics of this type, it is necessary to understand exactly how the patient reacts to this solution, what exactly should be used to dilute the medicine in powder: water, saline solution or anesthetic. It is necessary to make sure that the patient does not have an allergy to anesthetics, which could cause harm to the sick person’s body. It is very important to know where exactly the injection should be given; solutions of Ceftriaxone with lidocaine and Cefotaxime with lidocaine cannot be used if the injection must be given intravenously.

Rules for the manufacture of injections of drugs Ceftriaxone and Cefotaxime

Making intramuscular injections:

  • Cefotaxime and Ceftriaxone - do not mix with any antibacterial drugs, this can lead to an allergic reaction;
  • for the preparation of antibiotic solution Ceftriaxone - Novocaine and Cefotaxime - Novocaine - is not used. Novocaine reduces the therapeutic effect of the antibiotic and can lead the patient to a state of anaphylactic shock;
  • Ceftriaxone and Cefotaxime diluted in anesthetic - do not store for more than 6 hours;
  • for 1 gram of antibiotic, you need to take 3.5 ml of 1% lidocaine, mix everything thoroughly and then inject it into the body;
  • for intravenous use of drugs - it is prohibited to dilute them in anesthetics;
  • make the injection into the buttock and administer the drug quite slowly.

Making intravenous injections:

  • to prepare a solution of the antibacterial agent Ceftriaxone, Cefotaxime for injection into a vein, saline sodium chloride solution is used;
  • the drug should be injected into a vein as slowly as possible;
  • if it is necessary to introduce more than 1 gram of antibiotic into the body in one procedure, then there is a need to administer the medicine by dropper instead of an intravenous injection. The procedure using a dropper should last at least 30 minutes and use 100 ml of liquid sodium chloride to prepare a drop solution;
  • The prepared solution for intravenous use in the form of a dropper or injection must be used immediately after preparation. Freshly prepared medicine gives much faster positive results in treatment.

The daily dose of Cefotaxime is for children from one month after birth, mg per kilogram of the child’s weight, 3 times a day. For adults - the maximum dose is 6 grams, calculated per dose.

The daily dose of Ceftriaxone is for children from one month after birth, mg per kilogram of the child’s weight, 1 time per day. Adults: once a day.

Contraindications to the use of this medication

According to the instructions for use, the drug Ceftriaxone and the drug Cefotaxime are contraindicated for various diseases of the body:

  • intolerance to components;
  • allergic reaction to penicillin substances;
  • allergic intolerance to cephalosporins;
  • increased level of bilirubin in the blood;
  • myocardial infarction and heart failure;
  • epilepsy;
  • nervous excitability;
  • patients undergoing hemodialysis - drugs are removed from the body by the kidneys;
  • chronic and acute liver diseases - the time taken to remove antibiotics from the body increases;
  • cirrhosis of the liver - failure to remove drugs from the body in a timely manner;
  • diseases of the kidneys and adrenal glands - drugs are excreted from the body by the kidneys;
  • alcoholism;
  • carrying a child (use in the first trimester is especially dangerous);
  • breastfeeding;
  • taking anticoagulants - there is a risk of bleeding.

Complications from taking Ceftriaxone and Cefotaxime

Complications after taking the drug Ceftriaxone and Cefotaxime usually develop with an overdose or improper use.

The action of the drug is aimed at suppressing microbes and, together with harmful infections, beneficial microbes in the microflora of the stomach and intestines can die and against the background of this indicator, dysbiosis develops in the body with pronounced symptoms:

  • abdominal pain;
  • frequent and loose stools;
  • nausea and possibly vomiting.

If you have abdominal pain, this is the first sign of dysbiosis. Taking probiotics during this period is mandatory.

The consequences of dysbacteriosis can be fungal infections, and with disturbed microflora, these infections tend to multiply quite quickly.

Symptoms of fungal infection in the body:

  • thrush in children of breastfeeding age;
  • vaginitis or thrush in girls, which causes pain when urinating;
  • itching of the genitals with redness of the vulva;

Before taking these medications, it is imperative to consult with your doctor.

Side effects from the use of Ceftriaxone and Cefotaxime

After using the antibiotic Ceftriaxone and the antibiotic Cefotaxime, a number of side effects occur:

  • constant nausea, vomiting after eating;
  • painful diarrhea, constipation;
  • acute form of dysbacteriosis;
  • stomatitis with severe pain;
  • overexcitement;
  • anxiety;
  • insomnia;
  • sharp pain in the head;
  • severe morning dizziness;
  • acute conjunctivitis;
  • anaphylactic shock and possible coma;
  • itching in the genitals;
  • candidomycosis of the vaginal mucosa.

Self-medication with antibacterial agents Ceftriaxone and Cefotaxime is not acceptable.

Which is better Ceftriaxone or Cefotaxime

Ceftriaxone or Cefotaxime, which is better? From all the information known, there is only one conclusion - these are two of the strongest antibacterial drugs with a wide range of activities, which have the same purpose, similar side effects and the same contraindications. The only difference is that Ceftriaxone is more active in severe forms of the disease.

Both of these antibiotics differ from each other in that Ceftriaxone is more easily tolerated by patients who are allergic to drugs of the penicillin group.

Before prescribing one or another drug from cephalosporin antibiotics, it is necessary to conduct a diagnosis and carry out a study of tests to determine the susceptibility of the patient’s body to the composition of antibacterial drugs.

Source: http://wmedik.ru/zabolevaniya/urologiya/ceftriakson-ili-cefotaksim-chto-luchshe.html