Which is better Augmentin or Flemoxin Solutab

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Which is better Augmentin or Flemoxin Solutab?

When it comes to treating ENT organs, broad-spectrum antibiotics are often used to combat bacterial infections. Which is better Augmentin or Flemoxin Solutab?

Table of contents:

These two drugs are distinguished because they are too similar in composition, but they still have differences.

What is special about Flemoxin?

Flemoxin and Flemoklav are often confused because they are thought to be similar drugs. They both contain amoxicillin, but Flemoklav also includes clavulanic acid, which allows you to further expand the spectrum of action of the drug.

Flemoxin is a semi-synthetic penicillin antibiotic. Has a negative effect on the synthesis of gram-positive and gram-negative pathogenic microorganisms.

  • Quickly dissolves in the oral cavity;
  • It is not affected by stomach acid;
  • Not able to influence a group of bacterial enzymes;
  • The peak of action occurs 2 hours after administration;
  • Minimal risk of side effects even in children;

The use of the drug is appropriate in the treatment of ENT organs (often sore throat), respiratory tract, infectious processes on the skin, and urinary system.

Features of Augmentin

Augmentin is a well-improved version of Flemoxin, since this drug is able to influence an even larger number of pathogenic organisms, including groups of bacterial enzymes. Augmentin contains clavulanic acid, which provides such high resistance.

Because of this versatility, Augmentin causes serious adverse reactions. Only the attending physician can prescribe this drug to a child or adult, because an incorrectly selected dosage can lead to a deterioration in well-being. For objectivity, it is appropriate to compare drugs with each other.

What is the difference between the drugs

At first glance, the difference between Augmentin and Flemoxin is insignificant, but it still exists. A person who is far from medicine may not understand the importance of the differences between these drugs.

Main differences:

  • According to the spectrum of action, Augmentin is stronger than Flemoxin, since it is resistant to a group of bacterial enzymes;
  • Flemoxin or Augmentin for children in the first months of life. In terms of the number of contraindications, Flemoxin has fewer of them. Augmentin should not be taken by infants when the opposite drug allows such treatment;
  • By cost. Augmentin is more expensive;
  • In terms of the safety of its composition, Flemoxin is more health-friendly, as it has more neutral and less allergenic components.

The patient must understand the seriousness of the drugs prescribed by the doctor, so the option of purchasing an analogue is not suitable for treatment. You need to take medications strictly according to the instructions. There is no point in taking the drugs together, since they both have the main active ingredient amoxicillin.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Source: http://pillsman.org/24577-augmentin-ili-flemoksin-solyutab.html

Children's health

And another question: I also have a sore throat, but I immediately have traffic jams. A rate of 37.5 is a 100% indication for an antibiotic?

Lenchik and two miracles: Ivanushka 11/2/2004 + Matyusha 03/20/2007

Never be afraid to do what you don’t know how to do: for the ark was built by an amateur, but professionals built the Titanic!

Nemo me impune lacessit.

Don't ask me questions and I won't lie to you.

Mom Tamara, babies Yaroslav (01/2/2003) and Nazar (07/6/2005)

Nemo me impune lacessit.

Don't ask me questions and I won't lie to you.

Nemo me impune lacessit.

Don't ask me questions and I won't lie to you.

The fact is that microorganisms quickly adapt to antibiotics, especially if treated incorrectly, and produce special antibiotics. enzymes for inactivating the antibiotic (beta-lactamase). A (I quote):

“Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases”

“Treating a throat with augmentin at 37.5 is somehow short-sighted :))) Amoxicillin alone is quite enough.”

By profession I am a pharmacist, although I work after maternity leave in the field of internal pharmacy control, I don’t know much about the new assortment. But still.

Now it has become very fashionable to treat mild bacterial infections with the latest generations of antibiotics, and then, when life encounters serious problems, there is not much to choose from:((

Nemo me impune lacessit.

Don't ask me questions and I won't lie to you.

you would also benefit from an antibiotic, but you can try gargling, for example, with an ectericide

Lenchik and two miracles: Ivanushka 11/2/2004 + Matyusha 03/20/2007

Never be afraid to do what you don’t know how to do: for the ark was built by an amateur, but professionals built the Titanic!

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Augmentin or Flemoxin Solutab for cough?

List of messages in the topic “Augmentin or flemoxin solutab for cough?” forum Parent meeting > Children's health

Author: maxusha Status: User Time: 16:50 Date: 10 Apr 2008

Author: liza117 Status: User Time: 17:16 Date: 10 Apr 2008

Author: Los Angeles Status: Advanced User Time: 17:28 Date: Apr 10, 2008

Author: maxusha Status: User Time: 17:31 Date: 10 Apr 2008

Author: ovig Status: Corypheus Time: 21:25 Date: 10 Apr 2008

Author: Elena A. Status: Corypheus Time: 17:27 Date: 10 Apr 2008

Author: Chinchilla Status: VIP Time: 17:54 Date: 10 Apr 2008

Author: maxusha Status: User Time: 18:10 Date: 10 Apr 2008

Cough, prevents you from sleeping at night - wakes up, been sick since Friday - today suddenly the temperature is 37 again, isn't this a reason to take antibiotics?

Author: Los Angeles Status: Advanced User Time: 18:35 Date: Apr 10, 2008

Author: Lesnichok Status: User Time: 21:00 Date: 10 Apr 2008

Author: maxusha Status: User Time: 06:11 Date: 11 Apr 2008

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Treating the Heart

Tips and Recipes

Flemoclav solutab or augmentin which is better

Instructions for use Flemoxin Solutab

Price, rub.

Flemoxin Solutab is an antibacterial medicine with a wide range of uses. It contains amoxicillin trihydrate, a substance that has an active effect. Its area of ​​application is the suppression of harmful microflora. As a semisynthetic penicillin, it is effective against over a dozen gram-positive and gram-negative bacteria. It does not have a pronounced effect against pathogens of intestinal infections. It is not active against a group of bacterial enzymes (beta-lactamases), the action of which is aimed at combating penicillin.

Medicinal properties

After taking the drug Flemoxin Solutab orally, it is quickly processed in the gastrointestinal tract (gastrointestinal tract), and the properties of the drug ensure almost complete absorption of the active substance into the blood.

Within minutes after taking the medicine, the highest level of amoxicillin in the blood plasma is reached. The active substance is acid-resistant. When taken orally, Flemoxin increases the level of amoxicillin in the blood more than taking this antibiotic in an insoluble pharmacological form.

During the course of treatment with Flemoxin Solutab, its accumulation occurs:

  • In liquid secretions
  • In the oral mucosa, genitourinary system
  • In the bones of the skeleton.

Approximately 26-31% of the active substance (relative to presence in the blood) enters the umbilical vessels and amniotic fluid. The content of amoxicillin in the spinal cord fluid during meningitis is at the level of 20% (relative to the presence in the blood).

85-90% of the active component is released after 7-8 hours when the bladder is emptied.

Features of using Flemoxin Solutab by children

In children born prematurely and children under 7 months of age, the active substance is eliminated by half in 2.5-4 hours. With healthy kidney function, the active substance is eliminated by half in 1-2 hours. If there are problems with the kidneys, the time during which the drug is eliminated by half is up to 9 hours.

Release form

Elongated tablets are available in weights from 100 mg to 1 g, white or yellow-white in color. Flemoxin Solutab has a citrus fruit flavor. Stored at room temperature.

Compound

In addition to the active substance (amoxicillin trihydrate), the medicine includes the following components:

Indications for use of Flemoxin Solutab

The medicine is used for infections caused by microflora susceptible to amoxicillin. Used for diseases:

Directions for use and doses

Sequence of tablet use:

  • Without chewing before and after meals
  • Use in parts, can be chewed and washed down with water
  • First dissolve the tablet in water.

Flemoxin Solutab is used for infections of moderate severity in a dose of up to 2 grams per day, which is divided into two doses for adults. In severe cases of the disease - a dose of 0.8-1 g. three times a day.

For infection with microflora that causes gonorrhea without complications - 3 g. in one dose with the drug Probenicid (dose 1 g).

  • From 1-3 years to 0.12 g. 3 times a day or 0.24 g. 2 times a day
  • From 3-6 years - in the amount of 0.24 g. three times a day or 0.37 g. twice a day.

The duration of treatment is from 5 days to a week. The presence of streptococcal infection in the body extends the period of taking pills to 10 days. The average rate of medication prescribed to children is: mg/kg body weight per day (divided into 3 doses), 60 mg/kg body weight - in case of chronic diseases, severe infections. The doctor selects the exact dosage individually after examining the child.

The intake rate of Flemoklav is reduced by 20-45% in case of kidney dysfunction. After the signs of infection disappear, use of the drug continues for another two days.

Side effects

Side effects caused by the medicine:

  • Itching near the anus
  • Quincke's edema
  • Skin allergies
  • Diarrhea.

Contraindications

Contraindication to taking the drug: allergy to penicillin and additional components of Flemoxin.

During pregnancy and breastfeeding, the medicine is used only when the possible benefit for the woman from therapy is greater than the risk of complications in the fetus or child.

Cross-drug interactions

When combined with other drugs it was revealed:

  • Reduced effect of using hormonal contraceptives when combined with amoxicillin
  • Tetracycline has a neutralizing effect on amoxicillin.

Overdose

In case of overdose of the drug, vomiting and diarrhea may occur. Laxative saline solutions and enterosorbents help with overdose.

Self-medication with the drug is not a useful or harmless way to restore health. It is the prerogative of the doctor to prescribe the medicine, its dose and method of administration.

Instructions for use Augmentin

Price, rub.

The antibiotic has a depressing effect and destroys bacteria, including strains of microflora that provoke the appearance of an enzyme (beta-lactamase), which neutralizes the effect of penicillin. Clavulanic acid makes amoxicillin resistant to beta-lactamases.

Release form

  • Tablet form
  • In the form of syrup
  • As powder for injection
  • In dry form, for making drops.

Compound

Augmentin contains amoxicillin trihydrate and clavulanic acid.

Indications for use

The drug is used to suppress bacterial infections that cause the disease:

Directions for use and doses

For children under 1 year of age, Augmentin is prescribed in the form of drops. Before starting treatment with the drug, it is advisable to identify the susceptibility of the microorganisms that caused the disease to it. Every two weeks of treatment with the drug, the doctor reviews the clinical situation.

The maximum permissible single dose of the drug is 1.15 g. When injecting the drug, the daily dose does not exceed 7 g.

The content of Augmentin in the body decreases with the artificial method of blood purification (dialysis). A patient on dialysis is additionally prescribed 0.5 g. the drug intravenously during the blood purification procedure and the same amount after it.

Side effects

When using Augmentin, adverse reactions in the patient's body are possible. Ailments caused by taking the medication:

  • Hives
  • Quincke's edema
  • Indigestion (the severity of the malaise decreases when taking the drug with food)
  • Candidiasis
  • Phlebitis (inflammation of the vein at the injection site).

Contraindications

Contraindications to taking Augmentin are:

  • Increased susceptibility to substances contained in the drug
  • Severe liver dysfunction
  • Pregnancy and breastfeeding
  • The patient is allergic to the medicine.

Which is better Flemoxin Solutab or Augmentin

By comparing data on both drugs, it is easy to come to a conclusion which drug should be preferred in different situations.

By action

Augmentin has a wider range of effects on pathogenic microflora than Flemoxin Solutab, which makes its use more universal.

For contraindications

Flemoxin Solutab has fewer contraindications than Augmentin. Self-medication is a dangerous method of restoring health, so medications should be used after being prescribed by a doctor.

Security

These medications have a wide range of side effects, the range of which is slightly larger for Augmentin, so its use is less preferable for health.

By price

The second medicine, Augmentin, costs a little more.

By composition

The first medicine contains a larger number of chemicals that are not neutral for the body, the use of which can cause allergies.

For children

The antibiotics in question are suitable for use by children and have a convenient release form, but the dosage should be selected by a doctor.

It is difficult to say exactly which medicine is better for children - Flemoxin Solutab or Augmentin; in each particular case, a specialist will give a competent answer to this question.

For less aggressive pathogens, Flemoxin is often used, and if the case is more complex, the doctor will recommend the more versatile Augmentin. In any case, the doctor will determine the complexity of the disease and select a therapeutic course, and individually.

Flemoclav Solutab instructions for use are extensive, so you need to know for what diseases this drug is prescribed and how to use it correctly.

Antibiotic flemoklav solutab (dose 125, 250, 500, 875) instructions for use

The main composition of this 250 mg concentration of the drug is clavulanic acid, the second name of the drug substance is potassium clavulanate. There are 62.5 mg of this component per 250 mg. In addition, 250 mg of the drug also contains amoxicillin, whose second name is trihydrate.

Auxiliary components: 250 mg contains a small concentration of dispersed cellulose, MCC, saccharin, magnesium stearate.

Main composition 125 mg of the drug

For 125 mg of this drug, there is 31.25 mg of potassium clavulanate. In addition, 125 mg also contains amoxicillin trihydrate. All auxiliary components are identical to the dosage described above.

As for the dosage of 500 mg. 500 mg contains all the same components, but the concentration will be different. For 500 of the first component there are 125 mg. The second component of 500 mg of the drug also has a concentration of 125 mg.

The last dosage of the drug is flemoklav solutab 875 mg. Based on the main substances in the composition, the dosage is similar to 500 mg.

In addition to the additional components described above, the preparations also have tangerine or lemon flavor, crospovidone and vanillin.

Main release form and pharmacological action

The tablets are white or, for example, straw-colored. The tableted drug has a specific engraving, “425”. In addition, the tablet shows the logo directly produced by the company.

It is worth noting that the presence of isolated brown spots in the medicinal product is acceptable.

Some doctors may prescribe large concentrations, for example 1000 mg. If you buy a drug with a dose of 1000 mg, then it is produced in 7 tablets. In this case, the main component is 125 mg, amoxicillin in Flamoclave Solutab is 875 mg.

The drugs are contained in blisters and have paper packaging, which contains complete instructions for use.

This drug has a good pharmacological spectrum of action, namely antibacterial. Some doctors, depending on the severity of the disease, may prescribe salutab as part of complex treatment.

Indications for use

The tablet form of the drug can be prescribed in complex treatment for infections of the ENT organs or for COPD, otitis media, pharyngitis and other diseases of the upper and lower respiratory tract.

In addition, the drug is used in the treatment of gynecological infections, if the patient has an infection in the joints, or osteomyelitis.

Often prescribed for infections in the genitourinary system, for example, for diseases such as cystitis or pyelonephritis.

It was noted that the drug helps relieve the patient from infections of the skin and soft tissues.

Contraindications

Like other drugs in this group, Solutab flemoklav has certain contraindications. Tablets should not be used in the treatment of lymphocytic leukemia, mononucleosis, or renal failure.

Please note that contraindications for renal failure apply only to dosages of 875 and 125 mg.

In childhood, high concentrations of the drug are not prescribed. Treatment of children is carried out from the age of 12.

In addition, the medicine cannot be used in case of hypersensitivity to the main composition.

Side effects

The drug has a lot of side effects, so it cannot be used independently in treatment.

  • From the side of the central nervous system: severe headaches are often observed, in rare cases convulsions may occur. In approximately 0.0001% of all patients, after taking the drug, anxiety, anxiety, or consciousness is impaired.
  • The blood supply system may also be disrupted, and hemolytic anemia and thrombocytopenia may occur.
  • In approximately 0.1% of patients, disturbances in the functioning of the digestive organs occur. Nausea, diarrhea, and vomiting often occur.
  • From the blood vessels and liver, vasculitis, hepatitis and jaundice may be observed.
  • Since the drug is prescribed for infections in the genitourinary system, burning and itching may occur during urination. Women often experience white discharge from the vagina.
  • Allergic reactions can also occur, such as dermatitis, a rash like urticaria. In rare cases, angioedema or anaphylactic shock occurs.
As you can see, the list of side effects is huge, so you should consult a doctor before use.

Additional information about the drug

Flemoklav solutab and alcohol cannot be used together. Despite the fact that the drug itself is not alcoholic, it can cause serious side effects when interacting with alcohol.

The conditions for dispensing the medicine are different in different countries. For example, in Ukraine, medicine is dispensed only with a prescription. But in Russia, the drug can be bought without a prescription from a doctor.

The shelf life of the product is 2 years.

The most common analogues: Amoxiclav 2x, Klavam. You can also use cheaper drugs in treatment, for example: Trifamox or Recut and Medoclav.

Flemoklav solutab for sinusitis

The tablets can be used for sinusitis, for example, with mild to moderate disease; doctors prescribe taking the tablets 2 times a day, in a dosage of 0.5-2 g.

In childhood, the drug is prescribed in a lower dosage; the standard dosage regimen should not exceed 0.125 g.

If the drug is used in children from one to three years of age, then doctors prescribe a dosage of 0.25 g, which must be taken only three times a day. If necessary, a dose of 1.375 g may be prescribed. In this case, you need to take the drug twice a day.

For mild to moderate sinusitis, the course of treatment can last from 5-7 days.

If the disease becomes severe or is in a chronic stage. Then an adult is prescribed 0.75-1 g. This dosage should be divided into three doses.

For chronic sinusitis in childhood, the dose of medication is calculated based on body weight. For example: 60 mg/kg body weight, taken three times a day.

In addition, the drug may be prescribed to prevent relapse of the disease. Therefore, you need to take it according to a specific regimen, which will be prescribed to you by your doctor.

Which is better: Augmentin or Flemoclav?

In order to understand which drug is best for your disease, you need to carefully study the two instructions. For the main drug, we have given you instructions. As for Augmentin, then

this medicine has a wider spectrum of action, directly on the painful microflora. According to statistical data, it was noted that Augmentin is more effective for some diseases.

If we take security into account, we can build a small comparative characteristic. Augmentin's spectrum of action is wider, so it is prescribed only for severe cases of the disease. This medicine should not be used to prevent relapse. And of course the cost, the price of Augmentin is much less than Flemoclav.

Conclusion. Despite all the positive qualities of each drug from this group. Before use, you should consult a doctor. Since if taken incorrectly, all of the above-described side effects may occur, thereby worsening the general condition of the sick person.

When it comes to treating ENT organs, broad-spectrum antibiotics are often used to combat bacterial infections. Which is better Augmentin or Flemoxin Solutab? These two drugs are distinguished because they are too similar in composition, but they still have differences.

What is special about Flemoxin?

Flemoxin and Flemoklav are often confused because they are thought to be similar drugs. They both contain amoxicillin, but Flemoklav also includes clavulanic acid, which allows you to further expand the spectrum of action of the drug.

Flemoxin is a semi-synthetic penicillin antibiotic. Has a negative effect on the synthesis of gram-positive and gram-negative pathogenic microorganisms.

  • Quickly dissolves in the oral cavity;
  • It is not affected by stomach acid;
  • Not able to influence a group of bacterial enzymes;
  • The peak of action occurs 2 hours after administration;
  • Minimal risk of side effects even in children;

The use of the drug is appropriate in the treatment of ENT organs (often sore throat), respiratory tract, infectious processes on the skin, and urinary system.

Augmentin is a well-improved version of Flemoxin, since this drug is able to influence an even larger number of pathogenic organisms, including groups of bacterial enzymes. Augmentin contains clavulanic acid, which provides such high resistance.

Because of this versatility, Augmentin causes serious adverse reactions. Only the attending physician can prescribe this drug to a child or adult, because an incorrectly selected dosage can lead to a deterioration in well-being. For objectivity, it is appropriate to compare drugs with each other.

What is the difference between the drugs

At first glance, the difference between Augmentin and Flemoxin is insignificant, but it still exists. A person who is far from medicine may not understand the importance of the differences between these drugs.

Main differences:

  • According to the spectrum of action, Augmentin is stronger than Flemoxin, since it is resistant to a group of bacterial enzymes;
  • Flemoxin or Augmentin for children in the first months of life. In terms of the number of contraindications, Flemoxin has fewer of them. Augmentin should not be taken by infants when the opposite drug allows such treatment;
  • By cost. Augmentin is more expensive;
  • In terms of the safety of its composition, Flemoxin is more health-friendly, as it has more neutral and less allergenic components.

The patient must understand the seriousness of the drugs prescribed by the doctor, so the option of purchasing an analogue is not suitable for treatment. You need to take medications strictly according to the instructions. There is no point in taking the drugs together, since they both have the main active ingredient amoxicillin.

Found a mistake? Select it and press Ctrl + Enter

A broad-spectrum penicillin antibiotic with a beta-lactamase inhibitor.

Drug: FLEMOCLAVE SOLUTAB®

Active substance of the drug: amoxicillin, clavulanic acid

ATX coding: J01CR02

KFG: Broad-spectrum penicillin antibiotic with beta-lactamase inhibitor

Registration number: P No. 016067/01

Registration date: 09/15/06

Owner reg. credential: ASTELLAS PHARMA EUROPE BV

Release form Flemoklav solutab, drug packaging and composition.

Dispersible tablets are oblong, from white to yellow in color with brown dotted spots, without marks, marked “421” and the company logo. Dispersible tablets 1 tablet. amoxicillin trihydrate 145.7 mg, which corresponds to the content of amoxicillin 125 mg; potassium clavulanate 37.2 mg, which corresponds to the content of clavulanic acid 31.25 mg

Excipients: microcrystalline cellulose, crospovidone, vanillin, apricot flavor, saccharin, magnesium stearate.

4 things. - blisters (5) - cardboard packs.

Dispersible tablets are oblong, from white to yellow in color with brown dotted spots, without marks, marked “422” and the company logo. Dispersible tablets 1 tablet. amoxicillin trihydrate 291 mg, which corresponds to the content of amoxicillin 250 mg, potassium clavulanate 74.5 mg, which corresponds to the content of clavulanic acid 62.5 mg

Excipients: microcrystalline cellulose, crospovidone, vanillin, apricot flavor, saccharin, magnesium stearate.

4 things. - blisters (5) - cardboard packs.

Dispersible tablets are oblong, from white to yellow in color with brown dotted spots, without marks, marked “424” and the company logo. Dispersible tablets 1 tablet. amoxicillin trihydrate 528.8 mg, which corresponds to the content of amoxicillin 500 mg; potassium clavulanate 148.9 mg, which corresponds to the content of clavulanic acid 125 mg

Excipients: microcrystalline cellulose, crospovidone, vanillin, apricot flavor, saccharin, magnesium stearate.

4 things. - blisters (5) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Flemoklav solutab

Broad-spectrum antibiotic; a combination drug of amoxicillin and clavulanic acid, an β-lactamase inhibitor. Active against gram-positive and gram-negative microorganisms (including strains producing β-lactamases).

Amoxicillin has a bactericidal effect and inhibits the synthesis of the bacterial wall. Clavulanic acid inhibits β-lactamases II, III, IV and V types (according to the Richmond-Sykes classification). Inactive against type I β-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of β-lactamases and expands its spectrum of action.

Flemoklav Solutab is active against aerobic gram-positive bacteria: Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Staphylococcus aureus (including strains producing β-lactamases), Staphylococcus epidermidis (including strains producing β-lactamases), Enterococcus faecalis, Corynebacterium spp., Bacillus anthracis, Listeria monocytogenes; anaerobic gram-positive bacteria: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; aerobic gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Yersinia enterocolitica, Salmonella spp., Shigella spp., Haemophilus influenzae, Haemophilus ducreyi, Neisseria gonorrhoeae (including strains of the above bacteria that produce β-lactamases), Neisseria meningitidis, Bordetella pertussis, Gardnerella vaginalis, Brucella spp., Pasteurela multocida, Campylobacter jejuni, Vibrio cholerae, Moraxella catarrhalis, Helicobacter pylori; anaerobic gram-negative bacteria: Bacteroides spp., including Bacteroides fragilis (including strains that produce β-lactamases).

Pharmacokinetics of the drug.

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability reaches 94%. Concomitant food intake does not affect absorption. Cmax in blood plasma is achieved 1-2 hours after administration. After taking a single dose of 500/125 mg (amoxicillin/clavulanic acid), the average amoxicillin concentration (after 8 hours) is 0.3 mg/l.

Serum protein binding is approximately 17-20%. Amoxicillin crosses the placental barrier and is excreted in small quantities into breast milk.

Amoxicillin is metabolized in the liver (10% of the administered dose).

It is excreted by the kidneys (52±15% of the dose unchanged within 7 hours) and a small amount is excreted in the bile. T1/2 in patients with normal renal function is approximately 1 hour (0.9-1.2 hours).

Pharmacokinetics of the drug.

in special clinical cases

In case of impaired renal function (creatinine clearance within ml/min) T1/2 is 6 hours, and in the case of anuria it ranges between 10 and 15 hours. It is excreted during hemodialysis.

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60%. Concomitant food intake does not affect absorption. Cmax in blood plasma is achieved approximately 1-2 hours after administration. After taking a single dose of 500/125 mg (amoxicillin/clavulanic acid), the average concentration of clavulanic acid reaches 0.08 mg/l (after 8 hours).

Serum protein binding is 22%. Clavulanic acid penetrates the placental barrier. There is no reliable data on excretion in breast milk.

Metabolized in the liver (50-70%).

About 40% of the administered dose is excreted by the kidneys (18-38% unchanged). The total clearance is approximately 260 ml/min.

T1/2 in patients with normal renal function is approximately 1 hour.

Pharmacokinetics of the drug.

in special clinical cases

In case of impaired renal function (creatinine clearance from 20 to 70 ml/min), T1/2 is 2.6 hours, and in case of anuria it ranges from 3-4 hours. It is excreted by hemodialysis.

Indications for use:

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- infections of the upper respiratory tract and ENT organs (including otitis media, sinusitis, tonsillitis, pharyngitis);

— infections of the lower respiratory tract (chronic bronchitis and its exacerbation, community-acquired pneumonia);

- infections of the skin and soft tissues;

- kidney and urinary tract infections.

Dosage and method of administration of the drug.

For adults and children weighing more than 40 kg, the drug is prescribed 500/125 mg 3 times a day. For severe, chronic, recurrent infections, this dose can be doubled.

Dosage and method of administration of the drug.

for children is presented in the table. The daily dose is usually mg amoxicillin and 5-7.5 mg clavulanic acid per kg body weight. Age Body weight Daily dose from 3 months to 2 years from 5 to 12 kg tablets 125 mg/31.25 mg 2 times/day from 2 to 7 years from 13 to 25 kg tablets 125 mg/31.25 mg 3 times/day from 7 to 12 years from 25 to 37 kg tablets 250 mg/62.5 mg 3 times a day

For severe infections, these doses can be doubled (the maximum daily dose is 60 mg amoxicillin and 15 mg clavulanic acid per kg body weight).

The duration of treatment depends on the severity of the infection and should not exceed 14 days unless necessary.

If renal function is impaired, the excretion of clavulanic acid and amoxicillin by the kidneys slows down. Depending on the severity of renal failure, the dose of Flemoklav Solutab (calculated as amoxicillin) should not exceed that presented in the table. Creatinine clearance Adults Children ml/min 500 mg 2 times/day 15 mg/kg 2 times/day less than 10 ml/min 500 mg/day 15 mg/kg/day hemodialysis 500 mg/day and 500 mg during and after dialysis 15 mg /kg/day and 15 mg/kg during and after dialysis

To prevent side effects from the digestive system, it is recommended to take the drug at the beginning of a meal. The tablet is swallowed whole with a glass of water, or dissolved in half a glass of water (minimum 30 ml), stirring thoroughly before use.

Side effects of Flemoklav solutab:

Allergic reactions: urticaria, erythematous rashes; rarely - exudative erythema multiforme; in isolated cases - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), anaphylactic shock, angioedema. In some cases, a so-called “fifth day rash” (measles exanthema) appears. Allergic reactions depend on the dose of the drug and the patient's condition.

From the digestive system: nausea, vomiting, diarrhea, abdominal pain, impaired liver function, increased activity of liver transaminases; rarely - hepatitis, cholestatic jaundice; in isolated cases - pseudomembranous colitis. An increase in the activity of transaminases (AST and ALT), bilirubin and alkaline phosphatase is usually observed in males and in elderly patients, especially over 65 years of age. The risk of such changes increases when taking the drug for more than 14 days. These phenomena are very rarely observed in children. The above changes usually appear during treatment or immediately after. Sometimes they may appear several weeks after stopping the drug. Basically, reactions from the digestive system are transient and minor, but sometimes they are pronounced.

From the hematopoietic system: rarely - leukopenia, thrombocytopenia, hemolytic anemia.

Other: development of superinfection (including candidiasis), exanthema; rarely - reversible increase in prothrombin time, interstitial nephritis, vasculitis.

Contraindications to the drug:

- liver dysfunction (including jaundice) with a history of taking amoxicillin/clavulanic acid;

— infectious mononucleosis or lymphocytic leukemia (risk of exanthema);

- hypersensitivity to amoxicillin, clavulanic acid and other components of the drug;

- hypersensitivity to other beta-lactam antibiotics such as penicillins and cephalosporins.

The drug should be prescribed with caution in case of severe liver failure, chronic renal failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins).

Use during pregnancy and lactation.

When using Flemoclav Solutab during pregnancy, no negative effects on the fetus or newborn were noted. The use of the drug in the second and third trimester of pregnancy is considered safe. In the first trimester of pregnancy, Flemoclav Solutab should be used with caution.

Amoxicillin is excreted in breast milk. There is no data on the secretion of clavulanic acid into breast milk. There were no negative effects on the baby during breastfeeding while taking Flemoclav Solutab.

Special instructions for use Flemoklav solutab.

If anaphylactic reactions develop, the drug should be stopped immediately and appropriate therapy administered: treatment of anaphylactic shock may require urgent administration of epinephrine (adrenaline), corticosteroids and elimination of respiratory failure.

When taking Flemoclav Solutab, there is a possibility of cross-resistance and hypersensitivity with other penicillins or cephalosporins.

Superinfection (in particular, candidiasis) may develop, especially in patients with chronic diseases and/or impaired immune system function. If superinfection occurs, the drug is discontinued and/or antibacterial therapy is adjusted accordingly.

If liver function is impaired, the drug should be prescribed with caution and under constant medical supervision. The drug should not be used for more than 14 days without assessing liver function.

While taking the drug, an increase in prothrombin time may be observed. Therefore, Flemoklav Solutab should be prescribed with caution to patients receiving anticoagulant therapy (blood clotting parameters must be monitored).

Amoxicillin should not be given with disulfiram.

During the period of use of Flemoklav Solutab, non-enzymatic methods for determining glucose in urine, as well as a test for urobilinogen, may give false positive results.

During a course of treatment, it is necessary to monitor the functions of the hematopoietic organs, liver and kidneys.

Drug overdose:

Symptoms: nausea, vomiting, diarrhea with possible disturbances in water and electrolyte balance.

Treatment: activated carbon is prescribed, it is necessary to maintain water and electrolyte balance, and symptomatic therapy is carried out. For convulsions, diazepam is prescribed. In case of severe renal failure, hemodialysis is performed.

Interaction of Flemoklav solutab with other drugs.

When used simultaneously with Flemoklav Solutab, antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of the active components of the drug; ascorbic acid - increases.

When used simultaneously with Flemoclav Solutab, bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

With simultaneous use, Flemoklav Solutab increases the effectiveness of indirect anticoagulants by suppressing intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index.

Flemoclav Solutab, when used simultaneously, reduces the effectiveness of oral contraceptives, drugs that metabolize PABA, and ethinyl estradiol (the risk of developing acyclic bleeding).

Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs that block tubular secretion, when used simultaneously with Flemoklav Solutab, increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration).

The simultaneous use of Flemoclav Solutab with allopurinol increases the risk of developing a skin rash.

The simultaneous use of amoxicillin and digoxin may lead to an increase in the concentration of digoxin in the blood plasma.

Terms of sale in pharmacies.

The drug is available with a prescription.

Storage conditions for the drug Flemoklav solutab.

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years.

Source: http://lechim-serdce.ru/2017/12/15/flemoklav-solyutab-ili-augmentin-chto-luchshe/

Flemoxin and Augmentin

Augmentin or Flemoxin?

Augmentin and amoxiclav

A paid pediatrician spoke badly about Flemoxin to me, he said that with this series, Flemoklav would be better, it helped us well.

Amoxiclav allowed for children at this age? I remember what they told me in the hospital about Flemoxin.

Is Flemoxin also penicillin?

Augmentin

play it safe with antibiotics? famously... we had a terrible allergy to Augmentin, even though the child was not allergic. It took 2 months. It’s an antibiotic, and not a weak one

We only have augmentin and help, how many times have we tried to change the antibiotic, but we go back to augmentin

Allergy to Flemoxin, what next? Need some advice.

augumentin is the same active ingredient as amoxicillin of the pinecillin series. Do not take risks under any circumstances. Let them prescribe you an antibiotic of a different group. We are also allergic to flemoxin

All antibiotics are taken together with an antihistamine! On the last 5th day, hives started anyway, and it persisted for a week, so an antihistamine is in your hands.

Augmentin and Flemoxin Salutab, tell me

Only a doctor can tell in each specific case. Their manufacturing method is different.

Augmentin and pregnancy. Bacterial tonsillitis.

I drank it at your time, but I had pneumonia and otitis media, I was choking, I couldn’t hear anything really, I had no choice. Everything was fine at the second screening, although it wouldn’t affect it further...

For traffic jams I simply gargled with Happy Lore, Miramistin, and chamomile. I still took Givalex, I wouldn’t take antibiotics for traffic jams, they often come out for me, this is not the right disease just for such measures, in my opinion.

I drank it when I had purulent mastitis, the doctor said you can breastfeed, everything will be OK... But the little one screamed like a siren, removed the breast milk - silence. Apparently, some components still end up in the milk, which is not good.

who gave their children Augmentin

Let's do what the doctor ordered. the doctor knows best. I crushed the tablets in a spoon and filled them with water. Flemoxin is sweet, the child drank normally.

Hello! what did you get sick with? if you need it in syrup, then I buy amoxicillin, it’s not an expensive analogue of these drugs

The doctor calculated it for me. Go to the doctor and let him calculate it

augmentin antibiotic or flemoxin

Len, we fought with purulent tonsillitis on flemoxin 3-days against the background of teeth with high T. I took solutab - there were no side effects

We took flemoxin for bronchitis, it helped immediately, there were no side effects

Flemoxin solutab.

An antibiotic will not work against a viral infection; therefore, antiviral agents are needed.

Helped us well (3) years. And he’s not bitter, he just didn’t drink others. Now I drink it myself.

Why antibiotics for ARVI? Did your doctor prescribe it for you?

who gave the children AUGMENTIN?

laryngitis

analogues of imported drugs

Suprax, antibiotic, who gave it?

WE DO NOT KNOW THIS... BUT I HAVE FACED THE WORSE PROBLEM OF ANTIBIOTIC SIDES... DYSBKTERIOSIS IS THIS CALLED... THE POOR DAUGHTER IS COMPLAINING ABOUT THE TUMMY, THE STOOL IS STRANGE, THE TEMPERATURE IS BACK FROM SOMEWHERE.

AND YOU WILL EVEN FOLLOW THE GHOSTS OF WHEELES AND DON’T GET SICK

we drank this for a urinary tract infection... It helped the disease instantly, the side effects were in the form of diarrhea... In parallel with the antibiotic, we drank normobact powder for 10 days... The stool returned to normal quickly.

But they say the children tolerate it well

Have you recovered since that time? Did you go to kindergarten?

We have a fever today

Should I hit the frying pan or not?

It means you are not so important to him if he treats children this way. Or did not understand the seriousness of the problem. Maybe you should have said outright that all hope is in him, since you have no funds.

He doesn’t owe your children anything... you have to take care of them yourself... and if I were you, I would think a hundred times about getting involved with such an unnecessary young man.

Just ask next time not to promise if you don’t want to keep it. Or to warn you in advance.

What kind of bacillus? terrible symptoms. the whole family fell ill.

I'm freaking out. MONTH? And just today you called the pediatrician? Does your husband not respect medicine? Well, I have no words! You know, there are diseases that, if not treated on time, lead to death. You have children, and on the forum you are wondering what kind of illness it is? Mommy! Excuse me, but... I would have already been in the hospital a month ago when it all started, and - first of all - I would have had tests. Is it more important for you not to quarrel with your husband or children?

I understood correctly, you are trying to cure green snot with vasoconstrictors. For children, protorgol after Nazivin, rinse your nose with saline solution, then apply syntomycin liniment, it draws out pus well. and the husband, oh my husband, gets fed up and asks for treatment himself.

girls, what kind of bacilli? Perhaps we are all sick of the same thing?

My husband also apparently needs an antibiotic, plus an antiviral. But if he doesn’t want to drink anything, then at least increase the content of vitamin C and drink plenty of fluids.

Are you not breastfeeding? We have almost the same system, the eldest daughter, I, the youngest daughter. Now everyone has snot, we can’t get rid of it. You can do some turunda with Vishnevsky’s ointment.

question

Augmentin makes a lot of people sick! I wouldn’t give it to something else, I’d change it!

About the problem (Antibiotics for children - how to choose and treat so as not to harm

Thank you, bookmarked, otherwise I don’t understand this at all, but it may come in handy in the future. I’m generally against them and I don’t drink myself. At one time I was addicted, I got a little sick - I immediately drank, then I stopped completely and stopped getting sick with anything except colds, TTT, of course. I had to give it to my daughter once, they prescribed Zinnat as a prophylaxis after surgery, I was very worried, I gave Bifidumbacterin along with it, but there were no side effects.

A doctor I know recommended Cedex to a 6-year-old child with a sore throat, in suspension, and it was cured. I read the instructions there since 6 months it is possible

Suprax is a waste, 800 wasted rubles on it and 800 on primadophilus. He can only kill flora.

Antibiotics for ARVI.

I’m generally shocked by doctors who prescribe antibiotics for ARVI or Influenza. These conditions are caused by viruses, on which antibiotics have no effect.

In case of acute respiratory viral infections, antibiotics are not prescribed at all, because they are ineffective against viral diseases. and it’s strange, if you just took a course of antibiotics, why do you need antibiotics again? especially since the diagnosis is now ARVI?

If you have a sore throat, you had to take a throat swab to determine the pathogen, and then you would be prescribed the right antibiotic so you don’t have to eat handfuls of different pills.

If there is no temperature, do not give the antibiotic.

Girls, which is better?

Flemoxin gets you back on your feet quickly! But along with it you need to drink Hilak-Forte or Linex, which restores the microflora... and not only of the stomach.

I’ve never even heard of these, we like Suprax, give it once a day, it’s a strong antibiotic

With Augumentin we had severe diarrhea to the point of dehydration. Apparently it didn’t work.

Medicines for hepatitis B

A lot of things are wrong. Many drugs with generally unproven effectiveness, dummies, some are generally prohibited in all countries, only in Russia they are prescribed to mothers and children, having come up with their own instructions. There is a lot of useful information on Russian Med, and most importantly it describes how effective the drugs are in principle. Yes, and from other sources, but the main thing is that they are based not on the instructions, but on where it was produced, what kind of research was done, whether there is a license, there is no such lawlessness regarding medicines in any country. Unfortunately, 90% of our pharmacies are pacifiers. Not only should they not be taken during breastfeeding, but they are also dangerous for people who are neither pregnant nor on breastfeeding at the moment. I believe facts more. And for us, mothers, they are more important than advertising and instructions for the medicine. Be careful!)))))))))))))

Therapists very often prescribe medications to nursing mothers that are contraindicated during breastfeeding. Pediatricians definitely put on the black list: anti-inflammatory drugs - butadione, indomethacin; metronidazole (Trichopol), tetracyclines (doxycillin), chloramphenicol, tsiprobay, grammidin, tarivid; bromides, remantadine, phenylin, nystatin.

But there are drugs that do not pass into mother’s milk and in small doses do not cause side effects: amoxicillin, verapamil, heparin, cerucal, cefazolin, diuretics.

Let there be more doctors who are not indifferent to the health of mother and child during breastfeeding and will be able to correctly prescribe the drug!

Good day to all! My son was injected with suprastin in the maternity hospital on the 3rd day of life due to an allergy (I don’t know the dosage). Although Suprastin is a first generation antihistamine (obsolete in other words).

After discharge, the pediatrician prescribed my son a course of fenistil drops.

The conclusion is that what is possible for children is also possible for mothers (not to be confused with pregnancy.). Check with your doctor for dosage.

P\S: I take children's Panadol for headaches.

Medicines

How to cure sinusitis - methods

Indeed, it’s definitely not worth self-medicating here. With my sinusitis, I went to a bunch of doctors - they constantly prescribed antibiotics and mountains of other pills that do nothing but kill the gastrointestinal microflora. And then a friend said that her doctor recommended Fluimucil, an IT antibiotic for inhalation. I run to the doctor to find out what and how. Yes, it is an antibiotic, but it also contains a mucolytic. Moreover, thanks to inhalation through a nebulizer, the substance reaches the site of inflammation locally, and is not distributed throughout the body. She gets back on her feet very quickly, after 3 days she could already exist normally!

I have sinusitis again, I haven’t had it for a long time, my immunity has weakened after childbirth and this is the result: my head hurts, I can’t bend over and my nose is pouring like a bucket, cough and fatigue. I was also recommended cyclamen juice and rinsing with saline solution. Instead of cyclamen juice, I bought Sinuforte, it’s not bad, my nose is already much better, the bags under my eyes have disappeared, everything is working out.

My daughter has bronchitis and about medications

Lay the baby on your knees, tummy down, the head should be lower than the butt, gently on the back (don’t do anything stupid)))) but not weakly, you need to pat it. You need to do this 5 times a day, always after sleep.

On December 25 we were admitted, on January 1 the child no longer coughed at all, we were discharged home on the 28th after lunch, at home she continued only inhalations and pats on the back until the 2nd.

Olya, I don’t know, of course, but Bronchipret helped us, I had been coughing for a month, nothing helped, the pediatrician recommended it to us. And I gave it to my niece, and it immediately improved.

Get well, don't get sick.

Drugs allowed for hepatitis B

Nah! Once again I am convinced that it is better not to read anything. Before copying the message, you could have studied it more carefully. Half of the drugs are prohibited during breastfeeding, for example, Magne B6 - the instructions clearly indicate - NOT allowed during breastfeeding. But no, since breastfeeding consultants allowed it, then of course you can drink, they know better. This is how you read too much of people like you and lose your health.

Thanks for the post, I’ve already looked at it 3 times =))

medications for gw

The information is very different. You can’t look at half of the drugs; it’s not written in the instructions there, but here you can. Yes, and doctors themselves never really know who prescribes something and who says it’s forbidden. You won’t understand what the treatment is, and whether it will work on the child or not.

It's very useful to know)))

What about Berodual and Ambrobene? Looks like it's not on the list? Or did I miss it?

Source: http://www.baby.ru/popular/flemoksin-i-augmentin/