How many times a day is ceftriaxone injected?

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How many days can you inject Ceftriaxone?

Ceftriaxone is an antimicrobial and antibacterial drug, a cephalosporin antibiotic.

Prescribed for bacterial infections, infections of internal organs, lower respiratory tract, acute otitis media and other infectious diseases.

Table of contents:

It has great bactericidal activity against a wide range of infectious diseases.

The drug is administered intramuscularly or intravenously.

Children under 12 years of age and adults should be administered 2 g once a day.

In case of exacerbation and severe infection, the dose can be increased to 4 g.

Infants and children under 12 years of age should be administered depending on body weight, i.e. from 20 to 80 mg/kg once a day.

Elderly people are given the same dose as adults.

The course of treatment ranges from 5 days to two weeks, depending on the severity of the infectious disease, but not more than 14 days.

If the disease is not too complex, then Ceftriaxone can be injected for 5 days, but on the fifth day of treatment, doctors additionally advise taking an antifungal drug, for example - Fluconazole - 1 tablet (one-time use). This combination of antifungal and antiviral drugs is most effective in treating infections.

For more complex inflammations and infections, Ceftriaxone is prescribed as a course, but in order not to spoil the intestinal microflora with antibiotics, probiotics are additionally prescribed, for example, bifidumbacterin.

The doctor prescribed the drug Ceftriaxone to me when I started having a sore throat accompanied by a high fever. Therefore, I can reliably say that this is an antibiotic, and all antibiotics are injected for 7 days, even if you are on the mend. If necessary, the course can be extended to 10 days. From the very first days of the drug, antifungal drugs are taken, otherwise there is a risk of thrush.

Ceftriaxone is an antibiotic from the Cephalosporin group. Any antibiotic must be injected for at least 5 days. If the disease is complex, then ceftriaxone injections are prescribed for up to 10 days in a row, but no more. It is usually well tolerated as it is used with the analgesic lidocaine.

The drug Ceftriaxone is used to treat many diseases: it is also used to treat serious diseases that pose a real threat to life: bacterial meningitis, Lyme disease, typhoid fever, some sexually transmitted diseases, and it is also used to prevent postoperative complications.

The dosage, duration of treatment, number of injections can only be prescribed by the attending physician. It primarily depends on the disease itself and the degree of its severity.

In not very advanced cases, you can get by with seven to ten injections, and, for example, for the treatment of Lyme disease or granulocytic ehrlichiosis, the course of treatment can be extended to 30 days.

The duration of the course of pharmacotherapy with Ceftriaxone is determined by the clinical picture of the ongoing disease, depends on the type of pathogen and is at least 4 days. After restoring normal temperature and improving general condition, medication should be continued for another two days. Stopping the use of antibiotics early can lead to the development of resistance to them, and in the event of a subsequent infection, the drug may be useless.

For the purpose of perioperative antibiotic prophylaxis, the medicine is administered once an hour before surgery.

Ceftriaxone is a third-generation cephalosporin antibiotic.

A group of cephalosporin antibiotics is prescribed for syphilis, bronchitis, pneumonia, typhoid, chronic laryngitis, acute cholecystitis and other diseases, as well as for intolerance to penicillin antibiotics, like my son.

I know that for bronchitis, ceftriaxone is injected for 5 days, 2 times a day, 12 hours apart; for pneumonia, it is injected for 7 days.

No matter what drug it is, even the most harmless one, it is prescribed by a doctor depending on the severity of the disease. During the treatment itself, the degree of change in the disease is diagnosed and the course of taking the drug can be reduced or increased by the doctor. Therefore, the answer is this: without the supervision of a doctor, you cannot give even one injection. And even more so to inject for several days.

Ceftriaxone is an antibiotic with a bactericidal effect.

This antimicrobial drug is indicated for the following diseases:

The duration of treatment with ceftriaxone depends on both the severity of the patient's condition and the type of infection.

Usually this antibiotic is prescribed intramuscularly for a period of 7 to 10 days.

Self-medication is our enemy. As for Ceftriaxone, it is necessary to take into account the patient’s age; of course, it is better if the doctor prescribes the dose.

In general, children are given an injection once a day (not laziness, just a day), adults a couple of times a day for at least 5 days in a row, of course, this is an antibiotic.

The number of antibiotic injections is prescribed by the attending physician. I was given this drug for pneumonia. At first, 7 injections were prescribed, and since the wheezing did not go away completely, they extended it to 10 days. More than 10 injections are usually not prescribed.

Antibiotics must be injected for at least five to seven days.

Source: http://www.bolshoyvopros.ru/questions/skolko-dnej-mozhno-kolot-ceftriakson.html

Ceftriaxone - instructions for use, reviews, analogs and release forms (powder for injection) of the drug for the treatment of infections in adults, children and pregnancy. How to dilute medicine for intramuscular and intravenous injections

In this article you can read the instructions for use of the drug Ceftriaxone. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Ceftriaxone in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Ceftriaxone analogues in the presence of existing structural analogues. Use for the treatment of infectious diseases of a bacterial nature (peritonitis, sepsis, pneumonia, pyelonephritis and others) in adults, children, as well as during pregnancy and lactation. We will tell you how to dilute Ceftriaxone with lidocaine and water for injection.

Ceftriaxone is a 3rd generation broad-spectrum cephalosporin antibiotic. It has a bactericidal effect, inhibiting the synthesis of the cell wall of microorganisms. Resistant to beta-lactamases of most gram-positive and gram-negative bacteria.

Active against gram-positive aerobic bacteria, gram-negative aerobic bacteria and anaerobic bacteria.

Has in vitro activity against most strains of the following microorganisms, although the clinical significance is unknown: Citrobacter diversus, Citrobacter freundii, Providencia spp. (including Providencia rettgeri), Salmonella spp. (including Salmonella typhi), Shigella spp., Streptococcus agalactiae, Bacteroides bivius, Bacteroides melaninogenicus.

Methicillin-resistant staphylococci are also resistant to cephalosporins, incl. to ceftriaxone. Many strains of group D streptococci and enterococci (including Enterococcus faecalis) are also resistant to ceftriaxone.

After intramuscular administration, ceftriaxone is quickly and completely absorbed into the systemic circulation. Penetrates well into tissues and fluids of the body: respiratory tract, bones, joints, urinary tract, skin, subcutaneous tissue and abdominal organs. In case of inflammation of the meningeal membranes, it penetrates well into the cerebrospinal fluid. The bioavailability of ceftriaxone with intramuscular administration is 100%. In adult patients, within 48 hours, 50-60% of the drug is excreted unchanged by the kidneys, 40-50% is excreted with bile into the intestines, where it is biotransformed into an inactive metabolite.

Pharmacokinetics in special clinical situations

In newborns, about 70% of the drug is excreted by the kidneys.

Bacterial infections caused by susceptible microorganisms:

  • infections of the abdominal organs (peritonitis, inflammatory diseases of the gastrointestinal tract, biliary tract, including cholangitis, empyema of the gallbladder);
  • diseases of the upper and lower respiratory tract (including pneumonia, lung abscess, pleural empyema);
  • bone and joint infections;
  • skin and soft tissue infections;
  • urinary tract infections (including pyelonephritis);
  • bacterial meningitis;
  • endocarditis;
  • sepsis;
  • gonorrhea;
  • syphilis;
  • chancroid;
  • Lyme disease (borreliosis);
  • typhoid fever;
  • salmonellosis and salmonella carriage;
  • infected wounds and burns.

Prevention of postoperative infection.

Infectious diseases in persons with weakened immune systems.

Powder for preparing a solution for intravenous and intramuscular use 0.5 g, 1 g, 2 g.

The drug is administered intramuscularly and intravenously (stream or drip).

For adults and children over 12 years of age, the dose is 1-2 g once a day or 0.5-1 g every 12 hours. The maximum daily dose is 4 g.

For newborns (up to 2 weeks of age) the dose is mg/kg per day

For infants and children under 12 years of age, the daily dose is mg/kg. In children weighing 50 kg or more, adult doses are used.

A dose of more than 50 mg/kg body weight should be administered as an intravenous infusion over 30 minutes. The duration of treatment depends on the nature and severity of the disease.

For bacterial meningitis in infants and young children, the dose is 100 mg/kg 1 time per day. The maximum daily dose is 4 g. The duration of therapy depends on the type of pathogen and can range from 4 days for meningitis caused by Neisseria meningitidis, to days for meningitis, caused by sensitive strains of Enterobacteriaceae.

For the treatment of gonorrhea, the dose is 250 mg IM, once.

To prevent postoperative infectious complications, a dose of 1-2 g (depending on the degree of risk of infection) is administered once before the operation. During operations on the colon and rectum, additional administration of a drug from the group of 5-nitroimidazoles is recommended.

For children with infections of the skin and soft tissues, the drug is prescribed in a daily dose of mg/kg body weight 1 time/or 25-37.5 mg/kg every 12 hours, but not more than 2 g per day. For severe infections of other localization - at a dose of 25-37.5 mg/kg every 12 hours, but not more than 2 g per day.

For otitis media, the drug is administered intramuscularly at a dose of 50 mg/kg body weight, but not more than 1 g.

In patients with impaired renal function, dose adjustment is required only in cases of severe renal failure (creatinine clearance less than 10 ml/min), in which case the daily dose of ceftriaxone should not exceed 2 g.

Rules for the preparation and administration of injection solutions (how to dilute the drug)

Injection solutions should be prepared immediately before use.

To prepare a solution for intramuscular injection, 500 mg of the drug is dissolved in 2 ml, and 1 g of the drug is dissolved in 3.5 ml of a 1% lidocaine solution. It is recommended to inject no more than 1 g into one gluteal muscle.

Dilution for intramuscular use can also be done using water for injection. The effect is the same, only the injection will be more painful.

To prepare a solution for intravenous injection, 500 mg of the drug is dissolved in 5 ml, and 1 g of the drug is dissolved in 10 ml of sterile water for injection. The injection solution is administered intravenously slowly over 2-4 minutes.

To prepare a solution for intravenous infusion, 2 g of the drug is dissolved in 40 ml of one of the following calcium-free solutions: 0.9% sodium chloride solution, 5-10% dextrose (glucose) solution, 5% levulose solution. The drug at a dose of 50 mg/kg or more should be administered intravenously over 30 minutes.

Freshly prepared solutions of ceftriaxone are physically and chemically stable for 6 hours at room temperature.

  • headache, dizziness
  • oliguria, renal dysfunction
  • glucosuria
  • hematuria
  • hypercreatininemia
  • increase in urea content
  • nausea, vomiting
  • taste disturbance
  • flatulence
  • stomatitis, glossitis
  • diarrhea
  • dysbacteriosis
  • abdominal pain
  • anemia, leukopenia, leukocytosis, lymphopenia, neutropenia, granulocytopenia, thrombocytopenia,
  • nosebleeds
  • hives, rash, itching
  • anaphylactic shock
  • bronchospasm.

Local reactions: with intravenous administration - phlebitis, pain along the vein; with intramuscular injection - pain at the injection site.

  • hypersensitivity to the components of the drug;
  • hypersensitivity to other cephalosporins, penicillins, carbapenems.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus (in this case, it is usually not recommended to use the drug due to possible complications during pregnancy and fetal disorders). If it is necessary to use the drug during lactation, breastfeeding should be stopped.

When using the drug, the risk of developing anaphylactic shock and the need for appropriate emergency treatment should be taken into account.

When severe renal failure and severe liver failure are combined in patients on hemodialysis, the plasma concentration of the drug should be regularly determined.

With long-term treatment, it is necessary to regularly monitor the peripheral blood picture, indicators of the functional state of the liver and kidneys.

In rare cases, ultrasound of the gallbladder reveals darkening, which disappears after cessation of treatment. Even if this phenomenon is accompanied by pain in the right hypochondrium, continued therapy with Ceftriaxone and symptomatic treatment are recommended.

Elderly and debilitated patients may require vitamin K.

During treatment, alcohol consumption is contraindicated, because disulfiram-like effects are possible (facial hyperemia, spasms in the abdomen and stomach area, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).

Ceftriaxone and aminoglycosides are synergistic against many gram-negative bacteria.

When used together with NSAIDs and other antiplatelet agents, the likelihood of bleeding increases.

When used simultaneously with loop diuretics and other nephrotoxic drugs, the risk of nephrotoxicity increases.

The drug is incompatible with ethanol (alcohol).

Pharmaceutically incompatible with solutions containing other antibiotics.

Analogues of the drug Ceftriaxone

Structural analogues of the active substance:

How to dilute Ceftriaxone (memo)

Similar medications:

Other medicines:

News edited by: admin014, 11:14

Reason: added reminder on dilution of Ceftriaxone

Source: http://instrukciya-otzyvy.ru/31-ceftriakson-po-primeneniyu-analogi-poroshok-dlya-inekciy-infekciya-kak-razvodit-lekarstvo.html

Ceftriaxone injections - instructions, analogues and reviews

Ceftriaxone is a bactericidal antibiotic belonging to the class of 3rd generation cephalosporins. The drug is characterized by a prolonged action and high efficiency against most gram-negative and gram-positive pathogens, including strains that secrete penicillinases and cephalosporinases.

Swiss Ceftriaxone produced by the pharmaceutical company Hoffmann La Roche costs about 550 rubles per ampoule.

Ceftriaxone instructions for use of injections

The antibiotic has powerful bactericidal activity and an ultra-wide spectrum of antimicrobial effects. The mechanism of the antibacterial action of Ceftriaxone is realized through the active acetylation of membrane-bound transpeptidases, leading to destabilization of the cross-linking of supporting polymers in the bacterial cell. Violation of the membrane strength leads to rapid cell death.

The active substance, Ceftriaxone, easily penetrates into body fluids and media and accumulates significantly in inflamed tissues. With inflammation of the meninges, the antibiotic can accumulate in the cerebrospinal fluid.

It should be noted that the drug is able to overcome the placental barrier, therefore Ceftriaxone is not recommended to be administered during pregnancy in the 1st trimester. During lactation, up to four percent of the antibiotic concentration in the blood can be excreted in breast milk.

The required bactericidal indicators in the blood are achieved 1.5 hours after administration. Since the drug has a prolonged effect, the minimum antimicrobial concentration in the body is maintained in the blood throughout the day, which allows it to be administered once a day. However, in case of severe infection or a high risk of complications, it is preferable to divide the daily dose into 2 administrations. This allows you to maintain higher bactericidal concentrations. Also, the daily dose should be divided into 2 times when prescribing high doses of Ceftriaxone.

In patients over seventy-five years of age, the elimination period of the antibiotic is prolonged due to age-related decline in renal function. In this regard, adjustment of the prescribed dose may be required. It is preferable to administer the daily dose to such patients at one time.

This medication is eliminated from the body primarily through urine. Part of the drug is disposed of along with bile.

Ceftriaxone - release form

The antibiotic is sold in pharmacies with a doctor's prescription.

The group of ceftriaxone antibiotics are third-generation parenteral cephalosporins, that is, the antibiotic can only be used intramuscularly or intravenously. Ceftriaxone is sold in ampoules: 500, 1000 and 2000 mg of antibiotic. Rocephin is available in an additional dosage of 250 mg.

Ceftriaxone recipe in Latin

Ceftriaxone in Latin is Ceftriaxoni.

Rp.: Ceftriaxoni 1.0

S. In the supplied solvent IM, once a day.

Ceftriaxone - composition of the drug

The antibiotic is produced in the form of a sodium salt.

Rofecin – in the form of a disodium derivative (disodium hydrate). Each ampoule of Rofecin is completed with a solvent (lidocaine or injection water).

Ceftriaxone - what does it help with?

The antibiotic has an ultra-wide spectrum of antimicrobial effects, covering staphylococci, streptococci, pneumococci, citrobacter, most strains of enterobacter, Escherichia coli, Ducray's bacillus, Haemophilus influenzae, Klebsiella, Moraxella, gonococci, meningococci, Proteus, Salmonella, Serracia, Shigella, Yersinia, some Clostri diy and fusobacteria, peptococci, peptostreptococci, white treponema.

Ceftriaxone is absolutely resistant to methicillin-resistant staphylococci, some enterococci, listeria, bacteroides and clostridium deficille.

Ceftriaxone - indications for use

An antibiotic can be used for:

  • bacterial infection of the abdominal cavity (abdominal organs). Ceftriaxone can be prescribed for the treatment of abscess, phlegmon, empyema of the gallbladder, bacterial inflammation of the bile ducts, peritonitis, etc.;
  • infections of ENT organs and respiratory organs. systems (including complicated pneumonia, abscesses of lung tissue, pleural empyema);
  • carriage of salmonella and salmonellosis;
  • typhoid fever;
  • osteomyelitis, septic arthritis, bursitis;
  • bacterial damage to the skin and pancreas, including burns, wounds, erysipelas, furunculosis, etc., complicated by bacterial flora;
  • Lyme disease;
  • infectious pathologies of the genitourinary system (including gonorrhea, chancroid, syphilis);
  • meningitis;
  • endocarditis;
  • generalization of infection (development of sepsis);
  • infections, in patients with immunodeficiency conditions;
  • preventive antibiotic therapy before surgical intervention on the obstructive kidney and pelvic organs.

Ceftriaxone - contraindications

An absolute contraindication to the use of Ceftriaxone is an allergy to the drug or other beta-lactam antibiotics. This is because among all beta-lactams there is a risk of cross-allergic reactions.

Also, the antibiotic is not prescribed in the 1st trimester of pregnancy and women who are breastfeeding.

Considering the mechanism of disposal (urine and bile), the solution can be prescribed for kidney or liver dysfunction, but is not used for combined renal and hepatic failure.

The antibiotic is contraindicated in premature infants less than 41 weeks of age, taking into account gestational age and age after birth. It is also contraindicated in newborns with hyperbillirubinemia.

During antibiotic treatment, it is prohibited to administer calcium solutions intravenously, as there is a risk of the formation of Ceftriaxone Ca salt precipitate.

The drug can be prescribed to children from the first days of life, however, up to two weeks of life, the antibiotic can only be used for health reasons. This is due to the ability of Ceftriaxone to displace bilirubin from its association with serum albumin. This can lead to the development of hyperbilirubinemia and cause kernicterus.

Given partial disposal with bile, the drug is not prescribed to patients with biliary obstruction.

An antibiotic containing lidocaine is not administered to children under 12 years of age.

Also, it must be taken into account that lidocaine is contraindicated in women who are pregnant, breastfeeding, patients with atrioventricular block, HF (heart failure), SVC or Stokes-Adams syndrome, sinus node weakness, complete transverse block, severe bradyarrhythmia or severe decrease in blood pressure.

Ceftriaxone - dosage

Ceftriaxone IV is administered in 10 ml saline. solution 0.9%. The drug must be administered slowly, over two to four minutes.

It is administered intramuscularly with lidocaine, saline. solution, water for injection. It is not recommended to administer more than a gram intramuscularly. Higher dosages are prescribed intravenously.

After 12 years, 1 g medium is administered 1-2 times a day. In severe cases of the disease, a maximum of four grams per day can be administered (in two doses, with an interval of 12 hours).

Babies under 2 weeks of age are prescribed mg/kg per day for 1 administration.

Bacterial meningitis is an indication for prescribing one hundred mg/kg of the drug per day during initial therapy. Subsequently, the dose is reduced.

From 14 days to 12 years mg/kg at knocks. If the child weighs more than 50 kg, adult doses must be prescribed.

For patients with kidney pathologies, the dose is reduced in accordance with the GFR. Impaired liver function is also an indication for reducing the daily dose.

How many times a day should an adult inject Ceftriaxone?

The drug is administered 1-2 times a day. In case of severe infection, the risk of complications, the prescription of high doses of the drug, and also if the patient has an immunodeficiency, it is preferable to divide the daily dose into two administrations.

Ceftriaxone - side effects

The antibiotic is usually well tolerated by patients. However, the risk of developing allergic reactions should be taken into account. They can have varying degrees of severity from redness and rash at the injection site, urticaria, to angioedema or anaphylactic shock.

The risk of anaphylaxis increases when administered with lidocaine. Therefore, when prescribing a medication, a test is required. Also, contraindications and restrictions on the use of lidocaine are taken into account.

It is forbidden to self-prescribe the drug, adjust the dosage and duration of treatment. Therapy should be carried out in a hospital setting, under the supervision of the attending physician.

Other undesirable effects may include dyspeptic reactions, diarrhea, phlebitis at the injection site, dysbacteriosis, thrush, changes in the blood count and biochemical analysis. Coagulation disorders are rare (the antibiotic inhibits the intestinal microflora that synthesizes vitamin K) and, as a rule, is typical for patients receiving antiplatelet therapy.

In rare cases, antibiotic-associated diarrhea may develop.

Ceftriaxone during pregnancy and breastfeeding

The antibiotic is able to cross the placental barrier, but does not have embryotoxic or teratogenic effects. Ceftriaxone during pregnancy is not recommended for administration in the first trimester, since there is insufficient data on the safety of its use in this category of patients. Controlled animal studies have not shown toxic effects on the fetus, so antibiotics can be used in the 2nd and 3rd trimester.

During lactation, ceftriaxone can be excreted in breast milk, therefore, when prescribing it to breastfeeding women, a temporary cessation of breastfeeding is recommended. This is due to the fact that the antibiotic released in breast milk can cause sensitization of the baby, the development of oral thrush and intestinal dysbiosis.

Ceftriaxone and alcohol - compatibility

Ceftriaxone and alcohol are absolutely incompatible. Firstly, given that the solution is partially utilized by the liver, such a combination can lead to the development of jaundice and drug-induced hepatitis.

Secondly, drinking alcohol during antibiotic therapy can cause severe intoxication and toxic kidney damage.

Thirdly, this can lead to the development of a severe disulfiram-like reaction. It can manifest itself as tachycardia, chills, tremors of the limbs, convulsions, cardiac arrhythmias, arterial hypotension, even collapse.

Allergy to Ceftriaxone

Ceftriaxone is not prescribed to patients with allergies to other beta-lactams, due to the high risk of cross-allergic reactions.

Also, before administration it is always necessary to perform a test.

Allergic manifestations can vary from urticaria to anaphylaxis (in the absence of timely medical care, death is possible).

Deaths from the use of the antibiotic have been associated with its administration with lidocaine. Considering the risk of anaphylactic shock, independent use of antibiotics is strictly prohibited. The drug should be used exclusively in a hospital setting, after testing.

Ceftriaxone with lidocaine is not prescribed to children under 12 years of age.

Analogs

  • Emsef;
  • Loraxone;
  • Lendatsin;
  • Rocephin;
  • Terzef;
  • Medakson.

How to dilute ceftriaxone with lidocaine and water for injection

The prepared solution can be stored for up to six hours, and administered 1-2 times a day, that is, at intervals of 24 or 12 hours. In this regard, the drug needs to be diluted only once, immediately before use.

How to dilute Ceftriaxone for intramuscular injection?

For intramuscular use, the antibiotic is diluted with lidocaine or injection water.

The drug diluted with lidocaine is administered only intramuscularly; intravenous use is strictly contraindicated.

When prescribed intramuscularly, 250 or 500 mg of the solution is diluted in two ml of 1% lidocaine. One gram of antibiotic is diluted with 3.5 milliliters of one percent lidocaine.

If 2% lidocaine is used, injection water should also be used. When administering 250 and 500 ml of antibiotic, it is diluted with 1 ml of lidocaine (2%) and 1 ml of water for injection. One gram of antibiotic is diluted with 1.8 ml lidocaine + 1.8 ml injection water.

Can ceftriaxone be diluted with novocaine?

Recent studies have shown that novocaine is not recommended for administration with Ceftriaxone. Its use carries a risk of anaphylaxis. It also reduces the activity of cephalosporin and relieves pain worse than lidocaine.

Ceftriaxone injections - reviews from doctors

The medicine has repeatedly proven its effectiveness in the treatment of infections of the ENT and respiratory organs. system, infections of the acute respiratory disease, skin, etc.

However, it must be remembered that the product should be used only as directed and under the supervision of a physician. This will reduce the risk of developing unwanted effects.

Patients prescribed Ceftriaxone report rapid and sustained improvement. Negative reviews of the drug are most often associated with its pain when administered intramuscularly.

The article was prepared by an infectious disease doctor

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How many days can you inject Ceftriaxone?

To treat various bacterial diseases, people are prescribed antibiotics. Among the medications, the most effective against a large number of bacteria is Ceftriaxone. To start therapy, you need to find out exactly how many days to inject Ceftriaxone and the dosage for a certain age and weight. And also read the instructions for use and identify the rules for taking the drug.

Description of the drug

Ceftriaxone is a 3rd generation antibiotic of drugs belonging to the cephalosporin series of drugs. The medicine effectively eliminates both gram-positive and -negative microorganisms, as well as about 40 other different bacteria.

Ceftriaxone injections must be used for a long period of time. Even after the end of exposure and discontinuation of the daily dosage, the therapeutic effect remains for some time. Only after a certain period the active agent (ceftriaxone) is excreted in the urine through the kidneys.

Ceftriaxone is available only in the form of injections in powder form, which must be diluted with purified water. To obtain a therapeutic effect for purulent sore throat or developing pneumonia, you can inject Ceftriaxone both into the gluteal muscle, intramuscularly and intravenously.

When ingested, the active substance easily penetrates through the bloodstream into the inflamed organs. From there it begins to affect pathogenic microorganisms, invading the cell and neutralizing its membrane, which leads to the complete death of the bacterium and neutralization of the infection.

It is important that injections can be administered to almost all people in adult patients, with the exception of the following situations:

  • patients with individual intolerance;
  • pregnant women, due to the fact that the active substance easily penetrates the placenta and negatively affects the developing child;
  • with improper functioning of the liver and kidneys;
  • when ulcerative colitis is diagnosed.

If you do not pay attention to the indications and inject Ceftriaxone continuously for 4-14 days, you can provoke the development of serious complications, including death.

Rules for taking Ceftriaxone

The course of treatment with Ceftriaxone and the required dosage for injections are recommended only by the attending physician based on the tests performed and the symptoms identified.

A doctor can prescribe a specific therapeutic regimen for injections for various diseases:

  • Purulent tonsillitis, if the temperature reaches critical levels, must be treated within a day. If a positive effect is achieved earlier, in any case, you must drink the recommended dosage to the end;
  • Pneumonia - the recommended treatment rate is 10 days. Most often, after 7 days of exposure, all wheezing in the bronchi area disappears, but therapy must be carried out until the last minute;
  • Sinusitis - we recommend it at the moment when the disease enters the chronic stage. The duration of use is prescribed individually for each patient, but most often Ceftriaxone is injected for children for 7 days, and for adults up to 10 days.
  • Bronchitis - the doctor has to draw up a treatment regimen based on the clinical course and neglect of the process. Most often, when injections are administered within 5-7 days, all symptoms disappear completely.

Prescribing treatment on your own is dangerous. There is a possibility of such dangerous diseases developing into a chronic condition, which leads to a general deterioration of the condition. You should definitely consult with your doctor; Ceftriaxone, perhaps chosen by the patient, is not suitable for the patient’s indications.

Instructions for use

To inject Ceftriaxone, it must first be prepared. To do this, the powder from the bottle must be diluted with water for injection. The product is diluted with saline solution 0.9% in a volume of 10 ml. It should be injected into a vein or muscle gradually, slowly, over 2-4 minutes. This is due to the fact that the product gives a strong pain effect.

It is recommended that babies under 2 weeks of age receive injections. per 1 kg per 24 hours one time. It is necessary to inject Ceftriaxone 1-2 times for adults and children under 12 years of age. The input rate is calculated individually from a volume of 2 grams per day. Infants from 14 days and children 2, 5, up to 12 years old should inject Ceftriaxone once a day in the mass. per kg.

Thus, adults are injected with Ceftriaxone for 7-10 days on average, depending on the severity of the disease, and children are recommended to receive injections for no more than 7 days. In any case, both the rate for administration and the duration of the effect of the antibiotic on pathogenic microorganisms are strictly recorded by the doctor.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

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Ceftriaxone

Description current as of 07/21/2015

  • Latin name: Ceftriaxone
  • ATX code: J01DD04
  • Active ingredient: Ceftriaxone
  • Manufacturer: JSC Pharmaceutical Company Darnitsa (Ukraine), Shreya Life Sciences Pvt. Ltd. (India), JSC LECCO (Russia)

Compound

The drug contains ceftriaxone, an antibiotic from the class of cephalosporins (β-lactam antibiotics whose chemical structure is based on 7-ACA).

What is Ceftriaxone?

According to Wikipedia, ceftriaxone is an antibiotic whose bactericidal effect is due to its ability to disrupt the synthesis of peptidoglycan in bacterial cell walls.

The substance is a slightly hygroscopic, finely crystalline powder of yellowish or white color. One bottle of the drug contains 0.25, 0.5, 1 or 2 grams of sterile sodium salt of ceftriaxone.

Release form

Powder 0.25/0.5/1/2 g for preparation:

Ceftriaxone is not available in tablets or syrup.

pharmachologic effect

Bactericidal. A third-generation drug from the “Cephalosporins” group of antibiotics.

Pharmacodynamics and pharmacokinetics

A universal antibacterial agent, the mechanism of action of which is determined by the ability to suppress the synthesis of the bacterial cell wall. The drug exhibits greater resistance to most β-lactamases of Gram (+) and Gram (-) microorganisms.

Active regarding:

  • Gram (+) aerobes - St. aureus (including penicillinase-producing strains) and Epidermidis, Streptococcus (pneumoniae, pyogenes, viridans group);
  • Gram (-) aerobes - Enterobacter aerogenes and cloacae, Acinetobacter calcoaceticus, Haemophilus influenzae (including penicillinase-producing strains) and parainfluenzae, Borrelia burgdorferi, Klebsiella spp. (including pneumoniae), Escherichia coli, Moraxella catarrhalis and diplococci of the genus Neisseria (including penicillinase-producing strains), Morganella morganii, Proteus vulgaris and Proteus mirabilis, Neisseria meningitidis, Serratia spp., some strains of Pseudomonas aeruginosa;
  • anaerobes - Clostridium spp. (exception: Clostridium difficile), Bacteroides fragilis, Peptostreptococcus spp..

In vitro (clinical significance remains unknown) activity is observed against strains of the following bacteria: Citrobacter diversus and freundii, Salmonella spp. (including against Salmonella typhi), Providencia spp. (including in relation to Providencia rettgeri), Shigella spp.; Bacteroides bivius, Streptococcus agalactiae, Bacteroides melaninogenicus.

Methicillin-resistant Staphylococcus, many strains of Enterococcus (including Str. faecalis) and group D Streptococcus are resistant to cephalosporin antibiotics (including ceftriaxone).

  • bioavailability - 100%;
  • T Cmax when Ceftriaxone is administered intravenously - at the end of the infusion, when administered intramuscularly;
  • connection with plasma proteins - from 83 to 96%;
  • T1/2 with intramuscular administration - from 5.8 to 8.7 hours, with intravenous administration - from 4.3 to 15.7 hours (depending on the disease, the patient’s age and the condition of his kidneys).

In adults, the concentration of ceftriaxone in the cerebrospinal fluid when administered 50 mg/kg after 2-24 hours is many times higher than the MIC (minimum inhibitory concentration) for the most common pathogens of meningococcal infection. The drug penetrates well into the cerebrospinal fluid during inflammation of the meninges.

Ceftriaxone is excreted unchanged:

  • kidneys - by 33-67% (in newborn babies this figure is 70%);
  • with bile into the intestines (where the drug is inactivated) - by 40-50%.

Indications for use of Ceftriaxone

The annotation states that the indications for the use of Ceftriaxone are infections caused by bacteria sensitive to the drug. Intravenous infusions and injections of medications are prescribed to treat:

The drug is also used for perioperative prophylaxis and for the treatment of immunocompromised patients.

What is Ceftriaxone used for for syphilis?

Although penicillin is the drug of choice for various forms of syphilis, its effectiveness may be limited in some cases.

The use of cephalosporin antibiotics is resorted to as a backup option in case of intolerance to drugs of the penicillin group.

The valuable properties of the drug are:

  • the presence in its composition of chemical substances that have the ability to suppress the formation of cell membranes and mucopeptide synthesis in the walls of bacterial cells;
  • the ability to quickly penetrate organs, fluids and tissues of the body and, in particular, into the cerebrospinal fluid, which in patients with syphilis undergoes many specific changes;
  • Possibility of use for the treatment of pregnant women.

The medicine is most effective in cases where the causative agent of the disease is Treponema pallidum, since the distinctive feature of Ceftriaxone is its high treponemocidal activity. The positive effect is especially pronounced with intramuscular administration of the drug.

Treatment of syphilis with the use of the drug gives good results not only in the early stages of the disease, but also in advanced cases: with neurosyphilis, as well as with secondary and latent syphilis.

Since T1/2 of Ceftriaxone is approximately 8 hours, the drug can be used equally successfully in both inpatient and outpatient treatment regimens. It is enough to administer the drug to the patient once a day.

For preventive treatment, the drug is administered over 5 days, for primary syphilis - a 10-day course, early latent and secondary syphilis are treated within 3 weeks.

For non-advanced forms of neurosyphilis, the patient is administered a single dose of 1-2 g of Ceftriaxone for 20 days; in the later stages of the disease, the drug is administered at a dose of 1 g/day. for 3 weeks, after which an interval of 14 days is maintained and treatment with a similar dosage is carried out for 10 days.

For acute generalized meningitis and syphilitic meningoencephalitis, the dose is increased to 5 g/day.

Ceftriaxone injections: why is the drug prescribed for angina in adults and children?

Despite the fact that the antibiotic is effective for various lesions of the nasopharynx (including sore throat and sinusitis), it is, as a rule, rarely used as a drug of choice, especially in pediatrics.

For angina, the medicine can be administered through a dropper into a vein or in the form of regular injections into the muscle. However, in the vast majority of cases, the patient is prescribed intramuscular injections. The solution is prepared immediately before use. The finished mixture remains stable at room temperature for 6 hours after preparation.

For children with angina, Ceftriaxone is prescribed in exceptional cases when acute angina is complicated by severe suppuration and inflammation.

The appropriate dosage is determined by the attending physician.

During pregnancy, the drug is prescribed in cases where penicillin antibiotics are not effective. Although the medicine crosses the placental barrier, it does not have a significant effect on the health and development of the fetus.

Treatment of sinusitis with Ceftriaxone

For sinusitis, antibacterial agents are first-line drugs. Completely penetrating the blood, Ceftriaxone is retained at the site of inflammation in the required concentrations.

As a rule, the medicine is prescribed in combination with mucolytics, vasoconstrictors, etc.

How to inject the drug for sinusitis? Typically, the patient is prescribed Ceftriaxone to be injected into the muscle twice a day, 0.5-1 g. Before injection, the powder is mixed with Lidocaine (it is preferable to use a one percent solution) or d/i water.

Treatment lasts at least 1 week.

Contraindications

Ceftriaxone is not prescribed in case of known hypersensitivity to cephalosporin antibiotics or auxiliary components of the drug.

Side effects of Ceftriaxone

Side effects of the drug appear as:

If the medicine is administered intravenously, inflammation of the venous wall, as well as pain along the vein, is possible. The injection of the drug into the muscle is accompanied by pain at the injection site.

Ceftriaxone (injections and IV infusion) may also affect laboratory parameters. The patient's prothrombin time decreases (or increases), the activity of alkaline phosphatase and liver transaminases increases, as well as the concentration of urea, hypercreatininemia, hyperbilirubinemia, and glycosuria develop.

Reviews of the side effects of Ceftriaxone allow us to conclude that with intramuscular administration of the drug, almost 100% of patients complain of severe pain from the injection, some report muscle pain, dizziness, chills, weakness, itching and rash.

The injections are easiest to tolerate if you dilute the powder with an anesthetic. In this case, it is necessary to do a test both for the drug itself and for the painkiller.

Instructions for use of Ceftriaxone. How to dilute Ceftriaxone for injection?

The manufacturer's instructions and the Vidal reference book indicate that the drug can be injected into a vein or into a muscle.

Dosage for adults and children over 12 years of age/day. The antibiotic is administered once or once every 12 hours at half the dose.

In particularly serious cases, as well as if the infection is caused by a pathogen moderately sensitive to Ceftriaxone, the dose is increased to 4 g/day.

For gonorrhea, a single injection of 250 mg of the drug into the muscle is recommended.

For preventive purposes, before an infected or suspected infected operation, depending on the degree of danger of infectious complications, the patient should be administered a single dose of 1-2 g of Ceftriaxone 0.5-1.5 hours before surgery.

For children in the first 2 weeks of life, the medicine is administered 1 time per day. The dose is calculated using the formula mg/kg/day. The highest dose is 50 mg/kg (which is due to the underdevelopment of the enzyme system).

The optimal dosage for children under 12 years of age (including infants) is also selected depending on weight. The daily dose varies from 20 to 75 mg/kg. For children weighing more than 50 kg, Ceftriaxone is prescribed in the same dose as for adults.

Doses greater than 50 mg/kg should be administered as an intravenous infusion over at least 30 minutes.

For bacterial meningitis, treatment begins with a single dose of 100 mg/kg/day. The highest dose is 4 g. As soon as the pathogen is isolated and its sensitivity to the drug is determined, the dose is reduced.

Reviews about the drug (in particular, about its use in children) allow us to conclude that the drug is very effective and affordable, but its significant drawback is severe pain at the injection site. As for side effects, according to the patients themselves, there are no more of them than with any other antibiotic.

How many days to inject the drug?

The duration of treatment depends on what pathogenic microflora causes the disease, as well as on the characteristics of the clinical picture. If the causative agent is Gram (-) diplococci of the genus Neisseria, the best results can be achieved in 4 days, if enterobacteria are sensitive to the drug - posterior.

Ceftriaxone injections: instructions for use. How to dilute the drug?

To dilute the antibiotic, use Lidocaine solution (1 or 2%) or water for injection (d/i).

When using water d/i, it should be taken into account that intramuscular injections of the drug are very painful, so if the solvent is water, there will be discomfort both during the injection and for some time after it.

Water for diluting the powder is usually taken in cases where the use of Lidocaine is impossible due to the patient being allergic to it.

The best option is a one percent solution of Lidocaine. It is better to use water as an adjuvant when diluting the drug with Lidocaine 2%.

Is it possible to dilute Novocaine with Ceftriaxone?

Novocaine, when used to dilute the drug, reduces the activity of the antibiotic, while at the same time increasing the likelihood of the patient developing anaphylactic shock.

Based on the reviews of the patients themselves, they note that Lidocaine is better than Novocaine in relieving pain when Ceftriaxone is administered.

In addition, the use of a non-freshly prepared solution of Ceftriaxone with Novocaine increases pain during injection (the solution remains stable for 6 hours after preparation).

How to dilute Ceftriaxone with Novocaine?

If Novocain is used as a solvent, it is taken in a volume of 5 ml per 1 g of the drug. If you take a smaller amount of Novocaine, the powder may not completely dissolve, and the syringe needle will become clogged with lumps of medicine.

Dilution with Lidocaine 1%

For injection into the muscle, 0.5 g of the drug is dissolved in 2 ml of a one percent solution of Lidocaine (the contents of one ampoule); For 1 g of the drug take 3.6 ml of solvent.

The dosage of 0.25 g is diluted in the same way as 0.5 g, that is, with the contents of 1 ampoule of 1% Lidocaine. After this, the finished solution is drawn into different syringes, half the volume in each.

The medicine is injected deep into the gluteal muscle (no more than 1 g in each buttock).

The drug diluted with Lidocaine is not intended for intravenous administration. It is allowed to be injected strictly into the muscle.

How to dilute Ceftriaxone injections with Lidocaine 2%?

To dilute 1 g of the drug, take 1.8 ml of water and two percent Lidocaine. To dilute 0.5 g of the drug, also mix 1.8 ml of Lidocaine with 1.8 ml of water, but only half of the resulting solution (1.8 ml) is used for dissolution. To dilute 0.25 g of the drug, take 0.9 ml of a solvent prepared in a similar way.

Ceftriaxone: how to dilute children for intramuscular administration?

This method of intramuscular injection is practically not used in pediatric practice, since Ceftriaxone with novocaine can cause severe anaphylactic shock in a child, and in combination with lidocaine, it can contribute to the occurrence of convulsions and disruption of the heart.

For this reason, the optimal solvent when using the drug in children is ordinary water. The impossibility of using painkillers in childhood requires an even slower and more careful administration of the medicine in order to reduce pain during the injection.

Dilution for intravenous administration

For intravenous administration, 1 g of the drug is dissolved in 10 ml of distilled water (sterile). The drug is administered slowly over 2-4 minutes.

Dilution for intravenous infusion

When carrying out infusion therapy, the drug is administered for at least half an hour. To prepare a solution, 2 g of powder is diluted in 40 ml of a Ca-free solution: dextrose (5 or 10%), NaCl (0.9%), fructose (5%).

Additionally

Ceftriaxone is intended exclusively for parenteral administration: manufacturers do not produce tablets and suspensions due to the fact that the antibiotic, when in contact with body tissues, is highly active and severely irritates them.

Doses for animals

The dosage for cats and dogs is selected taking into account the body weight of the animal. As a rule, it is mg/kg.

If a 0.5 g bottle is used, 1 ml of two percent Lidocaine and 1 ml of water d/i (or 2 ml of Lidocaine 1%) should be added to it. After vigorously shaking the medicine until the lumps are completely dissolved, it is drawn into a syringe and injected into the muscle or under the skin of the sick animal.

The dosage for a cat (Ceftriaxone 0.5 g is usually used for small animals - cats, kittens, etc.), if the doctor prescribed 40 mg of Ceftriaxone per 1 kg of weight, is 0.16 ml/kg.

For dogs (and other large animals), take bottles of 1 g. The solvent is taken in a volume of 4 ml (2 ml Lidocaine 2% + 2 ml water for injection). For a dog weighing 10 kg, if the dose is 40 mg/kg, you need to administer 1.6 ml of the prepared solution.

If it is necessary to administer Ceftriaxone intravenously through a catheter, sterile distilled water is used for dilution.

Overdose

Signs of a drug overdose are convulsions and central nervous system stimulation. Peritoneal dialysis and hemodialysis are ineffective in reducing ceftriaxone concentrations. The medicine does not have an antidote.

Interaction

In one volume, it is pharmaceutically incompatible with other antimicrobial agents.

By suppressing intestinal microflora, it prevents the formation of vitamin K in the body. For this reason, using the drug in combination with agents that reduce platelet aggregation (sulfinpyrazone, NSAIDs) can provoke bleeding.

The same feature of Ceftriaxone enhances the effect of anticoagulants when used together.

In combination with loop diuretics, the risk of nephrotoxicity increases.

Terms of sale

A recipe in Latin is required to purchase.

Recipe in Latin (sample):

S. In the supplied solvent. V/m, 1 rub./day.

Storage conditions

Keep away from light. The optimal storage temperature is up to 25°C.

When used without medical supervision, the drug can cause complications, so bottles with powder should be kept out of the reach of children.

Best before date

special instructions

The drug is used in a hospital setting. In patients who are on hemodialysis, as well as with simultaneous severe hepatic and renal failure, plasma concentrations of Ceftriaxone should be kept under control.

With long-term treatment, regular monitoring of the peripheral blood picture and indicators characterizing the function of the kidneys and liver is required.

Sometimes (rarely) an ultrasound of the gallbladder may show shadows that indicate the presence of sediment. The darkening disappears after stopping the course of treatment.

In some cases, it is advisable for weakened sick and elderly patients to prescribe vitamin K in addition to Ceftriaxone.

If there is an imbalance of water and electrolytes, as well as arterial hypertension, the level of sodium in the blood plasma should be monitored. If the treatment is long-term, the patient is advised to undergo a general blood test.

Like other cephalosporins, the drug has the ability to displace bilirubin bound to serum albumin, and therefore it is used with caution in newborns with hyperbilirubinemia (and, in particular, in premature infants).

The drug does not affect the speed of neuromuscular conduction.

Ceftriaxone analogues: what can replace the drug?

Ceftriaxone or Cefazolin - which is better?

Both drugs belong to the “Cephalosporins” group, but Ceftriaxone is a third generation antibiotic, and Cefazolin is a first generation drug.

An important feature of first generation cephalosporin antibiotics is that they are not effective against listeria and enterococci, have a narrow spectrum of action and a low level of activity against Gram (-) bacteria.

Cefazolin is used mainly in surgery for perioperative prophylaxis, as well as for the treatment of soft tissue and skin infections.

Its prescription for the treatment of infections of the genitourinary system and respiratory tract cannot be considered as justified, which is associated with a narrow spectrum of antimicrobial activity and high resistance to it among potential pathogens.

Which is better: Ceftriaxone or Cefotaxime?

Cefotaxime and Ceftriaxone are the basic antimicrobial agents of the third generation cephalosporin group. The drugs are almost identical in their bactericidal properties.

Alcohol compatibility

You should not drink alcohol during treatment with the drug. The combination of “Ceftriaxone + ethanol” can provoke symptoms similar to those of severe poisoning, and in some cases lead to the death of the patient.

Ceftriaxone during pregnancy and breastfeeding

The drug is contraindicated in the first trimester of pregnancy. If it is necessary to prescribe to a nursing woman, the child should be switched to formula.

Reviews of Ceftriaxone during pregnancy confirm that the drug is indeed a very powerful and very effective antibacterial agent that can not only cure the underlying disease, but also prevent the development of its complications.

Considering that the drug (like other antibiotics) has side effects, it is prescribed only in cases where potential complications of the disease could be more harmful than the use of the drug (in particular, for infections of the urogenital tract, to which pregnant women are very susceptible).

Reviews of Ceftriaxone

Ceftriaxone - reviews from doctors confirm this fact - is a potent antibiotic that helps cure the disease in a short time and with a minimum number of side effects. It is allowed to be used for children and during pregnancy (exception - 1st trimester).

According to the patients themselves, the main disadvantage of the drug is that the injections are very painful.

In reviews of Ceftriaxone injections for children, to facilitate the procedure, mothers (on the advice of the attending physician) are recommended to use Emla cream, which is a local anesthetic. It is applied in about half an hour to the intended injection site.

How much does an antibiotic cost in Russian pharmacies?

The price of Ceftriaxone injections varies depending on which company produces it, as well as the number of ampoules in each package and the concentration of the active substance in the vial.

The price of Ceftriaxone in Ukraine is from 6.6 UAH per 0.5 g bottle. However, there is no significant difference between prices in the capital’s pharmacies and pharmacies in other cities (Kharkov, Dnepropetrovsk, Lvov).

The price of Ceftriaxone in Russian pharmacies is from 17 rubles per bottle.

It is impossible to buy Ceftriaxone tablets. The drug is intended exclusively for parenteral administration.

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BIOSPHERE

Cetrin 1 tablet per day and Comfoderm cream. I gave injections to my mother, she also had hives all over her body. But thank God everything went away thanks to these drugs.

I have the same thing: eleven injections with lidocoine and intravenous injection. no pain but with a very swollen face))

I gave myself ceftriaxone once, then vomited worms all night. I highly recommend this miracle.

This is a very scary antibiotic. The EGR should be prescribed and installed with great caution. Correctly written, only in a hospital setting. A woman we know died after one injection. Anaphylactic shock! And the ambulance didn't help. And he was prescribed by an ENT specialist for sinusitis, treatment at home. Horror! The child remained 13 years old. Everything happened in front of my husband and daughter

Can ceftriaxone be used to treat swollen lymph nodes?

Karina, Lidocaine is safer than novocaine due to its chemical structure. The drug belongs to the second generation of analgesics, according to its chemical structure to the group of amides, which provides greater pain relief effectiveness than when using predecessor analgesics (Novocaine). Novocaine belongs to the first generation essential analgesics, so there is a high probability of allergic reactions. Since the breakdown of Novocaine produces para-aminobenzoic acid and its esters in the body, which often cause allergies. Lidocaine has been widely used in clinical practice by doctors for a long time, so there is no doubt about its effectiveness and good tolerability. To avoid side effects of the drug, consult your doctor before use. All the best!

What is the effect of lidocaine? Why is it safer than Novocaine?

Since intramuscular injections cause discomfort at the injection site and unpleasant pain, the optimal choice for dissolving cephalosporin antibiotics is Lidocaine in a 1% concentration of 3.5 ml. This concentration ensures effective dissolution of the antibiotic and a powerful analgesic effect when administered intramuscularly. For comparison, Novocaine has a less pronounced analgesic effect (4 times weaker than Lidocaine), and the frequency of adverse allergic reactions with its use occurs 3 times more often. Lidocaine belongs to the second generation of drugs, so it is more effective and well tolerated. Consult your healthcare practitioner before use. Good health to you!

Not a bad drug, I injected my husband, although he complained very much that the injections were quite painful with it. At first I did it with water for injection, but later I read that this was wrong. To dissolve cephalosporins, including Ceftriaxone, Lidocaine must be used. The optimal dosage is 1% 3.5 ml. The use of Lidocaine is rarely complicated by allergic reactions (3 times less likely than Novocaine), and Lidocaine also has a powerful analgesic effect (4 times more effective than Novocaine). Lidocaine belongs to the second generation of analgesic drugs, therefore it is safer than its predecessors - representatives of the first generation of ether analgesics, such as Novocaine. The drug has long proven itself in the clinical practice of many doctors, so its effectiveness and good tolerability are confirmed by time. Consult your healthcare practitioner before use. All the best!

I liked Ceftriaxone, it quickly got me back on my feet, although the injections were very painful. Since these intramuscular injections cause discomfort at the injection site and unpleasant pain, the optimal choice for dissolving cephalosporin antibiotics is Lidocaine at a 1% concentration of 3.5 ml. This concentration ensures effective dissolution of the antibiotic and a powerful analgesic effect when administered intramuscularly. For comparison, Novocaine has a less pronounced analgesic effect (4 times weaker than Lidocaine), and the frequency of adverse allergic reactions with its use occurs 3 times more often. Lidocaine belongs to the second generation of drugs, so it is more effective and well tolerated. Consult your healthcare practitioner before use. Good health to you!

Regarding Konstantin’s comment, I do not agree with the statement that WHO recommends lidocaine as a solvent for antibiotics. WHO recommends lidocaine as an anesthetic, but nevertheless, lidocaine is also excellent for dissolving cephalosporins, this tactic is time-tested.

Very informative article. thank you. But I have information regarding Lidocaine. The article states that a 2% lidocaine solution can be diluted with water for injection. This is not recommended, since according to the standards of the World Health Organization, the solvent for cephalosporin antibiotics is a 1% solution of lidocaine; it is in this concentration that the optimal result of dissolving the drug is achieved. The WHO has no recommendations regarding Novocaine, and its instructions do not indicate its properties as a solvent for cephalosporin antibiotics. Also, before using Lidocaine, it is necessary to perform an allergy test if the patient is using this drug for the first time. During pregnancy at any stage of gestation and nursing mothers, Lidocaine is also contraindicated, so consult a specialist when using and dissolving antibiotics. Good health to you!

After the next injection, my wife developed spots all over, like hives, severe itching all over her body, after which the skin on her legs turned blue, we are in a panic, what should we do? ? ?

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

Victoria: I don’t put my daughter in a car without taking a Dramamine tablet. We already had it.

Nastja: Please tell me, is Fluconazole a hormonal drug?

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Source: http://medside.ru/tseftriakson