What is vilprafen prescribed with?

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Vilprafen tablets

Vilprafen is widely used to treat bacterial and fungal diseases.

The drug belongs to the group of macrolides - antibiotics similar in action to penicillins. It has a bacteriostatic and, in large doses, a bactericidal effect.

Table of contents:

It is almost completely metabolized in the body, and its residues and metabolites are excreted in the urine.

On this page you will find all the information about Vilprafen: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Vilprafen. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic of the macrolide group.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

How much does Vilprafen cost? The average price in pharmacies is 600 rubles.

Release form and composition

The drug Vilprafen is available in the form of tablets for oral administration in cardboard packaging in blisters of 10 pieces. Each tablet is coated with a white film coating and has a horizontal notch on one side.

  • active ingredient: josamycinmg,
  • excipients: microcrystalline cellulose, polysorbate 80, colloidal silicon oxide, sodium carboxymethylcellulose, magnesium stearate, hydroxypropylmethylcellulose, Macrogol 6000, talc, titanium dioxide, aluminum hydroxide, copolymer of methacrylic acid and its esters.

Pharmacological effect

The bactericidal effect of the active substance of the drug is due to the fact that josamycin is able to bind to the large subunit of the ribosomal membrane (50S), prevents the fixation of transport RNA, and also blocks the translocation of A-center peptides (a type of mutation that is accompanied by chromosomal rearrangement that affects the properties of the cell) and suppresses the intracellular production of proteins from amino acids.

The spectrum of action of josamycin, which is part of Vilprafen, is quite wide.

The substance is active against gram-positive aerobic microorganisms, including:

  1. Peptococci secreted by the body during inflammatory processes;
  2. Peptostreptococci, which provoke the development of mixed infections;
  3. Staphylococcus;
  4. The causative agent of anthrax is anthrax bacillus;
  5. Bacteria of the genus Corynebacterium, which are the causative agents of diphtheria;
  6. Clostridium perfringens – causative agents of gas gangrene and toxic infections in humans;
  7. Streptococci.

Vilprafen is also active against gram-negative microorganisms, including:

  1. Hemophilus, which is the cause of hemophilus infections, including purulent meningitis, acute pneumonia, pericarditis, septicemia, etc.;
  2. Neisseria, which are the causative agents of diseases such as gonorrhea and meningitis;
  3. Some varieties of Shigella, which provokes the development of dysentery;
  4. Bacteroides fragilis, which are causative agents of purulent-infectious diseases that develop after injuries, surgical interventions, immunodeficiency, etc.;

Josamycin also has activity against various intracellular parasites: chlamydia, legionella, mycoplasma, ureaplasma.

Indications for use

According to the instructions, Vilprafen is prescribed for the treatment of the following infectious and inflammatory diseases caused by microorganisms sensitive to josamycin:

  1. Psittacosis;
  2. Whooping cough;
  3. Infections in ophthalmology (dacryocystitis, blepharitis);
  4. Infections in dentistry (pericoronitis, alveolitis, gingivitis, periodontitis and alveolar abscess);
  5. Burn and wound (including postoperative) infections;
  6. Gonorrhea, lymphogranuloma venereum, syphilis (with hypersensitivity to penicillin);
  7. Infections of the ENT organs and upper respiratory tract, including pharyngitis, sinusitis, tonsillitis, laryngitis, paratonsillitis and otitis media;
  8. Lower respiratory tract infections, including community-acquired pneumonia, acute and chronic bronchitis (exacerbations);
  9. Scarlet fever (Vilprafen is prescribed in case of hypersensitivity to penicillin antibiotics);
  10. Diphtheria (in complex therapy together with diphtheria antitoxin);
  11. Infections of the genital organs and urinary tract (cervicitis, prostatitis, urethritis and epididymitis caused by mycoplasmas and/or chlamydia);
  12. Infections of soft tissues and skin (furunculosis, furuncle, anthrax, acne, abscess, folliculitis, erysipelas, lymphadenitis, panaritium, lymphangitis and phlegmon);
  13. Diseases of the gastrointestinal tract caused by Helicobacter pylori, including chronic gastritis and peptic ulcer of the stomach and duodenum.

Contraindications

The drug is contraindicated in severe liver dysfunction or in the presence of hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is not prescribed to pregnant women if there are severe disorders in the liver or sensitivity to the constituent components.

Instructions for use

The instructions for use indicate that the recommended dose for adults and adolescents over 14 years of age is 1-2 g in 2-3 divided doses. The initial recommended dose is 1 g.

  1. For the treatment of rosacea - 500 mg 2 times a day for days.
  2. For the treatment of pyoderma - 500 mg 2 times a day for 10 days.
  3. For the treatment of urogenital chlamydia - 500 mg 2 times a day for a day.
  4. For the treatment of chronic periodontitis, with abscessation of the periodontal bone - 500 mg 2 times a day for days.
  5. For ordinary and spherical (conglobate) acne, 500 mg 2 times a day is prescribed for the first 2-4 weeks, then 1 mg 1 time a day as maintenance therapy for 8 weeks.

The tablets should be swallowed without chewing, with a small amount of liquid, between meals. Usually the duration of treatment is determined by the doctor. In accordance with WHO recommendations on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

Infants and children under 14 years of age are preferably prescribed the drug in the form of a suspension. The daily dose is mg/kg body weight, divided into 3 doses. In newborns and children under 3 months of age, the dose should be adjusted according to the exact body weight of the child.

The bottle of suspension must be shaken before use.

Side effects

If the drug is used correctly and the dosage specified in the instructions is strictly followed, Vilprafen is well tolerated by patients, however, in some cases the following side effects may develop:

  1. Allergic skin reactions: urticaria, rash, Quincke's edema, in very rare cases anaphylactic shock.
  2. Gastrointestinal tract: nausea, abdominal pain, excessive salivation, heartburn, vomiting, indomitable diarrhea, development of an inflammatory process in the intestines in rare cases.
  3. From the liver and biliary tract: an increase in the activity of hepatic transminases, rarely a violation of the outflow of bile and the functioning of the gallbladder, due to which patients developed jaundice.

Overdose

To date, no cases of overdose have been registered with this drug. In case of overdose after taking the drug, it is necessary to expect increased side effects and carry out symptomatic therapy.

special instructions

  1. In patients with renal failure, adjustment of the dosage regimen is required in accordance with CC values.
  2. Josamycin is not prescribed to premature babies. When used in newborns, it is necessary to monitor liver function.
  3. If pseudomembranous colitis develops, josamycin should be discontinued and appropriate therapy should be prescribed. Drugs that reduce intestinal motility are contraindicated.

The possibility of cross-resistance to various macrolide antibiotics should be taken into account (for example, microorganisms that are resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin).

Drug interactions

  1. Vilprafen inhibits the elimination of xanthines, which can provoke the development of intoxication.
  2. It is recommended to avoid the simultaneous use of Vilprafen with other antibiotics. This may reduce their effectiveness.
  3. Concomitant use of an antibiotic with cyclosporine may lead to an increase in the concentration of the latter, so its level should be monitored throughout treatment.
  4. Taking Vilprafen may reduce the effectiveness of hormonal contraceptives, therefore, in order to avoid unwanted pregnancy, it is recommended to additionally use non-hormonal contraceptives.
  5. The combined use of Vilprafen with antihistamines, including astemizole and terfenadine, increases the concentration of the latter, which can lead to the development of serious cardiac arrhythmias that are life-threatening.

Reviews

We have selected some people's reviews about the drug Vilprafen:

  1. Masha. I was examined during pregnancy, took tests and it turned out that I had ureaplasmosis. The doctor prescribed me Vilprafen + drugs for dysbacteriosis. I was very worried whether they could be used during pregnancy, but she convinced me that they were quite gentle, but at the same time effective. I completed the full course, no side effects were observed. But the most important thing is that it helped! I took note of these tablets because I read that they have a fairly wide spectrum of action and are reasonably priced.
  2. Artem. I used this antibiotic for the first time this year when I got sick. My throat hurt badly and my runny nose was bothering me. My mother recommended the medicine. The doctor prescribed this medicine to her that year when she had a severe sore throat, and she treated it for more than two months. What can I say about the medicine? I don’t know if it was this that helped me or the other set of medications that I used. But I cured my illness within ten days when I started taking this antibiotic. I had no allergies or intestinal disorders, nor did I have any rashes. The device is well tolerated. I’m not happy with the price of the medicine; in our city it costs about four hundred rubles!

According to reviews, Vilprafen is a fairly effective drug, but the risk of adverse reactions during treatment is quite high. Patients who have been diagnosed with chlamydia and ureaplasmosis report that within a few days after starting to use the drug, the symptoms of the diseases disappear without a trace. There are reports of side effects of Vilprafen such as gastrointestinal disturbances and allergic rashes, which are relatively common.

Analogs

An analogue of Vilprafen is Vilprafen Solutab.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Tablets should be stored out of the reach of children, avoiding direct sunlight on the packaging. The optimal temperature for storage is no more than 25 degrees.

The shelf life of the tablets is 3 years from the date of manufacture; at the end of this period, unused medicine should be thrown away.

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One comment

After 2 weeks of use, hives began, one arm, shoulder and neck were covered with large, very itchy spots. When discontinued + antihistamines, it went away after 2 days. I couldn’t complete the 20-day recommended course. Since the therapy was complex together with other potent drugs, I cannot separately evaluate the effectiveness. In addition to hives, nausea, heaviness and abdominal pain.

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Source: http://simptomy-lechenie.net/vilprafen/

Vilprafen

Vilprafen and Vilprafen Solutab are antibiotics belonging to the group of macrolides, the antimicrobial effect of which is caused by a violation of protein synthesis on the ribosomes of the microbial cell. Like other macrolides, they exhibit a post-antibiotic effect against gram-positive cocci, and also have immunomodulatory and moderate anti-inflammatory activity.

Josamycin is used as the active ingredient of the drugs.

Release form and composition

  • In the form of tablets, each containing 500 mg of josamycin. The tablets are film-coated in white or a similar color, have an oblong shape, convex edges and cuts in the middle;
  • In the form of a suspension for oral administration. One measuring cup with a capacity of 10 ml contains 300 mg of josamycin. The suspension is a viscous white liquid with a pronounced fruity odor and without sediment.

Vilprafen Solutab is available in the form of soluble, fast-acting tablets, the color of which can vary from white to yellowish. The tablets have an oblong shape, a sweet taste and a distinct strawberry smell. Each contains 1000 mg of josamycin in the form of josamycin propionate.

Pharmacological properties

Vilprafen and Vilprafen Solutab are broad-spectrum antibiotics and are used as an antibacterial agent for systemic treatment.

The bactericidal effect of the active substance of the drug is due to the fact that josamycin is able to bind to the large subunit of the ribosomal membrane (50S), prevents the fixation of transport RNA, and also blocks the translocation of A-center peptides (a type of mutation that is accompanied by chromosomal rearrangement that affects the properties of the cell) and suppresses the intracellular production of proteins from amino acids.

The spectrum of action of josamycin, which is part of Vilprafen, is quite wide.

The substance is active against gram-positive aerobic microorganisms, including:

  • Staphylococcus;
  • The causative agent of anthrax is anthrax bacillus;
  • Bacteria of the genus Corynebacterium, which are the causative agents of diphtheria;
  • Peptococci secreted by the body during inflammatory processes;
  • Peptostreptococci, which provoke the development of mixed infections;
  • Clostridium perfringens – causative agents of gas gangrene and toxic infections in humans;
  • Streptococci.

Vilprafen is also active against gram-negative microorganisms, including:

  • Neisseria, which are the causative agents of diseases such as gonorrhea and meningitis;
  • Some varieties of Shigella, which provokes the development of dysentery;
  • Hemophilus, which is the cause of hemophilus infections, including purulent meningitis, acute pneumonia, pericarditis, septicemia, etc.;
  • Bacteroides fragilis, which are causative agents of purulent-infectious diseases that develop after injuries, surgical interventions, immunodeficiency, etc.;

Josamycin also has activity against various intracellular parasites: chlamydia, legionella, mycoplasma, ureaplasma.

According to reviews of Vilprafen, resistance to its constituent josamycin develops much less frequently than to other antibiotics that belong to the macrolide group.

Medical reviews of Vilprafen indicate that after oral administration, the drug is well and quickly absorbed from the gastrointestinal tract. In this case, the maximum concentration of josamycin in the blood plasma is observed after 1-4 hours. Approximately 15% of the active substance is bound to plasma proteins, and its highest concentration is found in the lungs, tonsils, salivary fluid, secretion of the sweat and lacrimal glands.

Biotransformation of josamycin occurs in the liver. As a result of this process, metabolites with less activity are formed, which are excreted from the body mainly through bile and approximately 20% through the kidneys and urine.

Indications for use

The prescription of Vilprafen, according to the instructions, is advisable for the treatment of acute and chronic infectious and inflammatory diseases caused by the activity of microorganisms sensitive to the action of josamycin, namely:

  • Infectious diseases affecting the upper and lower respiratory tract, ENT organs, oral cavity, soft tissues and skin, reproductive and urinary systems;
  • Diphtheria;
  • Scarlet fever;
  • Infectious diseases caused by chlamydia and mycoplasma;
  • Mixed infections affecting the genitals and urinary tract.

Contraindications

Vilprafen's instructions list a number of contraindications for its use. Among them:

  • Individual intolerance to drugs belonging to the pharmacological group of macrolides;
  • Severe liver dysfunction;
  • Prematurity.

The medication is prescribed with caution if the patient is diagnosed with renal failure.

It is forbidden to give antibiotics to children weighing up to 10 kg.

Use during pregnancy

Vilprafen is prescribed during pregnancy and breastfeeding if the benefits to the mother outweigh the potential risks to the child.

Directions for use and dosage

The drug in tablets and suspension form is intended for oral administration. It is recommended to swallow the tablets without chewing and with a small amount of liquid. Vilprafen Solutab soluble tablets are diluted in at least 20 ml of liquid before use; they can also be swallowed with water.

The daily dose of the drug for adults and children over 14 years of age is 1-2 g, which is recommended to be divided into three doses, with the first dose not being less than 1 g.

The suspension is prescribed mainly to children under 14 years of age. The daily dose depends on the age and weight of the patient. According to the instructions for Vilprafen, it is calculated according to the following scheme: mg per kilogram of body weight. The frequency of doses is 3. It is recommended to shake it before use.

  • For children under three months of age, the dose must be calculated very accurately depending on weight.
  • The course of therapy for diseases caused by streptococcal infection should not be less than 10 days.

Side effects

Reviews of Vilprafen indicate that sometimes the drug can cause the development of negative reactions from the gastrointestinal tract and hearing organs (hearing disorders are quite rare, but the likelihood of their occurrence cannot be excluded; they are usually reversible and dose-dependent). Sometimes there may be signs of allergies. Much less often, taking the drug provokes the development of candidiasis.

Additional Information

Vilprafen does not affect psychomotor reactions, therefore, during treatment with the drug, it is allowed to drive vehicles and work with potentially dangerous mechanisms.

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Source: http://zdorovi.net/preparaty/vilprafen.html

Vilprafen Solutab – instructions for use + analogues + reviews

Vilprafen is an antibacterial drug that can selectively suppress the activity of many pathogenic prokaryotic cells, including obligate intracellular parasitic bacteria. The main active ingredient is josamycin, a natural antibiotic synthesized by streptomycetes.

Pharmacological group: josamycin - sixteen - a member of the macrolide group of antibiotics. It is on the list of vital therapeutic agents approved by the Russian government. Produced by French or German brands.

Has the following advantages:

  • does not affect bacteria of the Enterobacteriaceae family, therefore does not cause dysbacteriosis;
  • effective against pathogens resistant to natural erythromycin;
  • the risk of developing immunity to josamycin is unlikely in evolutionary terms.

Vilprafen solutab - instructions for use

Prescribed by a doctor after carrying out the necessary diagnostic procedures. At the first stage, the causative agent of the infectious disease is isolated and identified to the species, less often to the genus. At the second stage, the sensitivity of the isolated microorganism to various groups of antibiotics is determined. If the result is positive for sensitivity to macrolides, it is used as a therapeutic agent.

Is Vilprafen an antibiotic or not?

Yes, Vilprafen is an antibiotic and has antibacterial activity against various bacteria, so the following rules must be followed:

  • Take strictly as prescribed by your doctor. It is known that bacteria develop mechanisms of resistance to the action of substances that are harmful to them. Uncontrolled and independent use accelerates the development of resistance. As a result, all currently known antibacterial drugs may be ineffective in the near future;
  • identification of the causative agent of the disease is necessary. Indications for use are bacterial infections that are exclusively sensitive to macrolides. Antibiotics do not have a detrimental effect on viruses;
  • You should strictly follow your doctor’s recommendations and do not stop taking the drug when symptoms first subside. It is necessary to carry out not only symptomatic treatment, but also to eliminate the pathogen itself; otherwise, relapses of the disease will develop.

Composition of Vilprafen

Release form

There are three main options for producing the drug:

  • Vilprafen - white elongated tablets in a coating. The content of the active component josamycin is 500 mg per aqueous tablet. The package contains 1 contour cell with 10 tablets.
  • The antibiotic Vilprafen Solutab is characterized by an increased concentration of josaminin (1 g), fast action, strawberry smell and a sweetish taste. Each package contains 2 contour cells of 5-6 tablets each.
  • Vilprafen suspension is available in 10 ml dark glass vials with 300 mg of active substance.

Recipe for Josamycin in Latin

Rp.: Josamycinum 0.5

S. 1 tablet twice a day.

Vilprafen - what are these tablets for?

The microbiology of the drug is quite extensive; Vilprafen exhibits antibacterial activity against:

  • gram-negative obligate cell parasites - chlamydia (trachomatis and C. pneumoniae) and ureaplasma (U. urealyticum)
  • bacteria that have lost their cell wall - mycoplasmas (M. pneumoniae, M. hominis)
  • gram-negative rod-shaped legionella (L. pneumophila), belonging to pathogenicity group II
  • gram-positive prokaryotes of the Streptococcaceae and Corynebacterium families
  • gram-negative diplococci, pathogens of gonorrhea (N.gonorrhoeae) and meningococcal infection (N. meningitidis)
  • gram-negative Pfeiffer bacilli (H. influenzae) - causative agents of hemophilic inflammatory processes and Bordet-Gengou bacterium (B. pertussis) - causative agents of whooping cough
  • anaerobic prokaryotic cells - peptococci, peptostreptococci and clostridia.

Mechanism of action

The mechanism of antibacterial activity is the disruption of protein biosynthesis in the prokaryotic cell. The effect is achieved through binding to the large (50S) ribosomal subunit. As a result, a failure occurs in the translation process and the synthesis of mutant peptides that are unable to function properly.

Minimum therapeutic concentrations have a bacteriostatic effect, which consists in stopping the growth and number of pathogenic bacteria. The concentration of the pathogen decreases and it is eliminated from the body naturally. With a local increase in dose, it exhibits a bactericidal effect, destroying infectious agents.

Vilprafen - indications for use

Treatment with Vilprafen is effective for the pathologies presented in the table.

Contraindications

This drug should not be used by children under 10 kg, or by people with individual intolerance (allergic reaction) to macrolides or additional substances of the drug. And also for patients with severe pathologies of the liver and ducts for the removal of bile. When treating patients with renal failure, use with extreme caution and exclusively for life-threatening infections.

Vilprafen dosage and method of administration

The medicine Vilprafen must be taken between meals, without violating the integrity of the shell, swallowing the tablet whole.

Dosage regimen for children

The instructions for use of Vilprafen note that children under 14 years of age are prohibited from taking the drug directly in tablet form. The preferred form of treatment is Vilprafen suspension for children or tablets dissolved in distilled water.

The dosage regimen must be strictly observed.

The dosage of Vilprafen for children is as follows:

It is important to note that the drug is used for newborn children only in situations that threaten the child’s life. Administration to premature infants is strictly prohibited. When treating children with Vilprafen, you must strictly follow the instructions for use of the drug and all recommendations of the attending physician.

Patients 14 years of age and older

The drug concentration of the drug is from 1 to 2 g and should not exceed 0.5 g at a time. In case of severe pathologies that are life-threatening to the patient, the concentration of Vilprafen increases, but should not exceed 3 g per day.

Vilprafen - side effects and effects

Negative symptoms that occur during treatment with this drug are shown in the table.

Josamycin - instructions for use during pregnancy

Based on the results of preclinical and clinical trials, it is known that the antibiotic Vilprafen can be used during pregnancy from the 20th week, when all the child’s organ systems are formed. In situations that threaten the life of the mother or fetus, an antibiotic is prescribed if the benefits outweigh the negative consequences. In the 3rd trimester of pregnancy, the safety of using the drug Vilprafen is high, since the drug does not have a negative effect on the intrauterine growth and development of the child. However, contraindications should be taken into account and the recommendations of the attending physician and gynecologist should be strictly followed.

The antibiotic josamycin during pregnancy is recommended by the European Branch of the World Health Organization as the drug of choice for the treatment of chlamydia.

Vilprafen during breastfeeding

Due to the fact that josamycin passes into a woman’s milk, it is important to stop breastfeeding during the course of therapy. An antibiotic can negatively affect the child’s intestinal biocenosis, in the form of the formation of dysbacteriosis or allergic reactions.

Compatibility with other drugs

  • the effectiveness of Vilprafen decreases when used in combination with other antibacterial agents
  • Vilprafen inhibits the effectiveness of Lincomycin
  • Inhibits the removal of 1,3-dimethylxanthine from the body, which leads to dangerous intoxication
  • Stops the removal of allergy medication components from the body, resulting in cardiac arrhythmia.
  • When combined with immunosuppressants, toxic kidney damage develops
  • Significantly reduces the contraceptive properties of oral contraceptives; additional protection measures are needed
  • On the part of the microorganism – development of immunity to macrolide antibiotics

Acquisition and storage

Despite the fact that the drug is listed as essential, it is not possible to buy it at a pharmacy without a prescription. After purchase, it is important to store the drug at the same temperature - no higher than 25 C. It is forbidden to take it after the expiration date (4 years).

Vilprafen and alcohol - compatibility

The general rule for taking antibiotics and alcohol is known - they are completely incompatible. Minimal negative consequences - the antibacterial drug will be ineffective, maximum - aggravating consequences from the gastrointestinal tract, central nervous system and other organs and systems.

Vilprafen and alcohol should not be taken at the same time. Violation of this rule entails an immediate malfunction of the digestive system - nausea, vomiting, diarrhea and pain in the abdominal area. With long-term combined use of antibiotics and alcohol, liver cirrhosis develops due to a cytotoxic effect on the liver. Vilprafen solutab and alcohol follow similar recommendations.

At the first manifestations of negative consequences, it is necessary to contact a specialist, perform gastric lavage and eliminate toxic substances from the patient’s body.

Drug analogues

Cheap analogues of josamycin, the main active component of the drug Vilprafen, are macrolide antibiotics, which are summarized in the table.

The average price of Vilprafen is 550 rubles.

Reviews of Vilprafen solutab

Practitioners positively characterize this therapeutic drug. An important advantage is that the use of the drug Vilprafen Solutab 500 during pregnancy is allowed. In order to prevent the development of candidiasis in women, doctors recommend combination therapy of Vilprafen with vaginal suppositories. Maximum effectiveness was observed with complex treatment with Vilprafen and the drug Terzhinan. This point of view is confirmed by both specialists and patient reviews.

The authors of positive reviews of the drug Vilprafen solutab 1000 mg note minimal side negative symptoms in children. In general, side effects were noted in cases of individual intolerance to the antibiotic or violation of the dosage regimen.

In order to prevent the development of immunodeficiency, it is recommended to take immunostimulants simultaneously with the antibiotic.

Correct identification of the pathogen, determination of its sensitivity and strict adherence to all recommendations of specialists will allow achieving maximum results of therapy with complete illumination of pathogenic bacteria from the human body.

The instructions were prepared by microbiologist Yu.I. Martynovich.

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Vilprafen (tablets, suspension) - instructions for use, analogues, reviews, price

Antibiotic Vilprafen

Release forms

  • White, oblong, film-coated tablets containing 500 mg of the active substance josamycin. The cardboard package contains a blister of 10 tablets.
  • Dispersible (fast-acting soluble) tablets Vilprafen Solutab have a sweet taste and smell of strawberries. They contain 1000 mg of the active ingredient josamycin. The package contains two blisters with 5 or 6 tablets.
  • Vilprafen suspension contains 300 mg of josamycin per 10 ml. Packaged in dark glass bottles of 100 ml.

Instructions for use of Vilprafen

Indications for use

  • pharyngitis (inflammation of the pharynx);
  • laryngitis (inflammation of the larynx);
  • sinusitis;
  • otitis media (inflammation of the middle ear);
  • tonsillitis (inflammation of the tonsils);
  • paratonsillitis;
  • diphtheria (in complex treatment together with diphtheria toxoid);
  • scarlet fever (if the patient has an increased sensitivity to penicillin drugs).

Infectious and inflammatory processes in the lower respiratory tract:

  • whooping cough;
  • acute bronchitis;
  • exacerbation of chronic bronchitis;
  • pneumonia;
  • bronchopneumonia;
  • psittacosis (ornithosis is an infectious disease transmitted to humans from a sick bird).

Oral infections (dental):

  • stomatitis;
  • gingivitis (inflammation of the gums);
  • pericoronitis (inflammation of the gums around the molars);
  • periodontitis;
  • alveolitis (inflammation of the socket after tooth extraction);
  • alveolar abscess.

Infectious processes in ophthalmology:

  • blepharitis (inflammation of the eyelids);
  • dacryocystitis (inflammation of the lacrimal sac due to obstruction of the nasolacrimal duct).

Infectious lesions of the skin and soft tissue:

  • anthrax;
  • pyoderma;
  • furunculosis;
  • lymphogranuloma venereum;
  • lymphadenitis (inflammation of the lymph nodes);
  • lymphangitis (inflammation of the lymphatic vessels);
  • blackheads (acne);
  • folliculitis;
  • panaritium (purulent inflammation of the fingers or toes);
  • phlegmon;
  • abscess;
  • erysipelas (if the patient has hypersensitivity to penicillin drugs);
  • wound infections that arise as a result of injuries, burns and operations.

Infectious diseases of the genitourinary system:

Diseases of the digestive tract associated with Helicobacter pylori, including peptic ulcers of the stomach, duodenum and chronic gastritis.

Contraindications

  • Hypersensitivity to the active substance - josamycin, or auxiliary components of the drug;
  • allergy to taking other antibiotics from the macrolide group;
  • liver diseases leading to severe impairment of its functions or disruption of the bile ducts;
  • prematurity of children.

Side effects

From the biliary tract and liver:

  • transient (sudden and transient) increase in the activity of liver enzymes in the blood;
  • violation of the outflow of bile;
  • jaundice.
  • Quincke's edema;
  • exudative erythema multiforme and erythema malignant (Stevens-Johnson syndrome);
  • anaphylactoid reaction;
  • bullous dermatitis (an allergic reaction in which large blisters filled with fluid appear on the skin);
  • hives.

Other side effects that are rare:

  • thrush;
  • transient hearing loss;
  • purpura (small capillary hemorrhages in the skin).

Treatment with Vilprafen

The drug is taken orally between meals, without chewing, with water.

The dosage and course of treatment depend on the diagnosis. Vilprafen can only be prescribed by a doctor.

Vilprafen for children

Vilprafen during pregnancy and lactation

Drug interactions of Vilprafen

  • It is not recommended to prescribe Vilprafen simultaneously with bactericidal antibiotics, for example, penicillins and cephalosporins, as their effectiveness may be reduced.
  • Lincomycin and Vilprafen should not be prescribed together, because their therapeutic effect is mutually reduced.
  • Vilprafen slows down the elimination of Theophylline from the body, which can lead to intoxication of the body.
  • When co-administered with Vilprafen and antiallergic drugs containing astemizole or terfenadine, their elimination from the body may slow down, which leads to the development of arrhythmia.
  • When taking Vilprafen and ergot alkaloids simultaneously, vasoconstriction (narrowing of the lumen of blood vessels) increases.
  • When taking Vilprafen and cyclosporines, it is possible to increase the level of the latter in the blood, which can result in a toxic effect on the kidneys. Therefore, constant monitoring of the amount of cyclosporines in the blood is necessary.
  • During treatment with Vilprafen, the effectiveness of birth control pills may decrease. In such cases, it is recommended to resort to additional non-hormonal methods of contraception during the treatment period.
  • If you take Vilprafen with Digoxin, the concentration of the latter in the blood may increase.

Vilprafen for ureaplasmosis

Vilprafen for chlamydia

Vilprafen and alcohol

Vilprafen's analogs

Vilprafen has no synonyms (structural analogues), since the active substance josamycin is not included in any other drug.

Reviews about the drug

Price of the drug in Russia and Ukraine

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Source: http://www.tiensmed.ru/news/vilprafen-ab1.html

Vilprafen - instructions for use

Pharmacological properties

The drug is used to treat bacterial infections; The bacteriostatic activity of josamycin, like other macrolides, is due to inhibition of bacterial protein synthesis. When high concentrations are created at the site of inflammation, it has a bactericidal effect. Josamycin is highly active against intracellular microorganisms (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum. Legionella pneumophila); gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Сorynebacterium diphteriae), gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), as well as against some anaerobic bacteria (Peptococcus, Reptostreptococcus, Clostr idium perfringens). It has a slight effect on enterobacteria, and therefore little changes the natural bacterial flora of the gastrointestinal tract. Effective against resistance to erythromycin. Resistance to josamycin develops less frequently than to other macrolide antibiotics.

Pharmacokinetics. After oral administration, josamycin is quickly and completely absorbed from the gastrointestinal tract; food intake does not affect bioavailability. The maximum serum concentration of josamycin is achieved 1-2 hours after administration. About 15% of josamycin is bound to plasma proteins. Particularly high concentrations of the substance are found in the lungs, tonsils, saliva, sweat and tear fluid. The concentration in sputum exceeds the concentration in plasma by 8-9 times. Accumulates in bone tissue. Crosses the placental barrier and is secreted into breast milk. Josamycin is metabolized in the liver to less active metabolites and excreted mainly in bile. Excretion of the drug in urine is less than 20%.

Indications for use of Vilprafen

Acute and chronic infections caused by microorganisms sensitive to the drug, for example: Infections of the upper respiratory tract and ENT organs Sore throat, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis; diphtheria (in addition to treatment with diphtheria toxoid), as well as scarlet fever in case of hypersensitivity to penicillin. Lower respiratory tract infections: Acute bronchitis, exacerbation of chronic bronchitis, pneumonia (including those caused by atypical pathogens), whooping cough, psittacosis. Dental infections. Gingivitis and periodontal diseases. Infections in ophthalmology. Blepharitis, dacryocystitis. Infections of the skin and soft tissues. Pyoderma, furunculosis, anthrax, erysipelas (with hypersensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum. Infections of the genitourinary system. Prostatitis, urethritis, gonorrhea, syphilis (with hypersensitivity to penicillin), chlamydial, mycoplasma (including ureaplasma) and mixed infections.

Directions for use and doses

The recommended daily dosage for adults and adolescents over 14 years of age is 1 to 2 g of josamycin. The daily dose should be divided into 2-3 doses. The initial recommended dose is 1 g of josamycin. For acne vulgaris and acne globulus, it is recommended to prescribe josamycin 500 mg twice daily for the first 2-4 weeks, followed by mg josamycin once daily as maintenance treatment for 8 weeks. Vilprafen film-coated tablets should be swallowed whole with a small amount of water. Usually the duration of treatment is determined by the doctor. In accordance with the recommendations of the World Health Organization on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

Features of application

In patients with renal failure, treatment should be carried out taking into account the results of appropriate laboratory tests. The possibility of cross-resistance to different macrolide antibiotics should be considered (for example, microorganisms that are resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin).

Side effects

Rarely - loss of appetite, nausea, heartburn, vomiting, dysbacteriosis and diarrhea. In the case of persistent severe diarrhea, one should keep in mind the possibility of life-threatening pseudomembranous colitis developing against the background of antibiotics. In extremely rare cases, allergic skin reactions (for example, urticaria) are possible. In some cases, a transient increase in the activity of liver enzymes in the blood plasma was observed, in rare cases accompanied by a violation of the outflow of bile and jaundice. In rare cases, dose-related transient hearing impairment has been reported. Very rarely - candidiasis.

Interaction with other drugs

Vilprafen / other antibiotics. Since bacteriostatic antibiotics can reduce the bactericidal effect of other antibiotics, such as penicillins and cephalosporins, co-administration of josamycin with these types of antibiotics should be avoided. Josamycin should not be prescribed together with lincomycin, as a mutual decrease in their effectiveness is possible.

Vilprafen / xanthines. Some representatives of macrolide antibiotics slow down the elimination of xanthines (theophylline), which can lead to possible intoxication. Clinical experimental studies indicate that josamycin has less effect on theophylline release than other macrolide antibiotics.

Vilprafen / antihistamines. After co-administration of josamycin and antihistamines containing terfenadine or astemizole, there may be a slowdown in the elimination of terfenadine and astemizole, which in turn can lead to the development of life-threatening cardiac arrhythmias.

Vilprafen/ergot alkaloids. There are individual reports of increased vasoconstriction following co-administration of ergot alkaloids and macrolide antibiotics. There was one case of patient's lack of tolerance to ergotamine while taking josamycin. Therefore, the concomitant use of josamycia and ergotamine should be accompanied by appropriate monitoring of patients.

Vilprafen / cyclosporine. Co-administration of josamycin and cyclosporine may cause an increase in the level of cyclosporine in the blood plasma and the creation of nephrotoxic concentrations of cyclosporine in the blood. Plasma concentrations of cyclosporine should be regularly monitored.

Vilprafen / digoxin. When administered together, josamycin and digoxin may increase the level of the latter in the blood plasma.

Vilprafen/hormonal contraceptives. In rare cases, the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case, it is recommended to additionally use non-hormonal contraception.

Contraindications

Hypersensitivity to antibiotics - macrolides; severe liver dysfunction. Pregnancy and lactation. Permitted for use during pregnancy and breastfeeding according to indications. WHO Europe recommends josamycin as the drug of choice for the treatment of chlamydial infection in pregnant women.

Overdose

To date, there is no data on specific symptoms of poisoning. In case of overdose, the symptoms described in the “Side Effects” section should be expected, especially from the gastrointestinal tract. If one dose is missed, you must immediately take a dose of the drug. However, if it is time for the next dose, do not take the “forgotten” dose, but return to your normal treatment regimen. You should not take double the dose. A break in treatment or premature discontinuation of the drug will reduce the likelihood of treatment success.

Source: http://www.diagnos-online.ru/lekarstvennye-preparaty/vilprafen.html

Vilprafen

Release forms and packaging of the drug Vilprafen

Film-coated tablets.

Composition and active substance

Vilprafen contains:

1 tablet contains:

Active substance: josamycin 500 mg,

Excipients: methylcellulose MCC silica colloidal anhydrous polysorbate 80 carboxymethylcellulose sodium talc magnesium stearate macrogol 6000 titanium dioxide (E171) aluminum hydroxide poly-(ethacrylate methyl methacrylate)-30% dispersion

pharmachologic effect

Vilprafen is an antibiotic of the macrolide group.

Inhibits protein synthesis by bacteria. When high concentrations are created at the site of inflammation, it has a bactericidal effect. It is highly active against intracellular microorganisms (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila) gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae (pneumococ cus) , Corynebacterium diphteriae), gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), as well as against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringens). It has a slight effect on enterobacteria, and therefore little changes the natural bacterial flora of the gastrointestinal tract. Effective against resistance to erythromycin. Resistance to josamycin develops less frequently than to other macrolide antibiotics.

What does Vilprafen help with: indications

Infections (including chlamydial, mycoplasma and mixed) of the respiratory tract and ENT organs (tonsillitis, pharyngitis, otitis media, sinusitis, laryngitis, tonsillitis and paratonsillitis, acute bronchitis, pneumonia, (including atypical form) skin integument and soft tissues (pyoderma, furunculosis, anthrax, erysipelas (with hypersensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum) genitourinary system (pyelonephritis, prostatitis, chlamydia, mycoplasmosis, ureaplasmosis, gonorrhea, syphilis) dental infections (gingivitis, periodontal disease) in ophthalmology (blepharitis, dacryocystitis) diphtheria (in addition to treatment with diphtheria toxoid), scarlet fever (in case of hypersensitivity to penicillin), whooping cough, psittacosis.

Contraindications

Hypersensitivity, severe liver dysfunction, prematurity.

Caution should be used against the background of renal failure.

Vilprafen during pregnancy and breastfeeding

Possibly according to indications. It is the drug of choice for the treatment of chlamydial infection in pregnant women.

Vilprafen: instructions for use

Orally, tablets - without chewing, with a small amount of water, the suspension is prescribed between meals (the contents of the bottle are pre-shaken): 1-2 g per day in 2-3 doses.

The duration of treatment for streptococcal infections is at least 10 days.

For the treatment of ordinary and globular acne - 500 mg 2 times a day for 2-4 weeks, then 1 mg 1 time a day for 8 weeks.

For newborns and children up to 14 years of age, mg/kg per day in 3 divided doses.

Side effects

From the gastrointestinal tract: rarely - loss of appetite, nausea, heartburn, vomiting, dysbacteriosis, diarrhea. In the case of persistent severe diarrhea, one should keep in mind the possibility of life-threatening pseudomembranous colitis developing against the background of antibiotics.

Allergic reactions: in extremely rare cases - urticaria.

From the hearing aid: in rare cases - dose-dependent transient hearing impairment.

Other: very rarely - candidiasis.

special instructions

If one dose is missed, you should take a dose immediately, but if it is time for the next dose, you should return to your usual treatment regimen. You should not take double the dose. A break in treatment or premature discontinuation of the drug will reduce the likelihood of treatment success.

The possibility of cross-resistance to various macrolide antibiotics should be taken into account (for example, microorganisms that are resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin)

Compatibility with other drugs

Other antibiotics. Since bacteriostatic antibiotics can reduce the bactericidal effect of other antibiotics, such as penicillins and cephalosporins, co-administration of josamycin with these types of antibiotics should be avoided. Josamycin should not be prescribed together with lincomycin, because a mutual decrease in their effectiveness is possible.

Xanthines. Some representatives of macrolide antibiotics slow down the elimination of xanthines (theophylline), which can lead to possible intoxication. Clinical experimental studies indicate that josamycin has less effect on theophylline release than other macrolide antibiotics.

Antihistamines. After co-administration of josamycin and antihistamines containing terfenadine or astemizole, there may be a slowdown in the elimination of terfenadine and astemizole, which in turn can lead to the development of life-threatening cardiac arrhythmias.

Ergot alkaloids. There are individual reports of increased vasoconstriction following co-administration of ergot alkaloids and macrolide antibiotics. There was one case of patient's lack of tolerance to ergotamine while taking josamycin. Therefore, the concomitant use of josamycin and ergotamine should be accompanied by appropriate monitoring of patients.

Cyclosporine. Co-administration of josamycin and cyclosporine may cause an increase in the level of cyclosporine in the blood plasma and the creation of nephrotoxic concentrations of cyclosporine in the blood. Plasma concentrations of cyclosporine should be regularly monitored.

Digoxin. When administered together, josamycin and digoxin may increase the level of the latter in the blood plasma.

Hormonal contraceptives. In rare cases, the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case, it is recommended to additionally use non-hormonal contraception.

Overdose

To date, there is no data on specific symptoms of poisoning. In case of overdose, the symptoms described in the “Side Effects” section should be expected, especially from the gastrointestinal tract.

Storage conditions and shelf life

In a place protected from light, at a temperature not exceeding 25 °C

Analogues and prices

Among foreign and Russian analogues of Vilprafen there are:

Reviews

We automatically found these reviews about the drug Vilprafen on the Internet:

Staphylococcus was discovered. This is an opportunistic microbe that everyone has, but if the immune system is weakened, it begins to multiply rapidly, and problems appear. For me, these problems began in the form of small frequent trips to the toilet. This antibiotic eliminated the problem. Easy to drink, one tablet 3 times a day for 10 days. I didn't notice any side effects. Together with him, he was prescribed to take one tablet of flucostat so that thrush would not develop. Minus a point for the price - the course turns out to be very expensive.

You can leave your review below! Does Vilprafen help cope with the disease?

See also:

Unidox Solutab

Erythromycin

Ciprofloxacin

One review

I was treated with this medicine when I was pregnant, it did not have a bad effect on the development of the fetus. I gave birth to a healthy child; he had no allergies to drugs of this group.

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