Papaverine analgin diphenhydramine injection

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Analgin + Diphenhydramine + Papaverine

Combination of diphenhydramine with analgin and anti-allergy drugs

Diphenhydramine and papaverine remain the most commonly used drugs, which is associated with the low cost of drugs and the rapid onset of effects.

Table of contents:

Moreover, along with them, analgin is used, which is part of the “triad” injection. This mixture is used in a medical hospital and in the emergency department. The “triad” is administered intramuscularly, which allows the onset of the desired effect to be accelerated.

The “triad” is used in surgical, trauma, and therapeutic patients. The injection composition, due to analgin, has a mild analgesic effect and is also effective against fever. Diphenhydramine is a blocker of histamine receptors in the periphery and is used as a central sedative. Papaverine is a strong antispasmodic with a predominant effect on vascular smooth muscle.

The combination of drugs in the “triad” is considered universal for providing first aid in the case of many pathologies. For surgical diseases, papaverine with diphenhydramine and analgin helps relieve pain by relaxing the muscles of the ducts, areas of the urinary tract and intestines. Due to diphenhydramine, it is possible to significantly alleviate the symptoms of acute surgical, urological and gynecological pathologies. It helps to calm the patient. Analgin can replace aspirin if it is available in the form of an injection solution.

In a therapeutic hospital and in the emergency department, in an ambulance and in paramedic and obstetric centers, the “troika” can be used to relieve a hypertensive crisis and to relieve anxiety. Papaverine is used to lower blood pressure in the triad. It very gently corrects blood pressure by relaxing muscular arteries. They are located on the periphery, which means that the action of papaverine improves blood supply to peripheral tissues without disrupting blood flow in the brain, kidneys, and heart.

In most regions of the country there are no large hospitals with special allergy departments. As a result, patients with allergic diseases are admitted either to therapeutic hospitals or to the intensive care unit. However, the first stage of their hospitalization is the emergency room or emergency room. Here, the “troika” can be used to reduce the activity of the allergic reaction. Due to the presence of diphenhydramine, the mixture reduces the risks for the patient in case of a systemic allergic reaction.

Composition of the triad, dosage of drugs

The triad contains three pharmacological drugs, which are extremely cheap, have a relatively small number of side effects, and also have a rapid onset of effect. These include analgin, diphenhydramine and papaverine.

The dosage of analgin in the mixture is 2 ml of a 50% solution. The dose of diphenhydramine is 1 ml of a 1 percent solution. Papaverine dosage – 2 ml – 2% solution.

The drug analgin is not used in Western countries due to the large number of adverse reactions and because it is not economically profitable for pharmaceutical companies. It belongs to the class of non-steroidal anti-inflammatory drugs and has many analogues. One of them is aspirin. Both drugs have many adverse reactions associated with inhibition of 2 types of cyclooxygenase. However, to reduce fever, analgin and aspirin remain excellent means.

The drug diphenhydramine belongs to the class of histamine receptor inhibitors and is listed among the first generation drugs. In fact, diphenhydramine is already outdated and is not the most effective for the treatment of allergic diseases. This is due to the suppression of nervous activity at the highest level. After taking diphenhydramine, the vast majority of patients experience drowsiness. For this reason, the “troika” is not an effective means of permanent treatment of allergies, although it can be used at the initial stage of development of a systemic reaction: urticaria, anaphylactic shock, angioedema.

A full-fledged analogue of diphenhydramine that does not have a central effect is loratadine, known under the trade name Claritin. This drug belongs to the class of second generation histamine blockers. In the same category for the treatment of allergies there is fenkarol, peritol, diazolin, simplex. The most effective at the moment are representatives of the third generation of histamine receptor blockers: cytirizine, desloratadine, fexofenadine. Moreover, loratadine remains one of the most commonly used drugs for the treatment of all types of allergies.

Papaverine, as part of the triad, acts as an antispasmodic agent, which is most active in relation to the vascular muscles. An intramuscular injection leads to a decrease in blood pressure, relaxation of the smooth muscles of the intestines, the sphincter of the gallbladder, the major duodenal papilla, and the ureter. Moreover, the functional analogue of papaverine is “No-shpa”.

This drug contains drotaverine, which is more active against the smooth muscles of internal organs rather than blood vessels. No-spa is used in surgical, therapeutic and gynecological practice. Due to the relaxation of smooth muscles, drotaverine and papaverine are able to relieve pain. They are not superior to novocaine in terms of potency, but they eliminate the cause of pain, which is why they are chosen for treatment much more often than other drugs.

Author of the article: Alina Samsonova

Source: http://myallergiya.ru/lechenie/trojchatka.html

Treating the Heart

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Diphenhydramine analgin drotaverine

Troychatka is a lytic mixture consisting of the three most popular pharmacological agents, the action of which is aimed at reducing temperature. The triad contains Analgin, Drotaverine and Diphenhydramine. All components have low cost and significant efficiency. The product has a mild effect and is given to both adults and children. The dosage and proportions of therapeutic products are calculated individually in each individual case.

Composition and release form

Troychatka consists of Analgin, Drotaverine and Diphenhydramine, which are available in the form of tablets and injections for injections. In some situations, the composition of the triad can be changed by replacing the components with analogues.

  • Drotaverine can be replaced by another antispasmodic agent, for example No-shpa or Papaverine. These drugs relieve pain in joints and muscles that appears at high temperatures.
  • Diphenhydramine, which is not available in pharmacies without a prescription, is an antihistamine - its action is aimed at blocking histamine H1 receptors. This drug can be replaced with other drugs that have a similar pharmacological effect - Tavegil, Dexamethasone or Diazolin. Diphenhydramine and its analogs relieve vasospasm, suppress inflammation and swelling of the mucous membranes.
  • Analgin, as the main component of the triad, also has analogues that help reduce temperature. The drug belongs to the group of antipyretic, anti-inflammatory and analgesic drugs. Analgin acts as a powerful analgesic that helps eliminate the discomfort that occurs at high temperatures. Often the drug is replaced with Toralgin, Metamizole sodium or Nobol.

Indications for use

The use of the medicine is advisable for any condition that is accompanied by an increase in body temperature. However, it is important to follow the rule - it is not recommended to lower the temperature if it has not risen above 38-38.5 degrees, since such an increase in itself is critical for many microorganisms.

Taking the combined drug is allowed in the following conditions that occur with an increase in thermometer readings:

  • acute infectious diseases and inflammatory processes;
  • attacks of heart rhythm disturbances;
  • fainting or convulsions caused by fever;
  • in the postoperative period;
  • as part of the treatment of muscle and stomach pain, migraines, as well as pain arising from urolithiasis and ailments affecting the genitourinary system;
  • for neurotic disorders;
  • epileptic seizures;
  • to relieve symptoms and prevent the development of a hypertensive crisis (the method is used by doctors at ambulance stations and in medical hospitals);
  • critically elevated blood pressure (in this case, an intramuscular injection is necessary);
  • diseases of the cardiovascular system;
  • for acute allergic reactions with asthmatic complex. The action of the active components of the medicinal mixture is aimed at reducing the activity of the allergic reaction and suppressing symptoms: fever, headache, itching, breathing problems, etc.

Directions for use and dosage

The method of application and dosage of triadic acid depending on temperature is determined by a number of individual indicators: weight, age, hyperthermic status. It is not recommended to use triad as a lytic mixture on your own, without a doctor’s prescription and supervision.

Pills

To take triad in tablet form, you must combine the active components in equal proportions. To quickly reduce the temperature, you need to take one tablet of Diphenhydramine, Papaverine and Analgin. This method is used in situations where the rate of decrease in body temperature is not critically important. After taking the drugs, the temperature subsides after 25 minutes, when the concentration of active substances in the body reaches its maximum value.

Injections

For injections, it is necessary to observe the proportions for combining the active components. The main parameter for determining dosage, both for adults and children, is weight. To prepare a mixture corresponding to a mass of 50 kilograms, you need to mix the drugs in ampoules:

  • Analgin - 2 milliliters of a 50 percent solution;
  • Diphenhydramine – 1 milliliter of 1 percent solution;
  • Drotaverine or Papaverine - 2 milliliters of a 2 percent solution.

Children weighing less than 50 kilograms should receive a reduced dose of the drug equivalent to their body weight. Adults accordingly need to increase the proportions of the components of the composition. In certain conditions determined by the doctor, it may be necessary to increase the volume of Analgin or Diphenhydramine in the composition of the medicine.

The peculiarity of administration by injection is that the speed of delivery of the components of the lytic mixture is significantly higher than when taking the medicine in tablet form. After the injection of intramuscular mass, the patient’s temperature drops after 3-6 minutes, which is especially important in severe conditions when the temperature is critical - a degree.

Contraindications

Troychatka has numerous contraindications due to the action of each component of the lytic mixture:

  • neonatal period and children under 3 years of age;
  • glaucoma;
  • peptic ulcers of the stomach and intestines;
  • bladder neck stenosis and other conditions requiring surgical intervention;
  • pregnancy and breastfeeding;
  • bronchial asthma;
  • state of alcohol and drug intoxication;
  • rheumatic attacks;
  • heart, kidney and liver failure;
  • leukopenia, anemia and other blood diseases;
  • lactose intolerance (Drotaverine contains lactose monohydrate), etc.

Overdose

If the permissible dose is exceeded, a number of side effects are possible:

  • dizziness;
  • nausea;
  • stomach pain;
  • violation of orientation in space;
  • headache;
  • hypotension;
  • drowsiness;
  • weakness;
  • convulsions;
  • sleep disturbance, etc.

Storage conditions and shelf life

The pharmacological agents included in the triad in tablet form can be stored for three years. Drugs in ampoule form are stored for up to two years. After combining the medicinal components, the product should be consumed within several hours. According to the instructions, the medicine must be stored in a dark place at room temperature without oxygen entering the package.

How does triad help with temperature? This question is of interest to many patients. Most people don't want to lower their temperature unless it's above 38.5 degrees. Patients give the body the opportunity to cope with the disease itself. But it often happens that the immune system is unable to fight the disease, and the temperature remains elevated. In this case, certain measures should be taken. Sometimes standard medications do not help a weakened body. Then you need to take a fairly effective and efficient remedy - triad, which will help reduce the temperature.

Features of the drug

What is included in the triad? Troikatka for fever is one of the most effective medical remedies that reduce fever. Moreover, this medicine effectively helps not only with acute respiratory viral infections or acute respiratory infections, but also in the case of serious inflammatory diseases.

From the name you can judge that the temperature triad consists of 3 components:

In some cases, Drotaverine can be replaced with the following antispasmodic agents: Papaverine or No-shpa. Diphenhydramine is not available without a prescription at the pharmacy, for this reason it is sometimes replaced with Tavegil or Diazolin, which have similar medicinal properties.

To introduce this drug into the body, you need to give an injection. You need to inject the triad into the gluteal muscle for fever. This procedure can be called the most effective. Typically, this method leads to normalization of body temperature in just 15 minutes.

Proportions of the medicinal mixture

For adults with an average weight of about 60 kilograms, the following ratio of medications is recommended - mix tablet solutions in the following quantities: 2 ml of Analgin, 2 ml of Drotaverine and 1 ml of Diphenhydramine. But if one of the components of the medicinal mixture is replaced, then before use it is better to consult with a doctor about the correct ratio of the components of the triad.

How does the triad act on temperature?

Not every one of its ingredients has an antipyretic effect. The main component of this remedy is Analgin. It quite effectively lowers the temperature, while also eliminating pain and aches.

Diphenhydramine strongly complements the antipyretic properties of Analgin. It also has remarkable antiallergic properties and perfectly relieves swelling of the mucous membrane. The drug Drotaverine has good antispasmodic and vasodilating properties.

No-shpa has a similar medicinal effect to Drotaverine. It dilates blood vessels, lowers blood pressure and eliminates spasms. These drugs help increase heat transfer, thereby enhancing the effect of Analgin, making it more pronounced.

The above composition provides effective assistance to the patient, even if he has a very high temperature. Another advantage of this medicinal mixture: it must be used in cases where an unhealthy person cannot take drugs in the form of tablets. This need usually arises when there is uncontrollable vomiting, loss of consciousness, or a sick person refuses to take medications internally.

A triad injection should only be given if there is a temperature of more than 38 degrees. It is prohibited to use this composition more than 2 times a day.

But we must remember that triad is a rather serious mixture. Therefore, it must be used very carefully. The 3 medications mentioned above will certainly help reduce fever if chosen correctly. But in the case when the process of inflammation is just beginning in the body, the triad will lower the temperature for 3-4 hours, and then the temperature will rise again. It is for this reason that the triad is used only in complex treatment.

What contraindications exist when using troika for temperature? Sometimes it is contraindicated for a patient to inject troika. You cannot relieve fever with this remedy if:

  1. The patient has a high temperature and at the same time abdominal pain. This medicine relieves any pain. And if the patient has acute appendicitis, this therapeutic effect of the mixture turns out to be extremely dangerous.
  2. An unhealthy person is allergic to one of the components of the triad. Before administering the medicine, you should check for an allergic reaction by placing 1 drop of the medicine under the lower eyelid. In case of discomfort or redness, the use of triad is strictly prohibited.
  3. If the patient has already tried to bring down the temperature with the drugs included in the triad, such an action will lead to an overdose.

Is it possible to use triad to lower the temperature in children? Troychatka for children for temperature and its dosage is determined by the doctor. Most doctors do not recommend using this drug in children because it may harm the kidneys and liver. In a particular case, you need to consult with a competent specialist who will determine the required dosage of the medicine, if it is acceptable for treating the child. Usually, doctors allow the use of triad for treating children using Papaverine. Its amount is calculated based on the age of the child.

Combination of diphenhydramine with analgin and anti-allergy drugs

Diphenhydramine and papaverine remain the most commonly used drugs, which is associated with the low cost of drugs and the rapid onset of effects. Moreover, along with them, analgin is used, which is part of the “triad” injection. This mixture is used in a medical hospital and in the emergency department. The “triad” is administered intramuscularly, which allows the onset of the desired effect to be accelerated.

The “triad” is used in surgical, trauma, and therapeutic patients. The injection composition, due to analgin, has a mild analgesic effect and is also effective against fever. Diphenhydramine is a blocker of histamine receptors in the periphery and is used as a central sedative. Papaverine is a strong antispasmodic with a predominant effect on vascular smooth muscle.

The combination of drugs in the “triad” is considered universal for providing first aid in the case of many pathologies. For surgical diseases, papaverine with diphenhydramine and analgin helps relieve pain by relaxing the muscles of the ducts, areas of the urinary tract and intestines. Due to diphenhydramine, it is possible to significantly alleviate the symptoms of acute surgical, urological and gynecological pathologies. It helps to calm the patient. Analgin can replace aspirin if it is available in the form of an injection solution.

In a therapeutic hospital and in the emergency department, in an ambulance and in paramedic and obstetric centers, the “troika” can be used to relieve a hypertensive crisis and to relieve anxiety. Papaverine is used to lower blood pressure in the triad. It very gently corrects blood pressure by relaxing muscular arteries. They are located on the periphery, which means that the action of papaverine improves blood supply to peripheral tissues without disrupting blood flow in the brain, kidneys, and heart.

In most regions of the country there are no large hospitals with special allergy departments. As a result, patients with allergic diseases are admitted either to therapeutic hospitals or to the intensive care unit. However, the first stage of their hospitalization is the emergency room or emergency room. Here, the “troika” can be used to reduce the activity of the allergic reaction. Due to the presence of diphenhydramine, the mixture reduces the risks for the patient in case of a systemic allergic reaction.

Composition of the triad, dosage of drugs

The triad contains three pharmacological drugs, which are extremely cheap, have a relatively small number of side effects, and also have a rapid onset of effect. These include analgin, diphenhydramine and papaverine.

The dosage of analgin in the mixture is 2 ml of a 50% solution. The dose of diphenhydramine is 1 ml of a 1 percent solution. Papaverine dosage – 2 ml – 2% solution.

The drug analgin is not used in Western countries due to the large number of adverse reactions and because it is not economically profitable for pharmaceutical companies. It belongs to the class of non-steroidal anti-inflammatory drugs and has many analogues. One of them is aspirin. Both drugs have many adverse reactions associated with inhibition of 2 types of cyclooxygenase. However, to reduce fever, analgin and aspirin remain excellent means.

The drug diphenhydramine belongs to the class of histamine receptor inhibitors and is listed among the first generation drugs. In fact, diphenhydramine is already outdated and is not the most effective for the treatment of allergic diseases. This is due to the suppression of nervous activity at the highest level. After taking diphenhydramine, the vast majority of patients experience drowsiness. For this reason, the “troika” is not an effective means of permanent treatment of allergies, although it can be used at the initial stage of development of a systemic reaction: urticaria, anaphylactic shock, angioedema.

A full-fledged analogue of diphenhydramine that does not have a central effect is loratadine, known under the trade name Claritin. This drug belongs to the class of second generation histamine blockers. In the same category for the treatment of allergies there is fenkarol, peritol, diazolin, simplex. The most effective at the moment are representatives of the third generation of histamine receptor blockers: cytirizine, desloratadine, fexofenadine. Moreover, loratadine remains one of the most commonly used drugs for the treatment of all types of allergies.

Papaverine, as part of the triad, acts as an antispasmodic agent, which is most active in relation to the vascular muscles. An intramuscular injection leads to a decrease in blood pressure, relaxation of the smooth muscles of the intestines, the sphincter of the gallbladder, the major duodenal papilla, and the ureter. Moreover, the functional analogue of papaverine is “No-shpa”.

This drug contains drotaverine, which is more active against the smooth muscles of internal organs rather than blood vessels. No-spa is used in surgical, therapeutic and gynecological practice. Due to the relaxation of smooth muscles, drotaverine and papaverine are able to relieve pain. They are not superior to novocaine in terms of potency, but they eliminate the cause of pain, which is why they are chosen for treatment much more often than other drugs.

Author of the article: Alina Samsonova

When a person suffers from severe hyperthermia, one of the best methods to combat it is the triad. Many doctors consider it an indispensable way to reduce high fever. The issue of the safety of this product is quite controversial, and opinions here are radically divided, but its effectiveness and relevance today are beyond doubt. Therefore, the triplet for temperature is very often used in the practice of pediatricians, infectious disease specialists, therapists and doctors of other specialties.

When the temperature needs to be “knocked down”

With the development of severe hyperthermia, the body gives us a signal that the infectious process is defeating its defenses. Most often, hyperthermia manifests itself in the early stages of viral infections, as well as during severe bacterial processes. The temperature reaction is an indicator of the development of similar processes in our body.

Our immunity responds to the introduction of foreign agents very quickly. One of its methods of action is precisely to increase the temperature. It is at numbers above 38C that our natural human interferon, tumor necrosis factor, begins to be produced, and the activity of leukocytes increases. This environment is very unfavorable for bacteria and viruses. In addition, the activity of antibiotics against the background of high temperature reaction figures is much higher than at the usual 36.6C. Doctors do not recommend using antipyretics until the thermometer shows that the temperature has risen above 38.5C.

The temperature should be brought down with medications when it continues to increase. Extremely high hyperthermia leads to exhaustion of the body and also overloads the cardiovascular system.

When should the temperature be “brought down” if it has not reached 38.5C:

  • heart rhythm disturbances;
  • development of fainting or convulsive conditions;
  • instability of the nervous system - epilepsy, schizophrenia, risk of developing cerebral edema.

Triadic acid is sometimes called a lytic mixture among doctors, which means a remedy that allows you to quickly normalize the temperature curve. Another beneficial effect of this combination of drugs is its analgesic, that is, pain-relieving effect.

The traditional triad contains three substances - analgin, drotaverine and diphenhydramine. However, drotaverine and diphenhydramine sometimes need to be replaced with substances of similar action. Drotaverine is known to everyone under the trade name no-shpa, but other antispasmodics - spasmabrew, papaverine - are often used instead. Diphenhydramine is usually sold by prescription, so it can often be replaced with drugs such as suprastin or tavegil.

How does the triad work at a temperature whose composition does not include direct antipyretic drugs? The composition of this product is balanced and fights the main side effects of fever: headache, joint pain, tachycardia by eliminating pain effects with analgin, eliminating spasm with drotaverine, and also eliminates swelling and allergic inflammation with diphenhydramine. At the same time, all three participants in this mixture began to be administered to patients when they began to note that together they cope well with hyperthermia and its side effects, regardless of the cause of this condition.

This remedy is contraindicated in the following cases:

  • development of severe pain in the abdomen. Perhaps we are dealing with an acute abdomen - a surgical pathology in which the use of painkillers is strictly prohibited;
  • taking analgin or diphenhydramine the day before. In this case, there is a risk of overdose of the triad components, which will also require treatment;
  • previously diagnosed allergic reactions to any substance included in the lytic mixture.

Troychatka is a remedy containing as many as three drugs, so it should be used with extreme caution by both adults and children. The dosage is always selected individually, and intramuscular administration shows the greatest effectiveness. Three-way fever for children is a completely separate matter, since in this case it is necessary to calculate the children's dose of each individual drug per kilogram of body weight.

The drug is used when the patient is in serious condition. Typically, the effect of the mixture occurs within 15 minutes after administration, but after a couple of hours the temperature will most likely rise again. However, these hours can allow you to gain time in which the patient will receive the medical care he needs.

Instructions for use

There are unspoken rules for using this medicinal mixture:

  1. First of all, it is necessary to warm the preparations. To do this, the patient can take them into his own hands.
  2. Then the ampoules should be disinfected with a cotton ball soaked in alcohol.
  3. Analgin should be drawn into the syringe first, after which no-spa and diphenhydramine should be drawn. Remember that the dose of drugs is indicated exclusively by the doctor.
  4. When administered intramuscularly, the upper outer quadrant of the buttock is treated with alcohol, and the needle should be inserted 2/3 at a right angle. This reduces the risk of the needle breaking in the muscle. If an infiltrate has formed at the injection site, magnesium compresses or iodine nets should be applied.

Features of analgin as part of a lytic mixture

Since analgin tablets have an excellent antipyretic effect, its solution is used quite rarely for this purpose. The drug is administered exclusively intramuscularly at a low speed. The maximum daily dose is 2 ml, and with rapid administration, vascular collapse may develop, during which blood pressure will drop sharply.

The drug is prohibited for:

  • pregnancy or lactation;
  • allergic reactions to analgin;
  • anemia and impaired hematopoietic function.

The use of triad in childhood

For children, such a remedy is prescribed exclusively by a pediatrician, because the doses of each individual substance from the composition of the lytic mixture are calculated for the child. A child with a high temperature is a direct indication for calling an ambulance. You can help yourself with vinegar compresses and rubdowns, as well as by drinking plenty of fluids.

It is extremely rare that children need to lower their temperature at any cost, because with high temperatures, the development of fainting states, delirium or even convulsions is possible, and at a very young age, high hyperthermia can lead to the death of the baby. You should consult with your doctor by phone to clarify the dosages of the drugs, and administer the lytic mixture to your baby yourself. This is the only option when administering this remedy at home without medical supervision is allowed.

How else can you “bring down” the temperature?

In some cases, it is necessary to look for an alternative to the lytic mixture for various reasons. Alternatively, all these drugs can be given to the patient in tablet form. An adult should take one tablet of each substance.

The temperature can also drop when using traditional medicine: vinegar compresses and rubdowns, cold on the temple area, wrists and knees, wrapping with wet clothes.

Every person should be able to bring down the temperature, because in special cases, delay can cost the life of a person or a child. Hyperthermia also negatively affects the respiratory, cardiovascular systems and hematopoietic organs.

Source: http://lechim-serdce.ru/2018/01/03/dimedrol-anal-gin-drotaverin/

Using Analgin with Diphenhydramine to reduce fever

A very common occurrence is when a child or adult develops a high fever. Antipyretic drugs in the form of Paracetamol and Ibuprofen are not always able to help with a decrease in temperature. Then they resort to something else and use Analgin with Diphenhydramine. In what cases should you resort to these drugs and what is the dosage for a child?

The action of Analgin and Diphenhydramine

Analgin is a powerful anti-inflammatory medication that has antipyretic and analgesic effects. The medicine begins to act within a few minutes after the injections are given. At the same time, it is quickly absorbed and has high bioavailability.

Diphenhydramine is an antihistamine that has a pronounced sedative effect. The drug also has a weak anti-inflammatory effect.

When Analgin is combined with Diphenhydramine, doctors create a drug that allows you to reduce the temperature to normal levels in a short time. When an injection is given to a child for fever, the inflammatory syndrome and fever stop within fifteen minutes.

It should be noted that Analgin and Diphenhydramine have a number of limitations in the form of stomach ulcers, diabetes, and bronchial asthma. Also, Diphenhydramine and Analgin can cause severe dehydration of the body, so after giving injections you should drink at least one glass of liquid.

Use of Diphenhydramine and Analgin

As a rule, Analgin with Diphenhydramine is used in the form of injection solutions. It is generally accepted that in this form, drugs enter the bloodstream much faster and instantly reach the inflamed area. The active components they contain act directly on the nerve endings, due to which temperature indicators decline.

If Analgin and Diphenhydramine are not available in the form of a solution, then you can use the products in the form of tablets. An important condition is compliance with the exact dosage, which depends on the age and weight of the child or adult.

If the patient is going to give an antipyretic injection of Analgin at a high temperature, then you need to take it in a dosage of one hundred milligrams. After this, Diphenhydramine, one gram in volume, is added to it. The mixture is thoroughly shaken.

When Analgin is administered with Diphenhydramine, the dosage of the finished mixture should be one milliliter. During the day, an injection at a high temperature can only be given twice.

If for some reason the patient cannot be given an injection, then the resulting solution can be taken orally. But it is worth noting that the effect of the medication in such a situation will be slower.

To give an injection to an adult or child, you need to follow a number of recommendations.

  1. Take a new syringe and use it to first draw Analgin, and then Diphenhydramine. Shake thoroughly.
  2. Slowly introduce the mixture into the muscle tissue and apply cotton wool.

If the procedure needs to be repeated, this can only be done after six hours.

Use of Analgin, Diphenhydramine with Papaverine or No-shpa

Analgin with Diphenhydramine does not always help children instantly and effectively lower their temperature. This is due to the fact that babies often experience vasospasm, as a result of which blood circulation is impaired. Because of this, medications do not have time to reach the inflammatory process, and therefore are ineffective.

Then doctors resort to another method. To eliminate spasm and dilation of blood vessels, take a mixture of Analgin, Diphenhydramine, Papaverine. The third component acts as an antispasmodic agent. In medicine, such a solution is usually called a lytic mixture. The injection allows you to remove high fever in a few minutes.

To prepare the solution you will need two milliliters of Analgin, one milliliter of Diphenhydramine and two milliliters of Papaverine. This dosage is indicated for adults and children over twelve years of age.

If the injection is given to a baby, then Analgin should be added in half as much.

If the components are available only in tablet form, then the solution may include Analgin, Diphenhydramine, No-spa.

It should be noted that the lytic mixture of Analgin, Papaverine with Diphenhydramine can cause side effects that manifest themselves:

  • in nausea and vomiting. These signs are observed repeatedly. In this case, vomiting does not bring relief to the patient;
  • increased heart rate;
  • in impaired digestive function. The patient may experience constipation or diarrhea;
  • in the occurrence of sweating;
  • in the deterioration of blood counts. Hemoglobin levels drop sharply.

In pediatrics, Papaverine and Analgin are used only in extreme cases, when the high temperature lasts for quite a long time and poses a threat to the baby’s life.

In rare cases, a mixture based on Analgin and Novocaine is used. In most cases, Novocain causes an allergic reaction. If the patient tolerates all components well, then to prepare the solution, mix one milliliter of Novocain and Analgin. Shake thoroughly and inject into muscle tissue. Novocaine will not speed up the effects of the mixture, but will provide instant pain relief and reduce intense inflammation.

Reducing high fever using gentle methods

Analgin with papaverine is given to children only in extreme situations. If temperatures do not exceed more than 39.6 degrees and they remain for three to four days, then you can resort to more gentle methods.

Today, the drug Ibuklin is sold in pharmacy kiosks. It contains two components in the form of Paracetamol and Ibuprofen. In this combination, they actively fight high temperatures. If the medication will be given to a child, then you need to take half the tablet and dissolve it in water.

Also, the same combination of Paracetamol and Ibuprofen can be used as an effective antipyretic in children. Just give, for example, Paracetamol syrup and after five minutes put a Nurofen suppository. Or do it differently. Give Ibuprofen syrup and put on a Cefekon suppository. It is recommended to use this combination no more than twice a day.

If Paracetamol or Ibuprofen do not help, then you can resort to Nimulid. This drug has anti-inflammatory, analgesic and antipyretic effects. Conveniently, it is also available in syrup form. But you should carefully give it to your child, calculating the exact dosage based on the age and weight of the baby.

For vascular spasm, an effective combination will be Paracetamol, No-shpa and Suprastin. Paracetamol acts as an antipyretic medication. Suprastin, as an antihistamine, will relieve swelling from tissues, facilitate breathing and have a sedative effect. No-spa acts as a spasmodic agent that dilates blood vessels and provides full access of Paracetamol to the inflammatory process.

Some recommendations on the use of medicines

Many parents complain about why Paracetamol and Ibuprofen are ineffective in reducing fever in children. The effect of the drug depends on what caused the disease.

It is generally accepted that Paracetamol perfectly reduces fever if the patient has a viral infection. In this case, it is necessary to use syrup. Candles are used only if the temperature does not exceed 38 degrees and the fever is not caused by a bacterial or viral infection.

Nurofen suppositories are also not always effective, since parents do not comply with the prescribed dosage. Candles should be placed based on the child’s age.

Ibuprofen also has anti-inflammatory properties, which allows you to stop the inflammatory process and lower the temperature to normal levels.

But if a child’s illness is caused by a bacterial infection, then no antipyretics will help. In such a situation, mandatory use of antibiotics is required.

The combination of Analgin with Diphenhydramine and Papaverine is most often used in stationary conditions, when temperatures remain above 39.6 for several days.

Although the lytic mixture has such an antipyretic effect, its frequent use can lead to adverse effects. Analgin causes disturbances in blood composition and leads to the development of various defects. In addition, such an injection cannot be given if you have allergic reactions, chronic diseases and congenital defects.

The content of all content presented on the site is for educational and informational purposes only, aimed at giving visitors to the resource a clearer understanding of the prevention, symptoms and methods of treating colds. Be sure to consult your doctor.

Source: http://przab.ru/simptomy/temperatura/analgin-s-dimedrolom.html

Analgin with diphenhydramine at temperature

When your child or loved one develops a high temperature that does not respond to paracetamol, aspirin and other antipyretics, panic occurs. You don't know what to do.

In such cases, the best solution is to seek medical help. But often this is not possible.

In such cases, you should know that analgin is an antipyretic drug, which is much stronger than acetylsalicylic acid and paracetamol. A special effect is achieved by intramuscular injection of a proportional mixture of analine and diphenhydramine. This helps reduce high body temperature within minutes.

However, analgin as an antipyretic works best under three conditions:

  • if it is administered intramuscularly;
  • in combination with diphenhydramine;
  • in combination with papaverine.

It is for this reason that your home medicine cabinet should always contain:

  • five gram syringe;
  • five ampoules of papaverine hydrochloride;
  • five ampoules of analgin;
  • five ampoules of diphenhydramine.

Today, analgin with diphenhydramine at a temperature has a quick and safe effect. The high temperature decreases within 15 minutes after the injection. All that remains is to learn how to do analgin with diphenhydramine at a temperature correctly.

Parents must strictly follow the rules of asepsis and antiseptics. With intramuscular injection, there is a risk of subsequent abscess with suppuration of the subcutaneous layer and muscle fibers.

Dosage

Before making analgin with diphenhydramine, the dosage must be carefully calculated. For adults and children over 14 years of age, take 1 ampoule of analgin, diphenhydramine and papaverine. All medications are taken into one syringe.

For children, the dosage is calculated in a slightly different way. How to do this - see the attached table. If you make analgin with diphenhydramine yourself, the dosage is calculated based on:

  • child's age;
  • body weight of a child up to three years old;
  • severity of the condition.

Remember that the correctly selected dosage of analgin with diphenhydramine will help you quickly and efficiently provide assistance to your baby at a high temperature.

Is it possible to take paracetamol and analgin together?

If you take paracetamol and analgin at a high temperature, then it is only important to follow the correct dose. Analgin and paracetamol are not antagonists. They also do not enhance each other’s pharmacological effects on the human body.

Despite this, when choosing medications to reduce fever, take into account the substances that the person has taken up to this point. You should not take paracetamol, analgin and other types of anti-inflammatory drugs at the same time.

How does analgin help with fever?

In most cases, analgin helps with fever much more effectively than acetylsalicylic acid and paracetamol. This is due to the fact that analgin belongs to the pharmacological group of non-steroidal anti-inflammatory drugs. This allows analgin not only to reduce temperature, but also to have an anti-inflammatory effect.

How to give an injection correctly?

A small reminder will help you make the right injection of analgin with diphenhydramine:

  • before opening the ampoules, you need to warm them up to the patient’s body temperature;
  • before opening the ampoule should be treated with an alcohol solution;
  • You must first draw analgin into the syringe, then diphenhydramine;
  • the drug mixture should be administered slowly and carefully;
  • An injection of analgin with diphenhydramine is given only intramuscularly in the upper outer quadrant of the buttock.

If you have the opportunity, it is better to consult an emergency physician to provide medical assistance at a high temperature. Home injections should only be used as a last resort.

Lytic mixture: analgin + diphenhydramine + papaverine

Analgin most effectively reduces temperature as part of the so-called lytic mixture. It contains analgin papaverine and diphenhydramine. In this case, it will be correct if you take:

Naturally, this dosage is designed for adults and adolescents over 14 years of age.

Analgin with diphenhydramine should not be administered at a temperature more than once every 6 hours. If this measure does not help you bring down the high temperature, then you should immediately consult a doctor for adequate treatment.

How analgin lowers the temperature

The drug analgin brings down temperatures quite sharply. This should be taken into account during subsequent treatment of the patient. If your loved one has a body temperature above 39 degrees Celsius, then we recommend that you immediately after the injection of analgin with diphenhydramine give him to drink about half a liter of warm boiled water.

When the temperature drops sharply, dehydration may occur. This will lead to increased symptoms of intoxication.

Is it possible for children to take analgin with diphenhydramine?

If you want to use analgin with diphenhydramine, the dosage for children should be calculated based on their age and body weight. The calculation is shown in more detail in the following table.

Injection at fever analgin for children dose

What to drink for pain: analgin or no-spa

Analgin no-spa effectively relieves pain. However, their mechanism of action is completely different. No-spa is an antispasmodic agent. It helps with cramps. And analgin is a pain reliever.

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The material is published for informational purposes only and under no circumstances can it be considered a substitute for medical consultation with a specialist in a medical institution. The site administration is not responsible for the results of using the posted information. For questions of diagnosis and treatment, as well as prescribing medications and determining their dosage regimen, we recommend that you consult a doctor.

Source: http://sovdok.ru/?p=351

Papaverine - injections

Under the influence of the drug Papaverine, the smooth muscles of the internal organs relax, the blood vessels dilate, and the pain goes away. The drug is available in various forms, but Papaverine injections are characterized by a high degree of absorption and are distributed most quickly throughout the body. Combining it with other painkillers will help enhance the effect of the medicine.

Injections of the drug are the most commonly used pharmacological form. Simplicity of administration and rapidity of impact on the body allows you to achieve the desired effect almost instantly. Today, papaverine hydrochloride injections are often used together with other similar drugs.

Injection of Papaverine, Diphenhydramine and Analgin

This combination is a universal first aid remedy. The drugs are well compatible, and their use is not accompanied by side effects. Already fifteen minutes after the injection you can forget about the pain.

An injection of Analgin helps relieve pain by relaxing muscles, and the inclusion of Papaverine will reduce pressure due to the dilation of the arteries. Thanks to Analgin's antipyretic ability, this mix will help quickly bring down a high fever.

For therapeutic purposes, this combination is used to combat hypertensive crisis.

Papaverine with Diphenhydramine in the form of injections in combination with Analgin helps reduce the symptoms of acute gynecological, urological and surgical ailments.

The trio of drugs can be used at the initial stage of allergies in the event of systemic urticaria, Quincke's edema and anaphylactic shock, but they should not be used for permanent treatment.

How to give a Papaverine injection?

A combination of drugs is used in cases where conventional methods to bring down a temperature exceeding 38.5 degrees do not help. The medicine is administered intramuscularly. For children over 14 years of age and adults, the drugs are mixed in the following quantities:

Injections should be administered no more often than once every six hours.

Very often, this solution is administered to children to reduce fever. The dosage of the drug is then calculated based on age. For a year of life, take 0.1 ml of each drug. So, children aged two years will need:

Copying information is permitted only with a direct and indexed link to the source

Source: http://womanadvice.ru/papaverin-ukoly

Analgin with diphenhydramine: indications, contraindications and recommended dosage

If a child or an adult has a high temperature for a long time, no antipyretics help, then those around them, as a rule, panic - the loved one is “burning”, and no measures bring relief. Of course, the most reasonable thing in this situation would be to call an ambulance team, which will not only help alleviate the patient’s condition, but also assess his well-being and determine the advisability of placing the patient in a medical facility. What if calling a doctor or an ambulance is impossible? In this case, an injection of analgin with diphenhydramine will help cope with high body temperature. How to give this injection correctly, in what proportions the two medications should be combined and what is the dosage for adults and children - these questions will be answered in the material presented.

When to use analgin with diphenhydramine

Each medication instruction contains a section that provides information about possible combinations of medications. This combination can have an extremely negative impact on the patient’s condition, but in some cases, the simultaneous use of two drugs has a positive effect - the drugs simply complement each other and bring noticeable relief to the patient. These drugs are Analgin and Diphenhydramine.

Analgin is an analgesic drug that can be used as an anti-inflammatory and antipyretic agent. Diphenhydramine is an antihistamine, antiemetic and sedative.

The combination of these two medications is recommended by doctors not only in case of high fever, which does not subside on its own and does not respond to antipyretic drugs. Here are just some of the conditions in which the use of analgin with diphenhydramine is quite advisable:

  • renal and hepatic colic;
  • toothache (acute);
  • inflammatory processes in various organs and systems;
  • condition after injury - intense pain;
  • myalgia, joint pain, neuralgia;
  • condition after high degree burns;
  • recovery period after surgical interventions.

Analgin and diphenhydramine are available in different pharmacological forms - tablets, suppositories, injections, but it is the combination of solutions of the drugs in question that is most effective.

Please note: after administering a solution of analgin with diphenhydramine, the patient’s condition improves within 15 minutes - pain subsides, body temperature decreases. This is the fastest way to reduce even too high a temperature, but this measure is urgent, emergency and in no way curative.

It is worth knowing that the administration of analgin and diphenhydramine solutions is accompanied by dehydration. To prevent this, doctors recommend that the patient drink plenty of fluids - immediately after administering analgin with diphenhydramine, the patient needs to drink at least 500 ml of water.

Contraindications to the use of analgin with diphenhydramine

The drugs in question have many contraindications for use. But in combination they only enhance each other’s effects, so you need to be extremely careful about possible contraindications. So, the use of analgin solution with diphenhydramine is strictly contraindicated if the patient has previously been diagnosed with:

  • diabetes mellitus of any type;
  • renal failure, which is severe;
  • any blood pathologies;
  • bronchial asthma with frequent relapses;
  • diseases of the bladder, in particular – stenosis of the neck of this organ;
  • ophthalmic diseases - for example, glaucoma
  • liver failure occurring in a severe stage.

In addition, analgin with diphenhydramine is not used to provide emergency medical care to pregnant women, during breastfeeding and children under 12 months of age.

Please note: diphenhydramine has a powerful sedative effect, accompanied by increased drowsiness, therefore, when using this combination of drugs, you should avoid driving a vehicle and doing dangerous activities. It is strictly forbidden to drink alcoholic beverages when administering analgin with diphenhydramine - such a combination can provoke severe poisoning, even leading to the patient’s coma.

Dosage of analgin with diphenhydramine

Violation of the dosage of the drugs in question in the direction of increase can lead to convulsive syndrome and death of the patient . Therefore, you need to know how to correctly calculate the dose and be extremely careful when administering drugs to children.

Dosage of analgin with diphenhydramine for children

By the way, Analdim suppositories are recommended for use in childhood - this is a ready-made combination of the medications in question. Dosage of suppositories:

  • in children 1-4 years old - 100 milligrams once a day;
  • at the age of 4 years – 12 years – 1 time per day no more than 250 milligrams;
  • adolescents over 12 years of age - twice a day with suppositories.

If we talk about solutions for injections, the following dosage is recommended for children:

  • Analgin - at the rate of 10 milligrams of the drug per kilogram of the patient’s weight;
  • Diphenhydramine - at the rate of 0.41 milligrams for each year of the patient’s age.

The medications in question are drawn into one syringe and always in the sequence analgin-diphenhydramine. The drugs cannot be mixed/shaken in a syringe, but must be injected intramuscularly and very slowly.

Please note: papaverine is often added to the combination of analgin with diphenhydramine, but this can only be done as prescribed by a doctor.

Separately, it is worth mentioning the possible side effects that may appear when administering the medications in question:

  • nausea and vomiting – repeated, and vomiting does not bring relief;
  • cardiopalmus;
  • bowel dysfunction – there may be constipation or diarrhea;
  • severe sweating;
  • deterioration of blood counts - decreased hemoglobin levels, diagnosis of anemia.

In pediatric practice, the use of analgin with diphenhydramine is an emergency measure; it should be one-time and in no case permanent.

Dosage for adults

If the drugs in question are intended to be administered to adults, then the need to maintain a safe dosage does not disappear. It is generally accepted that it is advisable for adults to administer 0.3 ml of Analgin and 0.2 ml of Diphenhydramine once. The effect of this complex solution lasts 6 hours, so there is simply no point in injecting too often. In general, if after the administration of analgin with diphenhydramine there is no improvement in well-being after 30 minutes, then this is a reason to immediately seek qualified medical help.

It is advisable for adults to give preference to injections of analgin with diphenhydramine (although there are also tablet forms of these drugs), since with this administration the mucous membrane of the gastrointestinal tract, kidneys and liver are less exposed to stress.

Please note: if it is possible to improve the patient’s condition in other ways, then you should abandon analgin with diphenhydramine - these drugs are too aggressive in combination.

The administration of the analgin + diphenhydramine solution is carried out according to the standard scheme:

  • ampoules with drugs are wiped with alcohol and opened;
  • first, analgin is drawn into the syringe, then diphenhydramine;
  • You cannot shake the solution in the syringe;
  • the medicine is administered intramuscularly;
  • the rate of administration should be as slow as possible.

If the medications in question were administered, then after completion of treatment the patient must undergo a laboratory blood test, since its picture may change dramatically.

Analgin with diphenhydramine is a combination of solutions that will be effective for many pathological conditions. But it is worth remembering that such drugs must be administered either as prescribed by a doctor, or if it is impossible to seek qualified medical help. Be sure to follow the permitted dosages; the best option would be to consult a doctor before the need to use analgin with diphenhydramine occurs.

Tsygankova Yana Aleksandrovna, medical observer, therapist of the highest qualification category

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