Ciprofloxacin - instructions for use, reviews, analogs and release forms (tablets 250 mg, 500 mg and 750 mg, eye and ear drops 0.3%, solution for injections) of a drug for the treatment of infections in adults, children and pregnancy

In this article you can read the instructions for use of the drug Ciprofloxacin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Ciprofloxacin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Ciprofloxacin in the presence of existing structural analogues. Use for the treatment of infectious diseases of various organs and body systems in adults, children, as well as during pregnancy and lactation.

Ciprofloxacin is a broad-spectrum antimicrobial drug from the group of fluoroquinolones. Acts bactericidal. The drug inhibits the enzyme DNA gyrase of bacteria, as a result of which DNA replication and the synthesis of cellular proteins of bacteria are disrupted. Ciprofloxacin acts both on microorganisms that are reproducing and those in the resting phase.

Ciprofloxacin is active against gram-negative and gram-positive aerobic bacteria; intracellular pathogens: Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare. Most staphylococci resistant to methicillin are also resistant to ciprofloxacin.

Streptococcus pneumoniae and Enterococcus faecalis are moderately sensitive to the drug.

Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides are resistant to the drug.

The effect of the drug against Treponema pallidum has not been sufficiently studied.

Rapidly absorbed from the gastrointestinal tract. Food intake has little effect on the absorption of ciprofloxacin. Distributed in tissues and body fluids. Penetrates into the cerebrospinal fluid: concentrations of ciprofloxacin with non-inflamed meninges reach 10%, with inflamed meninges - up to 37%. High concentrations are achieved in bile. Excreted in urine and bile.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory tract;
• ear, nose and throat;
• kidneys and urinary tract;
• genital organs (including gonorrhea, prostatitis);
• gynecological (including adnexitis) and postpartum infections;
• digestive system (including the oral cavity, teeth, jaws);
• gallbladder and bile ducts;
• skin, mucous membranes and soft tissues;
• musculoskeletal system;
• sepsis;
• peritonitis;
• prevention and treatment of infections in patients with reduced immunity (during therapy with immunosuppressants).

For topical use:

• acute and subacute conjunctivitis;
• blepharoconjunctivitis;
• blepharitis;
• bacterial corneal ulcers;
• keratitis;
• keratoconjunctivitis;
• chronic dacryocystitis;
• meibomites;
• infectious eye lesions after injury or foreign bodies;
• preoperative prophylaxis in ophthalmic surgery.

Film-coated tablets 250 mg, 500 mg, 750 mg.

Eye and ear drops 0.3%.

Solution for intravenous administration (injections in injection ampoules) 2 mg/ml.

Instructions for use and dosage

The dose of Ciprofloxacin depends on the severity of the disease, type of infection, body condition, age, body weight and renal function of the patient.

For uncomplicated diseases of the kidneys and urinary tract - 250 mg, in complicated cases - 500 mg 2 times a day.

Diseases of the lower respiratory tract of moderate severity - 250 mg, in more severe cases - 500 mg 2 times a day.

For the treatment of gonorrhea, a single dose of Ciprofloxacin is recommended.

Gynecological diseases, enteritis and colitis with severe course and high temperature, prostatitis, osteomyelitis - 500 mg 2 times a day (for the treatment of banal diarrhea, you can use a dose of 250 mg 2 times a day).

The drug should be taken on an empty stomach with sufficient liquid.

Patients with severe renal impairment should be prescribed half the dose of the drug.

The duration of treatment depends on the severity of the disease, but treatment should always continue for at least two more days after the symptoms of the disease have disappeared. Usually the duration of treatment is 7-10 days.

The drug should be administered intravenously by drip over 30 minutes (dose 200 mg) and 60 minutes (dose 400 mg). The infusion solution can be combined with 0.9% sodium chloride solution, Ringer's solution, 5% and 10% dextrose (glucose) solution, 10% fructose solution, a solution containing 5% dextrose solution with 0.225% or 0.45% sodium chloride solution.

The dose of Ciprofloxacin depends on the severity of the disease, type of infection, body condition, age, weight and kidney function of the patient.

A single dose is 200 mg, for severe infections mg. Frequency of administration - 2 times a day; The duration of treatment is a week; if necessary, the course of treatment can be increased.

For acute gonorrhea, the drug is prescribed intravenously in a single dose of 100 mg.

To prevent postoperative infections - pre-surgery injection intravenously.

• nausea, vomiting;
• diarrhea;
• stomach ache;
• flatulence;
• anorexia;
• dizziness;
• headache;
• increased fatigue;
• anxiety;
• tremor;
• insomnia;
• "nightmare" dreams;
• peripheral paralgesia (anomaly in the perception of pain);
• sweating;
• increased intracranial pressure;
• depression;
• hallucinations;
• disturbances of taste and smell;
• visual impairment (diplopia, changes in color vision);
• noise in ears;
• hearing loss;
• tachycardia;
• heart rhythm disturbances;
• decrease in blood pressure;
• rushes of blood to the skin of the face;
• leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia;
• hematuria (blood in the urine);
• glomerulonephritis;
• urinary retention;
• arthralgia;
• tendon ruptures;
• myalgia;
• skin itching;
• hives;
• formation of blisters accompanied by bleeding;
• drug fever;
• pinpoint hemorrhages (petechiae);
• swelling of the face or larynx;
• dyspnea;
• increased photosensitivity;
• vasculitis;
• erythema nodosum;
• pain and burning at the injection site;
• general weakness;
• superinfections (candidiasis, pseudomembranous colitis).

• deficiency of glucose-6-phosphate dehydrogenase;
• pseudomembranous colitis;
• children under 18 years of age (until the process of skeletal formation is completed);
• pregnancy;
• lactation period (breastfeeding).

Use during pregnancy and breastfeeding

Ciprofloxacin is contraindicated for use during pregnancy and lactation (breastfeeding).

If severe and prolonged diarrhea occurs during or after treatment with Ciprofloxacin, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate discontinuation of the drug and the appointment of appropriate treatment.

During treatment with Ciprofloxacin, it is necessary to provide a sufficient amount of fluid while maintaining normal diuresis.

During treatment with Ciprofloxacin, contact with direct sunlight should be avoided.

With simultaneous intake of alcohol, the hepatotoxic effect of the drug increases.

Impact on the ability to drive vehicles and operate machinery

Patients taking Ciprofloxacin should be careful when driving a car and engaging in other potentially hazardous activities that require increased attention and speed of psychomotor reactions (especially when consuming alcohol at the same time).

When used simultaneously with non-steroidal anti-inflammatory drugs (with the exception of acetylsalicylic acid), the risk of developing seizures increases.

Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to reach the maximum concentration of the latter.

Co-administration of uricosuric drugs leads to a slower elimination (up to 50%) and an increase in plasma concentrations of ciprofloxacin.

When combined with other antimicrobial drugs (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed. Therefore, Ciprofloxacin can be successfully used in combination with azlocillin and ceftazidime for infections caused by Pseudomonas spp.; with mezlocillin, azlocillin and other beta-lactam antibiotics - for streptococcal infections; with isoxazolepenicillins and vancomycin - for staphylococcal infections; with metronidazole and clindamycin - for anaerobic infections.

Ciprofloxacin enhances the nephrotoxic effect of cyclosporine, and an increase in serum creatinine is also noted, so in such patients it is necessary to monitor this indicator 2 times a week.

When taken simultaneously, Ciprofloxacin enhances the effect of indirect anticoagulants.

The infusion solution of the drug is pharmaceutically incompatible with all infusion solutions and drugs that are physicochemically unstable in an acidic environment (pH of the ciprofloxacin infusion solution is 3.5-4.6). Do not mix the solution for intravenous administration with solutions having a pH greater than 7.

Analogues of the drug Ciprofloxacin

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/133-ciprofloksacin-po-primeneniyu-analogi-tabletki-kapli-glaznye-ushnye-rastvor-dlya-ukolov.html

Ciprofloxacin

Ciprofloxacin is an antibiotic that is used to treat bacterial infections. Ciprofloxacin stops the growth of bacteria by inhibiting reproduction and altering their genetics. The FDA approved ciprofloxacin in October 1987.

Ciprofloxacin belongs to the fluoroquinolone class, which includes levofloxacin (Levaquin), ofloxacin (Floxin), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), trovafloxacin (Trovan), and others.

Ciprofloxacin: instructions for use

Spelling errors - cicroproxotin.

Release forms and composition

Film-coated tablets

1 film-coated tablet contains:

Active ingredient: ciprofloxacin hydrochloride (in terms of ciprofloxacin) - 250, 500 or 750 mg.

Auxiliary components: starch 1500 (potato starch) or corn starch, lactose (milk sugar), magnesium stearate, crospovidone, MCC (microcrystalline cellulose), talc, hypromellose, croscarmellose sodium, colloidal anhydrous silicon dioxide, macrogol 6000, additive E171 (titanium dioxide ), polysorbate 80.

Shell: the content and number of components depend on the manufacturer.

Packaging: 10, 20, 30, 40, 50, 60 or 100 tablets.

Ear and eye drops 0.3%

Active ingredient: ciprofloxacin hydrochloride (in terms of ciprofloxacin) at a concentration of 3 mg per 1 ml of solution

Excipients: Trilon B, benzalkonium chloride, sodium chloride, purified water.

Bottles of 3 or 5 ml.

The ophthalmic ointment contains the active substance at a concentration of 3 mg/ml.

Solution for infusion

The active ingredient is ciprofloxacin hydrochloride (in terms of ciprofloxacin) - 2 mg per 1 ml of solution.

Excipients: sodium chloride, disodium edetate, lactic acid, diluted hydrochloric acid, water for injection.

Bottles of 100 ml.

Indications for use

Respiratory tract infections.

The use of ciprofloxacin is indicated for so-called difficult pathogens (for example, Klebsiella, Enterobacter, Proteus, Pseudomonas, Legionella, Staphylococcus, Escherichia coli).

Infections of the middle ear and paranasal sinuses, especially if they are caused by gram-negative pathogens, including Pseudomonas, or Staphylococcus.

Infections of the eyes, kidneys and (or) urinary tract, genital organs, including inflammation of the appendages, gonorrhea, prostatitis; infections of the abdominal cavity (for example, bacterial infections of the gastrointestinal tract, biliary tract, peritonitis), skin and soft tissues, bones and joints (for example, osteomyelitis), sepsis.

Treatment and prevention of threatening infections in patients with weakened protective functions of the body, for example, during treatment with immunosuppressive drugs or in patients with neutropenia.

Selective intestinal decontamination in patients receiving treatment with immunosuppressive drugs.

• Balanoposthitis
• Skin abscess, boil and carbuncle
• Retropharyngeal and parapharyngeal abscess
• Peritonsillar abscess
• Local infection of the skin and subcutaneous tissue
• Bronchitis
• Arthritis and polyarthritis
• Monoarthritis
• Bartholin gland diseases
• Eyeball diseases
• Otitis media
• Otitis externa
• Inflammation and blockage of the auditory (Eustachian) tube
• Purulent endophthalmitis
• Gonococcal infection
• Acute and gonococcal pharyngitis
• Inflammatory diseases of the uterus, cervix, prostate gland, male genital organs
• Posterior cyclitis
• Iridocyclitis
• Intestinal infections
• Impetigo
• Keratitis
• Mastoiditis and related conditions
• Orchitis and epididymitis
• Postpartum sepsis
• Bronchiolitis
• Laryngitis and tracheitis, acute and chronic
• Acute obstructive laryngitis [croup] and epiglottitis
• Prostatitis
• Myringitis
• Salpingitis and oophoritis
• Sinusitis
• Acute tonsillitis [tonsillitis], chronic tonsillitis
• Tubulointerstitial nephritis
• Osteomyelitis
• Peritonitis
• Chronic diseases of the tonsils and adenoids
• Urethritis and urethral syndrome
• Chlamydial conjunctivitis
• Typhoid and paratyphoid
• Phlegmon
• Chorioretinal inflammation
• Cholangitis
• Cholecystitis
• Episcleritis
• Diarrhea and gastroenteritis of suspected infectious origin
• Disseminated chorioretinal inflammation
• Cholelithiasis
• Cystitis
• Shigellosis

Pharmacodynamics

Ciprofloxacin, a synthetic derivative of 4-fluoroquinolone, inhibits bacterial DNA gyrase, which despirals sections of chromosomal DNA molecules, which is necessary for reading genetic information. The low toxicity of the drug for the cells of the macroorganism is explained by the absence of gyrases in them.

Ciprofloxacin is a broad-spectrum bactericidal antibacterial drug (primarily against gram-negative flora, in this regard it is close to aminoglycosides). On gram-positive microorganisms, ciprofloxacin has a bactericidal effect only during the division period, on gram-negative organisms - and during the dormant period, since it affects not only DNA gyrase, but also causes lysis of the cell wall.

Prevents the transcription of bacterial genetic material necessary for their normal metabolism. This leads to a rapid decrease in the ability of bacteria to divide. As a result of its action, there is no parallel development of resistance to other antibiotics that do not belong to the group of gyrase inhibitors, which makes it highly effective against bacteria that are resistant, for example, to aminoglycosides, penicillins, cephalosporins, tetracyclines and many other antibiotics.

The following pathogenic microorganisms are highly sensitive to ciprofloxacin: E. coli, Shigella, Salmonella, Citrobacter, Klebsiella, Enterobacter, Serratia, Hafnia, Edwardsiella, Proteus (indole-positive and indole-negative), Providencia, Morganella, Yersinia; Vibrio, Aeromonas, Plesiomonas, Pasteurella, Haemophilus, Campylobacter, Pseudomonas, Legionella, Neisseria, Moraxella, Acinobacter, Brucella; Staphylococcus, Listeria, Corynebacterium, Chlamydia. The following microorganisms are moderately susceptible to ciprofloxacin: Gardnerella, Flavobacterium, Alcaligenes, Streptococcus agalactiae, Enterococcus faecalis, Streptococcus pyogenes, Streptococcus pneumoniae, Viridans group of streptococci, Mycoplasma hominis, Mycobacterium tuberculosis and Mycobacterium fortuitum.

The following microorganisms are considered usually sensitive to ciprofloxacin: Enterococcus faecium, Ureaplasma urealyticum, Nocardia asteroides. With some exceptions, anaerobic microorganisms are moderately sensitive (eg, Peptococcus, Peptostreptococcus) or resistant (eg, Bacteroides) to ciprofloxacin. Ciprofloxacin is not effective against Treponema pallidum.

Resistance develops extremely slowly, since on the one hand, after its action there are practically no persistent microorganisms left, and on the other hand, bacterial cells do not have enzymes that inactivate it. No cross-resistance to other antimicrobial drugs was observed.

Pharmacokinetics

It is quickly absorbed after oral administration, well distributed in body tissues (excluding fat-rich tissue, such as nervous tissue), its volume of distribution is 2-3 l/kg, which is greatly facilitated by its low connection with blood plasma proteins (20-30 %) and the fact that at physiological blood pH values ​​it is in a non-ionized state.

Intracellular concentrations are quite high, which makes it more effective against intracellular bacteria (for example, Legionella). The drug is well absorbed (mainly in the small intestine), the percentage of its absorption reaches 70-80%.

The maximum concentration in blood plasma is created after a minute; the content of ciprofloxacin in tissues is 2-12 times higher than in plasma. The serum concentration of ciprofloxacin has a linear relationship with the dose taken.

The drug is practically not inactivated during the first passage through the liver and the degree of its bioavailability practically does not differ from the percentage of its absorption. The concentrations of ciprofloxacin detected in blood plasma exceed the MIC values ​​even for such multidrug-resistant bacteria as enterobacteria, Staphylococcus aureus and bacilli of blue-green pus.

When using ciprofloxacin, therapeutic concentrations are achieved in saliva, bile, intestines, abdominal and pelvic organs, kidneys and urinary organs, lung tissue, bronchial secretions, bone tissue, muscles, synovial fluid and articular cartilage, peritoneal fluid, skin. In cerebrospinal and intraocular fluids it is found in 10% concentration compared to plasma. Activity decreases slightly at acidic pH values. T1/2 - about 4 hours, from 50 to 70% is excreted unchanged by the kidneys (tubular filtration and tubular secretion), the rest - in the form of metabolites and through the intestinal wall.

In case of renal failure, the percentage of ciprofloxacin excreted through the kidneys decreases, but its accumulation in the body does not occur when creatinine clearance is above 20 ml/min, since in parallel with this there is an increase in the metabolism of ciprofloxacin and excretion in feces. With parenteral administration of ciprofloxacin, the percentage of it excreted unchanged by the kidneys is greater than after oral administration.

Dosage regimen

As a rule, treatment should be continued for at least 3 more days after the fever has subsided or clinical symptoms have disappeared.

Average duration of treatment:

• 1 day for acute uncomplicated gonorrhea and cystitis,
• up to 7 days for infections of the kidneys, urinary tract and abdominal cavity,
• during the entire period of the neutropenic phase in patients with weakened body defenses,
• no more than 2 months for osteomyelitis
• 7-14 days for all other infections.
• For streptococcal infections, due to the risk of late complications, as well as chlamydial infections, treatment should continue for at least 10 days.

For urinary tract infections

Prescribe 0.25-0.5 g 2 times/day; course of treatment days.

For uncomplicated gonorrhea

Prescribed in a dose of 0.25-0.6 g once; when a gonococcal infection is combined with chlamydial and mycoplasma, a dose of 0.75 g every 12 hours is indicated for 7-10 days.

0.5 g 2 times/day for several days.

For uncomplicated urinary tract and gastrointestinal infections

You can give a single daily dose of up to 0.6 g (orally).

With meningococcal carriage in the nasopharynx

Prescribed once in a dose of 0.5 or 0.75 g.

For chronic carriage of salmonella

Prescribed orally at 0.25 g 4 times or intravenously at 0.2 g 2 times a day; course of treatment - up to 4 weeks. If necessary, the dosage can be increased to 0.5 g 3 times a day.

For pneumonia and osteomyelitis

Prescribe 0.75 g orally or 0.2 g intravenously 2 times a day. The duration of treatment for osteomyelitis can be up to 2 months.

For gastrointestinal infections caused by Staphylococcus aureus

Prescribe 0.75 g every 12 hours for 7-28 days.

For severe infections (especially those caused by multidrug-resistant pathogens)

The drug should be administered intravenously in a single dose of 0.1-0.2 g; frequency of administration - 2 times/day. If intravenous treatment is necessary, for particularly severe, life-threatening or recurrent infections caused by Pseudomonas, staphylococci or Streptococcus pneumoniae, the dose can be increased to 0.4 g with a frequency of administration up to 3 times a day. If the glomerular filtration rate (GFR) is from 31 to 60 ml/min/1.73 sq.cm or the serum creatinine concentration is from 1.4 to 1.9 mg/100 ml, the maximum daily dose should be 1 g/day when administered orally and 0.8 g/day when administered intravenously. /in the introduction. When the glomerular filtration rate is below 30 ml/min/1.73 sq.cm or the serum creatinine concentration is above 2.0 mg/100 ml, the maximum daily dose should be 0.5 g/day for oral administration and 0.4 g/day for intravenous administration. If the patient is undergoing hemodialysis or peritoneal dialysis, the dose of the drug should be 0.25-0.5 g/day orally, but the drug should be taken after the hemodialysis session. For elderly patients, the dose should be reduced (usually by 1/3). For peritonitis, it is permissible to use intraperitoneal administration of ciprofloxacin infusion solutions.

For particularly dangerous infections

For example, for recurrent attacks of infection in patients with cystic fibrosis, infections of the abdominal cavity, bones and joints caused by Pseudomonas or staphylococci, acute pneumonia caused by Streptococcus pneumoniae, and chlamydial genitourinary infections, the dose should be increased to 0.75 g (orally) every 12 hours After IV use, you can continue treatment orally. The tablets should be swallowed whole with a small amount of liquid. They can be consumed regardless of meal time. If the tablets are taken on an empty stomach, the active substance is absorbed more quickly. IV use: infusion duration is 30 minutes at a dose of 0.2 g and 60 minutes at a dose of 0.4 g. Eye drops: for mild to moderately severe infection, 1-2 drops into the affected eye (or both eyes) every 4 hours; for severe infection - 2 drops every hour. If necessary, as directed by your doctor, a different dosage may be chosen. Infusion solutions are ready for use; if necessary, they can be combined with the following infusion solutions: physiological sodium chloride solution, Ringer's solution and lactated Ringer's solution, 5% and 10% glucose solution, 10% fructose solution, and 5% glucose solution containing 0.225 % NaCl or 0.45% NaCl.

Side effects

Long-term or repeated use of ciprofloxacin may lead to superinfection with resistant bacteria or yeasts.

Gastrointestinal Tract

Nausea, diarrhea, vomiting, dyspepsia, abdominal pain, flatulence, loss of appetite.

Central nervous system

Dizziness, headache, fatigue, anxiety, trembling; very rare: insomnia, peripheral paralgesia (anomaly in the perception of pain), sweating, increased intracranial pressure, anxiety, nightmares, confusion, depression, hallucinations, psychotic reactions (occasionally even progressing to states in which the patient may harm himself) , thrombosis of cerebral vessels.

Impaired taste and smell, visual disturbances (for example, diplopia or double vision, changes in color vision), tinnitus, temporary hearing impairment.

The cardiovascular system

Tachycardia; flushing, migraine, fainting.

Blood and blood components

Eosinophilia, leukocytopenia, granulocytopenia, anemia, thrombocytopenia; leukocytosis, thrombocytosis, hemolytic anemia, changes in prothrombin levels. Under the influence of the drug, a temporary increase in the level of transaminases, alkaline phosphatase, or cholestatic jaundice may occur, especially in patients with previous liver diseases; temporary increase in urinary creatinine or serum bilirubin; hyperglycemia, crystalluria or hematuria.

Organs of the urinary system

Crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, transient renal failure, interstitial nephritis.

Itching, drug fever.

When using eye drops

There may be a hypersensitivity reaction to the drug in the form of itching, burning, injection of the sclera; pinpoint skin hemorrhages (petechiae), blistering accompanied by bleeding, and small nodules that form scabs, as well as vasculitis; erythema nodosum, exudative erythema multiforme; Stevens-Johnson syndrome (malignant exudative erythema), Lyell's syndrome, hepatitis, liver necrosis. Anaphylactic and anaphylactoid reactions, for example, swelling of the face, blood vessels or larynx; dyspnea; joint pain, arthritis; general feeling of weakness, muscle pain, tendovaginitis, increased photosensitivity.

Contraindications

Pregnancy and lactation

Contraindicated during pregnancy and lactation.

Ciprofloxacin penetrates the placental barrier and is excreted in breast milk. Experimental studies have shown that it causes arthropathy.

Interaction

When administered together, ciprofloxacin increases the concentration of theophylline (and other xanthines, for example, caffeine), oral hypoglycemic drugs in the blood plasma and prolongs their T1/2 due to a slight decrease in the activity of microsomal oxidation processes in hepatocytes (the severity of this effect is weaker than that of cimetidine). For the same reason, the simultaneous administration of indirect anticoagulants and ciprofloxacin can increase the severity of the decrease in the prothrombin index.

The combination of very high doses of ciprofloxacin and some non-steroidal anti-inflammatory drugs (excluding acetylsalicylic acid) can cause seizures.

Oral administration together with iron-containing drugs, sucralfate and antacid drugs containing magnesium, aluminum and calcium ions leads to a decrease in its absorption, so ciprofloxacin should be given either 1-2 hours before or at least 4 hours after taking antacids.

Food also slows down the rate of absorption of ciprofloxacin, however, does not change its completeness, so that its peak concentration is observed approximately 30 minutes later than when taken on an empty stomach.

Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time until its maximum plasma concentration is reached.

When combined with other antimicrobial drugs, synergistic interactions are usually observed (beta-lactams, aminoglycosides, clindamycin, metronidazole): ciprofloxacin can be successfully used in combination with azlocillin and ceftazidime for infections caused by Pseudomas; with mezlocillin, azlocillin and other beta-lactam antibiotics - for streptococcal infections; with isoxazolepenicillins and vancomycin - for staphylococcal infections; with metronidazole and clindamycin - for anaerobic infections.

With the simultaneous use of ciprofloxacin and cyclosporine, an increase in serum creatinine is observed, so in such patients it is necessary to monitor this indicator 2 times a week.

When taken simultaneously with warfarin, an increase in the effect of warfarin is observed.

Ciprofloxacin infusion solution is incompatible with all infusion solutions and drugs that are physicochemically unstable at acidic pH (ciprofloxacin infusion solution pH 3.9-4.5). Do not mix the solution for intravenous administration with solutions having a pH greater than 7.

special instructions

The drug may affect reaction speed and reduce the ability to drive a car or operate complex machines (especially when ciprofloxacin and alcohol are used simultaneously).

Use with caution in patients with cerebral atherosclerosis, cerebrovascular accident, convulsive syndrome, due to the threat of adverse reactions from the central nervous system.

With simultaneous intravenous administration of ciprofloxacin and anesthetics from the group of barbituric acid derivatives, constant monitoring of heart rate, blood pressure, and ECG is necessary.

To avoid the development of crystalluria, it is unacceptable to exceed the recommended daily dose; sufficient fluid intake and maintaining an acidic urine reaction are necessary.

Eye drops cannot be used as injections.

Best before date

Film-coated tablets 250 mg - 5 years.

Film-coated tablets 500 mg - 5 years.

Film-coated tablets 750 mg - 5 years.

Film-coated tablets 250 mg - 2 years.

Eye drops 0.3% - 2 years. After opening - 1 month.

Solution for infusion 2 mg/ml - 2 years.

Analogs

• Aquacipro
• Alcipro
• Arflox
• Afenoxin
• Vero-Ciprofloxacin
• Zindolin
• Ificipro OD
• Ificipro
• Quintor
• Quipro
• Lyproquin
• Liproquin
• Medociprin
• Microflox
• Neofloxin
• Proxacin
• Procipro
• Recipro
• Syphlox
• Tacip
• Tseprova
• Tsefobak
• Ciloxane
• Ciplox
• Tsiprinol
• Tsiprobay
• Ciprobid
• Cyprobrine
• Tsiprova
• Ciprovin 250
• Tsiprodar
• Ciprodox
• Ciproquin
• Ciproxin
• Ciprolacare
• Tsiprolet
• Ciprolone
• Tsipromed
• Cypronate
• Cypropane
• Tsiprosan
• Tsiprosin
• Ciprosol
• Ciprofloxacin hydrochloride
• Ciprocinal
• Citeral
• Cyflozin
• Cifloxinal
• Tsiflosin
• Ciflocin
• Tsifran OD
• Tsifran

Reviews

I was prescribed Ciprofloxacin by my doctor for 5 days twice a day (every 12 hours). I didn't have any side effects, but it did make me feel worse.

This is my first time using ciprofloxacin. There were no side effects for the first 3 days. About 99% of UTIs went away and I experienced immediate relief within the first 24 hours. No problems with discomfort, only when urinating the color of the urine changed, no odor. I was hesitant to use it because of the side effects, but I'm glad I didn't experience any.

I had symptoms frequently - blood in my urine, pressure on my bladder, needing to pee every 10 seconds. After taking ciprofloxacin 500 mg twice, almost all the symptoms disappeared, but the side effects were terrible. I had nausea, headache, diarrhea, drowsiness and chest pain. The size of the tablet is kind of huge, so one day it got stuck in my throat.

This medicine is amazing. Ciprofloxacin solved three different urinary tract infections and cured them in one day, seriously.

I initially took amoxicillin for my UTI, but after 3 days I still had a fever, cloudy urine and general malaise. The doctor then prescribed ciprofloxacin. Wow. in less than 24 hours, the fever was gone and the urine was normal in color. My head cleared. The list of side effects is a little scary, but so far, no problems.

I'm on day 4 of 5 treatment so I can't say that the ciprofloxacin has eliminated the bacteria causing my infection, but I no longer have any symptoms of a urinary tract infection. Before I started taking it I had painful and frequent urination, fever and chills and these started to subside after the second pill, the fever and chills went away completely on the first day. I take 500 mg tablets twice a day. Luckily, I never experienced any side effects. I had a bad dream last night, but I wouldn't call it a nightmare.

I was prescribed 500 mg of ciprofloxacin twice a day for five days for my urinary tract infection. After one day (two doses), I honestly felt about 85% better. I was initially afraid to take it after reading horror stories about some of the possible side effects, but I'm glad I tried it. I have an allergy (anaphylaxis reaction) to penicillin, as this drug is (dare I say) a miracle cure for those who are allergic to penicillin.

It was a parade of stomach pains, but after taking it that day I felt much better.

I took ciprofloxacin (500 mg 2 times a day) to treat a bladder infection and the only side effect I got was drowsiness. After a few days of taking it, I made the mistake of reading reviews about the medicine and I was sure that it was slowly killing me. Well, I don't know, maybe some other side effects will come out in the future, but I can assure you that it really went away without any serious side effects. Conclusion - there are either a ton of people with their own psychomatics or I’m the only anomalous one.

I often suffer from urinary tract infections and since childhood, the only antibiotic that saved me was ciprofloxacin. I have never had any side effects.

Pregnancy progresses differently for each woman and each child, but being prepared for unpleasant sensations is half the battle won.

Continue reading “What is ciprofloxacin used for” →

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