What causes rhinitis tablets

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Rhinitis (tablets) instructions

Content

Indications

The main indications are:

  • functional dyspepsia;
  • duodenal disease;
  • peptic ulcer;
  • gastroesophageal disease or esophagitis;
  • chronic gastritis, especially in the acute stage.

Table of contents:

Contraindications

  • high sensitivity or allergy directly to ranitidine or the components of the drug;
  • malignant diseases in the stomach;
  • cirrhosis of the liver of a portosystemic nature;
  • lactation;
  • bearing a child;
  • children under 12 years old.

Directions for use and doses

Prescribed to children of a certain age and adults. Take it orally and do not chew it, as usual, wash it down with a small amount of liquid (water) at any time.

For duodenal disease and ulcers, the prescription is 150 mg twice a day or 300 mg immediately at night. Duration: administration for about 28 days, sometimes it can be more, especially for unhealed ulcers.

For functional dyspepsia, take 150 mg about 2 times a day for two or three weeks.

For chronic gastritis of acute stages, it is necessary to use 150 mg twice a day. Duration two to four weeks.

To relieve symptoms of reflux disease, 150 mg is prescribed twice a day for two weeks. You can continue the course for more than two weeks.

When reflux disease worsens, you can take 300 mg per day at night or 150 mg twice a day for about eight weeks. Treatment may take up to 12 weeks.

For renal failure, the dose of the drug per day is about 150 mg, that is, one tablet.

Source: http://03online.com/load/spravochnik_medicinskikh_prepparatov/r/rinit_tabletki/7

Rhinitis

Content

Pharmacological properties of the drug Rhinitis

Pharmacodynamics. Rhinitis is an H2-histamine receptor antagonist. By competitively reversibly binding to H2-histamine receptors of parietal cells of the gastric mucosa, it suppresses basal and stimulated secretion of hydrochloric acid and reduces the activity of pepsin, increasing the pH of the stomach contents. Reduces the volume of gastric juice caused by irritation of baroreceptors (gastric distension), food load, the action of hormones and biogenic stimulants (gastrin, histamine, pengastrin, caffeine). The duration of action of the drug after a single dose is about 12 hours.

Pharmacokinetics. Ranitidine is rapidly absorbed when taken orally. Absorption is independent of food intake. Cmax in blood plasma in the range of 300–500 mcg/ml is achieved 1–3 hours after oral administration of 150 mg of the drug. The bioavailability of ranitidine is 50%. The concentration of Rhinitis in the blood plasma is proportional to the dose taken. Plasma protein binding is 15%. Partially metabolized in the liver. The drug is eliminated primarily through urine (60–70% of the oral dose) and feces (26%). The half-life of the drug is 2–3 hours. About 30% of the oral dose is excreted unchanged.

Indications for use of the drug Rhinitis

Peptic ulcer of the stomach and duodenum in the absence of H. pylori or as a preventive treatment if eradication of H. pylori is impossible; gastroesophageal reflux disease (GERD); Zollinger-Ellison syndrome; chronic gastritis with increased acid-forming function of the stomach in the acute stage; non-ulcer dyspepsia.

Use of the drug Rhinitis

Peptic ulcer of the stomach in the absence of H. pylori or as a preventive treatment when eradication of H. pylori is impossible - 150 mg 2 times a day or 300 mg 1 time a day for 4–8 weeks.

Peptic ulcer of the duodenum in the absence of H. pylori or as a preventive treatment when eradication of H. pylori is impossible - 150 mg 2 times a day or 300 mg 1 time a day for 4–6 weeks.

GERD - 150 mg 4 times a day for 4–8 weeks. Maintenance therapy for GERD - 150 mg 1 time per day for up to 12 months.

Zollinger-Ellison syndrome - initial dose - 150 mg 4 times a day, if necessary, the dose can be increased. Dose selection is individual.

For patients with non-ulcer dyspepsia, a course of 150 mg 2 times a day or 300 mg 1 time a day for 2–4 weeks is recommended.

Chronic gastritis with increased acid-forming function of the stomach in the acute stage - 150 mg 2 times a day or 300 mg 1 time a day for 2-4 weeks.

In patients with severe kidney damage (creatinine clearance ≤50 ml/min), accumulation of ranitidine is possible. For such patients, the recommended dose is 150 mg once a day. For patients undergoing continuous ambulatory peritoneal dialysis or continuous hemodialysis, ranitidine (150 mg) should be administered immediately after the dialysis session.

Contraindications to the use of the drug Rhinitis

Hypersensitivity to the components of the drug; malignant diseases of the stomach; severe kidney and liver diseases, liver cirrhosis with a history of portosystemic encephalopathy; During pregnancy and breastfeeding; children under 14 years of age.

Side effects of the drug Rhinitis

headache and dizziness, drowsiness, anxiety, agitation. In some cases, hallucinations were noted, primarily in seriously ill and elderly patients. There have been several reports of reversible impairment of accommodation. They may experience dry mouth, constipation or diarrhea, nausea, vomiting, and abdominal pain. Reversible changes in laboratory parameters in liver function tests are possible. There are isolated reports of drug-induced jaundice and the possibility of developing acute pancreatitis.

Changes in the blood are usually reversible (leukopenia, thrombocytopenia, granulocytopenia, aplastic anemia). Isolated cases of agranulocytosis, pancytopenia, sometimes with bone marrow hypoplasia or aplasia have been reported.

When using ranitidine, arrhythmias (bradycardia or tachycardia, extrasystole) and atrioventricular blockade may develop. They can detect pain in joints and muscles, increased creatinine in the blood, increased prolactin levels, gynecomastia, amenorrhea, and alopecia.

Rarely allergic reactions: urticaria, angioedema, bronchospasm, anaphylactic shock, chest pain, arterial hypotension.

Special instructions for the use of the drug Rhinitis

At the beginning of treatment, it is necessary to exclude the possibility of the presence of malignant neoplasms of the stomach, since treatment with ranitidine may mask the symptoms of tumor development in the stomach.

In patients with severe kidney damage, the dose of the drug should be adjusted accordingly.

If the drug is quickly discontinued, rebound syndrome may develop, in which case gradual withdrawal of the drug is necessary. The drug should not be prescribed to patients with acute porphyria.

During pregnancy and breastfeeding. Ranitidine crosses the placenta and enters breast milk, so use during pregnancy is possible if absolutely necessary. If breastfeeding, the drug should be discontinued.

Drug interactions Rhinitis

Ranitidine does not suppress the activity of the liver enzyme system associated with cytochrome P450, so it does not potentiate the effect of drugs metabolized with the participation of this system (diazepam, lidocaine, phenytoin, propranolol, theophylline, warfarin).

When used with antacids, the break between taking antacids and Rhinitis should be at least 1-2 hours. When taking sucralfate in high doses (2 g) and ranitidine simultaneously, the absorption of the latter is reduced. The effect is not noticeable if sucrafalt is taken after a 2-hour interval.

Close monitoring of patients taking NSAIDs concomitantly with ranitidine is recommended, especially the elderly and patients with a history of peptic ulcers.

Drug overdose Rhinitis, symptoms and treatment

In case of overdose, it is necessary to rinse the stomach and carry out symptomatic therapy. If necessary, the drug can be removed from the blood plasma using hemodialysis.

Storage conditions for the drug Rhinit

In a dry place at a temperature not exceeding 25 °C.

Source: http://www.minclinic.ru/drugs/R/rinit.html

Rhinitis

Pharmacological properties

Pharmacodynamics

Rhinitis is an antagonist of H2 - histamine receptors. Competitively reversibly binding to H2 - histamine receptors of parietal cells of the gastric mucosa, it suppresses basal and stimulated secretion of hydrochloric acid and reduces the activity of pepsin, increasing the pH of the stomach contents. Reduces the volume of gastric juice caused by irritation of baroreceptors (gastric distension), food load, the action of hormones and biogenic stimulants (gastrin, histamine, pengastrin, caffeine). The duration of action of the drug after a single dose is about 12 hours.

Pharmacokinetics

Ranitidine is rapidly absorbed when taken orally. Absorption is independent of food intake. Cmax of 300–500 mcg/ml is achieved 1–3 hours after oral administration of 150 mg of the drug. The bioavailability of ranitidine is 50%. The concentration of Rhinitis in the blood plasma is proportional to the dose taken. Plasma protein binding is 15%. Partially metabolized in the liver. The drug is eliminated primarily through urine (60–70% of the oral dose) and feces (26%). The half-life of the drug is 2–3 hours. About 30% of the oral dose is excreted unchanged.

Indications

Peptic ulcer of the stomach and duodenum in the absence of H. pylori or as a preventive treatment if eradication of H. pylori is impossible; gastroesophageal reflux disease (GERD); Zollinger-Ellison syndrome; chronic gastritis with increased acid-forming function of the stomach in the acute stage; non-ulcer dyspepsia.

Application

Peptic ulcer of the stomach in the absence of H. pylori or as a preventive treatment when eradication of H. pylori is impossible - 150 mg 2 times a day or 300 mg 1 time a day for 4–8 weeks.

Peptic ulcer of the duodenum in the absence of H. pylori or as a preventive treatment when eradication of H. pylori is impossible - 150 mg 2 times a day or 300 mg 1 time a day for 4–6 weeks.

GERD - 150 mg 4 times a day for 4–8 weeks. Maintenance therapy for GERD - 150 mg 1 time per day for up to 12 months.

Zollinger-Ellison syndrome - initial dose - 150 mg 4 times a day, if necessary, the dose can be increased. Dose selection is individual.

For patients with non-ulcer dyspepsia, a course of 150 mg 2 times a day or 300 mg 1 time a day for 2–4 weeks is recommended.

Chronic gastritis with increased acid-forming function of the stomach in the acute stage - 150 mg 2 times a day or 300 mg 1 time a day for 2-4 weeks.

In patients with severe kidney damage (creatinine clearance ≤50 ml/min), accumulation of ranitidine is possible. For such patients, the recommended dose is 150 mg once a day. For patients undergoing continuous ambulatory peritoneal dialysis or continuous hemodialysis, ranitidine (150 mg) should be administered immediately after the dialysis session.

Contraindications

Hypersensitivity to the components of the drug; malignant diseases of the stomach; severe kidney and liver diseases, liver cirrhosis with a history of portosystemic encephalopathy; During pregnancy and breastfeeding; children under 14 years of age.

Side effects

Headache and dizziness, drowsiness, anxiety, agitation. In some cases, hallucinations were noted, primarily in seriously ill and elderly patients. There have been several reports of reversible impairment of accommodation. They may experience dry mouth, constipation or diarrhea, nausea, vomiting, and abdominal pain. Reversible changes in laboratory parameters in liver function tests are possible. There are isolated reports of drug-induced jaundice and the possibility of developing acute pancreatitis.

Changes in the blood are usually reversible (leukopenia, thrombocytopenia, granulocytopenia, aplastic anemia). Isolated cases of agranulocytosis, pancytopenia, sometimes with bone marrow hypoplasia or aplasia have been reported.

When using ranitidine, arrhythmias (bradycardia or tachycardia, extrasystole) and atrioventricular blockade may develop. They can detect pain in joints and muscles, increased creatinine in the blood, increased prolactin levels, gynecomastia, amenorrhea, and alopecia.

Rarely allergic reactions: urticaria, angioedema, bronchospasm, anaphylactic shock, chest pain, arterial hypotension.

special instructions

At the beginning of treatment, it is necessary to exclude the possibility of the presence of malignant neoplasms of the stomach, since treatment with ranitidine may mask the symptoms of tumor development in the stomach.

In patients with severe kidney damage, the dose of the drug should be adjusted accordingly.

If the drug is quickly discontinued, rebound syndrome may develop, in which case gradual withdrawal of the drug is necessary. The drug should not be prescribed to patients with acute porphyria.

During pregnancy and breastfeeding. Ranitidine crosses the placenta and enters breast milk, so use during pregnancy is possible if absolutely necessary. If breastfeeding, the drug should be discontinued.

Interactions

Ranitidine does not suppress the activity of the liver enzyme system associated with cytochrome P450, so it does not potentiate the effect of drugs metabolized with the participation of this system (diazepam, lidocaine, phenytoin, propranolol, theophylline, warfarin).

When used with antacids, the break between taking antacids and Rhinitis should be at least 1-2 hours. When taking sucralfate in high doses (2 g) and ranitidine simultaneously, the absorption of the latter is reduced. The effect is not noticeable if sucrafalt is taken after a 2-hour interval.

Close monitoring of patients taking NSAIDs concomitantly with ranitidine is recommended, especially the elderly and patients with a history of peptic ulcers.

Overdose

In case of overdose, it is necessary to rinse the stomach and carry out symptomatic therapy. If necessary, the drug can be removed from the blood plasma using hemodialysis.

Storage conditions

In a dry place at a temperature not exceeding 25 °C.

Source: http://it-apharm.ru/rinit.html

Tablets Rhinitis: indications for use of the medicine, instructions for treatment

Not everyone knows that rhinitis can be treated with tablets. Of course, a more effective therapy is considered to be targeting a specific affected area using topical sprays.

Despite the fact that the disease is most often treated with nasal drops and aerosols, there is a treatment method using tablet medications.

What tablets treat rhinitis

Before choosing a medicine and purchasing tablets, you need to find out the cause of the disease in order to begin proper treatment.

A doctor’s testimony is also necessary, but it is better not to self-medicate so as not to cause complications from the wrong type of therapy.

Today, modern medicine offers several types of medications that effectively treat rhinitis and eliminate the symptoms of the disease.

  • Anti-inflammatory and antihistamine drugs neutralize the allergic reaction and treat rhinitis.
  • Antibiotics destroy almost all pathogenic microorganisms in the nasopharynx area.
  • Homeopathic medicine strengthens the body, helps to increase the level of interferon in the blood, which triggers the protective immune mechanism.
  • The antiviral medicine kills numerous viruses in colds.

In general, there are no tablets that directly eliminate rhinitis. On sale you can only find medicines that eliminate the symptoms of allergies, flu, colds, ARVI in the form of a runny nose and other symptoms.

There are also no universal remedies among homeopathic medicines, but, as is known, homeopathy deals with the treatment of the general condition of the body, therefore, after studying the picture of the disease, the doctor can prescribe the necessary medications.

Below is information with photos about the most effective and popular tablets that treat rhinitis and related symptoms. The price of drugs depends on the manufacturer.

Antiviral tablets for runny nose and colds

As you know, a disease such as rhinitis is an inflammation of the nasal mucosa caused by a variety of reasons.

One of these reasons may be the common cold, which usually causes a profuse runny nose. To prevent the formation of an inflammatory process, you need to follow the doctor’s indications and take pills.

Most often, a runny nose is accompanied by severe sore throat, fever, body aches, and cough. Therefore, when the first signs of a cold appear, an antiviral medicine is used to stop excessive nasal discharge.

It is important to begin treatment immediately after cold symptoms appear. Only at the initial stage of the disease can antiviral tablets effectively stop the inflammatory process and avoid the development of complications.

Antiviral tablets such as Arbidol, Remantadine and Tamiflu have proven themselves to be very effective. This medicine not only treats rhinitis, but is also an effective preventative against seasonal colds and flu.

  1. Arbidol tablets are the most popular among consumers; this drug effectively relieves cold symptoms in the first two days after the onset of the disease. Contraindications include increased hypersensitivity to the drug and age under two years.
  2. The drugs Tamiflu and Remantadine help in the early stages of the disease, but they are contraindicated in children under one year of age.
  3. The drug Isoprinosine stimulates the production of interferon, which suppresses viral infections. Groprinosin is considered a similar remedy.
  4. The drug Polyoxidonium is considered an equally effective immunomodulator.

It is important to understand that antiviral tablets do not cure rhinitis, but only help alleviate the patient’s general condition and relieve the main symptoms of a cold. Also, the drugs cannot affect all types of modern viruses, so they may be useless in treatment.

Vasoconstrictor tablets for rhinitis

Tablets such as Coldact, Rinza, Coldrex and other medications help get rid of a severe runny nose thanks to the active ingredient phenylephrine, which is found in these medications.

The active substance constricts blood vessels and increases pressure, due to which the swelling of the mucous membrane in the nose disappears and the patient can breathe freely.

However, such tablets can only be used in emergency cases, since they have a one-time effect on the body.

The medicine is contraindicated for people with diseases of the cardiovascular system, since the amount of the active substance in the drug exceeds the permissible dosage.

In this case, the effect of phenylephrine occurs on all internal organs.

Homeopathic tablets for rhinitis

In addition to traditional medications, rhinitis is treated with homeopathic medicines, which are produced using natural herbal ingredients.

Such drugs have a positive effect on the body and do not cause harm due to the fact that a minimal amount of the drug is used.

Among homeopathic remedies, Corizalia tablets are very popular, which can cure rhinitis. The medicine contains such natural ingredients as:

  • Dream-grass;
  • Belladonna;
  • Onion juice;
  • Virginia jasmine;
  • Kalium bichromicum;
  • Schenokaulon.

According to the instructions for use, treatment with a homeopathic remedy should not exceed five days. The best therapeutic effect is achieved at the initial stage of the disease. The drug is contraindicated in the presence of individual sensitivity to plant substances. Corizalia tablets are also diluted with water for ease of use.

If viscous secretions form in the nasal passages, it is recommended to use homeopathic Sinupret tablets. They include primrose flowers, elderberry, gentian root, verbena, and sorrel.

The natural medicinal product thins mucus, relieves swelling of the mucous membrane, eliminates nasal congestion, and also strengthens the immune system. The drug is taken for one to two weeks.

Rhinitis is also effectively treated with Cinnabsin tablets, which can be used for the chronic form of the disease. The medicine contains echinacea extract, mercury sulfide, kalium bichromicum, and Canadian hemp. The homeopathic remedy is especially good at preventing relapse, including its use during exacerbation of the disease.

Echinacea extract, which is part of the medicine, strengthens the immune system and strengthens the body.

If rhinitis is caused by allergies

Antiviral drugs will not be effective if the cause of the disease is an allergic reaction. Therefore, it is necessary to know what medications are used for allergic rhinitis.

  1. Severe allergic rhinitis is treated with antihistamines. These include drugs such as Zyrtec, Claridol, Cetrin, Claritin, Clarotadine, Letizen, Analergin and many others. It is important to consult with your doctor before using them and find out exactly the cause of your symptoms.
  2. For mild allergic rhinitis, it is recommended to use Zodak and Cetrin, which have a gentle effect on the body without causing serious side effects. Such drugs do not have a depressing effect on the psyche, do not cause drowsiness or lethargy, and have a minimum of contraindications. They are taken one tablet once a day; they are also often used as a quick aid when allergies occur.
  3. If the patient has the most severe form of rhinitis, the doctor prescribes Diazolin tablets three times a day. It is important to understand that this medicine should not be taken as an emergency measure. The drug depresses the central nervous system and is able to penetrate the placenta. Of all the forms of this medicine, tablets have the gentlest effect on the body.

The most powerful medicine for rhinitis and allergic rhinitis is the drug Erius, which is prescribed to be taken if the patient has a serious condition.

Treatment with hormonal drugs

In severe cases of rhinitis, your doctor may prescribe hormone therapy. Such treatment is prescribed only if other methods are ineffective.

It is necessary to understand that hormonal therapy has numerous side effects, disrupts hormonal levels, and it is difficult to predict in advance whether such treatment will help.

Since hormonal pills can destroy the immune system, they should not be taken for a long time. During hormonal treatment, therapy should not be stopped infrequently.

To begin with, you should reduce the dosage, and only after some time you can completely stop taking the medication. Otherwise, a sudden refusal to take medications can disrupt the performance of the entire body and cause numerous diseases.

Treatment with systemic corticosteroids

The last hope for treating rhinitis is systemic corticosteroids. They have a powerful healing effect, the symptoms of the disease can be completely eliminated and quality breathing is restored.

However, such drugs have pronounced side effects, so before using the drugs you should carefully weigh the pros and cons. Treatment is carried out only under the supervision of the attending physician.

Use of immune therapy

If the medications taken do not have the desired effect on the body for a long time and relief does not occur for a long time, the doctor may prescribe immune therapy for allergic rhinitis.

Treatment consists of introducing a very strong dosage of the allergen into the patient’s body. This helps the immune system produce sufficient amounts of antibodies.

If this method helps, the allergic runny nose disappears completely. After this, the patient can safely return to normal life.

Using a therapeutic diet

A therapeutic diet can alleviate the patient’s general condition and strengthen the immune system. The diet should include foods rich in vitamin E, which helps increase the body's resistance to harmful microorganisms.

It is necessary to eat plenty of fruits, vegetables and juices every day. All foods that provoke exacerbations of allergic rhinitis should be excluded from the menu. In particular, you need to minimize the amount of carbonated drinks, spices and dairy products.

In the video in this article, a specialist will talk about choosing medications for a runny nose.

Source: http://stopgripp.ru/bolezn/rhinitis/rinit-tabletki-pokazaniya-k-primeneniyu.html

Rhinitis (ranitidine) instructions:

Manufacturer:

Active ingredient: Rhinitis

Release forms of Rhinitis

Who is Rhinitis indicated for?

  • Peptic ulcer of the stomach and duodenum in the absence of H. pylori or when it is impossible to eradicate H. pylori as a preventive treatment;
  • GERD (gastroesophageal reflux disease);
  • Zollinger-Ellison syndrome;
  • chronic gastritis with increased acid-forming function of the stomach in the acute stage;
  • non-ulcer dyspepsia.

How to use Rhinitis

Method of administration and dose.

Adults.

Peptic ulcer of the stomach in the absence of H. pylori or as a preventive treatment if it is impossible to eradicate H. pylori - 150 mg 2 times a day or 300 mg 1 time a day for weeks. Peptic ulcer of the duodenum in the absence of H. pylori or as a preventive treatment if eradication of H. pylori is impossible - 150 mg 2 times a day or 300 mg 1 time a day for 4 - 6 weeks.

Gastroesophageal reflux disease (GERD) – 150 mg 4 times a day of the week. Maintenance therapy for HERH – 150 mg 1 time per day for up to 12 months.

Zollinger-Ellison syndrome - the initial dose is 150 mg 4 times a day, but if necessary, the dose can be increased. Dose selection is individual.

For patients with non-ulcer dyspepsia, a course of 150 mg 2 times a day for a week or 300 mg 1 time a day is recommended.

Chronic gastritis with increased acid-forming function of the stomach in the acute stage - 150 mg 2 times a day for a week or 300 mg 1 time a day.

Kidney failure

In patients with severe kidney damage (creatinine clearance less than 50 ml/min), accumulation of ranitidine is possible. For such patients, a dose of 150 mg once a day is recommended.

For patients undergoing continuous ambulatory peritoneal dialysis or continuous hemodialysis, ranitidine (150 mg) should be administered immediately after the dialysis session.

Features of application.

Before starting treatment, it is necessary to exclude the possibility of the presence of malignant neoplasms of the stomach, since treatment with ranitidine may mask the symptoms of tumor development in the stomach.

Ranitidine is excreted by the kidneys, so plasma levels of the drug increase in patients with severe kidney damage. The dose of the drug for such patients should be adjusted accordingly.

In case of immediate discontinuation of the drug, rebound syndrome may develop. If it is necessary to discontinue the drug, this should be done gradually.

The drug should not be prescribed to patients with acute porphyria.

Pregnancy and lactation period.

Ranitidine passes through the placenta and enters a woman's breast milk. Like other medications, it should only be used during pregnancy if absolutely necessary. When breastfeeding children, you should stop taking the drug.

Side Effects of Rhinitis

A small proportion of patients experienced headache and dizziness, drowsiness, anxiety, and agitation. There are reports of isolated cases of hallucinations, primarily in seriously ill and elderly patients. There have been several reports of reversible blurring of vision, possibly due to changes in ocular accommodation.

Dry mouth, constipation or diarrhea, nausea, vomiting, and abdominal pain may occur.

Reversible changes in laboratory parameters in liver function tests are possible. There are isolated reports of hepatitis (with or without jaundice), usually negotiable.

The possibility of developing acute pancreatitis has been reported.

Changes in the blood, usually reversible (leukopenia, thrombocytopenia, granulocytopenia, applastic anemia) occurred in some patients.

Individual cases of agranulocytosis or pancytopenia, sometimes with bone marrow hypoplasia or aplasia, have been reported.

As is the case with other H2 receptor antagonists, and with the use of ranitidine, there are isolated reports of the possible development of arrhythmias (bradycardia or tachycardia, extrasystole), and atrioventricular block. There have been reports of joint and muscle pain.

Increases in blood cretinin, increases in prolactin levels, gynecomastia, amenorrhea, and alopecia may be observed.

Allergic reactions are rarely possible: urticaria, angioedema, bronchospasm, anaphylactic shock, chest pain, arterial hypotension.

Who is contraindicated for Rhinitis?

  • Hypersensitivity to the components of the drug.
  • The presence of malignant diseases of the stomach.
  • Severe kidney and liver diseases, liver cirrhosis, with a history of portosystemic encephalopathy.
  • Periods of pregnancy and lactation.
  • Children's age (up to 14 years).

Rhinitis interaction

When using standard recommended doses of ranitidine, the drug does not affect cytochrome P450, which is associated with the functional oxidative system in the liver. Accordingly, ranitidine in generally accepted therapeutic doses does not potentiate the effect of drugs that are inactivated by this enzyme, this applies to diazepam, lignocaine, phenotoin, propranolol, theophylline and warfarin.

When used simultaneously with an antacid, the interval between taking the antacid and Rhinitis should be at least 1-2 hours.

With the simultaneous use of large doses of sucralfate (2 g) and ranitidine, the absorption of the latter may be reduced. The effect is not noticeable if sucrafalt is taken after a 2-hour interval. Close monitoring of patients taking non-steroidal anti-inflammatory drugs concomitantly with ranitidine is recommended, especially the elderly and patients with a history of peptic ulcers.

Rhinitis overdose

There are no data regarding life-threatening consequences of overdose.

In case of overdose, it is necessary to rinse the stomach and carry out symptomatic therapy.

If necessary, drugs can be removed from the plasma by hemodialysis.

Rhinitis (ranitidine) analogs:

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Rhinitis tablets, 150 mg No. 10

Dosage form: Tablets

Compound

active ingredient: ranitidine;

1 tablet contains ranitidine hydrochloride, which is equivalent to ranitidine 150 mg;

excipients: microcrystalline cellulose, croscarmellose sodium, magnesium stearate, Opadry II 85G53691 orange coating: polyvinyl alcohol, lecithin, polyethylene glycol, talc, titanium dioxide (E 171), ponceau 4R (E 124), sunset yellow FCF (E 110), indigo carmine (E 132).

Dosage form

Film-coated tablets.

Pharmacotherapeutic group

Medicines for the treatment of peptic ulcers and gastroesophageal reflux disease.

ATS code A02B A02.

Indications

  • Peptic ulcer of the stomach and duodenum not associated with Helicobacter pylori (in the acute phase), including ulcers associated with taking non-steroidal anti-inflammatory drugs (NSAIDs);
  • functional dyspepsia;
  • chronic gastritis with increased acid-producing function of the stomach in the acute stage;
  • gastroesophageal reflux disease (to relieve symptoms) or reflux esophagitis.

Contraindications

Increased individual sensitivity to ranitidine or other components of the drug; the presence of malignant diseases of the stomach, cirrhosis of the liver with a history of portosystemic encephalopathy; pregnancy, breastfeeding period, children under 12 years of age.

Directions for use and doses

Prescribed to adults and children over 12 years of age. Take orally, without chewing, with a small amount of water, regardless of meals.

Peptic ulcer of the stomach and duodenum, not associated with Helicobacter pylori (in the acute phase). Prescribed 150 mg (1 tablet) 2 times a day or 300 mg

(2 tablets) 1 time per day at night for 4 weeks. For ulcers that have not healed, continue treatment for the next 4 weeks.

Prevention of peptic ulcers of the stomach and duodenum associated with the use of non-steroidal anti-inflammatory drugs. Prescribe 150 mg (1 tablet) 2 times a day for the period of NSAID therapy.

Functional dyspepsia. Prescribe 150 mg (1 tablet) 2 times a day for

Chronic gastritis with increased acid-removing function of the stomach in the acute stage. Prescribe 150 mg (1 tablet) 2 times a day for 2-4 weeks.

Gastroesophageal reflux disease. To relieve symptoms, prescribe 150 mg (1 tablet) 2 times a day for 2 weeks; if necessary, the course of treatment is continued.

For long-term treatment and for exacerbation of gastroesophageal reflux disease, 150 mg (1 tablet) 2 times a day or 300 mg (2 tablets) 1 time a day at night is prescribed for 8 weeks; if necessary, the course of treatment is extended to 12 weeks.

Patients with severe renal failure (creatinine clearance <50 ml/min). The daily dose of the drug for this category of patients is 1 tablet (150 mg).

Adverse reactions

Cardiac disorders: bradycardia, tachycardia, extrasystole, asystole, atrioventricular block, decreased blood pressure, arrhythmia.

Disorders of the blood and lymphatic system: leukopenia and thrombocytopenia (usually reversible); agranulocytosis or pancytopenia, sometimes with bone marrow hypoplasia or aplasia, neutropenia.

Neurological disorders: headache, dizziness, drowsiness, involuntary movements (reverse),

excitement, feeling tired.

Violations of the organ of vision: blurred vision, blurred vision, associated with impaired accommodation.

Gastrointestinal disorders: diarrhea, constipation, nausea, vomiting, abdominal pain, acute pancreatitis, lack of appetite, flatulence, dry mouth.

Disorders of the urinary system: acute interstitial nephritis, impaired renal function.

Changes in the skin and subcutaneous tissue: skin rash, erythema multiforme, alopecia, dry skin, itching.

Disorders of the musculoskeletal system and connective tissue: arthralgia, myalgia.

Vascular disorders: vasculitis.

Immune system disorders: hypersensitivity reactions (urticaria, angioedema, fever, bronchospasm, hypotension, chest pain), anaphylactic shock.

Disorders of the hepatobiliary system: transient and reversible changes in the level of certain laboratory parameters (transaminases, gammaglutamyltransferase, alkaline phosphatase, bilirubin); hepatitis (hepatocellular, cholestatic or mixed hepatitis) with or without jaundice (usually reversible).

Disorders of the reproductive system and mammary glands: reversible impotence, decreased libido, gynecomastia and galactorrhea.

Mental disorders: reversible mental disorders (hallucinations, disorientation, confusion, anxiety and restlessness, depression), mainly in elderly and seriously ill patients.

Overdose

Symptoms: increased adverse reactions.

Treatment: provide symptomatic and supportive therapy.

Use during pregnancy or breastfeeding

The drug is contraindicated during pregnancy. If it is necessary to use the drug for the period of treatment, you must stop breastfeeding.

For children over the age of 12 years, the use of the drug is indicated to reduce the treatment time for peptic ulcers of the stomach and duodenum, for the treatment of gastroesophageal reflux disease, including reflux esophagitis, and to alleviate the symptoms of gastroesophageal reflux disease.

Features of application

If you are allergic to other drugs in the group of histamine H2 receptor blockers, allergic reactions to ranitidine are possible, so if you have hypersensitivity to other drugs in this group, you should use the drug with caution.

The drug should be used with caution in cases of acute porphyria (including a history of) and immunodeficiency.

Ranitidine is excreted by the kidneys, so its plasma levels are elevated in patients with severe renal impairment (see dosage for such patients in the Dosage and Administration section).

In elderly patients with impaired liver or kidney function, a disturbance (confusion) of consciousness may occur, necessitating a dose reduction.

Treatment with the drug may mask the symptoms of gastric carcinoma, so before starting treatment, the presence of malignant neoplasms in the stomach should be excluded.

Regular monitoring of patients (especially elderly patients and those with a history of peptic ulcer of the stomach and/or duodenum) who take ranitidine together with non-steroidal anti-inflammatory drugs is necessary.

An increased tendency to develop community-acquired pneumonia was observed in elderly patients, persons with chronic lung diseases, diabetes mellitus, or those with weakened immune systems.

During simultaneous treatment with theophylline, it is necessary to monitor the plasma level of theophylline and adjust the dosage.

Treatment with the drug is discontinued gradually due to the risk of developing rebound syndrome with abrupt withdrawal.

The ability to influence the reaction rate when driving a vehicle or working with other mechanisms

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction with other drugs and other types of interactions

Ranitidine may affect the absorption, metabolism and renal excretion of other drugs.

Ranitidine in therapeutic doses does not change the activity of the cytochrome P450 enzyme system and does not potentiate the effect of drugs that are metabolized by this system (diazepam, lidocaine, phenytoin, propranolol, theophylline, etc.).

Ranitidine, by changing gastric acidity, may affect the bioavailability of certain drugs. This leads to either an increase in their absorption (triazolam, midazolam, glipizide) or a decrease in their absorption (ketoconazole, itraconazole, atazanavir, gefitinib).

Antacids and sucralfate slow down the absorption of ranitidine, as a result of which the interval between taking these medications and ranitidine should be at least 1-2 hours.

Concomitant use with metoprolol may lead to an increase in the concentration of metoprolol in the blood serum.

Ranitidine, when used concomitantly with coumarin anticoagulants (warfarin), may alter prothrombin time (monitoring of prothrombin time is recommended).

High doses of ranitidine may slow down the excretion of procainamide and N-acetylprocainamide, leading to an increase in their plasma levels.

There are no data on interactions between ranitidine and amoxicillin or metronidazole.

Pharmacological properties

Ranitidine is an H2 - histamine receptor antagonist. Competitively reversibly binding to H2 - histamine receptors of parietal cells of the gastric mucosa, it suppresses basal and stimulated secretion of hydrochloric acid and reduces the activity of pepsin, increasing the pH of the stomach contents. Reduces the volume of gastric juice caused by irritation of baroreceptors (gastric distension), food load, the action of hormones and biogenic stimulants (gastrin, histamine, pengastrin, caffeine). The duration of action of the drug after a single use is approximately 12 hours.

Ranitidine is rapidly absorbed when taken orally. Absorption is independent of food intake. Peak plasma concentrations, in the range of μg/ml, are achieved 1-3 hours after oral administration of 150 mg of the drug. The bioavailability of ranitidine is 50%. The concentration of ranitidine in plasma is proportional to the dose taken. Plasma protein binding is 15%. Partially metabolized in the liver.

The drug is excreted primarily by the kidneys (60-70% of the oral dose) and 26% in the feces. The half-life is 2-3 hours. Approximately 30% of the oral dose is excreted unchanged.

Basic physical and chemical properties

round, biconvex, orange film-coated tablets.

Best before date

Storage conditions

Store at a temperature not exceeding 25 °C in a dry place, protected from light and out of reach of children.

Package

10 tablets per strip, 10 strips per cardboard box.

Vacation category

Manufacturer

KUSUM HEALTHKER PVT. LTD.

Location

SP 289 (A), RIIKO Indl. Area, Chopanki, Bhiwadi (Raj), India.

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Rhinitis

Price: from 52.60 UAH Available in 3 pharmacies Rating:

About the drug:

Ranitidine is an H2-histamine receptor antagonist. By competitively reversibly binding to H2-histamine receptors of parietal cells of the gastric mucosa, it suppresses basal and stimulated secretion of hydrochloric acid and reduces the activity of pepsin, increasing the pH of the stomach contents. Reduces the volume of gastric juice caused by irritation of baroreceptors (gastric distension), food load, the action of hormones and biogenic stimulants (gastrin, histamine, pengastrin, caffeine).

Indications and dosage:

Peptic ulcer of the stomach and duodenum not associated with Helicobacter pylori (in the acute phase), including ulcers associated with taking NSAIDs

Chronic gastritis with increased acid-producing function of the stomach in the acute stage

Gastroesophageal reflux disease (to relieve symptoms) or reflux esophagitis

Prescribed to adults and children over 12 years of age. Take orally, without chewing, with a small amount of water, regardless of meals.

Peptic ulcer of the stomach and duodenum, not associated with Helicobacter pylori (in the acute phase):

Prescribe 150 mg (1 tablet) 2 times a day or 300 mg (2 tablets) 1 time a day at night for 4 weeks. For ulcers that have not healed, continue treatment for the next 4 weeks.

Prevention of gastric and duodenal ulcers associated with taking NSAIDs:

Prescribe 150 mg (1 tablet) 2 times a day for the period of NSAID therapy.

Functional dyspepsia: Prescribe 150 mg (1 tablet) 2 times a day for 2–3 weeks.

Chronic gastritis with increased acid-producing function of the stomach in the acute stage: Prescribe 150 mg (1 tablet) 2 times a day for 2–4 weeks.

Gastroesophageal reflux disease: To relieve symptoms, prescribe 150 mg (1 tablet) 2 times a day for 2 weeks; if necessary, the course of treatment is continued.

For long-term therapy and for exacerbation of gastroesophageal reflux disease, prescribe 150 mg (1 tablet) 2 times a day or 300 mg (2 tablets) 1 time a day at night for 8 weeks; if necessary, the course of treatment is continued for up to 12 weeks.

Patients with severe renal failure (creatinine clearance <50 ml/min). The daily dose of the drug for this category of patients is 1 tablet (150 mg).

Overdose:

Symptoms: increased adverse reactions.

Treatment: provide symptomatic and supportive therapy.

Side effects:

  • Русский
  • Cardiac disorders: bradycardia, tachycardia, extrasystole, asystole, AV block, decreased blood pressure, arrhythmia.
  • From the blood and lymphatic system: leukopenia and thrombocytopenia (usually reversible); agranulocytosis or pancytopenia, sometimes with bone marrow hypoplasia or aplasia, neutropenia.
  • Neurological disorders: headache, dizziness, drowsiness, involuntary movements (revolving), agitation, feeling of fatigue.
  • From the organ of vision: blurred vision, blurred vision associated with impaired accommodation.
  • From the digestive system: diarrhea, constipation, nausea, vomiting, abdominal pain, acute pancreatitis, lack of appetite, flatulence, dry mouth.
  • From the urinary system: acute interstitial nephritis, impaired renal function.
  • From the skin and subcutaneous tissue: skin rash, erythema multiforme, alopecia, dry skin, itching.
  • From the musculoskeletal system and connective tissue: arthralgia, myalgia.
  • Vascular disorders: vasculitis.
  • From the immune system: hypersensitivity reactions (urticaria, angioedema, fever, bronchospasm, arterial hypotension, chest pain), anaphylactic shock.
  • From the hepatobiliary system: transient and reversible changes in the level of certain laboratory parameters (transaminases, gamma-glutamyltransferase, alkaline phosphatase, bilirubin); hepatitis (hepatocellular, cholestatic or mixed) with or without jaundice (usually reversible).
  • Disorders of the reproductive system and mammary glands: reversible impotence, decreased libido, gynecomastia and galactorrhea.
  • Mental disorders: reversible mental disorders (hallucinations, disorientation, confusion, anxiety and restlessness, depression), mainly in elderly and seriously ill patients.

Contraindications:

Increased individual sensitivity to ranitidine or other components of the drug

Presence of malignant diseases of the stomach

Liver cirrhosis with a history of portosystemic encephalopathy

Breastfeeding period

Children's age up to 12 years

Interaction with other drugs and alcohol:

Ranitidine may affect the absorption, metabolism and renal excretion of other drugs.

The drug in therapeutic doses does not change the activity of the cytochrome P450 enzyme system and does not potentiate the effect of drugs that are metabolized by this system (diazepam, lidocaine, phenytoin, propranolol, theophylline, etc.).

Ranitidine, by changing gastric acidity, may affect the bioavailability of certain drugs. This leads to either an increase in their absorption (triazolam, midazolam, glipizide) or a decrease (ketoconazole, itraconazole, atazanavir, gefitinib).

Antacids and sucralfate slow down the absorption of ranitidine, so the interval between taking these medications and ranitidine should be at least 1-2 hours.

Concomitant use with metoprolol may lead to an increase in the concentration of metoprolol in the blood plasma.

Ranitidine, when used simultaneously with coumarin anticoagulants (warfarin), can change prothrombin time (its monitoring is recommended).

High doses of ranitidine may slow down the excretion of procainamide and N-acetylprocainamide, resulting in an increase in their plasma levels.

There are no data on interactions between ranitidine and amoxicillin or metronidazole.

Composition and properties:

Ranitidine 150 mg.

Film-coated tablets, 150 mg each, No. 10, No. 10x10.

Ranitidine is rapidly absorbed when taken orally. Absorption is independent of food intake. Cmax in blood plasma in the range of 300–500 mcg/ml is achieved 1–3 hours after oral administration of 150 mg of the drug. The bioavailability of ranitidine is 50%. The concentration of Rhinitis in the blood plasma is proportional to the dose taken. Plasma protein binding is 15%. Partially metabolized in the liver. The drug is eliminated primarily through urine (60–70% of the oral dose) and feces (26%). T½ of the drug is 2–3 hours. About 30% of the oral dose is excreted unchanged.

In a dry place, protected from light, at a temperature not exceeding 25 °C.

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The information published on the site is for informational purposes only. Described methods of diagnosis, treatment, traditional medicine recipes, etc. It is not recommended to use it yourself. Be sure to consult a specialist so as not to harm your health!

Source: http://www.likar.info/lekarstva/Rinit/