Oxymetazoline composition

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Oxymetazoline

Description current as of 03/07/2015

  • Latin name: Oxymetazoline
  • ATX code: S01GA04
  • Active ingredient: Oxymetazoline (Oxymetazoline)
  • Manufacturer: UPDATE (Russia), PHARMSTANDARD-LEKSREDSTVA (Russia), Pharmtechnology (Belarus)

Compound

One milliliter of Oxymetazoline nasal drops contains 500, 100 or 250 mcg of oxymetazoline hydrochloride.

Table of contents:

One milliliter of Oxymetazoline spray contains 500 mcg of oxymetazoline hydrochloride.

Additional substances: 12-water disodium phosphate, sodium hydroxide solution, disodium edetate, dihydrate sodium phosphate, benzalkonium chloride, water.

Release form

Nasal drops are a colorless transparent liquid.

  • 2 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 10 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 15 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 20 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.

The nasal spray is a colorless, clear liquid.

  • 15, 10 or 20 ml of liquid in a polyethylene bottle with a spray nozzle; one bottle in a cardboard pack.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Adrenomimetic type agent for local use. Has a vasoconstrictor effect. When administered intranasally, swelling of the mucous membranes of the respiratory tract is reduced. When administered into the conjunctival sac, it reduces swelling of the conjunctiva.

The effect appears a quarter of an hour after application and lasts for 7-8 hours.

Indications for use

  • Swelling of the conjunctiva.
  • Rhinitis with colds, eustachitis, inflammation of the sinuses, allergic diseases, hay fever.

Contraindications

Side effects

  • Reactions from breathing: temporary burning and dryness of the nasal mucosa, sneezing, dry mouth, reactive hyperemia or atrophy of the mucous membranes.
  • Reactions from the blood circulation: increased heart rate, arterial hypertension.
  • Reactions from the nervous system: excitability, dizziness, tachyphylaxis, headache, sleep disturbances.
  • Digestive reactions: nausea.
  • Reactions from the visual side: with the conjunctival route of administration, the development of mydriasis, irritation of the conjunctiva, accommodation paresis, and eyelid retraction is possible.

Instructions for use of Oxymetazoline (Method and dosage)

Children over 6 years old and adults are recommended to instill 1-2 drops of the drug into both nostrils up to two times a day.

For congestive processes and swelling of the conjunctiva, use 1-2 drops of the product in each eye.

At the recommended dosage, Oxymetazoline can be used alone for up to three days. If no visible improvement is observed within the specified period of time, you should consult a doctor.

Overdose

When used topically, an overdose is unlikely.

Interaction

Oxymetazoline inhibits the absorption of local anesthetics and prolongs their duration of action.

When co-administered with tricyclic antidepressants and MAO inhibitors, blood pressure may increase.

The simultaneous administration of other vasoconstrictor drugs increases the likelihood of developing undesirable effects.

Terms of sale

Storage conditions

Store at room temperature. Keep away from children.

Best before date

special instructions

It is advised to avoid contact of the product intended for nasal use with the eyes.

In recommended dosages, Oxymetazoline can be used for up to 3 days without consulting a doctor.

The drug affects vision, and the reaction may also slow down, which must be taken into account when driving.

Analogs

For children

Children 1-7 years old are recommended to instill 1-2 drops of a 0.025% solution into both nostrils twice a day. In children over 7 years of age, adult dosages of the drug are used.

During pregnancy and lactation

The drug is not intended for use during the specified periods.

Reviews

According to patients, Oxymetazoline effectively relieves swelling and restores breathing through the nose for up to 8 hours. There are almost no cases of side effects.

Oxymetazoline price, where to buy

The price of Oxymetazoline in drops 0.01% 10 ml in Russia starts from 40 rubles.

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Alexander: Is it possible to buy the drug now? If yes, where?

Alexander: I have been taking it for more than 15 years. I have chronic depression with asthenia. Then it was stopped.

Galina: I’ll definitely try it.

Alisa Alekseeva: I went on a buckwheat diet 5 times. So for me the worst thing was to shove this buckwheat into.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/oksimetazolin

Oxymetazoline

Oxymetazoline: instructions for use and reviews

Latin name: Oxymetazoline

ATX code: S01GA04

Active ingredient: oxymetazoline (oxymetazoline)

Manufacturer: VIPS-MED, LLC (Russia), Nanjing Tianlang Pharmaceuticals Co., Ltd. (China), Pharmstandard-Leksredstva, OJSC (Russia), Pharmtechnology (Republic of Belarus)

Update of description and photo: 11/30/2017

Oxymetazoline is a drug used locally in ENT practice and has a vasoconstrictor effect; alpha adrenergic agonist.

Release form and composition

Dosage forms of Oxymetazoline:

  • nasal spray 0.05%: colorless transparent liquid [10, 15 or 20 ml each in a polyethylene bottle with a spray nozzle or spray pump with a protective cap (for 10 ml); 1 bottle in a cardboard box];
  • nasal drops 0.01%, 0.025% or 0.05%: slightly opalescent or transparent, colorless or pale yellow liquid (0.01% - 5 or 10 ml each, 0.025 and 0.05% - 5, 10, 15 or 20 ml in a polyethylene bottle with a hermetically sealed dropper stopper and a screw cap, 1 bottle in a cardboard box).

Composition of 1 ml spray:

  • active substance: oxymetazoline hydrochloride – 0.5 mg;
  • additional components: benzalkonium bromide, hydrochloric acid solution qs, sodium chloride, purified water.

Composition of 1 ml drops:

  • active substance: oxymetazoline hydrochloride – 0.1; 0.25 or 0.5 mg;
  • additional components: benzalkonium chloride, purified water, sodium hydroxide 0.1M; additionally, depending on the manufacturer - sodium phosphate monosubstituted, sodium chloride, sodium phosphate disubstituted, Trilon B or disodium edetate dihydrate, sodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate.

Pharmacological properties

Pharmacodynamics

Oxymetazoline is a drug with vasoconstrictor (vasoconstrictor) and anticongestive effectiveness. When applied topically, the drug, stimulating alpha1-adrenergic receptors, leads to a narrowing of the vessels of the nasal mucosa, paranasal sinuses and eustachian tube, which eliminates their swelling. Thanks to the action of the drug, nasal breathing is facilitated against the background of allergic and infectious-inflammatory rhinitis, and blood flow to the venous sinuses is reduced. Oxymetazoline prevents the occurrence of bacterial complications such as sinusitis, sinusitis, and otitis media.

According to the results of clinical studies, the effect of the drug is observed within a few minutes after administration and lasts up to 12 hours.

Pharmacokinetics

When applied topically, oxymetazoline hydrochloride does not exhibit systemic effects. When administered intranasally, the half-life is 35 hours or more. Approximately 2.1% of the drug is excreted in urine, and 1.1% in feces.

Indications for use

  • acute respiratory diseases (ARI), accompanied by a runny nose (symptomatic therapy);
  • allergic rhinitis;
  • vasomotor rhinitis (for drops);
  • rhinitis of infectious-inflammatory nature (for spray);
  • otitis media;
  • eustachitis;
  • sinusitis;
  • hay fever.

According to the instructions, Oxymetazoline is also recommended for use to relieve swelling before rhinoscopy or other manipulations in the nasal passages.

Contraindications

  • angle-closure glaucoma;
  • atrophic rhinitis;
  • condition after transsphenoidal hypophysectomy;
  • history of surgical interventions on the dura mater;
  • age up to 1 year – for drops 0.025%;
  • age up to 6 years – for 0.05% drops and spray;
  • combined use with monoamine oxidase inhibitors (MAOIs), as well as a two-week period before and after completion of therapy with the latter;
  • pregnancy - for drops, depending on the manufacturer;
  • hypersensitivity to any of the components of the drug.

Relative (oxymetazoline is prescribed with extreme caution):

  • diseases of the cardiovascular system: arterial hypertension, arrhythmias, chronic heart failure, tachycardia, lesions of the coronary arteries, severe atherosclerosis;
  • chronic renal failure;
  • increased intraocular pressure;
  • diabetes;
  • hyperthyroidism;
  • pheochromocytoma;
  • porphyria;
  • prostatic hyperplasia (urinary retention);
  • pregnancy and breastfeeding;
  • combined use with tricyclic antidepressants, bromocriptine and other drugs that lead to an increase in blood pressure (BP).

Instructions for use of Oxymetazoline: method and dosage

Oxymetazoline is administered intranasally.

Nasal spray

Before each administration of the spray, the bottle must be shaken vigorously.

For children over 6 years of age and adults, it is recommended to apply 1 injection into each nasal passage at intervals of 10–12 hours. If the therapeutic effect is insufficient in adults, the frequency of use can be increased to 3 times a day. The indicated dose should not be exceeded.

Before using the bottle for the first time, it is necessary to calibrate it by pressing the head of the nozzle or spray pump several times.

If you need to take a course longer than 5 days, you should consult your doctor.

Nasal drops

Recommended single doses and frequency of administration (per day), taking into account the patient’s age and dosage of the drug:

  • children under 1 year: 0.01% solution - from birth to the 5th week of life, prescribed 2-3 times or 1 time (depending on the manufacturer), 1 drop in each nasal passage; from the 5th week to 1 year - 2-3 times, 1-2 drops in each nasal passage;
  • children from 1 year to 6 years: 0.025% solution - 2-3 times, 1-2 drops in each nasal passage;
  • children over 6 years old and adults: 0.05% solution - 2-3 times, 1-2 drops in each nasal passage.

Oxymetazoline drops should not be used for more than 7 days.

Side effects

  • cardiovascular system: uncommon – increased blood pressure, palpitations, tachycardia; extremely rarely - arrhythmia;
  • nervous system: rarely - headache, anxiety, fatigue (loss of energy, drowsiness), insomnia, hallucinations;
  • respiratory system: often – burning/dryness of the nasal mucosa (transient), hypersecretion, sneezing, for spray – dry mouth and throat; uncommon – reactive hyperemia (increased swelling of the nasal mucosa), nosebleeds.

Adverse reactions caused by the systemic effect of oxymetazoline may include dizziness, sleep disturbances (in children), increased anxiety, irritability, itching, Quincke's edema, exanthema, nausea, blurred vision (if in contact with the eyes), respiratory arrest (in infants), convulsions.

Against the background of long-term and continuous treatment with vasoconstrictor drugs, drug-induced rhinitis (recurrent swelling of the nasal mucosa), tachyphylaxis, and atrophy of the nasal mucosa may occur.

Overdose

Symptoms of overdose may include fever, vomiting, nausea, cyanosis, dilated pupils, mental disorders, shortness of breath, arterial hypertension, arrhythmia, tachycardia, cardiac arrest, pulmonary edema, depression of the central nervous system (decreased blood pressure, decreased body temperature, drowsiness, bradycardia, arrest breathing and coma).

Treatment in case of overdose is recommended to be symptomatic. In case of accidental oral administration of the drug, gastric lavage and activated charcoal are prescribed to evacuate the contents of the gastrointestinal tract; these measures should be carried out immediately since oxymetazoline is rapidly absorbed. If blood pressure decreases, selective alpha-blockers cannot be used. If necessary, anticonvulsants and antipyretics are administered and artificial ventilation is prescribed. Vasopressor drugs are contraindicated for use.

special instructions

You must be careful not to get Oxymetazoline into your eyes.

Continuous therapy with the drug should not be carried out for more than 7 days.

In case of prolonged or frequent use of the drug, symptoms of nasal congestion may recur or worsen. If this effect occurs, you must stop treatment and consult a specialist.

The nasal drops contain benzalkonium chloride, which can cause swelling and irritation of the nasal mucosa.

Impact on the ability to drive vehicles and complex mechanisms

When using Oxymetazoline spray and drops in therapeutic doses, no negative effect on the ability to drive vehicles or operate complex machinery was noted. However, with a long course of treatment using high doses, the possibility of developing systemic adverse reactions of the drug cannot be excluded. In this case, it is necessary to exercise caution when performing work that requires special concentration and quick reactions.

Use during pregnancy and lactation

There are no clinical data confirming the safety of using the drug during pregnancy and lactation. As a result, Oxymetazoline should only be used in pregnant or breastfeeding women in extreme cases, when, in the opinion of the attending physician, the expected benefit of drug therapy for the mother significantly outweighs the possible risk to the fetus/child.

Use in childhood

Children under 6 years of age are contraindicated to use spray and drops of 0.05%, children under 1 year of age - drops of 0.025%.

For impaired renal function

In the presence of chronic renal failure, it is recommended to use Oxymetazoline with extreme caution.

Drug interactions

  • local anesthetic drugs: their absorption slows down and the effect is prolonged;
  • MAO inhibitors (including 14 days before and after their use), other drugs that cause an increase in blood pressure: the risk of arterial hypertension is aggravated;
  • tricyclic antidepressants: the risk of arrhythmia and hypertension increases;
  • other vasoconstrictor drugs: the likelihood of adverse reactions increases.

Analogs

Analogues of Oxymetazoline are Afrin, Nazivin, Afrin extro, Nazol Advance, Nazivin Sensitive, Nazo-spray, Vicks Active Sinex, Nazol, Nesopin, Otrivin, Noxprey, Rinostop Extra, Oxyfrin, Sialor.

Terms and conditions of storage

Store at a temperature of 0–25 °C, in a place protected from light, out of reach of children.

The shelf life of the spray is 3 years, drops – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Oxymetazoline

According to most reviews, Oxymetazoline is an effective and inexpensive drug that helps adults and children quickly eliminate nasal congestion and reduce swelling of the nasal mucosa. Patients confirm that nasal breathing is restored within 5–10 minutes after administration of drops or spray, and this effect lasts up to 10–12 hours.

The disadvantages of Oxymetazoline include adverse reactions, the most common of which are transient dryness and burning that occur after its administration.

Price for Oxymetazoline in pharmacies

There is no reliable data on the price of Oxymetazoline, since the drug is currently not on sale.

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/oksimetazolin.php

Oxymetazoline: instructions for use

Active ingredient: Oxymetazoline

Manufacturer: Pharmstandard-Leksredstva, Russia

Condition for dispensing from the pharmacy: Without a prescription

Oxymetazoline is a pharmacological agent that is used to relieve inflammation and narrow blood vessels in the nasal cavity.

Indications for use

A product based on oxymetazoline is used for:

  • Runny nose caused by infectious pathogens, as well as various allergens
  • Eustacheite
  • Inflammatory process in the nasal sinuses
  • Hay fever.

Also, drops based on vasoconstrictor substances are used to relieve swelling of the conjunctiva.

Compound

The cold remedy in the form of drops (100 ml) contains oxymetazoline hydrochloride in volumes of 0.01 g, 0.025 g and 0.05 g.

1 ml of nasal spray contains 500 mcg of the main active ingredient.

  • Benzalkonium chloride
  • Disodium edetate
  • Sodium phosphate dihydrate monosubstituted and disubstituted 12-hydrate
  • Sodium hydroxide (solution)
  • Water.

Medicinal properties

Nasal drops and spray with oxymetazoline (chemical formula - C16H24N2O) promote local vasoconstriction and reduce the severity of swelling of the mucous membranes of the respiratory tract. In this case, better patency of the nasal passages is observed, normal nasal breathing is restored. If the product is instilled into the conjunctival sac, it is possible to locally reduce the severity of swelling of the conjunctiva itself.

The therapeutic effect of using the medicine (drops, spray) can be assessed after 15 minutes, it lasts for the next 8 hours.

Release form

Price: from 40 to 65 rubles.

Nasal drops with a vasoconstrictor effect in the form of 0.01%, 0.025%, 0.05% solution are available in 5 ml bottles.

Children's aerosol (spray) 0.05% is produced in bottles of 10 ml, 15 ml, 20 ml and 30 ml.

The package contains 1 fl. Oxymetazoline drug, instructions.

Instructions for use

Adults are usually prescribed to do 2-3 exercises; for children 6-12 years old – 1 vpr. in both nostrils or 1-2 drops. 0.025%, 0.05% nasal solution into each nasal passage twice or three times in 24 hours.

Dosage for infants during the first 4 weeks of life: 1 drop. The 0.01% solution is instilled into both nostrils.

Infants from 5 weeks to 12 months. Prescribe 1-2 drops. nasal agent 0.01% concentration.

The time interval between drug instillation procedures is hours.

The duration of use of the 0.025% and 0.05% solution is up to 4 weeks, and the 0.01% nasal solution is up to 7 days.

Use during pregnancy and pregnancy

The drug is contraindicated in pregnant and lactating women, since oxymetazoline hydrochloride crosses the placenta and enters breast milk.

Contraindications

Drugs containing oxymetazoline should not be taken for the following diseases and pathological conditions:

  • Diabetes
  • Impaired kidney function
  • Children's age (child under 1 year)
  • Excessive sensitivity to the components of the nasal product.

Precautionary measures

Use of the drug in the indicated dosages is recommended for 3 days.

The drug can reduce visual acuity; this should be taken into account when driving vehicles.

Cross-drug interactions

Do not use products containing oxymetazoline (Nazol) for intranasal administration at the same time.

Compatibility with other drugs should be discussed with your doctor.

Side effects

When using nasal medications with oxymetazoline, the following may occur:

  • Excessive excitability
  • Increased heart rate
  • Sharp jump in blood pressure
  • Dryness and burning sensation inside the nasal and oral cavity
  • Insomnia
  • Nausea.

Overdose

When used locally, the likelihood of an overdose is unlikely.

Storage conditions and shelf life

Nasal medications should be stored in a dry place, protected from sunlight. It is required to observe the temperature regime during storage (2-30C) for 2 years from the date of production.

Analogs

Nazol Advance

Nazol Advance is a drug intended for intranasal use. Prescribed for the treatment of rhinitis, pharyngitis, and sinusitis. The main component of the spray is oxymetazoline.

  • Convenient to use
  • Quickly relieves swelling of the mucous membrane
  • Resumes nasal breathing.
  • The spray is not prescribed for children under 6 years of age.
  • Contraindicated in cases of carbohydrate metabolism disorders
  • May cause excessive sweating.

Source: http://lekhar.ru/lekarstva/lor-sredstva/oksimetazolin-instrukcija-po-primeneniju/

Oxymetazoline nasal drops - instructions for use

Having no idea about the real pharmacological properties of nasal medications, many are guided by doctors’ prescriptions. It is important for us that the discomfort stops and the nose does not run.

Oxymetazoline: pharmacological properties, composition, price of the drug

A large selection of nasal products makes it difficult to choose the right one for each individual case. Guided by a doctor's prescription and not receiving the desired effect, a person with a cold has a desire to choose a remedy that will relieve a runny nose in the shortest possible time.

As an option, we offer a drug that has a quick and effective effect on the symptoms of a runny nose - Oxymetazoline, the instructions for the action of which will cover in detail all the questions that arise for those who have never used this remedy.

Oxymetazoline: clinical and pharmacological group - a vasoconstrictor drug for topical use for the common cold and conjunctivitis.

The medicine is recommended as the most suitable remedy for eliminating inflammation of the nasal mucosa, as it effectively constricts blood vessels and reduces swelling. The effect of the drug begins immediately after instillation into the nose. This is its main advantage over other drugs.

Drops with oxymetazoline are administered for inflammation of the sinuses, allergic manifestations, and are prescribed for use 2 times a day. The effect of the drug lasts 8 hours, during this period breathing normalizes, the nasal mucosa dries out, discharge stops, and the inflammatory process begins to decrease.

Oxymetazoline (nasal drops) when used topically is practically not absorbed into the blood. Even with a short stay in the nasal cavity, the product manages to have a therapeutic effect, so there is reason to talk about its high effectiveness.

The drug contains active substances:

  • Oxymetazoline hydrochloride.
  • Menthol.
  • Eucalyptus oil.
  • Sodium phosphate, aqueous.
  • Edetate disodium.
  • Benzalkonium chloride.
  • Sodium hydroxide solution.

The synthesis of these components eliminates congestion, allergic reactions, and swelling of the conjunctiva. This is the resorptive effect of oxymetazoline hydrochloride. Like many vasoconstrictor drugs, oxymetazoline is addictive after 5 days of use, but during this time it manages to have a therapeutic effect.

Drops are produced in droppers - tubes of 2, 10, 15, 20 ml with a separate sprayer; they are a transparent liquid. The cost of the drug depends on the volume of the tube and on the manufacturer, but is considered acceptable and ranges from 70 to 160 rubles.

Directions for use and dosage

The drug is prescribed for a runny nose in both adults and children. The frequency of instillation depends on the degree of nasal congestion, but, according to the instructions, it is undesirable to exceed the dose for adults more than 3 times a day, 2 drops. Oxymetazoline for children is indicated for patients aged 1 to 7 years, 1 drop 2 times a day.

You can buy oxymetazoline on your own without a doctor's prescription. In this case, it is recommended to use it for no more than 3 days. If swelling and nasal congestion do not go away, you should consult a doctor.

Advantages and disadvantages of the drug

Like any medicine, oxymetazoline has advantages and disadvantages.

First of all, it is necessary to mention the possible side effects of the drops:

  • The appearance of dryness and itching of the nasal mucosa.
  • Dry throat and mouth.
  • Increased blood pressure.
  • Nausea.
  • Dizziness.
  • Cardiopalmus.
  • Redness of the mucous membrane.

At the first sign of side effects, you should stop using the drug. This means that the patient’s body does not accept it. Side effects may occur if the instructions for use, which are important for oxymetazoline, are not followed, therefore it is necessary to follow the recommended doses and shelf life of the drug.

All the benefits of oxymetazoline will be fully realized if you adhere to the doctor’s recommendations: the burning and itching in the nose and the discharge accompanying a runny nose will stop. When using oxymetazoline to treat children, instructions for use and its strict use are mandatory to avoid undesirable consequences.

A distinctive feature of the drops is that they can effectively treat conjunctivitis. For swelling of the conjunctiva of the eye, instillation of a drop into each eye once a day is prescribed.

Contraindications for use

The insidiousness of oxymetazoline lies in its vasoconstrictor effect, unless the patient first finds out whether this drug is contraindicated for him. The main contraindication is the presence of hypersensitivity to the drug. This may appear during the initial stage of use or during a medical examination.

  • Hypertension.
  • Tachycardia.
  • Chronic renal failure.
  • Severe form of atherosclerosis.
  • Glaucoma.
  • Heart failure.
  • Diabetes mellitus.
  • Diseases of the thyroid gland.

Oxymetazoline is not recommended for use during pregnancy in the first two trimesters, as it is considered the most powerful of the nasal drugs. It affects not only the body of the expectant mother, but also the child, which is undesirable.

There are many other drugs that will not harm the developing body, so in order to avoid the risk of harming the baby, it is recommended that a pregnant woman not get carried away with such powerful drugs for treating a runny nose.

Analogues of the drug

In pharmacology, it is customary to divide drugs into analogues and synonyms. Drugs with the same substance are called synonyms, and analogues are drugs that are intended to treat the same diseases, but have different names.

Analogs of oxymetazoline, as close as possible to the original, are developed by large companies with modern equipment that produce the drug with a high degree of purification from impurities.

Analogues of Oxymetazoline with other names are produced by manufacturers all over the world: Afrin, Nazivin, Nazol, Nazospray, Fervex spray, Nesopin, Noxprey and many others. Their action is similar to the original, all differences are mentioned in the instructions for use.

The choice of drops for a runny nose in pharmacies is very large, but you should not experiment with your health and purchase products based on the indicators you like: low price, beautiful packaging, advice from a neighbor.

The human body is individual, and the selection of a drug should be based on this. Therefore, a doctor must prescribe a drug for treatment.

Source: http://moylor.ru/lekarstva/kapli-v-nos-oksimetazolin/

Oxymetazoline

10 ml - polyethylene bottles (1) with a spray nozzle - cardboard packs.

15 ml - polyethylene bottles (1) with a spray nozzle - cardboard packs.

20 ml - polyethylene bottles (1) with a spray nozzle - cardboard packs.

From the respiratory system: possible transient dryness and burning of the mucous membrane of the nasal passages, dry mouth and throat, sneezing; with long-term use, reactive hyperemia of the mucous membrane and atrophy of the mucous membrane may occur.

From the cardiovascular system: palpitations; rarely - arterial hypertension.

From the side of the central nervous system: increased excitability, dizziness, headache, sleep disturbances; with long-term use - tachyphylaxis.

From the digestive system: nausea.

On the part of the organ of vision: with conjunctival administration, mydriasis, accommodation paresis, irritation of the conjunctiva and surrounding tissues, and eyelid retraction are possible.

The recommended dosage can be used for no more than 3 days without consulting a doctor. Avoid contact of the drug intended for intranasal administration with the eyes.

Impact on the ability to drive vehicles and operate machinery

The drug affects vision and may reduce reaction speed.

With the simultaneous administration of MAO inhibitors and tricyclic antidepressants, an increase in blood pressure is possible.

Oxymetazoline slows down the absorption of local anesthetic drugs and prolongs their effect.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

A description of the active substances of the drug is presented. The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

There are contraindications, consult your doctor.

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Source: http://health.yandex.ru/pills/oksimetazolin-13467

Oxymetazoline

Content

Structural formula

Russian name

Latin name of the substance Oxymetazoline

Chemical name

3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol (as hydrochloride)

Gross formula

Pharmacological group of the substance Oxymetazoline

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Oxymetazoline

Oxymetazoline hydrochloride is easily soluble in water and alcohol. Practically insoluble in ether, chloroform, benzene. Molecular weight 296.84.

Pharmacology

Stimulates alpha-adrenergic receptors: in low concentrations it mainly has an α 2 -adrenomimetic effect, in high concentrations it also acts on α 1 -adrenergic receptors. Constricts blood vessels at the site of application. When administered intranasally, it reduces swelling of the mucous membrane of the upper respiratory tract, facilitates nasal breathing, and reduces blood flow to the venous sinuses. When instilled into the conjunctival sac, it reduces swelling of the conjunctiva. The action begins 15 minutes after application, duration is 6–8 hours.

When applied topically (spray), oxymetazoline undergoes systemic absorption to a small extent, so its concentration in the blood plasma is insignificant. It is excreted mainly unchanged in urine and feces. T 1/2 is 5–8 days.

Use of the substance Oxymetazoline

Acute rhinitis (including allergic), vasomotor rhinitis, paranasal sinusitis, eustachitis, otitis media; to narrow the vessels of the mucous membrane for diagnostic purposes (under medical supervision).

Contraindications

Hypersensitivity, incl. to other decongestants for intranasal use; atrophic rhinitis, angle-closure glaucoma, arterial hypertension, severe atherosclerosis, heart rhythm disturbances, chronic heart failure, diabetes mellitus, thyrotoxicosis, children under 1 year of age (for drops 0, 025 and 0.05%), children under 6 years of age (for spray 0.05%).

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding, the recommended dosage should not be exceeded. Use is possible after a careful assessment of the balance of benefit to the mother and risk to the fetus or child.

Side effects of the substance Oxymetazoline

Local reactions: dryness and burning sensation of the nasal mucosa, dry mouth or throat, sneezing, “ricochet” swelling of the mucous membrane (increased nasal discharge or nasal congestion).

Systemic effects: sleep disturbance, agitation, increased anxiety, dizziness, headache, palpitations, nausea, increased blood pressure.

Other: tachyphylaxis, reactive hyperemia of the mucous membrane and atrophy of the nasal mucosa (with long-term use).

Interaction

Slows down the systemic absorption of local anesthetics and prolongs their effect. Combined use with other vasoconstrictor drugs increases the risk of side effects. With the simultaneous use of oxymetazoline and MAO inhibitors or tricyclic antidepressants, an increase in blood pressure is possible.

Overdose

Symptoms (after a significant overdose or accidental ingestion): constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and the possible development of coma.

Treatment: gastric lavage, taking activated carbon, urgently consulting a doctor, symptomatic therapy.

Precautions for the substance Oxymetazoline

In children, the absorption of oxymetazoline into the blood may be increased, leading to the development of side effects.

After long-term use of cold remedies containing oxymetazoline in dosages higher than recommended, a general effect on the cardiovascular system and the central nervous system cannot be ruled out. In these cases, the ability to operate a vehicle or equipment may be impaired.

Interactions with other active ingredients

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Oxymetazoline: instructions for use

Compound

Excipients: benzalkonium chloride, disodium edetate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride, sodium hydroxide, purified water.

Description

clear or slightly opalescent, colorless or yellowish liquid.

pharmachologic effect

Indications for use

— to facilitate rhinoscopy and other manipulations in the nasopharynx area.

Contraindications

- hypersensitivity to oxymetazoline;

- children under 1 year of age (for oxymetazoline solution 0.05% and 0.025%);

- children under 6 years of age (for oxymetazoline solution 0.05%).

Pregnancy and lactation

The drug is contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Directions for use and doses

For children aged 1 to 6 years, drops of a 0.025% oxymetazoline solution into each nasal passage 2-3 times a day;

For infants, during the first 4 weeks of life, 1 calla of 0.01% oxymetazoline solution is instilled into each nasal passage per day;

Children from 5 weeks to the end of 1 year of life - 1-2 drops of 0.01% oxymetazoline solution in each nasal passage 2-3 times a day.

The duration of use of the 0.025% and 0.05% solution is no more than 4 weeks, and the 0.01% solution is no more than 7 days.

Side effect

Overdose

Interaction with other drugs

Oxymetazoline slows down the absorption of local anesthetics and prolongs their effect. Enhances the effect of monoamine oxidase inhibitors on the central nervous system.

Features of application

The possibility of systemic side effects should be kept in mind. With long-term use of the drug in high doses, its effect on the cardiovascular system and central nervous system cannot be ruled out. In this case, you should be careful when driving vehicles and machinery.

Release form

Storage conditions

Best before date

Conditions for dispensing from pharmacies

Oxymetazoline analogues, synonyms and group drugs

You should consult your doctor and read the instructions before use.

Source: http://apteka.103.by/oksimetazolin-instruktsiya/

OXYMETAZOLINE

Adrenomimetic agent for local use. Has a vasoconstrictor effect. When administered intranasally, swelling of the mucous membrane of the upper respiratory tract decreases. When instilled into the conjunctival sac, it reduces swelling of the conjunctiva.

The effect appears 15 minutes after application and lasts for 6-8 hours.

Difficulty in nasal breathing due to colds, inflammation of the sinuses, eustachitis, hay fever, allergic rhinitis, congestion and swelling of the conjunctiva.

Inflammation of the mucous membrane of the nasal passages without secretion, chronic heart failure, hyperthyroidism, diabetes mellitus, pregnancy, children under 6 years of age (for eye drops), increased sensitivity to oxymetazoline, atrophic rhinitis, lactation, arrhythmias, severe atherosclerosis, arterial hypertension, chronic renal failure , angle-closure glaucoma.

From the respiratory system: possible transient dryness and burning of the mucous membrane of the nasal passages, dry mouth and throat, sneezing; with long-term use, reactive hyperemia of the mucous membrane and atrophy of the mucous membrane may occur.

From the cardiovascular system: palpitations; rarely - arterial hypertension.

From the side of the central nervous system: increased excitability, dizziness, headache, sleep disturbances; with long-term use - tachyphylaxis.

From the digestive system: nausea.

On the part of the organ of vision: with conjunctival administration, mydriasis, accommodation paresis, irritation of the conjunctiva and surrounding tissues, and eyelid retraction are possible.

With the simultaneous administration of MAO inhibitors and tricyclic antidepressants, an increase in blood pressure is possible.

Oxymetazoline slows down the absorption of local anesthetic drugs and prolongs their effect.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

The recommended dosage can be used for no more than 3 days without consulting a doctor. Avoid contact of the drug intended for intranasal administration with the eyes.

Impact on the ability to drive vehicles and operate machinery

The drug affects vision and may reduce reaction speed.

Oxymetazoline is contraindicated for use during pregnancy and lactation (breastfeeding).

Contraindicated in children under 6 years of age (for eye drops).

Contraindicated in chronic renal failure.

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Source: http://health.mail.ru/drug/oksimetazolin/

Instructions for use of drugs, analogues, reviews

Instructions from tablet.rf

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Oxymetazoline*

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

Description of the active substance Oxymetazoline/Oxymetazolinum.

Formula: C16H24N2O, chemical name: 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol (as hydrochloride).

Pharmacological group: vegetotropic agents/adrenomimetic agents/alpha-adrenergic agonists; organotropic agents/respiratory agents/anticongestants.

Pharmacological action: vasoconstrictor, alpha-adrenomimetic, anticongestive.

Pharmacological properties

Oxymetazoline has a stimulating effect on alpha-adrenergic receptors (in low concentrations it acts on alpha2-adrenergic receptors, in high concentrations also on alpha1-adrenergic receptors). Oxymetazoline has a vasoconstrictor effect at the site of application. When used intranasally, oxymetazoline facilitates nasal breathing, reduces swelling of the mucous membrane of the upper respiratory tract, and reduces blood flow to the venous sinuses. Oxymetazoline, eliminating swelling of the nasal mucosa, helps restore the airiness of the paranasal sinuses and middle ear cavity, this prevents the development of bacterial complications (sinusitis, otitis media). When used intranasally in recommended doses, oxymetazoline does not irritate or cause hyperemia of the nasal mucosa. Reduces swelling of the conjunctiva when instilled into the conjunctival sac. The effect of oxymetazoline develops 15 minutes after instillation and lasts 6–8 hours. When used topically, oxymetazoline is absorbed to a small extent, so its content in the blood serum is insignificant. Oxymetazoline is excreted mainly unchanged in feces and urine; the half-life is 5–8 days.

Indications

Vasomotor rhinitis, acute rhinitis (including allergic), sinusitis, otitis media, eustachitis; restoration of drainage in case of eustachitis, inflammation of the paranasal sinuses, otitis media; acute respiratory diseases that are accompanied by a runny nose; for diagnostic purposes to narrow the vessels of the mucous membrane (under the supervision of a physician).

Method of administration of oxymetazoline and dose

Oxymetazoline is used intranasally: patients over 12 years old - 2 - 3 injections of 0.05% spray or 1 - 2 drops of 0.025 - 0.05% solution in each nasal passage 2 - 3 times a day; children 6 - 12 years old - one injection into each nostril; repeated administration is possible after 10–12 hours. The duration of the course of therapy should be no more than 3–5 days; Consultation with a doctor is necessary if further treatment is necessary.

In children, the absorption of oxymetazoline into the blood, leading to the development of systemic adverse reactions, may be increased.

When using drugs that contain oxymetazoline, a general effect on the nervous and cardiovascular systems is possible. In these cases, the ability to operate vehicles or equipment and perform activities that require increased attention and speed of psychomotor reactions may be reduced, so caution is required.

Contraindications for use

Hypersensitivity, including to other decongestants for intranasal use; closed-angle glaucoma, atrophic rhinitis, arterial hypertension, heart rhythm disturbances, severe atherosclerosis, chronic heart failure, angina pectoris, thyrotoxicosis, diabetes mellitus, age up to 6 years (for spray 0.05%), age up to 1 year (for drops 0.025 and 0 .05%).

Restrictions on use

Concomitant use of monoamine oxidase inhibitors and other drugs that increase blood pressure, as well as a period of up to 10 days after their use; increased intraocular pressure, pregnancy, lactation.

Use during pregnancy and breastfeeding

The use of oxymetazoline during breastfeeding and pregnancy is possible after careful assessment of the expected benefit to the mother and the possible risk to the child or fetus. Do not exceed the recommended dosage.

Side effects of oxymetazoline

Local reactions: burning sensation and dryness of the nasal mucosa, sneezing, dry mouth or throat, “rebound” swelling of the mucous membrane (nasal congestion or increased nasal discharge).

Systemic effects: agitation, insomnia, sleep disturbance, anxiety, increased anxiety, fatigue, headache, dizziness, nausea, palpitations, tachycardia, increased blood pressure.

Other (with prolonged use): recurrent swelling of the nasal mucosa, atrophy of the nasal mucosa and reactive hyperemia of the mucous membrane, tachyphylaxis.

Interaction of oxymetazoline with other substances

Oxymetazoline slows down the systemic absorption of local anesthetic drugs and prolongs their effect. Concomitant use of oxymetazoline with other vasoconstrictors increases the risk of adverse reactions. When oxymetazoline is used together with tricyclic antidepressants or monoamine oxidase inhibitors, an increase in blood pressure may occur. Oxymetazoline may temporarily reduce the absorption of levocabastine when administered intranasally. Acebutolol increases the possibility of developing a systemic hypertensive effect of oxymetazoline.

Overdose

In case of an overdose (or accidental ingestion) of oxymetazoline, nausea, constriction of the pupils, vomiting, increased body temperature, cyanosis, tachycardia, vascular insufficiency, arrhythmia, respiratory disorders, arterial hypertension, cardiac arrest, pulmonary edema develop; Mental disorders and depression of the central nervous system may also appear, which is accompanied by drowsiness, bradycardia, arterial hypotension, decreased body temperature, respiratory arrest, and coma. Necessary: ​​gastric lavage, intake of activated carbon, urgent hospitalization, symptomatic treatment.

Source: http://xn——8kceunaflgjrqyoqfbei8dxl.xn--p1ai/%D0%BE%D0%BA%D1%81%D0%B8%D0%BC%D0%B5%D1%82%D0%B0%D0 %B7%D0%BE%D0%BB%D0%B8%D0%BD