Oki ketoprofen instructions for use

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OKI granules for the preparation of solution for oral administration

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

INSTRUCTIONS for the use of the medicinal product for medical use OKI

Read these instructions carefully before you start taking this drug.

• Save the instructions; you may need them again.

• If you have any questions, consult your doctor.

• This drug is prescribed for you personally and should not be given to others because it may harm them even if they have the same symptoms as you.

Registration number: P N010598/

Trade name of the drug: OKI

International nonproprietary name: ketoprofen

Dosage form: granules for oral solution

One sachet contains:

Active ingredient: ketoprofen lysine salt 80 mg (equivalent to 50 mg of ketoprofen).

Auxiliary components: mannitol 1700 mg, povidone 132 mg, colloidal silicon dioxide 3 mg, sodium chloride 20 mg, sodium saccharinate 15 mg, ammonium glycyrrhizinate 20 mg, mint flavor 30 mg.

Granules are white to light yellow in color with a characteristic mint odor.

Non-steroidal anti-inflammatory drug (NSAID).

Pharmacological properties

It has anti-inflammatory, analgesic and antipyretic effects. By inhibiting cyclooxygenase types I and II, it inhibits the synthesis of prostaglandins. It has anti-bradykinin activity, stabilizes lysosomal membranes and delays the release of enzymes from them that contribute to tissue destruction during chronic inflammation. Reduces the release of cytokines, inhibits the activity of neutrophils.

Reduces morning stiffness and swelling of joints, increases range of motion. Ketoprofen lysine salt, unlike ketoprofen, is a rapidly soluble molecule with a neutral pH and is almost non-irritating to the gastrointestinal tract.

Suction. When administered orally, ketoprofen is quickly and fairly completely absorbed from the gastrointestinal tract, its bioavailability is about 80%. The maximum concentration in plasma when taken orally is observed 0.5-2 hours after oral administration, its value directly depends on the dose taken. The equilibrium concentration of ketoprofen is achieved 24 hours after the start of its regular use.

Distribution. Up to 99% of absorbed ketoprofen is bound to plasma proteins, mainly albumin. Volume of distribution - 0.1-0.2 l/kg. Easily passes through histohematic barriers and is distributed in tissues and organs. Ketoprofen penetrates well into synovial fluid and connective tissue. Although the concentrations of ketoprofen in synovial fluid are slightly lower than in plasma, they are more stable (lasting up to 30 hours).

Metabolism. Ketoprofen is primarily metabolized in the liver, where it undergoes glucuronidation to form esters with glucuronic acid.

Excretion. Metabolites are excreted by the kidneys. The drug does not accumulate.

Indications for use

Symptomatic treatment of inflammatory processes of various origins, accompanied by pain, including:

• tendonitis, bursitis, myalgia, neuralgia, radiculitis;

• painful menstruation (algomenorrhea);

• post-traumatic and postoperative pain syndrome;

• pain syndrome in oncological diseases;

- inflammatory and degenerative diseases of the musculoskeletal system:

• rheumatoid arthritis, seronegative arthritis, ankylosing spondylitis (ankylosing spondylitis), gout, pseudogout, osteoarthritis, psoriatic arthritis, reactive arthritis (Reiter's syndrome).

Children (over 6 years):

Short-term symptomatic treatment of inflammatory processes accompanied by pain in combination with or without fever in diseases of the musculoskeletal system, otitis media.

Relief of postoperative pain.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.

Contraindications for use

Hypersensitivity to the active substance and other components of the drug, as well as to other non-steroidal anti-inflammatory drugs.

Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history).

Erosive and ulcerative lesions of the gastrointestinal tract and duodenum (acute stage), active gastrointestinal, cerebrovascular or other bleeding, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) (acute stage), hemophilia and other bleeding disorders, decompensated cardiac insufficiency, period after coronary artery bypass surgery, severe liver failure or active liver disease, severe renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease, confirmed hyperkalemia, children (up to 6 years), pregnancy (III trimester), breastfeeding period.

Carefully

Peptic ulcer of the stomach and duodenum, ulcerative colitis, Crohn's disease, liver disease (history), hepatic porphyria, chronic renal failure (creatinine ml/min clearance), chronic heart failure, arterial hypertension, significant decrease in circulating blood volume (including after surgical intervention), elderly patients (including those receiving diuretics, debilitated patients and those with low body weight), bronchial asthma, simultaneous use of glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid , clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), coronary heart disease, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, Helicobacter pylori infection, long-term use of NSAIDs , tuberculosis, severe osteoporosis, alcoholism, severe somatic diseases, pregnancy (I, II trimester).

Use during pregnancy and breastfeeding

In the third trimester of pregnancy, the use of ketoprofen is contraindicated.

In the first and second trimesters of pregnancy, the drug can be prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus.

The drug should not be used during breastfeeding.

Directions for use and doses

Dissolve the contents of 1 double sachet (full dose) in half a glass of drinking water and take orally up to 3 times a day with meals. To obtain one full dose (80 mg), open the double sachet along the line labeled “full dose.”

For elderly patients, the dose is determined by the doctor; it is advisable to reduce the dosage by 2 times.

Children (from 6 to 14 years):

Dissolve the contents of 1/2 double sachet (half dose) in half a glass of drinking water and take orally up to 3 times a day with meals.

To receive half the dose (40 mg), open the double sachet along the line labeled “half dose.”

Children (from 14 to 18 years):

Dosages of the drug correspond to those in adults.

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible course.

Overdose

Cases of overdose with doses up to 2.5 g of ketoprofen have been reported. In most cases, symptoms were limited to lethargy, drowsiness, and nausea. vomiting and pain in the epigastric region.

Measures to help with overdose

A specific antidote is unknown. As symptomatic measures to ensure vital functions (stabilization of blood circulation, equalization of acidosis, or artificial respiration), measures to reduce resorption and accelerate elimination (medical charcoal, forced diuresis) are indicated.

Side effects

According to the World Organization (WHO), undesirable effects are classified according to their frequency of development as follows: very often (1/10), often (from 1/100 to ≤1/10), infrequently (from 1/1000 to ≤1/10). 100), rare (from 1/10000 to ≤1/1000), very rare (≤1/10000), frequency unknown (the frequency of events cannot be determined based on the available data).

The following side effects have been reported in connection with the use of ketoprofen.

Disorders of the hematopoietic organs and lymphatic system

Rarely: hemorrhagic anemia.

Not known: thrombocytopenia, thrombocytopenic purpura, agranulocytosis, bone marrow dysfunction, leukocytopenia, leukocytosis, inflammation of the lymphatic vessels, vasculitis.

Immune system disorders

Frequency unknown: anaphylactic reactions (including anaphylactic shock).

Disorders of the central nervous system and sensory organs

Uncommon: headache, dizziness, drowsiness.

Rarely: paresthesia, blurred vision, tinnitus.

Frequency unknown: convulsions, dysgeusia, mood changes, irritability, insomnia.

From the cardiovascular system

Not known: heart failure, tachycardia, palpitations, hypertension, hypotension, vasodilation.

From the respiratory system

Rarely: bronchial asthma.

Not known: bronchospasm (especially in patients with documented hypersensitivity to acetylsalicylic acid and other NSAIDs), rhinitis, shortness of breath, laryngeal edema and spasm.

From the digestive system

Common: nausea, vomiting, dyspepsia, abdominal pain.

Uncommon: constipation, diarrhea, bloating, gastritis.

Rarely: stomatitis, gastric and duodenal ulcers, hepatitis, increased levels of liver transaminases and increased levels of bilirubin in the blood serum caused by impaired liver function.

Frequency unknown: exacerbation of ulcerative colitis and Crohn's disease, gastrointestinal bleeding, perforation, heartburn.

From the skin and subcutaneous fat

Uncommon: rash, itching.

Frequency unknown: photosensitivity reactions, alopecia, urticaria, angioedema, bullous skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome), erythema and exanthema, maculopapular rash, dermatitis.

From the urinary system

Not known: acute renal failure, tubulointerstitial nephritis and nephritic syndrome, abnormal values ​​of renal function tests.

Uncommon: swelling, fatigue.

Not known: allergic and anaphylactoid reactions, oral edema, periorbital edema.

If any side effects occur, you should immediately stop taking the drug and consult a doctor.

Interaction with other drugs

Combinations to avoid

• Corticosteroids: Increases the risk of ulceration and gastrointestinal bleeding.

• Anticoagulants (parenteral heparin, warfarin): increased risk of bleeding caused by inhibition of platelet function and damage to the gastric and intestinal mucosa. NSAIDs may enhance the effects of anticoagulants such as warfarin.

• Antiplatelet agents (clopidogrel, ticlopidine) and selective serotonin reuptake inhibitors: increased risk of bleeding caused by inhibition of platelet aggregation and damage to the gastric and intestinal mucosa. Patients should be monitored if coadministration cannot be avoided.

• Other NSAIDs, including high doses of salicylates (> 3 g/day): Concomitant use of multiple NSAIDs may increase the risk of ulceration and gastrointestinal bleeding due to a synergistic effect.

• Lithium: NSAIDs increase plasma lithium levels (decreased renal excretion of lithium). which can reach toxic levels. This parameter must be monitored at the beginning of treatment, when adjusting the dose and after stopping treatment with ketoprofen.

• Methotrexate in high doses (more than 15 mg per week): the hematotoxicity of methotrexate increases, as its excretion by the kidneys, which occurs when taking anti-inflammatory drugs, is reduced. When used in combination with methotrexate in low doses (less than 15 mg per week), a complete blood count should be performed once a week during the first few weeks of treatment. More frequent monitoring of the clinical condition is mandatory in the presence of even a slight deterioration in renal function, as well as in elderly patients.

• Hydantoin and sulfonamides: the toxic effects of these substances may be enhanced.

Combinations that require precautions

• Diuretics, ACE inhibitors and angiotensin II antagonists: NSAIDs may reduce the effectiveness of diuretics and antihypertensive drugs. In patients with impaired renal function (eg, dehydrated patients or elderly patients), concomitant use of ACE inhibitors or angiotensin II antagonists with drugs that inhibit the cyclooxygenase system may cause additional impairment of renal function, including acute renal failure, which is usually reversible.

Patients should be adequately hydrated and renal function should be monitored after initiation of concomitant therapy.

• Pentoxifylline: increased risk of bleeding. More frequent monitoring of the clinical condition and control of blood clotting time is mandatory.

• Zidovudine: Increases the risk of red blood cell toxicity via effects on reticulocytes, with severe anemia occurring one week after starting NSAID treatment. It is necessary to perform a complete blood count and monitor the reticulocyte count once or twice a week after starting NSAID treatment.

• Sulfonylurea: NSAIDs may enhance the hypoglycemic effect of sulfonylurea by reducing its binding to plasma proteins.

Combinations to take into account:

• Beta blockers: NSAIDs may reduce the antihypertensive effects of beta blockers due to inhibition of prostaglandin synthesis.

• Cyclosporine and tacrolimus: NSAIDs may increase nephrotoxicity due to renal prostaglandin-related effects. When used together, it is necessary to monitor renal function.

• Thrombolytics: increased risk of bleeding.

• Probenecid: plasma concentrations of ketoprofen may increase. This increase may be due to an inhibitory mechanism at the site of renal tubular secretion and glucuronoconjugation and requires dose adjustment of ketoprofen.

special instructions

At the beginning of treatment, it is necessary to monitor the peripheral blood picture and the functional state of the liver and kidneys.

After 2 weeks of using the drug, monitoring of liver function indicators (transaminase levels) is necessary.

The use of ketoprofen by patients suffering from bronchial asthma can lead to an attack of bronchial asthma.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

The drug can change the properties of platelets, but does not replace the preventive effects of acetylsalicylic acid in cardiovascular diseases.

Taking the drug may mask signs of infectious diseases.

In elderly patients, patients with a history of ulcers, and patients taking low-dose aspirin or other drugs that may increase the risk of gastrointestinal reactions, the combined use of protective drugs (misoprostol or proton pump inhibitors) is indicated.

The use of the drug may adversely affect female fertility and is not recommended for women planning pregnancy.

The use of the drug should be discontinued in women with fertility problems or undergoing fertility research.

The drug does not interfere with low-calorie and controlled diets, and can also be used in diabetic patients.

The drug does not contain gluten; therefore, the drug is not contraindicated in patients with celiac disease.

The drug does not contain aspartame; therefore, the drug can be used in patients with phenylketonuria.

Cardiovascular and cerebrovascular effects

Patients with hypertension and/or moderate heart failure with a history of fluid retention and edema associated with NSAID use require careful monitoring and counseling.

Clinical studies and epidemiological data indicate that the use of some NSAIDs (especially at high doses over long periods of time) may be associated with a small increased risk of arterial thrombotic events (eg, myocardial infarction or stroke). There is insufficient data to exclude this risk for ketoprofen lysine salt.

Patients with uncontrolled hypertension, heart failure, established coronary artery disease, peripheral arterial disease and/or cerebrovascular disease should use ketoprofen lysine salt only after careful evaluation. Patients with risk factors for cardiovascular disease (for example, hypertension, hyperlipidemia, diabetes mellitus, smoking) should undergo the same examination before starting long-term treatment.

Impact on the ability to drive vehicles and machinery

The drug has a limited and moderate effect on the ability to drive vehicles or operate machinery due to the possible occurrence of dizziness and drowsiness.

If drowsiness, dizziness or convulsions are observed after using the drug, you should avoid driving vehicles and machinery, as well as other activities that require concentration.

Granules for the preparation of oral solution 80 mg/2 g.

2 g of the drug in a two-volume sachet (1.0 g in each volume) made of three-layer material: low-density polyethylene (inner part), aluminum (intermediate part), paper (outer part).

20 or 12 sachets along with instructions for use are placed in a cardboard pack.

Do not use the drug after the date indicated on the package.

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Dompe S.p.A., Via Campo di Pile - L'Aquila, Italy

Consumer complaints should be sent to:

CJSC "SSC LTD"

115478, Moscow, Kashirskoye shosse, 23, House of Scientists of the Russian Academy of Medical Sciences, 2nd floor, room. A.

Source: http://xn——8kceunaflgjrqyoqfbei8dxl.xn--p1ai/%D0%9E%D0%9A%D0%98_%D0%B3%D1%80%D0%B0%D0%BD%D1%83%D0 %BB%D1%8B

OKI - instructions for use, composition, release form, dosage, contraindications, analogues and price

Oki is intended to relieve swelling accompanying joint diseases - arthritis - the instructions for use of the medication contain information about other indications for use. Anti-inflammatory agent relieves fever, chills, can be used by adults and children. Read the instructions for use of the medicine to ensure that you take it correctly.

Oka's medicine

The generally accepted pharmacological classification classifies the Oki drug in question as a non-narcotic anti-inflammatory drug that has an analgesic and antipyretic effect. The medication relieves inflammation, reduces fever and relieves pain reactions due to the active ingredient – ​​lysine salt of ketoprofen.

Composition and release form

Oka is available in the form of rectal suppositories (for adults and children), granules for solution and solution for topical use. Detailed composition of each drug:

Concentration of ketoprofen lysine salt, mg

Additional components of the composition

Sodium chloride, mannitol, colloidal silicon dioxide, sodium saccharin, ammonium glycerate, mint flavor

Ethanol, glycerol, mint flavor, sodium saccharin, methyl hydroxybenzoate, menthol, brilliant green (verde certosa), water, sodium hydrogen phosphate

White or pale yellow, with a mint scent

White or light yellow, torpedo-shaped

Transparent solution, green in color, with mint aroma

12 or 20 sachets

150 ml bottles with 2 ml injection dispenser and plastic cap for reconstitution

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Pharmacodynamics and pharmacokinetics

The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). The active substance of the drug is a derivative of propionic acid and has an analgesic, antipyretic and anti-inflammatory effect. The mechanism of action of the component is associated with inhibition of the activity of the main enzyme in the metabolism of arachidonic acid, which is considered a precursor of prostaglandins that cause inflammation, pain and fever.

Ketoprofen has an analgesic effect due to peripheral and central mechanisms of action. The first is associated with the suppression of prostaglandin synthesis, the second - with the inhibition of the same process in the central and peripheral nervous system, the effect on the biological activity of neurotropic substances. Ketoprofen has anti-bradykinin activity, stabilizes liposomal membranes, inhibits the activity of neutrophils in rheumatoid arthritis, and inhibits platelet aggregation.

When taken orally or rectally, ketoprofen is absorbed from the gastrointestinal tract, reaching maximum concentration after 1-5 hours when administered orally, after a minute when administered rectally, after a minute when administered intramuscularly and after five minutes when administered intravenously. The component binds to blood plasma proteins by 99% and penetrates the blood-brain barrier. The effect of the drug lasts for 2-18 hours, it penetrates into the synovial fluid, the remainder is excreted by the kidneys or intestines.

Indications for use

Oki - the instructions for use of the drug indicate the following indications for its use:

  • articular syndrome, inflammatory diseases;
  • rheumatoid arthritis, osteoarthritis, ankylosing spondylosis, polyarthritis;
  • gout, periarthritis;
  • arthrosynovitis, tendonitis, tenosynovitis;
  • bursitis, lumbago;
  • neuralgia, myalgia, pain after dental treatment, other dental procedures;
  • uncomplicated injuries, including sports injuries, sprains, sprains or ruptures of ligaments and tendons;
  • bruises, post-traumatic and post-operative pain;
  • otitis;
  • stomatitis, gingivitis, sore throat, laryngitis;
  • combination therapy of phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis.

Directions for use and dosage

Inside each package of medicines there are instructions for use, which indicate the method of use and dosage. The solution can be applied topically, for gargling, or administered intravenously or intramuscularly. Suppositories are used for rectal administration, granules for preparing a solution - inside, orally.

Oka solution

In ENT practice and dentistry, Oka solution is used for the throat. According to the instructions, adults are prescribed two mouth rinses per day, each of which contains 10 ml of solution (five injections). For adolescents over 12 years of age, one mouth rinse requires 6 ml of solution (three injections). The solution is prepared in a glass that comes with the package. 100 ml of water is poured into it, the required amount of the drug is sprayed (one press corresponds to 2 ml). According to reviews, accidental ingestion of the solution does not lead to serious negative consequences.

For the treatment of acute conditions and relief of exacerbations in the process of chronic inflammation, the solution can be administered intravenously or intramuscularly, no more than 100 mg at a time. It is also allowed to use the drug externally - apply to affected surfaces twice a day. The course of treatment and dosage of the drug is prescribed by the attending physician.

Oka granules

Oka powder is intended for oral use. The dosage is determined individually. According to the instructions, adults are prescribed one full dose (the contents of a two-volume sachet is 80 mg). The granules are dissolved in half a glass of drinking water and taken three times a day with meals. For elderly patients, the dosage is halved. Children 6-14 years old should take half the dose of the 80 mg sachet (tear it along the line marked “half dose”). The maximum dose for adults is 300 mg/day, for children – 150.

Oka candles

The maximum dose for the use of rectal suppositories for adults is 480 mg/day. Patients over 18 years of age should use one suppository 2-3 times a day. Elderly patients should not use more than two rectal suppositories in one day. This is due to possible negative consequences for the body, an overdose of the active component.

Suppositories for children

According to the instructions, children should use suppositories with a ketoprofen concentration of 60 mg. Suppositories are administered rectally 1-2 times a day for a child 6-12 years old (with a body weight of more than 30 kg), or three times a day for children over 12 years old. The daily dosage for children is 5 mg/kg body weight. Doctors warn that suppositories should not be used for longer than five days, unless prescribed by a pediatrician.

special instructions

The instructions for use of the drug Oki indicate that it should be used with caution in patients with a history of liver, kidney, gastrointestinal diseases, dyspeptic symptoms, or immediately after major operations or implantations. During drug treatment, doctors must systematically monitor the patient's liver and kidney function. The drug affects the speed of psychomotor reactions, inhibiting concentration.

Okie during pregnancy

The drug Oki is contraindicated for use in the third trimester of pregnancy. According to the instructions, the use of the medication in the first and second trimesters is possible if the doctor evaluates the potential benefit to the mother versus the risk to the fetus. During breastfeeding, treatment with ketoprofen is prohibited due to the penetration of the active substance into breast milk.

In childhood

The instructions for use of the drug Oki warns that granules for preparing the solution and rectal suppositories are contraindicated for children under 12 years of age; the rinsing solution is prescribed only for those over 12 years of age. When using rectal suppositories, you should choose the option with ketoprofen concentrations of 30 or 60 mg; their packs may say “children’s.”

Drug interactions

When taking the drug Oki and other medications simultaneously, negative manifestations indicated in the instructions are possible:

  • other NSAIDs, thrombolytics, Heparin, Ticlopidine increase the risk of developing erosions, ulcers in the gastrointestinal tract, and bleeding;
  • Oki reduces the effectiveness of antihypertensive drugs, beta-blockers, diuretics, increases the hypoglycemic effect of insulin;
  • acetylsalicylic acid, probenecid reduce the effectiveness of ketoprofen;
  • when combined with lithium preparations, the concentration of lithium in the blood plasma increases to a toxic level;
  • diuretics lead to the development of renal failure;
  • increases the side effect of taking Methotrexate;
  • Warfarin causes severe, fatal gastrointestinal bleeding.

Side effects

The instructions for use of the drug Oki indicate the following possible actions when taking ketoprofen:

  • stomach pain, nausea, vomiting, constipation, diarrhea;
  • gastralgia, liver dysfunction, erosions, gastrointestinal ulcers, bleeding, perforation;
  • headache, tinnitus, drowsiness, dizziness;
  • peripheral edema, asthma attacks;
  • impaired renal function, skin rash, bronchospasm;
  • irritation of the rectal mucosa, pain during bowel movements, itching, burning.

Overdose

According to the information specified in the instructions for use, there have been no reports of cases of overdose with the drug Oka. Theoretically, the manifestations of an overdose can be similar to side effects, only amplified many times over. Treatment involves gastric lavage, sorbents and other therapy similar to NSAID poisoning.

Contraindications

Depending on the form of release of the drug Oki used, the contraindications for its use indicated in the instructions differ:

  • for oral administration: erosion, gastrointestinal ulcer in the acute phase, aspirin triad, impaired renal and liver function, third trimester of pregnancy, hypersensitivity to the components of the drug or salicylates, children under 12 years of age;
  • for rectal administration: proctitis, rectal bleeding;
  • for external use: weeping dermatosis, eczema, abrasions, wounds with infectious diseases;
  • general: peptic ulcer, hemophilia, Crohn's disease, diverticulitis, bronchial asthma, blood diseases.

Terms of sale and storage

Oka granules are dispensed from pharmacies with a prescription, all other forms of release are available without it. The drugs are stored at temperatures up to 25 degrees, away from children. The shelf life is two years for solution and granules, three years for suppositories with a concentration of 30 and 60 mg, five years for suppositories with a concentration of 120 mg.

Analogues of Oka

On the shelves of Russian pharmacies you can find direct and indirect analogues of Oka. The former are similar in composition, while the latter have a different active substance, but work the same way. Popular analogues produced by pharmacological enterprises:

Oka price

You can buy Oki through pharmacies or the Internet at a cost that depends on the chosen form of release and the concentration of the active ingredient. Approximate prices for Moscow and St. Petersburg:

Price when purchasing online, in rubles

Pharmacy price, in rubles

Sachets of granules 80 mg, 2 g, 12 pcs.

Rectal suppositories 120 mg, 10 pcs.

Solution, bottle 150 ml

Reviews

If I have a cold, I immediately go to the pharmacy and buy Oki for gargling in the form of a solution. I like that it instantly relieves pain and even brings down the onset of fever. The medicine also has a convenient format - it comes with a glass, so you don’t have to look for something to dilute it in. I gargle twice a day and forget about the disease.

The child sometimes develops an incomprehensible temperature and suffers from fever. The last time, to eliminate such symptoms, the doctor prescribed Oka rectal suppositories for us. They contain ketoprofen, which quickly relieves negative symptoms. I inserted suppositories once a day, at night, and after three days the child returned to normal life.

I play sports professionally, so injuries and bruises are not uncommon for me. If there is a nagging pain in the spine, I use Oka granules. To use them quickly and effectively - I dilute the contents of the sachet in water and drink. If the pain is not severe, it goes away immediately, otherwise it takes about a week to be treated. My review is positive!

I am showing the first signs of gout, my joints hurt, and my mobility is limited. During the examination, the doctor said that this can be prevented and the degree of pain can be reduced. I was prescribed Oka rectal suppositories, but I doubted how they could relieve pain. I’d rather take pills than use suppositories, they don’t inspire confidence in me.

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://sovets.net/14745-oki-instrukciya-po-primeneniyu.html

OKI ®

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and release form

in two-volume sachets made of three-layer material, 2 g each (half the dose - 1 g - in each volume); There are 12 or 20 sachets in a cardboard box.

5 pcs per strip; 2 strips in a cardboard pack.

5 pcs per strip; 2 strips in a cardboard pack.

in 150 ml bottles with a dispenser for injecting 2 ml of the drug and a plastic transparent cap for dilution with a capacity of 100 ml; 1 bottle in a cardboard pack.

Description of the dosage form

Granules for the preparation of a solution for oral administration: white to pale yellow in color with a characteristic mint odor.

Rectal suppositories for children: from white to light yellow, torpedo-shaped.

Rectal suppositories: from white to light yellow, torpedo-shaped.

Solution for topical use: transparent, green in color with a characteristic mint odor.

pharmachologic effect

Pharmacodynamics

It has anti-inflammatory, analgesic and antipyretic effects. By inhibiting COX-1 and -2, it inhibits PG synthesis. It has anti-bradykinin activity, stabilizes lysosomal membranes and delays the release of enzymes from them that contribute to tissue destruction during chronic inflammation. Reduces the release of cytokines, inhibits the activity of neutrophils.

Reduces morning stiffness and swelling of joints, increases range of motion.

Ketoprofen lysine salt, unlike ketoprofen, is a rapidly soluble molecule with a neutral pH and is almost non-irritating to the gastrointestinal tract.

Pharmacokinetics

Suction. When administered orally, ketoprofen is quickly and fairly completely absorbed from the gastrointestinal tract, its bioavailability is about 80%. C max in plasma when taken orally is observed after 0.5–2 hours, its value directly depends on the dose taken; after rectal use, Tmax is 45–60 minutes. Cmax of ketoprofen is achieved 24 hours after the start of its regular use.

Distribution. Up to 99% of absorbed ketoprofen is bound to plasma proteins, mainly albumin. V d - 0.1–0.2 l/kg. Easily passes through histohematic barriers and is distributed in tissues and organs. Ketoprofen penetrates well into synovial fluid and connective tissue. Although the concentration of ketoprofen in synovial fluid is slightly lower than in plasma, it is more stable (lasts up to 30 hours).

Metabolism. Ketoprofen is mainly metabolized in the liver, where it undergoes glucuronidation to form esters with glucuronic acid.

After using 160 mg of ketoprofen lysine salt in the dosage form of a topical solution, the plasma concentration of ketoprofen is low - less than 400 ng / ml - and, therefore, insufficient for a pronounced systemic pharmacological effect.

Indications for the drug OKI

Granules for the preparation of solution for oral administration, rectal suppositories for children, rectal suppositories

Symptomatic treatment of inflammatory processes accompanied by fever and pain, incl. inflammatory and rheumatic diseases of the joints:

inflammatory damage to periarticular tissues.

Children (over 6 years old)

Short-term symptomatic treatment of painful inflammatory processes in conditions such as:

diseases of the musculoskeletal system;

relief of postoperative pain.

Solution for topical use

Symptomatic treatment of inflammatory diseases of the ENT organs and oral cavity:

dental procedures (as an analgesic).

Contraindications

Common to all forms

hypersensitivity (including to other NSAIDs);

General for granules, rectal suppositories for children, rectal suppositories:

peptic ulcer of the stomach and duodenum (exacerbation)

ulcerative colitis (exacerbation);

hemophilia and other bleeding disorders;

chronic renal failure;

children's age up to 6 years (for granules and rectal suppositories for children), for rectal suppositories - up to 18 years;

pregnancy (III trimester);

chronic heart failure;

blood diseases (including leukopenia);

For granules and rectal suppositories additionally

alcoholic cirrhosis of the liver;

pregnancy (I, II trimesters).

For topical solution

peptic ulcer of the stomach and duodenum (exacerbation);

ulcerative colitis (exacerbation);

hemophilia and other bleeding disorders;

chronic renal failure;

children's age (up to 6 years);

pregnancy (III trimester);

Use during pregnancy and breastfeeding

For granules, rectal suppositories and solution for topical use. Like other NSAIDs, OCI should not be used in the third trimester of pregnancy. The use of the drug in the first and second trimester should be carefully monitored by the attending physician. Breastfeeding should be discontinued while using the drug.

Side effects

Common for granules, rectal suppositories for children and rectal suppositories

From the gastrointestinal tract: abdominal pain, diarrhea, duodenitis, erosive and ulcerative lesions of the gastrointestinal tract, gastritis, hematomesis, esophagitis, stomatitis, melena.

From the liver: increased bilirubin levels, liver enzyme activity, hepatitis, liver failure, increased liver size.

From the nervous system: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.

From the senses: conjunctivitis, visual impairment.

From the skin: urticaria, angioedema, erythematous exanthema, itching, maculopapular exanthema, increased sweating, exudative erythema multiforme (including Stevens-Johnson syndrome).

From the genitourinary system: painful urination, cystitis, edema, hematuria, menstrual irregularities.

From the hematopoietic organs: leukocytopenia, leukocytosis, lymphangitis, decreased PV, purpura, thrombocytopenia, thrombocytopenic purpura, enlarged spleen, vasculitis.

From the respiratory system: bronchospasm, dyspnea, sensation of laryngeal spasm, laryngospasm, laryngeal edema, rhinitis.

From the cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor.

Allergic reactions: anaphylactoid reactions, swelling of the oral mucosa, pharyngeal edema, periorbital edema.

Any other undesirable effect not listed in this instruction should be reported to your doctor. If side effects from the intestines are detected, the drug in the form of granules should be used with meals or with milk.

For rectal suppositories for children and rectal suppositories additionally

Local reactions: burning, itching, heaviness in the anorectal area, exacerbation of hemorrhoids.

For topical solution. Allergic reactions. If the drug is swallowed, systemic side effects may develop.

Interaction

For granules, rectal suppositories for children, rectal suppositories. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of mineralcorticosteroids, corticosteroids, estrogens. Reduces the effectiveness of antihypertensive and diuretic drugs.

Combined use with other NSAIDs, corticosteroids, ethanol, corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, increasing the risk of developing renal dysfunction.

Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefaperazone, cefamandole and cefotetan increases the risk of bleeding.

Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary).

Co-administration with sodium valproate causes disruption of platelet aggregation. Increases plasma concentrations of verapamil and nifedipine, lithium preparations, methotrexate. Antacids and cholestyramine reduce absorption.

For topical solution. No interactions were detected.

Directions for use and doses

Rectally, orally, locally.

Inside. Adults - dissolve the contents of 1 two-volume sachet (full dose) in half a glass of drinking water and take orally 3 times a day with meals. To obtain one full dose (80 mg), open the double sachet along the line labeled “full dose.”

For elderly patients, the dose is determined by the doctor (it is advisable to reduce the dosage by 2 times).

Children 6–14 years old: dissolve the contents of 1/2 of a two-volume sachet (half the dose) in half a glass of drinking water and take orally 3 times a day with meals. To receive half the dose (40 mg), open the double sachet along the line marked “half dose”; for children 14–18 years of age, dosages of the drug correspond to those for adults

Rectally. Children 6–12 years old (body weight more than 30 kg) - 1 suppository OKI 60 mg 1–2 times a day; over 12 years old - up to 3 times a day. The daily dose is no more than 5 mg/kg. Do not use for more than 5 days without consulting a doctor.

Dosages used to treat children are insufficiently effective in treating adults.

Adults - 1 suppository 2-3 times a day. The maximum daily dose is 480 mg. In elderly patients, it is necessary to use no more than 2 suppositories per day.

Locally. 2 rinses per day, 10 ml of OKI solution (5 injections) per dose. A solution of 5 injections should be diluted in a glass supplied with the package, half filled with drinking water. When you press the dispenser-injector located at the top of the bottle, the patient receives 1 injection - 2 ml of OKI solution. Accidental ingestion of rinse solution does not lead to serious consequences, because... a single dose for rinsing contains 160 mg of ketoprofen lysine salt, which corresponds to the dose intended for oral administration. Adolescents over 12 years of age should use no more than 3 sprays per cup.

Overdose

Currently, no cases of overdose with OCI have been reported.

Treatment: in case of overdose, carry out treatment prescribed for NSAID poisoning.

special instructions

During treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Taking ketoprofen can mask the signs of an infectious disease.

If renal or liver function is impaired, dose reduction and careful monitoring are necessary. The use of ketoprofen by patients suffering from bronchial asthma can lead to an attack of bronchial asthma.

Women planning pregnancy should refrain from taking the drug, because the likelihood of egg implantation may decrease.

Influence on the ability to drive vehicles and operate machinery. During the period of use of the drug, you should refrain from potentially hazardous activities associated with the need for concentration and rapid psychomotor reactions.

Solution for topical use. Long-term use of external drugs can lead to sensitization. In this case, you should stop using the drug and select adequate treatment methods.

Instructions for preparing the solution. Bring the sprayer to the functional position, turning the “spout” towards the inscription “open”, inject into the attached plastic cup by pressing the sprayer all the way (injections are repeated until the dose prescribed by the doctor is reached), dissolve the injected dose in 100 ml of drinking water (half a plastic cup ).

Conditions for dispensing from pharmacies

Granules. On prescription.

Storage conditions for the drug OKI

Keep out of the reach of children.

Shelf life of the drug OKI

solution for topical use 16 mg/ml - 2 years.

rectal suppositories for children 60 mg - 3 years.

rectal suppositories 160 mg - 5 years.

granules for the preparation of solution for oral administration 80 mg - 2 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Prices in Moscow pharmacies

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 N 61-FZ.

rectal suppositories 160 mg, 10 pcs.

solution for topical use 16 mg/ml, 1 pc.

granules for the preparation of solution for oral administration 80 mg, 12 pcs.

Dompe Farmaceutici (Italy)

granules for the preparation of solution for oral administration 80 mg, 20 pcs.

Dompe Farmaceutici (Italy)

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OKI powder: instructions for use of the drug

Antibiotics fight bacteria and viruses by acting on them from the inside, and anti-inflammatory drugs help make this fight more effective and speed up the healing process. OKI is an ambulance for sore throat, pharyngitis, laryngitis, stomatitis, periodontal disease, toothache, arthritis, osteoarthritis, rheumatism, sprains, and bruises.

The therapeutic effect of the drug OKI powder, the instructions for use of the drug describe as a complex effect, in addition to anti-inflammatory, effectively reduces fever and relieves pain. Therefore, OKI is used to relieve acute pain from a sore throat in the form of a solution, which is injected into water and used for rinsing.

Thanks to the active ingredient - ketoprofen - it is possible to quickly relieve inflammation and swelling in case of severe sore throat. With regular use of OKI powder according to the instructions for use, it is possible to cope with sore throat and other infectious diseases of the mouth and throat in a short time.

The analgesic (analgesic) effect of OKI granules, solution and suppositories is due to the effect on pain receptors in the central nervous system. Unlike Ketoprofen, OKI granules (powder) dissolve in water faster and have a neutral pH level, so the risk of irritation of the stomach and intestines during use of the drug is minimal.

In the course of clinical studies, it was found that pain during dental diseases and after surgical interventions in the oral cavity dynamically decreased within the first day after starting the use of the drug. The lasting effect persisted even after the end of the course of use, and the drug was well tolerated by patients of different ages and health conditions.

No severe reactions from the use of OCI or overdose were recorded. But the drug in the form of a powder for rinsing should not be swallowed, as it can cause bronchospasm and swelling of the larynx. This danger exists only when large doses of OCI powder are swallowed.

The instructions for use note that the drug is contraindicated for people who have an allergic reaction to substances in the medication, since urticaria and rhinitis are not excluded, and OCI is contraindicated for people with “aspirin” asthma.

When using OKI suppositories, allergic reactions to the rectal mucosa and exacerbation of hemorrhoids are possible. Typically, hypersensitivity to the drug develops with prolonged use.

OCI can be used with caution in people with diseases of the stomach and intestines, especially in the acute stage.

OCI powder instructions for use do not recommend use by those with a history of renal failure or impaired blood clotting.

The use of the drug in the third trimester of pregnancy and during breastfeeding is contraindicated, since the newborn may develop breathing difficulties, and the mother may experience delayed labor. In the first and second trimesters of pregnancy, the use of OCI under medical supervision is allowed. In women, when taking OCI orally, the likelihood of egg implantation is reduced, therefore, when planning pregnancy, it is necessary to refrain from using the drug in the form of granules.

Important

The drug in the form of granules is absolutely contraindicated for oral administration to children under 6 years of age.

Caution is required when taking it for bronchial asthma, as attacks of suffocation are possible.

Including in old age, therefore for older people the dose is reduced or selected individually by the treating doctor.

The use of OKI granules should be avoided when performing work activities related to driving or requiring increased concentration of attention.

OKI easily penetrates all organs and tissues, is metabolized in the liver and is excreted 75% in the urine.

You cannot prescribe OKI on your own, since its uncontrolled use can mask the course of an infectious disease!

OKI has the following effects:

  • reduces the effectiveness of drugs that normalize blood pressure, diuretics and drugs for the treatment of gout;
  • enhances the effect of ethanol and medications to normalize blood clotting (anticoagulants, antiplatelet agents, etc.).

The simultaneous use of OCI with thrombolytics, cefamandole can cause bleeding, and when using OCI orally together with acetylsalicylic acid and ethanol, the development of ulcers is possible; when taken together with hormonal drugs, their side effects increase.

When prescribing OKI in granules to patients with diabetes, a dose recalculation is required, since the drug increases the hypoglycemic effect of insulin.

When applied topically, OKI is not able to have a systemic effect on the body, and no side effects from interactions with other medications have been identified. OCI is absolutely incompatible with Tramadol (an opioid with an analgesic effect).

OKI solution: instructions for use for the treatment of various diseases

The drug is available in the form:

  • OKI solution with instructions for rinsing or topical use;
  • granules for dissolution and oral administration;
  • rectal suppositories (children and adults).

OKI solution with instructions for use has a greenish tint, as it contains brilliant green, which is an antiseptic. Mint flavoring gives the solution a pleasant taste and aroma. The main reason for the contraindication of the use of OCI in children under 6 years of age is the presence of ethanol in the composition of the drug, which often causes irritation and dryness of the child’s mucous membranes. If there are no side effects, the use of OCI solution is acceptable.

For rinsing the throat and mouth for various inflammations, an OKI solution is prepared.

According to the instructions, 100 ml of water (1/2 a standard plastic glass), always warm but not hot water, is poured into the measuring cup supplied with the drug, and then the drug is injected into it through a dispenser on the bottle. One press gives a dose of 2 ml of the drug. After two presses, a solution is obtained with a concentration suitable for gargling for a child 3-6 years old.

For children over 12 years of age, the OKI solution instructions require increasing the dose to 3 injections, and for adults – to 5.

The drug is used in the form of a rinse solution no more than 2 times a day, and each procedure should last 30 seconds or more. OKI is a strong and effective solution for topical use and therefore does not require frequent use.

As an antipyretic and analgesic, suppositories (rectal suppositories) OKI and water-soluble granules are used, which are taken orally 3 times a day with meals:

  • adults 80 mg (dissolve in 1/2 glass of water);
  • children (6-14 years old) 40 mg or half a sachet of 80 mg (dissolve in 1/2 cup of water).

Candles for adults are prescribed 3 times a day. The use of suppositories in elderly people should not exceed 2 times a day.

Use as an anti-inflammatory and analgesic agent for diseases of the musculoskeletal system gives a lasting effect on average a week after the start of oral use of OKI granules. The advantage of OCI as an analgesic and anti-inflammatory drug is that it does not have a negative effect on cartilage tissue.

If after 2-3 days of using OKI the therapeutic effect is not observed, you should consult a doctor. You may need to choose a different drug.

Analogues of the active substance (ketoprofen) are:

  • Rompharm;
  • Artrum;
  • Arketal;
  • Quickcap;
  • Valusal;
  • Artrosilene;
  • Ketoprofen;
  • Flamax;
  • Flexen;
  • Ketonal.

Similar in mechanism of action to OKI: MIG, Advil, Faspik.

There are no analogues of the OKI rinsing solution, but according to the mechanism of action, Chlorophyllipt, Hall's Max, Miramistin, Chlorhexidine and Kamistad have similar properties.

OCI is an Italian-made drug.

In terms of cost, it belongs to the average price category of medicines:

  • from 300 rubles for a solution for topical use;
  • from 250 rubles per package of granules or candles.

Specialty: Otorhinolaryngologist Work experience: 29 years

Specialty: Audiologist Work experience: 7 years

Source: http://gajmorit.com/angina/oki-poroshok-instrukcija-po-primeneniju/