Nasobek instructions price

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Nasobek

Description current as of 08/11/2014

  • Latin name: Nasobec
  • ATX code: R01AD01
  • Active ingredient: Beclometasone
  • Manufacturer: Teva Pharmaceuticals Industries, Israel

Compound

One dose of spray contains the active substance (beclomethasone dipropionate) 50 mcg + excipients (phenylethanol, dextrose anhydride, sodium carboxymethylcellulose, water, benzalkonium chloride, polysorbate, microcellulose, hydrochloric acid).

Table of contents:

Release form

The spray is a suspension, white, opaque, without inclusions. In bottles of 100, 180 and 200 doses.

pharmachologic effect

Anti-inflammatory, antiallergic agent. Relieves swelling.

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug is a synthetic glucocorticosteroid. It stimulates the reproduction of lipomodulin, which is an inhibitor of the phospholipase A enzyme and delays the process of arachidonic acid synthesis. Thus, there is a decrease in inflammatory exudation and the synthesis of lymphokines, and a slowdown in the process of marginal accumulation of neutrophil cells.

The processes of infiltration and granulation are inhibited due to the ability of beclomethasone to inhibit the migration of macrophages. Swelling subsides, less mucus is produced, mucociliary transport improves.

The product is well tolerated, even with very long-term use. Relief of symptoms occurs within a couple of days after starting treatment.

When administered by inhalation, it does not have high absorption capacity. A small amount of the substance that penetrates the gastrointestinal tract is destroyed in the liver. Half of the substance is excreted from the body after 15 hours, up to 90% of the active substance binds to plasma proteins. The drug is excreted in feces and, slightly, through the kidneys.

Indications for use

Contraindications

  • allergy to any of the components of the medicine;
  • hemorrhagic diathesis;
  • first trimester of pregnancy;
  • tendency to nosebleeds;
  • fungal or viral infection;
  • tuberculosis of the respiratory tract or organs.

The drug is contraindicated in children under 6 years of age.

You should be careful when:

Side effects

Rarely may occur:

Known cases of occurrence:

Instructions for Nasobek (Method and dosage)

Over the age of 12 years, 1-2 doses are prescribed in each nostril 2 times a day.

For children from 6 to 12 years old, the daily dose is up to 400 mg. As a rule, take 1 dose in each pass, 2 times a day.

Treatment with the drug is continued until there is an improvement in health.

According to the instructions for use of Nasobek, before using it for the first time (or after a long break), the bottle should be shaken.

Release several doses into the air until a white cloud appears.

Then, placing the spray nozzle between your middle and index fingers, exhale.

Pinch the free nasal passage with one finger and spray the medicine into the other. Spraying is done while inhaling, exhaling through the mouth.

You must repeat the above steps for the other nostril.

At the end of the procedure, clean the spray nozzle with a damp cloth or clean handkerchief.

Additionally, it is recommended to clean the applicator at least once a week. The spout should be removed, rinsed with warm running water, dried and put back on the bottle.

Overdose

With prolonged use of large doses, hypercortisolism may occur. You should gradually reduce the dose and stop taking the drug.

Interaction

When combined with phenobarbital, phenytoin, Rifampicin, glutethimide and Ephedrine, beclomethasone reduces its therapeutic properties.

Concomitant use with adrenomimetics, antithrombotics, digitalis preparations, oral hypoglycemic drugs and Indapamide leads to an increased risk of side effects, both on one side and the other.

The drug enhances the effect of antiasthmatic drugs and systemic corticosteroids.

Terms of sale

Storage conditions

Keep out of the reach of small children. Temperature range from 10 to 25 degrees.

Best before date

4 years. If the bottle has been opened, it should be used no more than 3 months in advance.

special instructions

Avoid getting the drug into your eyes.

The effect of taking the medicine does not appear immediately; sometimes it may take up to 7 days to achieve it. During this time, you should not try to reduce the dosage or stop taking the drug.

It is prohibited to use the medicine on damaged mucous membranes until wounds and ulcers have completely healed.

Particular attention should be paid to people at increased risk of developing adrenal insufficiency and young children.

Be careful when operating vehicles and machinery while taking the drug.

Nasobek's analogs

Other analogues on the market: Klenil, Bekotide, Beclat, Rinoklenil, Aldecin, Beklorin.

Nasonex is used to treat sinusitis, rhinitis (allergic rhinitis). It can be taken by children from two years of age and is considered to be less harmful. The cost of Nasobek is significantly lower than that of its analogue. In any case, the issue of replacing or discontinuing the drug should be decided together with the attending physician.

Reviews about Nasobek

Reviews about Nasobek are mostly positive. Many people use this remedy to fight not only allergies, but also the symptoms of sinusitis, when vasoconstrictor drugs no longer help. In combination with antibiotics, the drug copes with sinusitis.

Some patients who have become dependent on vasoconstrictors fight it with the help of Nasobek. Side effects are rare; many people like the floral scent of the drug and the convenient release form. The relatively low cost of the drug is also attractive.

Nasobek price, where to buy

The price of Nasobek is about 180 rubles per bottle containing 200 doses.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Kazakhstan Kazakhstan

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Source: http://medside.ru/nasobek

Nasobek

  • Teva, Israel
  • Expiration date: until 09/01/2021

Nasobek instructions for use

Buy with this product

Release form

Compound

    1 dose contains beclomethasone dipropionate 50 mcg; excipients: benzalkonium chloride; phenylethanol; polysorbate 80; dextrose anhydride; MCC; sodium carboxymethylcellulose; hydrochloric acid; purified water.

Package

100, 180 or 200 doses.

pharmachologic effect

Nasobek has anti-inflammatory, antiallergic, immunosuppressive effects.

Indications

Seasonal and year-round allergic rhinitis, vasomotor rhinitis.

Contraindications

Hypersensitivity to the components of Nasobek, hemorrhagic diathesis, frequent nosebleeds, children under 6 years of age, systemic infections (fungal, including candidiasis of the upper respiratory tract, bacterial, including pulmonary tuberculosis), herpetic eye damage, acute respiratory infections.

With caution: amoebiasis, glaucoma, severe liver failure, hypothyroidism, recent myocardial infarction, ulceration of the nasal septum, recent surgical interventions in the nasal cavity, recent trauma to the nose, breastfeeding period.

Directions for use and doses

Nasobek is used intranasally. Before use, clear the nasal passages. Adults and children over 6 years of age: 1 dose (50 mcg) in each nostril 2-4 times a day (mcg). The dose is then reduced depending on the patient's response.

Use during pregnancy and breastfeeding

Allowed only if the expected benefit to the mother outweighs the possible risk to the fetus. When treating with Nasobek during breastfeeding, caution should be exercised.

Side effects

When used in therapeutic doses they are rare.

From the respiratory system: sneezing, irritation, burning and dryness of the nasal mucosa and infections of the nasopharynx caused by fungal flora, rhinorrhea; in rare cases - nosebleeds, atrophy of the nasal mucosa, cough; extremely rarely - perforation of the nasal septum.

Allergic reactions: rash, urticaria, angioedema, conjunctival hyperemia.

Other: headache, increased intraocular pressure, myalgia, drowsiness, decreased sense of taste.

With long-term use in doses of more than 1500 mcg/day - systemic effects (including adrenal insufficiency).

special instructions

It is necessary to protect the eyes from contact with the drug.

Instructions for the correct use of Nasobek spray:

Before using the spray for the first time, remove the plastic strip between the bottle cap and the nasal applicator.

1. Before use, shake the bottle slightly and then remove the cap of the nasal applicator.

2. Hold the bottle between your thumb and index finger so that the bottom of the bottle rests on your thumb and your index and middle fingers rest on either opposite side of the bottom of the applicator.

3. Before the first use of the drug or in case of a week-long break in use, the first dose should be released into the free space.

4. Exhale lightly through your nose.

5. The nostril into which the drug will not be injected should be pinched with a finger, and the end part of the applicator should be inserted into the free nostril. Then tilt your head slightly so that the bubble is in a perpendicular position.

6. After this, inhale lightly through the open nostril and simultaneously press the nasal applicator and administer the dose.

7. Exhale through your mouth.

8. When re-introducing the drug Nasobek into the same nostril, repeat the operations described in paragraphs. 7 and 8.

9. When introducing the drug into the other nostril, repeat the operations described in paragraphs. 6, 7, 8 and 9.

After finishing using the drug, you should clean the end of the applicator with a clean cloth and return the cap to its place.

Cleaning the nasal applicator

The nasal applicator should be cleaned at least once a week to prevent the possibility of clogging.

To do this, lightly press the bottom of the bottle and remove the nasal applicator from the bottle. The applicator and cap are rinsed with warm water and allowed to dry. After this, the applicator and cap are put back on the bottle.

Drug interactions

When used together, phenobarbital, phenytoin, and rifampicin reduce the effectiveness of beclomethasone (induction of microsomal oxidation enzymes).

When used together, methandrostenolone, estrogens, beta2-adrenergic stimulants, theophylline, and corticosteroids for oral administration enhance the effect of beclomethasone.

When used together, Nasobek increases the effect of beta-agonists.

Check the interaction of other drugs with Nasobek

The drugs you have chosen

Overdose

With prolonged use in high doses, as well as with the simultaneous use of other (systemic) corticosteroids, symptoms of hypercortisolism may appear.

In this case, the use of the drug should be discontinued, gradually reducing the dose.

Storage conditions

In a dry place, protected from light, at room temperature no higher than 20°C.

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  • Nasobek nasal spray. fl. 50mcg/dose 200doses Czech Republic
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  • Nasobek nasal spray 50 mcg/dose, 200 doses

Latest reviews about Nasobek

It quickly helped with vasomotor rhinitis, which I had suffered from for six months.

Together with Sinupret (tablets) it helps to cure advanced sinusitis. I recommend.

Our whole family has allergies. Therefore, we survive autumn and spring only on tablets and with this spray. Nasobek sprays well and relieves itching very quickly. The nose also stops running. And I also noticed that if I had a headache before the spray, then after use the headache also went away. Why is not clear, but it is a fact.

Medicines in alphabetical order

** Delivery is carried out only for the preferential category of citizens on the basis of Art. 2 of the Federal Law of the Russian Federation of 01/09/1997 N 5-FZ “On the provision of social guarantees to heroes of socialist labor and full holders of the Order of Labor Glory” (as amended on 07/02/2013) and Article 1.1 of the RF Law of 01/15/1993 N “On the status of Heroes Soviet Union, Heroes of the Russian Federation and full holders of the Order of Glory." All orders are placed in a pharmacy (licensed) and collected by qualified pharmacists.

Source: http://www.piluli.ru/product/Nasobek

Nasobek (Beclomethasone)

There are contraindications. Before starting use, consult your doctor.

Commercial names abroad (abroad) - Beclo Rhino, Beclonasal, Beconase, Beconasol, Nasair, Pollenase Nasal, Qnasl, Rhinirex, Rhinivict, Rhinocort, Rhinomaxil, Rinaze, Rinosol, Rivanase, Sinase.

Other glucocorticosteroids (hormones) for the nasal cavity - Nasonex.

All medications for the treatment of the nasal cavity and sinuses are here.

All drugs used in ENT practice are here.

You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the drug in the text of the message) here.

Preparations for topical use in ENT practice containing Beclometasone (ATC code R01AD01):

Nasobek - official instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group:

GCS for intranasal use (glucocorticosteroid for administration into the nose).

pharmachologic effect

Synthetic GCS for topical use. It has anti-inflammatory, antiallergic and immunosuppressive effects. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, and inhibits the release of arachidonic acid. Prevents the marginal accumulation of neutrophils, reduces inflammatory exudation and the production of lymphokines, inhibits the migration of macrophages, reduces the intensity of the processes of infiltration and granulation, and the formation of a chemotaxis substance. Reduces swelling of the nasal mucosa and mucus production. Improves mucociliary transport.

The drug is well tolerated during long-term treatment, does not have mineralocorticoid activity, and has virtually no resorptive effect.

The therapeutic effect of the drug does not appear immediately (unlike vasoconstrictors for topical use). Relief from rhinitis symptoms usually becomes noticeable within a few days of starting therapy.

Pharmacokinetics

Suction and distribution

When administered by inhalation in recommended doses, it does not have significant systemic activity.

After intranasal use, it is quickly absorbed through the nasal mucosa. Part of the administered drug is swallowed. Absorption from the gastrointestinal tract is low. Plasma protein binding - 87%.

Metabolism and excretion

Most of the drug that enters the gastrointestinal tract is metabolized during the “first pass” through the liver. T1/2 – 15 hours. The main part of the drug (35-76%), regardless of the route of administration, is excreted within 96 hours with feces, mainly in the form of polar metabolites; 10-15% is excreted by the kidneys.

Indications for use of the drug NASOBEC

  • seasonal and year-round allergic rhinitis;
  • vasomotor rhinitis.

Dosage regimen

The drug is used intranasally. Before using Nasobek, the nasal passages must be free.

Adults and children over 6 years of age are prescribed 1 dose of spray (50 mcg) in each nostril 2-4 times a day (mcg). Then the dose is reduced depending on the effectiveness and tolerability of the drug. Maximum daily dose kg.

Side effect

Possible: sneezing, irritation, burning, dry nose; rash, urticaria, angioedema, nasopharyngeal infections caused by fungal flora, rhinorrhea, headache.

In rare cases: nosebleeds, conjunctival hyperemia, increased intraocular pressure, myalgia, drowsiness, cough, decreased sense of taste, atrophy of the nasal mucosa.

Extremely rare: perforation of the nasal septum, ulceration of the nasal mucosa.

With long-term use in doses of more than 1500 mcg per day, systemic side effects (including adrenal insufficiency) may develop.

When used in therapeutic doses, side effects are rare.

Contraindications to the use of the drug NASOBEC

  • hemorrhagic diathesis;
  • frequent nosebleeds;
  • respiratory tuberculosis;
  • fungal infections;
  • viral infections;
  • children under 6 years of age;
  • pregnancy (first trimester);
  • hypersensitivity to the components of the drug.

The drug is prescribed with caution for amebiasis, glaucoma, severe liver failure, hypothyroidism, recent myocardial infarction, ulceration of the nasal septum, after recent surgical interventions in the nasal cavity or nasal injuries, during pregnancy (II and III trimesters), during lactation.

Use of the drug NASOBEC during pregnancy and breastfeeding

During pregnancy, Nasobek should be used only when the expected benefit to the mother outweighs the potential risk to the fetus.

The drug Nasobek should be used with caution during lactation (breastfeeding).

Use for liver dysfunction

The drug is prescribed with caution in severe liver failure.

Use in children under 12 years of age

Contraindicated: children under 6 years of age.

special instructions

It is necessary to protect the eyes from contact with the drug.

Instructions for correct use of the spray

Before using the spray for the first time, remove the plastic strip between the bottle cap and the nasal applicator.

  1. Before use, shake the bottle slightly and then remove the cap of the nasal applicator.
  2. Hold the bottle between your thumb and index finger so that the bottom of the bottle rests on your thumb and your index and middle fingers rest on either opposite side of the bottom of the applicator.
  3. Before the first use of the drug or in case of a week-long break in use, the first dose should be released into the free space.
  4. Exhale lightly through your nose.
  5. The nostril into which the drug will not be injected should be pinched with a finger, and the end part of the applicator should be inserted into the free nostril. Then tilt your head slightly so that the bubble is in a perpendicular position.
  6. After this, inhale lightly through the open nostril and simultaneously press the nasal applicator and administer the dose.
  7. Exhale through your mouth.
  8. When re-introducing the drug into the same nostril, repeat the operations described in paragraphs. 7 and 8.
  9. When injecting the drug into the other nostril, repeat the operations described in paragraphs. 6, 7, 8 and 9.

After finishing using the drug, you should clean the end of the applicator with a clean cloth and return the cap to its place.

Cleaning the nasal applicator

The nasal applicator should be cleaned at least once a week to prevent the possibility of clogging.

To do this, lightly press the bottom of the bottle and remove the nasal applicator from the bottle. The applicator and cap are rinsed with warm water and allowed to dry. After this, the applicator and cap are put back on the bottle.

Overdose

With prolonged use in high doses, as well as with the simultaneous use of other (systemic) corticosteroids, symptoms of hypercortisolism may appear.

In this case, the use of the drug should be discontinued, gradually reducing the dose.

Drug interactions

When used together, phenobarbital, phenytoin, and rifampicin reduce the effectiveness of beclomethasone (induction of microsomal oxidation enzymes).

When used together, methandrostenolone, estrogens, beta2-adrenergic stimulants, theophylline, and corticosteroids for oral administration enhance the effect of beclomethasone.

When used together, Nasobek increases the effect of beta-agonists.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored in a place protected from light, out of reach of children, at a temperature of 10° to 25°C. Shelf life: 4 years.

After opening the bottle, the drug must be used within 3 months.

Source: http://xn—-7sbabkdpwufdsp9apq.xn--p1ai/nasobec

Nasobek - instructions for use, price

Instructions for use:

Release form and composition

Indications for use

Directions for use and dosage

Terms and conditions of storage

Conditions for dispensing from pharmacies

Prices in online pharmacies:

Nasobek is a glucocorticosteroid (GCS) with anti-inflammatory, antiallergic and immunosuppressive effects for intranasal use.

Release form and composition

Dosage form – dosed nasal spray: opaque suspension without visible foreign inclusions, white (200 doses in plastic bottles equipped with a mechanical dosing applicator, 1 bottle in cardboard packs).

Active substance: beclomethasone dipropionate, 50 mcg in 1 spray dose.

Additional components: microcrystalline cellulose + sodium carmellose (dispersed cellulose), phenylethanol, hydrochloric acid 35%, polysorbate 80, anhydrous dextrose, benzalkonium chloride (50% solution), purified water.

Indications for use

  • Allergic rhinitis (seasonal and year-round);
  • Vasomotor rhinitis.

Contraindications

  • Frequent nosebleeds;
  • Viral infectious diseases;
  • Fungal infections;
  • Respiratory tuberculosis;
  • Hemorrhagic diathesis;
  • I trimester of pregnancy;
  • Children under 6 years of age;
  • Hypersensitivity to the components of the drug.
  • Ulceration of the nasal septum;
  • Recent surgery in the nasal cavity, nasal trauma;
  • Glaucoma;
  • Amoebiasis;
  • Severe liver failure;
  • Hypothyroidism;
  • Recent myocardial infarction;
  • II and III trimesters of pregnancy;
  • Lactation.

Directions for use and dosage

Nasobek is intended for intranasal use.

  • Adults and adolescents over 12 years of age: 1-2 doses (mcg of beclomethasone) in each nostril 2 times a day;
  • Children 6-12 years old: 1 dose in each nostril 2 times a day. If necessary, it is possible to use 2 doses 2 times a day.

The maximum daily dose is 400 mcg, which can be divided into 2-4 applications.

After achieving a therapeutic effect, the dose should be gradually reduced, until the drug is completely discontinued.

Rules for using Nasobek:

  • Before first use, remove the protective plastic half-ring located between the dosing applicator and the screw-on part;
  • Clear the nasal passages;
  • Shake the bottle, then remove the cap;
  • Place the bottle in the palm of your hand so that its bottom rests on your thumb, and your middle and index fingers rest on both opposite sides of the bottom of the nasal applicator;
  • Press the dispenser several times until a cloud of aerosol appears (this procedure must be performed before the first use and repeated in cases of a long break in using the drug);
  • Exhale lightly through your nose;
  • Pinch the nasal passage with your finger into which the drug will not be injected;
  • Insert the applicator into the free nostril;
  • Tilt your head slightly so that the bottle is in a perpendicular position;
  • Inject a dose of the aerosol by pressing the applicator and at the same time inhaling lightly through an open nasal passage;
  • Exhale through your mouth;
  • If necessary, administer a second dose as described;
  • Repeat a similar procedure with the second nostril;
  • Clean the top (end) part of the applicator with a clean cloth and close with the cap.

At least once a week, you should clean the nasal applicator to prevent it from clogging: gently press the bottom of the applicator and disconnect it, rinse the applicator and cap with warm water, let them dry, then put it back on the bottle.

Side effects

Nasobek is generally well tolerated. The following side effects occur rarely (including isolated cases):

  • Allergic reactions: urticaria, skin rash, angioedema;
  • From the organ of vision: decreased vision, conjunctival hyperemia; with long-term use - increased intraocular pressure, including cataracts, glaucoma;
  • From the nervous system: disturbance of taste and smell, headache, drowsiness, dizziness;
  • From the respiratory system: sneezing, nasal congestion, burning, irritation and dryness of the nasopharynx, rhinorrhea, atrophy of the nasal mucosa, nosebleeds, ulceration of the nasal mucosa, cough, perforation of the nasal septum (more often in patients who have previously undergone surgery in the nasal cavity );
  • Other: myalgia; with long-term and/or use in high doses (more than 400 mcg/day) - candidiasis of the oral cavity and upper respiratory tract, adrenal insufficiency, decreased bone mineral density, decreased growth rate in children.

special instructions

Care should be taken when using the drug and do not allow it to come into contact with the eyes.

Unlike local vasoconstrictors, the therapeutic effect of Nasobek does not appear immediately. Improvement is usually observed after 5-7 days from the start of treatment. After achieving the effect, the dose of the drug must be reduced to the minimum effective, which will allow controlling the course of the disease.

Patients at risk of developing adrenal insufficiency should be under constant monitoring during treatment.

Infectious diseases of the nasal cavity and paranasal sinuses are not a contraindication to the use of Nasobek, but require appropriate therapy.

The drug slows down the healing of wounds, so patients with ulceration of the nasal septum, patients after nasal injuries or surgical interventions in the nasal cavity should not use Nasobek until the wounds have healed completely.

Benzalkonium chloride, which is part of the drug as a preservative, increases the likelihood of developing swelling of the nasal mucosa with long-term use. If such a reaction occurs, it is necessary to adjust the dose of Nasobek or prescribe another drug that does not contain benzalkonium chloride.

With long-term use of this drug in pediatrics, the growth dynamics of children should be monitored.

In some cases, Nasobek causes drowsiness and dizziness, so it is recommended to be careful when driving a car and performing tasks that require increased attention and high reaction speed.

Drug interactions

Nasobek enhances the effect of beta-agonists.

When used simultaneously, inducers of microsomal oxidation enzymes (rifampicin, phenytoin, phenobarbital) reduce the effectiveness of beclomethasone.

Oral glucocorticosteroids, beta2-adrenergic agonists, estrogens and methandrostenolone, when used together, enhance the effect of beclomethasone.

Analogs

Analogs of Nasobek are: Beklospira, Beklazon-Eko, Klenil, Bekotide, Beclat, Beclomethasone Orion Pharma, Rinoklenil, Aldecin, Beclorin.

Terms and conditions of storage

Store at temperatures up to 25 ºС out of reach of children, protected from light.

Shelf life – 4 years, after the first opening of the bottle – 6 months.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Nasobek: prices in online pharmacies

Nasobek nasal spray 50 mcg/dose 200 doses

Nasobek nasal spray 50 mcg/dose 200 doses

Nasobek nasal spray 50 mcg/dose 200 doses

Nasobek 50mcg/dose 200dose spray

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Source: http://novosti-mediciny.ru/nasobek/

Nasobek

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

Composition and release form

200 doses in a plastic bottle with an applicator with a protective cap; 1 bottle in a cardboard box.

Description of the dosage form

White opaque suspension without visible foreign inclusions.

pharmachologic effect

Pharmacodynamics

Beclomethasone dipropionate, a synthetic corticosteroid for topical use, has anti-inflammatory, antiallergic and immunosuppressive effects. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, inhibits the release of arachidonic acid. Prevents the marginal accumulation of neutrophils, reduces inflammatory exudation and the production of lymphokines, inhibits the migration of macrophages, reduces the intensity of the processes of infiltration and granulation, and the formation of a chemotaxis substance. Reduces swelling of the nasal mucosa and mucus production. Improves mucociliary transport. It is well tolerated during long-term treatment, does not have mineralocorticoid activity, and has virtually no resorptive effect.

The therapeutic effect of Nasobek, unlike local vasoconstrictors for the treatment of rhinitis, does not appear immediately when administered intranasally. Relief from rhinitis symptoms usually becomes noticeable within a few days of starting treatment.

Pharmacokinetics

When administered by inhalation in recommended doses, it does not have significant systemic activity. After intranasal use, it is quickly absorbed into the nasal mucosa. Part of the administered drug is swallowed. Most of the drug that enters the gastrointestinal tract is inactivated during its first passage through the liver.

Absorption from the gastrointestinal tract is low. T 1/2 - 15 hours. Communication with plasma proteins - 87%.

The main part of the drug (35–76%), regardless of the route of administration, is excreted within 96 hours in the feces, mainly in the form of polar metabolites, 10–15% by the kidneys.

Indications for the drug Nasobek

seasonal and year-round allergic rhinitis;

Contraindications

hypersensitivity to the components of the drug;

frequent nosebleeds;

respiratory tuberculosis;

children under 6 years of age;

pregnancy (first trimester);

viral, fungal diseases.

With caution: amebiasis, glaucoma, severe liver failure, hypothyroidism, recent myocardial infarction, ulceration of the nasal septum, recent surgical interventions in the nasal cavity, recent trauma to the nose, pregnancy (II-III trimester), lactation.

Use during pregnancy and breastfeeding

The use of Nasobek during pregnancy is allowed only if the expected benefit to the mother outweighs the possible risk to the fetus. Nursing mothers should be careful when using this drug.

Side effects

When used in therapeutic doses, side effects are rare, including: sneezing, irritation, burning, dry nose; rash, urticaria, angioedema and nasopharyngeal infections caused by fungal flora, rhinorrhea, headache.

In rare cases - nosebleeds, conjunctival hyperemia, increased intraocular pressure, myalgia, drowsiness, cough, decreased sense of taste, atrophy of the nasal mucosa. Extremely rarely - ulceration of the nasal mucosa, perforation of the nasal septum.

With long-term use in doses of more than 1500 mcg/day - systemic side effects (including adrenal insufficiency).

Interaction

Phenobarbital, phenytoin, rifampicin reduce effectiveness (induction of microsomal oxidation enzymes). Methandrostenolone, estrogens, beta 2 -agonists, theophylline, orally administered corticosteroids enhance the effect of beclomethasone. Increases the effect of beta-agonists.

Directions for use and doses

Before using Nasobek, the nasal passages must be free. Adults and children over 6 years of age: 1 dose (50 mcg) in each nasal passage 2–4 times a day (200–400 mcg). The dose is then reduced depending on the patient's response. The maximum daily dose is 400 mcg.

Directions for correct use:

Before using the spray for the first time, remove the plastic strip between the bottle cap and the nasal applicator.

1. Before use, shake the bottle slightly and then remove the cap of the nasal applicator.

2. Hold the bottle between your thumb and index finger so that the bottom of the bottle rests on your thumb and your index and middle fingers rest on either opposite side of the bottom of the applicator.

3. Before the first use of the drug or in case of a week-long break in use, the first dose should be released into the free space.

4. Exhale lightly through your nose.

5. The nasal passage into which the drug will not be injected should be clamped with a finger, and the end part of the applicator should be inserted into the free nasal passage. Then tilt your head slightly so that the bubble is in a perpendicular position.

6. After this, inhale lightly through the open nasal passage and at the same time press the nasal applicator and administer the dose.

7. Exhale through your mouth.

8. When re-introducing the drug into the same nasal passage, repeat the operations described in paragraphs 6 and 7.

9. When introducing the drug into the other nasal passage, repeat the operations described in paragraphs 4, 5, 6 and 7.

After finishing using the drug, you should clean the end of the applicator with a clean cloth and return the cap to its place.

Cleaning the nasal applicator:

The nasal applicator should be cleaned at least once a week to prevent the possibility of clogging.

To do this, lightly press the bottom of the bottle and remove the nasal applicator from the bottle.

The applicator and cap are rinsed with warm water and allowed to dry. After this, the applicator and cap are placed on the bottle.

Overdose

With prolonged use of high doses, as well as with simultaneous use of other systemic corticosteroids, symptoms of hypercortisolism may appear. In this case, the drug should be discontinued and the dose gradually reduced.

special instructions

It is necessary to protect the eyes from contact with the drug.

Conditions for dispensing from pharmacies

Storage conditions for the drug Nasobek

Keep out of the reach of children.

Shelf life of the drug Nasobek

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Prices in Moscow pharmacies

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 N 61-FZ.

dosed nasal spray 50 mcg/dose, 1 pc.

dosed nasal spray 50 mcg/dose, 1 pc.

IVAX Pharmaceuticals sro (Czech Republic)

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NASOBEK

Nasal spray dosed in the form of an opaque white suspension, without visible foreign inclusions.

Excipients: benzalkonium chloride (50% solution) - 0.04 µl, phenylethanolmkg, polysorbatemkg, anhydrous dextrose - 5 mg, microcrystalline cellulose + sodium carmellose (dispersed cellulose) - 1 mg, hydrochloric acid 35% - qs, purified water - up to 0.1 g .

200 doses - plastic bottles (1) with a mechanical dosing applicator - cardboard packs.

Synthetic GCS for topical use. It has anti-inflammatory, antiallergic and immunosuppressive effects. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, inhibits the release of arachidonic acid. Prevents the marginal accumulation of neutrophils, reduces inflammatory exudation and the production of lymphokines, inhibits the migration of macrophages, reduces the intensity of the processes of infiltration and granulation, and the formation of a chemotaxis substance. Reduces swelling of the nasal mucosa and mucus production. Improves mucociliary transport.

The drug is well tolerated during long-term treatment, does not have mineralocorticoid activity, and has virtually no resorptive effect.

Suction and distribution

When administered by inhalation in recommended doses, it does not have significant systemic activity.

After intranasal use, it is quickly absorbed through the nasal mucosa. Part of the administered drug is swallowed. Absorption from the gastrointestinal tract is low. Plasma protein binding - 87%.

Metabolism and excretion

Most of the drug that enters the gastrointestinal tract is metabolized during the “first pass” through the liver. T 1/2 – 15 hours. The main part of the drug (35-76%), regardless of the route of administration, is excreted within 96 hours with feces, mainly in the form of polar metabolites; 10-15% is excreted by the kidneys.

— seasonal and year-round allergic rhinitis;

- frequent nosebleeds;

- tuberculosis of the respiratory system;

- children under 6 years of age;

— I trimester of pregnancy;

- hypersensitivity to the components of the drug.

with caution for amebiasis, glaucoma, severe liver failure, hypothyroidism, recent myocardial infarction, ulceration of the nasal septum, after recent surgical interventions in the nasal cavity or nasal injuries, in the second and third trimesters of pregnancy, during breastfeeding.

The drug is used intranasally.

Adults and children over 12 years of age are prescribed pomkg (1-2 doses) in each nasal passage 2 times a day; The daily dose is mcg. Maximum daily dose kg. The daily dose can be divided into 2-4 doses.

Children aged 6 to 12 years are prescribed an initial dose of 50 mcg (1 dose) in each nasal passage 2 times a day, if necessary, kg (2 doses) in each nasal passage 2 times a day. Maximum daily dose kg. The daily dose can be divided into 2-4 doses.

When a therapeutic effect is achieved, the drug is discontinued, gradually reducing the dose.

Elderly patients do not require dose adjustment.

Rules for using the drug

Before using the drug, it is necessary to clean the nasal passages.

When using for the first time, you should unlock the spray mechanism: press the dispenser several times until a cloud of aerosol appears. If the drug has not been used for several days, the spray mechanism should be unlocked again.

Before using the drug for the first time, remove the plastic protective half-ring located between the screw-on part and the dosing nasal applicator.

1. Before use, shake the bottle slightly, then remove the cap of the nasal applicator.

2. Place the bottle between your thumb and index finger so that the bottom of the bottle rests on your thumb and your index and middle fingers rest on both opposite sides of the bottom of the applicator.

3. Before the first use of the drug, or in case of a long break in use, the first dose should be sprayed into the air.

4. Exhale lightly through your nose.

5. The nasal passage into which the drug will not be injected should be clamped with a finger, and the applicator should be inserted into the free nasal passage. Then tilt your head slightly so that the bottle is in a perpendicular position.

6. Inhale slightly through the open nasal passage and at the same time press the nasal applicator and inject a dose of the aerosol.

7. Exhale through your mouth.

8. When re-introducing the drug into the same nasal passage, you should repeat the steps described in paragraphs 6 and 7.

When administering the drug into the other nasal passage, you should repeat the steps described in paragraphs 5, 6, 7, 8.

After finishing using the drug, you should clean the end (upper) part of the applicator with a clean cloth and return the cap to its place.

The nasal applicator should be cleaned at least once a week to prevent the possibility of clogging. To do this, lightly press the bottom of the applicator and detach the nasal applicator. Rinse the applicator and cap with warm water and allow to dry. After this, put the applicator and cap back on the bottle.

Determination of the frequency of side effects (according to WHO recommendations): very common (≥10%); often (≥1%, but <10%); uncommon (≥0.1%, but <1%); rare (≥0.01%, but <0.1%); very rare (<0.01%), including isolated cases; unknown (insufficient data to estimate the frequency of the phenomenon in the population).

Allergic reactions: rarely - skin rash, urticaria, angioedema.

From the nervous system: rarely - disturbance of olfactory and taste sensations, drowsiness, headache, dizziness.

From the organ of vision: unknown - increased intraocular pressure, incl. glaucoma, cataracts (with long-term use), conjunctival hyperemia, decreased vision.

From the respiratory system: rarely - dryness and irritation of the nasopharynx, sneezing, burning, nasal congestion, nosebleeds, atrophy of the nasal mucosa, cough, rhinorrhea; very rarely - ulceration of the nasal mucosa, perforation of the nasal septum (usually in patients who have previously undergone surgery in the nasal cavity).

Other: rarely - myalgia, candidiasis of the oral cavity and upper respiratory tract (with long-term use and/or in high doses (more than 400 mcg/day)); unknown - with long-term use, the development of adrenal insufficiency, a decrease in growth rate in children, and a decrease in bone mineral density are possible.

Symptoms: with prolonged use in high doses, as well as with simultaneous use of other (systemic) corticosteroids, symptoms of hypercortisolism may appear.

Treatment: use of the drug should be discontinued, gradually reducing the dose.

When used together, phenobarbital, phenytoin, and rifampicin reduce the effectiveness of beclomethasone (induction of microsomal oxidation enzymes).

When used together, methandrostenolone, estrogens, beta 2 -adrenergic agonists, theophylline, and oral corticosteroids enhance the effect of beclomethasone.

When used together, Nasobek increases the effect of beta-agonists.

Patients should be warned to be careful not to get Nasobek into their eyes.

The therapeutic effect of the drug Nasobek, unlike local vasoconstrictors for the treatment of rhinitis, does not appear immediately when administered intranasally. Relief of rhinitis symptoms usually becomes noticeable after 5-7 days from the start of use of the drug. When a therapeutic effect is achieved, the dose of Nasobek should be reduced to the minimum effective dose that controls the course of the disease.

Patients at high risk of developing adrenal insufficiency require medical supervision.

Since the drug slows down wound healing, patients with ulceration of the nasal septum, after surgery in the nasal cavity, or nasal injuries should not use Nasobek until the wounds have completely healed.

For infectious diseases of the nasal cavity and paranasal sinuses, appropriate therapy should be carried out. These diseases are not contraindications to the use of the drug Nasobek.

Benzalkonium chloride contained in the drug Nasobek, with long-term use, increases the risk of swelling of the nasal mucosa. If such a reaction occurs, it is necessary to adjust the dose of Nasobek or use a drug that does not contain benzalkonium chloride.

Use in pediatrics

With long-term use of the drug Nasobek in children, it is necessary to monitor the dynamics of their growth.

Impact on the ability to drive vehicles and operate machinery

Due to the fact that drowsiness and dizziness may develop when using the drug Nasobek, patients should be careful when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The use of Nasobek is contraindicated in the first trimester of pregnancy. The use of Nasobek in the second and third trimesters of pregnancy is allowed only if the expected benefit to the mother outweighs the possible risk to the fetus.

Nasobek should be used with caution during breastfeeding.

The drug is available with a prescription.

The drug should be stored out of the reach of children, protected from light, at a temperature not exceeding 25°C; do not freeze. Shelf life: 4 years.

After opening the bottle for the first time, the drug must be used within 6 months.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/nasobec/

Nasobek: instructions for use

Nasobek is a drug in the form of a nasal spray that has anti-allergic, anti-inflammatory and local anti-edematous effects, used to treat rhinitis.

Glucocorticosteroids are hormones produced in the adrenal cortex. In addition to natural hormones, there are a large number of their synthetic analogues, which are divided into non-fluorinated (prednisone and its derivatives) and fluorinated (dexamethasone, betamethasone and others) glucocorticoids. Both groups of hormones are similar in action, but synthetic compounds have increased activity, which can occur in significantly lower doses, and lower absorption when applied topically, which reduces the likelihood of systemic adverse events. Another difference between natural and synthetic hormonal agents is the different ratio of glucocorticoid and mineralocorticoid properties.

The mechanism of action of glucocorticoid hormones is not completely clear. Scientists believe that the action is carried out through target cells at the level of regulation of RNA synthesis. It is mediated by the interaction of this group of hormones with glucocorticoid intracellular receptors, which, under the influence of hormones, form a “steroid + receptor” complex. Next, this complex enters the nucleus and binds to DNA. Regulation of gene transcription occurs, which causes either stimulation or inhibition of the formation of m-RNA and regulatory proteins and enzymes that cause certain cellular effects. These receptors were found in varying amounts in almost all cells. They differ in molecular weight, affinity for corticoids and other physicochemical parameters.

Glucocorticoids have the following pharmacological effects:

  • the anti-inflammatory effect develops through inhibition of the activity of phospholipase, an enzyme whose decreased activity leads to suppression of the release of arachidonic acid and a decrease in the formation of a number of inflammatory mediators;
  • the antiallergic effect is caused by the ability to reduce the synthesis and secretion of allergy mediators and inhibit their release from mast cells and basophils;
  • immunosuppressive activity occurs as a result of inhibition of certain stages of the immune response;
  • antishock and antitoxic properties are associated with an increase in blood pressure and activation of the enzymatic function of the liver.

The most widely used drugs for intranasal administration are beclomethasone, budesonide, fluticasone, and mometasone. In nasal dosage form, they have the greatest therapeutic effect in the treatment of non-infectious diseases of the nasal cavity, to prevent the recurrence of polyps, and for rhinitis, including medicinal, occupational, and allergic rhinitis.

When this group is used in therapeutic doses, the negative effects on the body are minimal. Rarely, nosebleeds, dryness and burning may occur, as well as sneezing or itching, which may be caused by a reaction to the irritant effect of the propellant. There is evidence of isolated cases of perforation of the nasal septum. A significant advantage of intranasal hormones of this group is the ability to minimize systemic undesirable effects and increase the effectiveness and safety of treatment.

Nasobek belongs to the prescription group of drugs and is used as prescribed by a specialist.

Release form and composition

The dosage form is a spray for nasal use with a dosage of beclomethasone 50 mcg per dose.

The production of the spray belongs to the company Galena (Czech Republic).

Indications for use

  • seasonal and year-round hay fever;
  • vasomotor rhinitis.

Contraindications

  • hypersensitivity to the active ingredient or other components;
  • hemorrhagic syndrome due to diathesis;
  • nosebleeds;
  • tuberculosis of the lungs;
  • age up to 6 years;
  • 1st trimester of pregnancy;
  • diseases caused by viruses or pathogenic fungi.

Caution is required when using Nasobek in the presence of amoebiasis, glaucoma, severe liver dysfunction, myxedema, heart attack, pathology of the nasal septum, previous surgery or trauma in the nasal area, pregnancy and lactation.

Directions for use and dosage

Nasobek is used nasally. The nose must be cleaned before use. Children over 6 years of age and adults are recommended to use 1 dose on each side 2-4 times a day. The dosage can then be reduced according to the course of the disease.

Side effects

Side effects most often occur when recommended doses are exceeded or the drug is used for a long time. Possible:

  • sneezing, irritation, burning and dry mucous membranes;
  • rashes, urticaria, Quincke's edema, mycosis of the nasopharynx, rhinorrhea, headache.

More rarely may occur:

  • nasal hemorrhages;
  • redness of the conjunctiva;
  • increased eye pressure;
  • muscle pain;
  • drowsiness;
  • cough;
  • deterioration of taste perception;
  • mucosal atrophy.

Rarely, but not excluded, ulceration in the nasal cavity or perforation of the septum may occur. In case of prolonged use of the spray in a high dose, undesirable effects of a systemic nature may occur.

special instructions

  • avoid getting the medicine in the eyes;
  • There are 5 drugs that inhibit the biosynthesis of corticosteroids: mitotane, metyrapone, aminoglutethimide, ketoconazole, trilostane. They can provoke adrenal insufficiency, so when using them, careful monitoring of the patient's condition is necessary;
  • barbiturates, phenytoin, rifampicin and other inducers of microsomal oxidation reduce the effectiveness of Nasobek;
  • when combined with androgens, estrogens, B2-adrenergic drugs, theophylline, and oral glucocorticosteroids, the effect of beclomethasone is enhanced;
  • when taken simultaneously with beta-adrenergic drugs, beclomethasone increases their effectiveness.

Nasobek analogues

Nasal sprays completely identical to Nasobek in terms of active substance and action are:

  1. Aldecin is a spray with a dosage of the active component of 50 mcg, 8.5 g each. It has the same indications. Also available in aerosol form with attachments for nasal and oral use. Manufactured by Schering-Plough Labo (Belgium).
  2. Beclomethasone Orion Pharma contains 0.555 mcg of active substance per 1 mg. Available in the form of a spray of 9, 10 and 23 ml. The production belongs to Orion Corporation/ORION PHARMA (Finland).
  3. Beconase is also used for the treatment and prevention of allergic rhinitis. The dosage and number of doses correspond to Nasobek. Produced by the Spanish company Glaxo Wellcome.
  4. Rinoclenil is completely identical in dosage form and indications. The dosage is 0.1 mg per dose. Manufacturer: Chiesi Farmaceutici (Italy).

Terms and conditions of storage

Shelf life – 4 years. The medicine should be stored within degrees, in a dark place, out of the reach of children.

Nasobek price

The average cost of Nasobek spray in Moscow pharmacies is:

Source: http://bezboleznej.ru/nasobek