Mechanism of action of Derinat

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Instructions for the drug Derinat: purpose, dosage and side effects

The patient's health largely depends on the state of his immunity. Strong immunity can resist various damaging factors, both infectious and tumor in nature.

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Some substances have the ability to “stimulate” the patient’s own immunity. In order to quickly and more successfully cope with a number of severe or protracted chronic diseases, modern medicine uses special drugs - immunomodulators. One of these popular remedies is Derinat.

Composition and properties of Derinat

Derint is available in different forms and has a wide spectrum of action.

This drug is an immunomodulatory agent that can affect cellular and humoral immunity. The main active ingredient is sodium deoxyribonucleate, which helps the body fight various types of infections and enhances its regenerative functions.

It helps restore the drainage function of the lymphatic system and protects cells from the harmful effects of radiation and chemotherapy drugs. Derinat contains sodium chloride and sterile distilled water as excipients.

This drug is devoid of carcinogenic effects and is not capable of destroying cells, therefore Derinat, whose side effects are minimal, is actively used to treat adults and children. The drug is usually well tolerated and has a pronounced positive effect on the patient's condition.

Since Derinat is used to stimulate the patient’s own immunity, the scope of its application is very wide.

It is used as part of complex therapy for viral, bacterial or fungal infections, in the treatment of various diseases accompanied by serious intoxication, complicated by poor function of the lymphatic system. This remedy stimulates the functioning of the lymph nodes and the entire system as a whole, helping to improve drainage and remove toxins. Derinat also helps to reduce the susceptibility of cells and tissues of the body during the treatment of cancer. It contributes to the patient's resistance to the negative effects of therapeutic radiation and chemotherapy. With this drug, the patient tolerates such difficult and intensive treatment much easier.

Release form, storage and shelf life

This drug is available in the form of drops and solutions for parenteral administration, as well as a product for topical use. Available in ampoules and glass bottles of 2, 5, 10 and 20 ml. You can also find Derinat on sale in bottles equipped with a dropper or a special spray for topical use, which greatly simplifies the use of the drug.

The shelf life of the medicine is within 5 years. Store Derinat at 4 – 18°C, protecting from the influence of light, high humidity and temperature changes.

If the container with the drug is opened (drops), then its maximum shelf life should not exceed two weeks, preferably in the refrigerator, especially in the hot season.

Purpose of the drug

Derinat drops are used for diseases of the upper respiratory tract

Derinat, whose side effects are practically reduced to zero, gives a positive effect when used against numerous diseases of different types.

Among them are the following diseases:

  • Malignant tumors of various organs.
  • Tuberculous lesions of the lungs.
  • Cardiac ischemia.
  • Damage to the body due to increased radiation and exposure.
  • Diseases of the female reproductive system (gynecology, mammology).
  • Lesions of the male genitourinary system.
  • Peptic ulcer of the stomach and duodenum.
  • Gastroduodenitis with erosions of the membranes.

Derinat in the form of drops is used for preventive and therapeutic purposes in children and adults. The drops are well tolerated and are actively used for the following diseases:

  • Runny nose of viral, bacterial, fungal or allergic origin.
  • Sinusitis, including sinusitis - prolonged and chronic.
  • Acute respiratory viral infections.
  • Vascular lesions (obliterating conditions of the vessels of the lower extremities).

Numerous studies and notes from specialists after using this drug show that its use significantly accelerates the recovery of patients and alleviates the severity of the disease.

The benefits of Derinat include its ability to help heal not only acute conditions, but also long-term chronic or recurring health problems.

Topical use of the drug is also very effective. It is used in the form of applications, tampons, irrigations and douching for the following diseases or lesions:

  • Severe, purulent, long-lasting wounds and postoperative scars.
  • Trophic ulcers.
  • Infected wounds.
  • Gangrene.
  • Stomatitis.
  • Burns of various origins.
  • Haemorrhoids.
  • Lesions of the mucous membranes of the vagina and internal genital organs of a viral, fungal or bacterial nature.

Useful video - Derinat: properties and application.

It should be noted that Derinat is an additional drug in the complex treatment of diseases, especially severe and chronic ones. It combines well with other medications, but only a doctor can decide on the rationality of using the medicine, dosage and duration of treatment.

Application Features

The injection drug is administered intramuscularly, but subcutaneous injections are sometimes practiced. Drops are instilled into each nasal passage, and the liquid for external use is used in the form of irrigation of damaged areas of the body by spraying or application of the drug is performed.

Each type of disease requires its own duration of treatment and regularity of injections:

  • For malignant tumors and metastases, the doctor usually prescribes a course of 3 to 10 injections in a single dose, depending on the type and severity of the disease. Injections are given every 2 or 3 days.

Derinat in drops - dosage for children and adults

Side effects

Derinat solution for local and external use

With normal dosage, the medicine is usually very well accepted by patients, both adults and children. Therefore, Derinat, whose side effects are minimal, is widely used in medical practice, including for the treatment of children.

Possible side effects of the drug include a short-term rise in temperature during injections. Typically, this phenomenon develops within about three hours after administration of the medicine. Also, sometimes minor pain is observed at the injection site, which goes away on its own.

An increase in temperature is also a temporary phenomenon that does not require specific treatment or discontinuation of Derinat. If the patient is feeling unwell, non-steroidal anti-inflammatory and painkillers, for example Diphenhydramine, can be prescribed.

It should be used with caution in patients with diabetes. When using Derinat, they may experience hypoglycemia, so constant monitoring of the condition will be required.

Contraindications

The main contraindications to the use of this drug include the following:

  • Individual intolerance to Derinat, allergic reactions when using it.
  • Use during pregnancy and lactation

Despite the fact that Derinat has minor side effects, its use during pregnancy is considered undesirable, since the use of any medications during this period poses a certain threat to the pregnant woman and the fetus. During pregnancy and breastfeeding, Derinat can be prescribed by a doctor only if he considers that the possible harm from the drug will be much less than the benefit it brings.

Derinat easily penetrates all barriers of the body and can influence the formation and development of the unborn child.

Using this drug on your own in any condition, not just during pregnancy or breastfeeding, can be very risky. Only a specialist with a medical education can decide on the need to take this drug and prescribe it to the patient. Strict adherence to the instructions guarantees the correct effect and a positive effect on the patient’s health.

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Comments (1)

Good angel

05/10/2017 at 20:19 | #

The drop form of the drug can be used without restrictions during pregnancy, and the injection form can be used in consultation with the doctor. unless it is really necessary for some reason. The main area of ​​application for pregnant women is the prevention of acute respiratory viral infections and the treatment of mild and moderately severe forms.

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The medical information published on this page is strictly not recommended for self-medication. If you feel negative changes in your health, immediately contact an ENT specialist. All articles published on our resource are for informational purposes only. If you use this material or a fragment of it on your website, an active link to the source is required.

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Derinat injections: instructions for use

Solution for parenteral administration Derinat is a drug that belongs to the pharmacological group of immunomodulators. This drug is used in complex therapy of various pathologies accompanied by impaired functional activity of the immune system.

Release form and composition

Solution for parenteral administration Derinat is a colorless transparent liquid. The main active ingredient of the drug is sodium deoxyribonucleinate; 1 ml of solution contains 15 mg of the active substance. The solution also contains additional components, which include sodium chloride and water for injection.

Solution for injection Derinat is contained in glass bottles of 2 and 5 ml. They are placed in special blister trays of 5 and 10 bottles. The cardboard pack contains one blister tray and instructions for use of the drug.

pharmachologic effect

The active ingredient of the drug Derinat has a number of pharmacological effects by stimulating and optimizing the functioning of the cellular and humoral components of the immune system. These effects include:

  • Stimulation of the functional activity of the main cells of the immune system - T-helpers, B-lymphocytes, macrophages.
  • Improving the energy metabolism of all cells of the body, increasing the intensity of DNA and RNA synthesis processes.
  • Binding free radicals (fragments of organic molecules that have one unpaired electron) in the body and improving their elimination, which reduces their destructive effect on cell membranes.
  • Improving the drainage and detoxification function of the lymphatic system - increasing the removal of harmful products and foreign agents from tissues in the area of ​​the inflammatory process.
  • Stimulating the processes of regeneration of damaged cells, in particular during the formation of stomach or duodenal ulcers.

Due to these pharmacological effects, the solution for parenteral administration Derinat stimulates a nonspecific protective reaction of the body during infectious processes caused by bacterial, viral or fungal infection. The drug also improves the nutrition of heart cells during coronary artery disease. The active ingredient of the drug stimulates hematopoiesis - the process of formation and maturation of blood cells in the red bone marrow.

After intramuscular injection of Derinat solution, sodium deoxyribonucleinate accumulates in the blood quite quickly to a therapeutic concentration (usually within minutes). The active substance distributes well throughout the body with a predominant accumulation in lymphoid tissue and red bone marrow. It penetrates through the placental barrier into the body of the developing fetus during pregnancy and through the blood-brain barrier into the structures of the central nervous system of an adult. The active substance of the drug is metabolized in the cells of the human body. Decomposition products (metabolites) are excreted from the body in the urine by the kidneys, and in small quantities with feces. The half-life (the period of time during which 50% of the entire dose of the administered drug is eliminated from the body) is about 72 hours.

Indications for use

The use of a solution for parenteral administration of Derinat is indicated for a number of pathological conditions of the body, which are accompanied by a violation of the functional activity of the immune system or other systems. These include:

  • Acute respiratory viral infections (ARVI), which have a severe or complicated course (the addition of a bacterial infection leading to bronchitis or pneumonia).
  • As part of complex therapy for chronic inflammatory diseases of various localizations that do not respond to standard therapy.
  • Chronic obstructive pulmonary pathology, which is accompanied by periodic bacterial complications.
  • Complex treatment of infectious diseases caused by various bacteria, viruses or fungi.
  • Urogenital infectious pathology, which is caused by a specific infection (chlamydia, ureaplasma, mycoplasma, genital herpes virus or human papilloma).
  • To accelerate regenerative processes (tissue restoration) after major surgical interventions, burns or injuries.
  • Treatment of peptic ulcers, erosions of the duodenum or stomach.
  • Inflammatory processes of the female reproductive system (endometritis, chronic inflammation of the uterine appendages).
  • Benign prostatic hyperplasia (prostate adenoma) or prostatitis (inflammation) in men.
  • Trophic ulcers are a long-term non-healing violation of the integrity of the skin and subcutaneous tissue in the form of erosion, which is the result of impaired tissue nutrition.
  • Infectious and inflammatory complications, the development of which is caused by long-term use of cytostatic drugs (in particular stomatitis - chronic infectious inflammation of the oral mucosa).
  • Pathology of peripheral arteries with impaired blood flow in them (obliterating endarteritis or atherosclerosis of the vessels of the lower extremities).
  • Complex therapy of coronary heart disease.
  • Treatment of radiation injury or radiation sickness.
  • Pulmonary tuberculosis.
  • Pathology of the blood system and red bone marrow, accompanied by disruption of the process of hematopoiesis.
  • Secondary immunodeficiency (insufficient functional activity of the immune system) of any origin.

Derinat injection solution is also used in the complex treatment of cancer patients who have been receiving radiation treatment or chemotherapy for a long time.

Contraindications for use

Administration of Derinat solution is contraindicated in the presence of individual intolerance, hypersensitivity to the active substance or auxiliary components of the drug.

Directions for use and doses

Solution for injection Derinat is administered intramuscularly. The recommended dose of the drug for a single administration is on average 75 mg (5 ml), the administration interval is an hour. The dosage and regimen of the drug may differ depending on the pathological process:

  • Acute infectious pathology - on average 3-5 injections with an interval of 24 hours (once a day).
  • Chronic infectious pathology - 5 injections with an interval of 24 hours (once a day), then another 5 injections with an interval of 72 hours (once every 3 days).
  • Gynecological pathology – 10 injections at hourly intervals.
  • Inflammatory or infectious pathology of the urogenital tract in men - 10 injections at an hourly interval.
  • Peptic ulcer of the duodenum or stomach - 10 injections with an interval of 48 hours (once every 2 days).
  • Oncological pathology (benign or malignant neoplasms) - depending on the severity and severity of the process, the solution is administered 3 to 5 times with an hourly interval.
  • Pulmonary tuberculosis - injections at hourly intervals.

For children, the drug administration regimen is the same. For children under 2 years of age, a single dose is 7.5 mg (0.5 ml); for children aged 2 to 10 years, the dose is calculated based on 0.5 ml per 1 year of the child’s life. For children over 10 years of age, the single dose of the drug is the same as for adults; the maximum course of treatment for them is 5 injections of the drug.

Side effects

In general, the solution for parenteral administration of Derinat is well tolerated. In patients with concomitant diabetes mellitus, hypoglycemia (a decrease in blood glucose levels below normal) may develop during administration of the drug. In this case, the glucose level must be corrected by changing dietary recommendations and the dosage of glucose-lowering drugs.

special instructions

Before starting to use the solution for parenteral administration of Derinat, you must carefully read the instructions for the drug. It is important to pay attention to several special instructions, which include:

  • Administration of the drug potentiates the effect of drugs from other therapeutic groups that are used in complex therapy.
  • Pregnant women may be administered Derinat solution only after consultation and under the supervision of a doctor, if the expected benefit to the mother outweighs the potential risk to the fetus.
  • There is no data on the effect of the drug on the speed of psychomotor reactions and concentration.

In the pharmacy network, the solution for parenteral administration of Derinat is dispensed with a doctor's prescription. Its introduction independently or on the recommendation of third parties is excluded.

Overdose

There is currently no data on significantly exceeding the recommended therapeutic dose of the drug.

Analogs of Derinat injections

In terms of active substance and therapeutic effect, the drugs Blastomunil and Lykopid are similar to the Derinat solution.

Terms and conditions of storage

The shelf life of the solution for parenteral administration of Derinat is 5 years. The drug must be stored in a dark place, out of reach of children, at an air temperature of +4° to +20° C.

Derinat injections price

The average cost of a solution for parenteral administration of Derinat (5 ml bottles, 5 pieces per package) in Moscow pharmacies varies within the ruble.

Source: http://bezboleznej.ru/derinat-ukoly

Solution and nasal drops Derinat: instructions for use

Derinat is a highly effective immunomodulator that affects cellular and humoral immunity. The safety and reliability of this drug has been clinically proven.

The active component - sodium deoxyribonucleate - stimulates reparative processes, has anti-inflammatory and analgesic effects, normalizes the condition of tissues during dystrophic changes of vascular origin. In addition, the drug exhibits lymphotropic, cardioprotective and anti-ischemic properties, antioxidant and membrane stabilizer properties, and has a weak anticoagulant effect.

On this page you will find all the information about Derinat: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Derinat. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

How much does Derinat solution cost? The average price in pharmacies is 250 rubles.

Release form and composition

The drug is available in the form of a 0.25% solution of 10 and 20 ml in the form of a 10 ml dropper bottle, a bottle with a spray nozzle of 10 ml. Compound:

  • 2.5 mg sodium deoxyribonucleate;
  • 1 mg sodium chloride.

Also in the form of a 1.5% solution for intramuscular injection. Compound:

  • 15 mg sodium deoxyribonucleate
  • 1 mg sodium chloride.

Pharmacological effect

Derinat activates the body's own cellular and humoral immunity:

  • acts on B-lymphocytes and macrophage cells;
  • includes the T-helper defense mechanism, which is involved in enhancing the formation of antibodies;
  • increases the rate of intracellular metabolism.

Under the influence of derinat, T-killer lymphocytes are activated, the target of which are body cells affected by pathogenic microorganisms.

Derinat reduces the concentration of free radicals, increases resistance to infections, activates the lymphatic system, which helps detoxify the body. The drug has cardioprotective properties due to its stabilizing effect on cardiac muscle cells, improves blood circulation, and restores the mucous membrane.

Indications for use

As monotherapy, Derinat in the form of a solution for local and external use is used for the following diseases:;

  1. Acute respiratory viral infection (treatment and prevention);
  2. Dystrophic and inflammatory eye diseases;
  3. Inflammatory diseases of the oral mucosa
  4. Acute respiratory diseases (ARI).

As part of a complex treatment, a solution for local and external use is prescribed for the treatment of diseases such as:

  1. Gangrene;
  2. Trophic ulcers;
  3. Post-radiation necrosis of the skin and mucous membranes;
  4. Frostbite;
  5. Burns;
  6. Haemorrhoids;
  7. Chronic and acute diseases of the upper respiratory tract (rhinitis, sinusitis, including sinusitis, frontal sinusitis);
  8. Fungal, chronic inflammatory diseases, bacterial and other infections of the mucous membranes in gynecological practice;
  9. Infected and persistently non-healing wounds (including those with diabetes mellitus);
  10. Obliterating diseases of the lower extremities.

Derinat in the form of a solution for intramuscular administration is used in the treatment of diseases/conditions such as:

  1. Hematopoiesis disorder;
  2. Radiation injuries;
  3. Purulent-septic complications, odontogenic sepsis;
  4. Long-term non-healing wounds, trophic ulcers;
  5. Pulmonary tuberculosis, inflammatory diseases of the respiratory tract;
  6. Burn disease;
  7. Rheumatoid arthritis;
  8. Endometritis, endometriosis, salpingoophoritis, fibroids;
  9. Ureaplasmosis, chlamydia, mycoplasmosis;
  10. Chronic obstructive pulmonary diseases;
  11. Benign prostatic hyperplasia, prostatitis;
  12. Stomatitis induced by cytostatic drugs;
  13. Erosive gastroduodenitis, peptic ulcer of the stomach and duodenum;
  14. Obliterating diseases of the vessels of the lower extremities (stage II-III);
  15. Coronary heart disease (CHD);
  16. Resistance and myelosuppression to cytostatics in cancer patients associated with radiation and/or cytostatic therapy (stabilization of hematopoiesis, reduction of myelo- and cardiotoxicity of chemotherapy drugs);
  17. Pre- and postoperative periods (in surgical practice).

Contraindications

Injections and drops of Derinat have no other contraindications, except for the patient’s intolerance to the components included in its composition.

Use during pregnancy and lactation

The patient should be warned that before using the drug during pregnancy and lactation, consultation with a doctor is necessary. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.

Instructions for use

The instructions for use indicate that Derinat in the form of a solution for external and local use is prescribed depending on the location of the pathological process.

The drug is prescribed to children from the first day of life and to adults:

  1. For inflammatory diseases of the oral cavity, rinse the mouth with a solution of the drug 4-6 times a day (1 bottle for 2-3 rinses). Duration of therapy: days.
  2. For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times a day; duration of the course days.
  3. To prevent ARVI, instill 2 drops into each nasal passage 2-4 times a day for 1-2 weeks. When symptoms of a respiratory disease appear, the drug is instilled 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops into each nasal passage 3-4 times a day. The duration of the course of therapy is from 5 days to 1 month.
  4. For chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - intravaginal administration of tampons with the drug or irrigation of the vagina and cervix 5 ml per procedure 1-2 times a day during the day.
  5. In ophthalmological practice, for severe inflammatory and dystrophic processes, Derinat is instilled into the eyes, 1-2 drops 2-3 times a day.
  6. For hemorrhoids, the drug is administered rectally using microenemas. The duration of treatment is 4-10 days.
  7. In case of post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, it is recommended to apply application bandages (gauze in 2 layers) to the affected areas with the application of the drug 3-4 times a day or treat the affected area surfaces with the preparation from a spray bottle 4-5 times a day. Course of treatmentmonths.
  8. For obliterating diseases of the lower extremities, in order to achieve a systemic effect, the drug is instilled 1-2 drops into each nasal passage 6 times a day, the course duration is up to 6 months.

Instructions for Derinat injections

For adults, Derinat in the form of a solution for intramuscular administration is administered over 1-2 minutes at an average single dose of 75 mg (5 ml of solution for intramuscular administration of 15 mg/ml). The administration interval is an hour.

Depending on the indications, the following treatment regimens are used:

  • Peptic ulcer of the stomach and duodenum - 5 ml of a solution of 15 mg/ml, break between injections - 48 hours. Treatment course – 5 injections;
  • Tuberculosis – 5 ml of a solution of 15 mg/ml, an hour interval between injections. Treatment course – injections;
  • Coronary heart disease – 5 ml of a 15 mg/ml solution, an hour between injections. Treatment course – 10 injections;
  • Oncological diseases - 5 ml (75 mg per day), an hour interval between injections. Treatment course – 10 injections;
  • Chronic inflammatory diseases - 5 ml of a solution of 15 mg/ml: the first 5 injections with a break of 24 hours each, subsequent ones - with an interval of 72 hours. Treatment course – 10 injections;
  • Benign prostatic hyperplasia, prostatitis – 5 ml of a 15 mg/ml solution, an hour interval between injections. Treatment course – 10 injections;
  • Chlamydia, endometriosis, endometritis, mycoplasmosis, ureaplasmosis, fibroids, salpingo-oophoritis - 5 ml of a 15 mg/ml solution, an hour break between injections. Treatment course – 10 injections;
  • Acute inflammatory diseases - 5 ml of a 15 mg/ml solution, an hour between injections. Treatment course – 3-5 injections.

When using a solution of 15 mg/ml, 2 ml injections should be carried out every day, recalculating, until the dose is reached per course.

Side effects

The instructions for use indicate that this medication is well tolerated by the body. Side effects of Derinat are completely absent, with the exception of the appearance of local and allergic reactions as a result of increased sensitivity to the components of the drug.

The manufacturer recalls skin rashes in the form of urticaria, which are complemented by itching, burning sensation, and hyperemia of the skin.

Overdose

No cases of drug overdose have been recorded.

special instructions

Numerous experimental and clinical laboratory studies have proven the absence of mutagenic, teratogenic, embryotoxic, carcinogenic effects, allergenic properties, and cytogenetic effects; its moderate antimutagenic effect was revealed.

In case of gangrenous processes under the influence of the drug, spontaneous rejection of necrotic masses in the foci of rejection is observed with restoration of the skin. For open wounds and burns, an analgesic effect is noted.

Drug interactions

When applied topically, the drug is not compatible with hydrogen peroxide and fat-based ointments.

The use of the drug in combination with the main therapy increases the therapeutic effect and reduces the duration of treatment. This also makes it possible to reduce the doses of antibiotics and antiviral drugs.

The use of Derinat increases the effectiveness of therapy with antitumor anthracycline antibiotics and cytostatic drugs; the effect of basic therapy prescribed to patients with peptic ulcer is potentiated; The iatrogenicity of drugs prescribed for the treatment of rheumatoid arthritis decreases (up to 50-70%, which is also accompanied by an improvement in a number of complex indicators of disease activity).

In cases where a surgical infection provokes the development of sepsis, the introduction of Derinat into combination therapy allows:

  • normalize hematopoietic function;
  • improve the performance of organs involved in removing toxins from the body;
  • reduce the level of intoxication in the body;

increase the activity of the immune system.

Reviews

We have selected some people's reviews about the drug Derinat:

  1. Anna . No matter how much I use Derinat for a runny nose, for some reason it doesn’t help me. Doctors praise it, there are a lot of positive reviews about it, but for me it is completely useless. I took several courses of treatment for colds, but did not feel any effect. It is possible that my body simply does not perceive its healing properties. A placebo of sorts. For colds, I prefer IRS-19; it is a similar analogue of Derinat, as the pharmacy explained to me.
  2. Lola. This is the third autumn before the onset of cold weather that I have been buying Derinat for my children and taking preventive measures to strengthen their immunity and protect them from viruses so that they don’t catch anything. The drug is good, there is nothing complicated to use, just put some drops in your nose in the morning, afternoon and evening. Well, follow the hygiene rules! But for two autumns my children have not been sick and attend school and kindergarten normally. For me it’s better to foresee everything in advance, prepare and then be calm.
  3. Svetlana . After the flu, I was given Derinat injections to prevent and strengthen the immune system. The runny nose went away quickly, my throat didn’t hurt, I felt better. The injections themselves are unpleasant, but I won’t argue that they are effective. The price is affordable, buying at the pharmacy is not a problem. Since the composition is natural, there is no need to select an analogue - everything works.
  4. Galina. These drops are good because they can be used not only for treatment, but also for the prevention of ARVI. To do this, they are dripped according to the scheme of 2 drops 3 times a day for one to two weeks. But if you have already felt the symptoms of a cold, then you need to instill 2-3 drops every 2 hours on the first day you get sick. And then two or three drops 3 times a day. Available in pharmacies without a prescription, they are suitable even for infants. A very good product to support your immune system.

Analogs

Pharmacies offer a number of Derinat analogues that have similar pharmaceutical effects: Deoxynate, Sodium Deoxyribonucleate, Panagen. These analogues also have pronounced regenerative properties, helping the body cope with bacterial, viral or fungal agents.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a dry place, protected from light, out of reach of children at a temperature of 4-20 °C.

Shelf life – 5 years.

The contents of an opened bottle of solution for topical and external use should be used within 14 days.

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2 comments

Be careful when using the drug in children. I am an adult, the ENT doctor first prescribed inhalations with Derinat, then a throat spray. More for preventive purposes (the throat often hurts). I did inhalations for 3 days, now I have been using the spray for the 4th day. The result is terrible! Sore throat, cough, sore throat. Before using it, my throat just hurt, but now everything is swollen. Bad drug! Definitely. Do not use in children.

I can’t agree, Natasha, because I’ve also been using derinat for a long time and, as a rule, with (+) results. The spray perfectly helped relieve pain and redness, although, in my opinion, if the process is very advanced (not at the beginning), then the spray alone will not help, you also need to add an antibiotic. And if only for the viral process, then you can use one. Perhaps you have an individual intolerance to the drug?

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Derinat drops - method of use, instructions

General information about the drug

The active ingredient of this product is the sodium salt of deoxyribonucleic acid. It is DNA that is considered the carrier of the genetic code (or genetic information) of all cells of a living organism. The abbreviation for the name of the acid formed the basis for the name of the drug. The history of the creation of Derinat began in the sixties of the twentieth century. At that time, large-scale research work was carried out at the Institute of Biophysics of the USSR Ministry of Health - the radioprotective properties of the sodium salt of deoxyribonucleic acid were studied. At that time, various nuclear programs were rapidly developing in our country, which resulted in the appearance of patients exposed to radioactive rays. DNA was then obtained from marine animals. In the mid-eighties, our research scientist Yu. P. Weinberg created a special installation that made it possible to extract a valuable native substance from sturgeon milt. In 1994, the drug Derinat began to be produced on an industrial scale. It was registered in 1996. Then it was recommended as a radioprotector, immunomodulator and stimulator of hematopoiesis (normalizing the number of different types of white cells in the blood).

  • 5 ml bottles for intramuscular administration (1.5% concentration solution);
  • dark glass bottles containing 10 (or 20) ml of solution used externally (concentration 0.25%);
  • drops (10 ml of solution in dropper bottles; the package may also contain a spray nozzle).
Most often, drops and a solution for topical application are used. The international name of the active substance is sodium deoxyribonucleate, the auxiliary components are water for injection and sodium chloride. The drops are a transparent, colorless liquid that should not contain any inclusions.

Action of Derinat

First of all, the medicine affects two types of immunity:

  • cellular (activation of macrophage production);
  • humoral (it is characterized by the synthesis of antibodies in response to the arrival of foreign antigens in the body.

How does Derinat work?

  • Activates B-lymphocytes (these are white blood cells endowed with the ability to turn into cells that produce antibodies).
  • Activates T-helpers (helpers of the immune system).
  • Normalizes the number of phagocytes that “devour” pathogenic foreign agents, as well as the number of platelets, important participants
  • blood clotting mechanism.

Thanks to Derinat, the body's resistance to the negative influence of pathogenic bacterial cells, viruses, and fungi increases. It is this effect that pediatricians and therapists count on when prescribing Derinat to patients who often suffer from infectious diseases of the respiratory tract.

When is the medicine used?

PoMedicine will list those situations when experts recommend Derinat drops:

  • for the prevention and treatment of acute respiratory viral infections, acute respiratory infections, influenza conditions;
  • in the treatment of sinusitis, frontal sinusitis, rhinitis, sinusitis, adenoiditis;
  • with inflammation of the oral mucosa (these are glossitis, gingivitis, stomatitis);
  • for dystrophic and inflammatory processes in ophthalmology;
  • for long-term non-healing wounds, trophic ulcers (including complications of diabetes mellitus);
  • for obliterating (causing narrowing, overgrowth) diseases of the lower extremities
  • for burns, frostbite, necrosis, gangrene;
  • in the case of post-radiation necrosis of the mucous membranes and skin (tissue necrosis);
  • for gynecological diseases that are chronic (for example, cervicitis, vulvitis).

Methods of application

Derinat drops are prescribed not only to adults, but also to children, starting from the first day of life. To prevent the occurrence of acute respiratory viral infections, the drug is instilled two drops into each nostril (or one spray is given) two to four times a day for one to two weeks.

Are there any contraindications or unwanted effects?

Clinical and marketing studies have proven that Derinat has no side effects. The medicine can be used both in newborn babies and in older people. There is only one contraindication - the medicine is not used if individual intolerance is detected. Pregnant women are allowed to use Derinat if prescribed by a doctor.

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Instructions for use Derinat

1 ml solution for injection Derinat contains:

Sodium deoxyribonucleate – 15 mg;

Sodium deoxyribonucleate – 25 mg;

Dosage form

injection

Pharmacotherapeutic group

Pharmacological properties

Derinat helps increase the body's resistance to infection, takes part in the regulation of hematopoiesis, stimulates the drainage and detoxification function of the lymphatic system, and also reduces the sensitivity of cells to the effects of chemotherapy drugs and radiation therapy.

The active component of the drug is quickly distributed in the body, has a high affinity for the organs of the hematopoietic system and is easily integrated into cellular structures.

When administered daily, Derinat accumulates in the bone marrow, lymph nodes, thymus and spleen, as well as other tissues of the body. The peak concentration of sodium deoxyribonucleate in the bone marrow is observed 5 hours after intramuscular injection of the solution, in the brain - after 30 minutes. Derinat easily penetrates the blood-brain barrier.

Derinat is excreted mainly by the kidneys, some part is excreted by the intestines.

Indications for use Derinat

Derinat injection solution is also prescribed for hematopoietic disorders, trophic ulcers and long-healing wounds, burn disease, rheumatoid arthritis, purulent-septic complications and odontogenic sepsis, as well as for patients with stomatitis, myelodepression and resistance to cytostatic agents in patients who receive cytostatic or radiation therapy.

Contraindications

Prescribing the parenteral form of the drug Derinat to women during pregnancy and lactation is not recommended.

The drug Derinat does not affect the reaction rate and can be used to treat patients whose work requires increased concentration.

Caution should be exercised when prescribing the drug to patients with diabetes.

Interactions with drugs

Derinat injection solution potentiates the effect of antitumor anthracycline antibiotics and cytostatic drugs.

Sodium deoxyribonucleate increases the effectiveness of basic drugs intended for the treatment of duodenal and gastric ulcers.

With the combined use of the drug Derinat and drugs used for surgical sepsis, patients experience activation of the body's defenses, a decrease in the level of intoxication, an improvement in the function of the hematopoietic system, as well as an improvement in the function of organs that regulate detoxification processes.

The drug should not be used topically at the same time as hydrogen peroxide.

Directions for use and dosage Derinat

To prevent acute respiratory infections, 2 drops of Derinat should be instilled into the nasal passages 2-4 times a day. The duration of prophylactic use of Derinat solution is 1-2 weeks.

For acute respiratory diseases, 2-3 drops of Derinat should be instilled into the nasal passages at intervals of 1-1.5 hours. Starting from the second day of therapy, they switch to instilling 2-3 drops of Derinat into the nasal passages 3-4 times a day. The duration of treatment is 2 weeks.

For inflammatory diseases of the nasal mucosa and paranasal sinuses, 3-5 drops of Derinat should be instilled into the nasal passages 3-6 times a day. In addition, instead of instilling the solution, you can moisten cotton swabs and insert them into the nasal passages 3-6 times a day. The duration of treatment is 1 month.

For various obliterating diseases (in particular the lower extremities), 1-2 drops of Derinat are instilled into the nasal passages up to six times a day. The duration of treatment ranges from 1 to 6 months.

For gangrene, trophic ulcers, burns and long-healing wounds, Derinat is used as applications. To do this, 2 layers of gauze are moistened with the solution and applied to the affected area of ​​the skin three times a day. To achieve the maximum therapeutic effect, the use of applications is supplemented by instillation of Derinat solution into the nasal passages (1-2 drops into the nasal passages up to six times a day). Duration of treatment is 1-3 months.

For diseases of the rectum, Derinat is used in the form of microenemas (15-40 ml of solution). The duration of treatment is 4-10 days.

In ophthalmic practice, Derinat is used in the form of eye drops, instilling 1-2 drops into the conjunctival sac twice or thrice a day. The duration of treatment is from 2 to 6 weeks.

For adults, as a rule, the drug Derinat is prescribed in a single dose of 5 ml.

Adults with coronary heart disease, gynecological and andrological diseases are prescribed a single dose every hour. The course dose is 10 injections.

Adults with cancer are prescribed a single dose every hour. The course dose ranges from 3 to 10 injections.

Adults with pulmonary tuberculosis are prescribed a single dose every hour. The course dose is injection.

Adults with chronic inflammatory processes are prescribed a single dose every 24 hours, after 5 days they switch to a single dose every 72 hours. The total course dose is 10 injections.

A single dose for children under 2 years of age is 0.5 ml of Derinat solution.

A single dose for children aged 2 to 10 years is 0.5 ml of Derinat solution for each year of life.

A single dose for children over 10 years of age is 5 ml of Derinat solution.

Side effects

In addition, some patients experienced an increase in body temperature of up to 38 degrees Celsius within 1.5-3 hours after injection of sodium deoxyribonucleate. The development of hyperthermia does not require discontinuation of the drug; to normalize body temperature, symptomatic drugs are prescribed (non-steroidal analgesics-antipyretics, diphenhydramine).

Hypoglycemia was observed predominantly in patients with diabetes mellitus when using the drug Derinat.

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Derinat

Derinat: instructions for use and reviews

Latin name: Derinat

Active ingredient: sodium deoxyribonucleate

Manufacturer: JSC FP Tekhnomedservis (Russia)

Update of description and photo: 01/17/2018

Prices in pharmacies: from 251 rub.

Derinat is an immunomodulatory drug.

Release form and composition

Derinat is produced in the following dosage forms:

  • Solution for intramuscular administration: colorless, transparent, without foreign inclusions (2 or 5 ml in glass bottles, 5 (5 ml) or 10 (2 ml) bottles in a pallet, 1 pallet in a cardboard box);
  • Solution for local and external use 0.25%: colorless, transparent, without foreign inclusions (10 or 20 ml in glass bottles or 10 ml in dropper bottles or bottles with a spray nozzle, 1 bottle in a cardboard box).

The composition of 1 ml of solution for intramuscular administration includes:

  • Active substance: sodium deoxyribonucleate – 15 mg;
  • Auxiliary components: sodium chloride, water for injection.

The composition of 1 ml of solution for local and external use includes:

  • Active substance: sodium deoxyribonucleate – 2.5 mg;
  • Auxiliary components: sodium chloride, water for injection.

Pharmacological properties

Pharmacodynamics

Derinat activates the processes of humoral and cellular immunity. The immunomodulatory effect is achieved through stimulation of B lymphocytes and activation of T helper cells. The drug activates the body's nonspecific resistance, optimizes inflammatory reactions, as well as the immune response to viral, fungal and bacterial antigens. Helps stimulate regenerative and reparative processes. Increases the body's resistance to infections, regulates hematopoiesis (ensures normalization of the number of lymphocytes, leukocytes, granulocytes, platelets, phagocytes).

Due to its pronounced lymphotropic properties, taking Derinat stimulates the drainage and detoxification functions of the lymphatic system. The drug significantly reduces the sensitivity of cells to the effects of radiation therapy and chemotherapy drugs. Does not have embryotoxic, teratogenic or carcinogenic effects.

Pharmacokinetics

It is quickly absorbed and distributed in tissues and organs along the endolymphatic transport route. It has a high affinity for the organs of the hematopoietic system, is integrated into cellular structures, due to which it actively participates in cellular metabolism. In the phase of intensive entry into the blood, in parallel with the processes of metabolism and excretion, the drug is redistributed between the blood plasma and its formed elements. After a single injection, in all pharmacokinetic curves of changes in the concentration of sodium deoxyribonucleate in the studied tissues and organs, rapid phases of increasing and decreasing concentrations are observed in the time interval from 5 to 24 hours. When administered intramuscularly, the half-life is 72.3 hours.

It is quickly distributed in the body, and during the daily course of treatment accumulates in tissues and organs (mainly in the lymph nodes, bone marrow, thymus, spleen). To a lesser extent, the drug accumulates in the brain, liver, stomach, large and small intestines. The time to reach maximum concentration in the bone marrow is 5 hours, and in the brain – 30 minutes. Penetrates the blood-brain barrier.

Metabolized in the body. It is excreted biexponentially in the form of metabolites in the urine and, to a lesser extent, in feces.

Indications for use

According to the instructions, Derinat in the form of a solution for intramuscular administration is used in the treatment of diseases/conditions such as:

  • Hematopoiesis disorder;
  • Radiation injuries;
  • Resistance and myelosuppression to cytostatics in cancer patients associated with radiation and/or cytostatic therapy (stabilization of hematopoiesis, reduction of myelo- and cardiotoxicity of chemotherapy drugs);
  • Stomatitis induced by cytostatic drugs;
  • Erosive gastroduodenitis, peptic ulcer of the stomach and duodenum;
  • Obliterating diseases of the vessels of the lower extremities (stage II-III);
  • Coronary heart disease (CHD);
  • Purulent-septic complications, odontogenic sepsis;
  • Long-term non-healing wounds, trophic ulcers;
  • Pulmonary tuberculosis, inflammatory diseases of the respiratory tract;
  • Burn disease;
  • Rheumatoid arthritis;
  • Endometritis, endometriosis, salpingoophoritis, fibroids;
  • Ureaplasmosis, chlamydia, mycoplasmosis;
  • Chronic obstructive pulmonary diseases;
  • Benign prostatic hyperplasia, prostatitis;
  • Pre- and postoperative periods (in surgical practice).

As monotherapy, Derinat in the form of a solution for local and external use is used for the following diseases:

  • Dystrophic and inflammatory eye diseases;
  • Inflammatory diseases of the oral mucosa;
  • Acute respiratory viral infection (treatment and prevention);
  • Acute respiratory diseases (ARI).

As part of a complex treatment, a solution for local and external use Derinat is prescribed for the treatment of diseases such as:

  • Chronic and acute diseases of the upper respiratory tract (rhinitis, sinusitis, including sinusitis, frontal sinusitis);
  • Fungal, chronic inflammatory diseases, bacterial and other infections of the mucous membranes in gynecological practice;
  • Infected and persistently non-healing wounds (including those with diabetes mellitus);
  • Obliterating diseases of the lower extremities;
  • Gangrene;
  • Trophic ulcers;
  • Post-radiation necrosis of the skin and mucous membranes;
  • Frostbite;
  • Burns;
  • Haemorrhoids.

Contraindications

The use of Derinat is contraindicated in the presence of hypersensitivity to the components of the drug.

Instructions for use of Derinat: method and dosage

For adults, Derinat in the form of a solution for intramuscular administration is administered over 1-2 minutes at an average single dose of 75 mg (5 ml of solution for intramuscular administration of 15 mg/ml). The administration interval is an hour.

Depending on the indications, the following treatment regimens are used:

  • Coronary heart disease – 5 ml of a 15 mg/ml solution, an hour between injections. Treatment course – 10 injections;
  • Oncological diseases - 5 ml (75 mg per day), an hour interval between injections. Treatment course – 10 injections;
  • Peptic ulcer of the stomach and duodenum - 5 ml of a solution of 15 mg/ml, break between injections - 48 hours. Treatment course – 5 injections;
  • Tuberculosis – 5 ml of a solution of 15 mg/ml, an hour interval between injections. Treatment course – injections;
  • Benign prostatic hyperplasia, prostatitis – 5 ml of a 15 mg/ml solution, an hour interval between injections. Treatment course – 10 injections;
  • Chlamydia, endometriosis, endometritis, mycoplasmosis, ureaplasmosis, fibroids, salpingo-oophoritis - 5 ml of a 15 mg/ml solution, an hour break between injections. Treatment course – 10 injections;
  • Chronic inflammatory diseases - 5 ml of a solution of 15 mg/ml: the first 5 injections with a break of 24 hours each, subsequent ones - with an interval of 72 hours. Treatment course – 10 injections;
  • Acute inflammatory diseases - 5 ml of a 15 mg/ml solution, an hour between injections. Treatment course – 3-5 injections.

When using a solution of 15 mg/ml, 2 ml injections should be carried out every day, recalculating, until the dose is reached per course.

The frequency of intramuscular administration of the drug in children is the same as in adults. The drug is used in the following doses:

  • Up to 2 years: average single dose – 7.5 mg (0.5 ml solution for intramuscular administration 15 mg/ml);
  • 2-10 years: a single dose is determined at the rate of 0.5 ml of the drug per year of life;
  • Over 10 years: average single dose – 75 mg (5 ml solution for intramuscular administration 15 mg/ml), course dose – up to 5 injections of the drug.

Derinat in the form of a solution for external and local use is used depending on the localization of the ongoing process.

The drug can be used by adults and children from the first day of life.

To prevent ARVI, Derinat is dripped into the nose: 2 drops of solution into each nasal passage 2-4 times a day. Duration of therapy is 7-14 days. If symptoms of a respiratory disease develop, during the first day Derinat is instilled into the nose, 2-3 drops in each nasal passage every 1-1.5 hours, then 3-4 times a day, 2-3 drops. The duration of the treatment course can vary from 5 to 30 days.

Depending on the disease, Derinat is used according to the following regimens:
  • Inflammatory diseases of the paranasal sinuses and nasal cavity - 4-6 times a day, 3-5 drops are instilled into each nasal passage. The duration of the treatment course is 7-15 days;
  • Inflammatory diseases of the oral cavity - rinse the mouth 4-6 times a day (1 bottle for 2-3 rinses). The duration of the treatment course is 5-10 days;
  • Chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - irrigation of the vagina and cervix or intravaginal administration of tampons with solution is indicated. Per procedure – 5 ml, frequency of use – 1-2 times a day. Duration of treatment course – days;
  • Severe inflammatory and degenerative processes in ophthalmological practice – Derinat should be instilled into the eyes 2-3 times a day, 1-2 drops. Duration of treatment course – days;
  • Hemorrhoids – rectal administration of the drug using microenemas is indicated. The duration of the treatment course is 4-10 days;
  • Post-radiation necrosis of the mucous membranes and skin, long-term non-healing wounds, burns, frostbite, gangrene, trophic ulcers of various etiologies - 3-4 times a day, application dressings (2 layers of gauze) with an applied solution should be applied to the affected areas. Also, the affected surface can be treated 4-5 times a day with the preparation from a poml sprayer. The duration of the treatment course is 1-3 months;
  • Obliterating diseases of the lower extremities - to achieve a systemic effect, Derinat is instilled 6 times a day into each nasal passage, 1-2 drops. The duration of the treatment course is up to 6 months.

Side effects

When Derinat is administered intravenously in patients with diabetes mellitus, a hypoglycemic effect may be observed, which must be taken into account when monitoring blood glucose levels.

No side effects have been identified with local and external use of the drug.

Overdose

No negative effects from overdose have been identified.

special instructions

Derinat does not have embryotoxic, carcinogenic or teratogenic effects.

Subcutaneous administration of the drug is possible.

In case of surgical sepsis, the use of Derinat as part of complex therapy activates the immune system, reduces the level of intoxication, and normalizes hematopoiesis. There is also an improvement in the functioning of the organs responsible for the processes of detoxification of the internal environment of the body (including the spleen and lymph nodes).

The drug reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis, achieving 50% and 70% improvement in a number of complex indicators of disease activity.

Derinat potentiates the therapeutic effect of basic therapy for gastric and duodenal ulcers.

According to clinical studies, the effectiveness of Derinat has been proven against the background of standard therapy in patients with exacerbation of chronic obstructive pulmonary disease of varying severity. In this case, 5 ml of a 15 mg/ml solution is used intramuscularly, the interval between injections is hours. Treatment course – 5-10 injections.

When applied externally and locally in the treatment of gangrenous processes under the influence of Derinat, spontaneous rejection of necrotic masses with restoration of the skin was noted in the areas of rejection. For burns and open wounds, an analgesic effect is noted.

Use during pregnancy and lactation

Derinat in the form of a solution for external and local use during pregnancy and lactation is used without restrictions.

Derinat in the form of a solution for intramuscular administration is used only after consulting a doctor. The decision to prescribe the drug to pregnant women should be made based on an assessment of the ratio of the expected benefit to the mother and the potential risk to the fetus.

Derinat in the form of a solution for intramuscular administration during lactation should be used exclusively as prescribed by a doctor.

Use in childhood

Derinat is allowed to be used to treat children from the first day of life.

Drug interactions

Derinat increases the effectiveness of cytostatics and antitumor antibiotics of the anthracycline series.

The use of Derinat as part of complex therapy makes it possible to increase the effectiveness and shorten the duration of treatment with a significant reduction in doses of antibiotics and antivirals with increasing periods of remission.

When applied topically, Derinat is incompatible with hydrogen peroxide and fat-based ointments.

Analogs

Analogues of Derinat are: Deoxynate, Sodium deoxyribonucleate, Panagen.

Terms and conditions of storage

Store in a dry place, protected from light, out of reach of children at a temperature of 4-20 °C.

Shelf life – 5 years.

The contents of an opened bottle of solution for topical and external use should be used within 14 days.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Reviews about Derinat

Reviews about Derinat are mixed: some users note its effectiveness, others report no changes in the course of the disease. The list of the main advantages of the drug includes ease of use, natural composition and safety. At the same time, some doctors note that the safety of Derinat has not yet been fully studied.

Patients who were prescribed the drug in drops and injections report that such treatment allowed them to quickly get rid of the symptoms of the disease and reduced the likelihood of relapse.

In gynecology, Derinat injections are successfully used in the treatment of inflammatory processes (including in the cervix), fibroids, mammary fibroids, chlamydia, endometriosis, as well as in the treatment of tumors and as a universal immunocorrector for hormonal-dependent endometrial hyperplasia.

Many parents also speak positively about Derinat as a means to combat “kindergarten infections”: according to them, the drug activates the body’s defenses and promotes faster maturation of the immune system. The drug has also proven itself in the treatment of children with adenoids, rhinitis, sinusitis, tonsillitis, and bronchial asthma. According to reviews from parents, the use of the drug in the treatment of viral infections significantly reduces the severity of symptoms of the disease and the likelihood of complications. To get the maximum effect from the drug, some users advise using it to prevent ARVI and influenza or in the early stages of the disease.

Negative reviews about Derinat mainly contain information about the pain of injections and the short-term effect of treatment.

Price for Derinat in pharmacies

The approximate price for Derinat is: spray 0.25% 10 ml – 405 rubles, dropper bottle 0.25% 10 ml – 340 rubles, 5 bottles with a solution for intramuscular administration 15 mg/5 ml – 2225 rubles.

Derinat solution topical and external 0.25% 10ml n1

Derinat solution 0.25% 10 ml

Derinat 0.25% solution 10ml bottle

Derinat solution for external and local use 0.25% 10 ml

Derinat solution topical and external 0.25% 10ml n1 (vial cap)

Derinat solution 0.25% 10 ml

Derinat 0.25% solution 10ml dropper bottle

Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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