Macropen antibiotic

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Indications for use of the antibiotic Macropen

"Macropen" is an antibiotic from the macrolide series, which is widely used in clinical practice for the treatment of bacterial infections of the ENT organs and respiratory system in children.

Table of contents:

It contains midecamycin acetate.

The big advantage of Macropen is its convenient dosage regimen for children, which allows you to take the required amount of the drug depending on the age of the child.

This antibiotic also has a low rate of antibiotic resistance among bacterial flora.

It also has a low incidence of side effects (even when compared with penicillins). All these factors influence the fact that Macropen for children is very often used and prescribed by many pediatricians.

Pharmacological features of the drug

Midecamycin has all the features of macrolide antibiotics. They are available only in oral form. In this case, the drug molecules are absorbed almost completely in the intestine. Midecamycin is a precursor to the active agent. This means that in order for the drug to enter its active form, it must first go through a metabolic stage in the body.

The mechanism of action of Macropen is its ability to inhibit the S50 ribosomal subunit of bacterial cells. This leads to the suppression of protein synthesis by pathogenic microorganisms, which undermines their metabolism and ability to further reproduce.

At the same time, the resistance of bacteria to the action of the body’s protective immune mechanisms decreases. The combination of these mechanisms leads to a decrease in the activity of inflammatory processes and the elimination of pathogenic agents from the body. This effect in pharmacology is called bacteriostatic.

The unique features of macrolides are their long-term presence in the body in therapeutic concentrations.

Many studies have shown that they have the ability to accumulate in body tissues (especially in the respiratory epithelium at the source of inflammation). Also, antibiotic molecules pass into the cells of the immune system, with which they are transported to the site of the pathological process in the body.

After taking the drug, the concentration of midecamycin in tissues may immediately exceed the amount of antibacterial agent in the blood. Moreover, the effect of the drug lasts 72 hours after the time of its administration, which makes it possible to reduce the duration of the course of treatment.

Macropen tablets are excreted from the body primarily by the liver, where they are converted into inactive metabolites and secreted into bile. A small proportion of midecamycin passes through the kidneys into the urine.

"Macropen" is effective against pathogens that cause the vast majority of bacterial pathologies of the respiratory system - streptococci, staphylococci, listeria, mycobacteria, corynebacteria, clostridia, moraxella, neisseria, helicobacteria and bacteroides.

Rules for prescribing antibacterial agents

Macropen contains an antibiotic, which, like other antibacterial drugs, has a systemic effect on the patient’s body. Therefore, it should only be used when prescribed by a qualified physician.

Self-administration of an antibiotic may not only not give the expected positive effect, but also lead to the development of side effects.

In addition, there are a number of conditions in which the use of drugs from a number of macrolides is strictly prohibited.

It is also necessary to make sure that the child has a bacterial infection before prescribing Macropen. Quite often, antibacterial agents are mistakenly used for viral or fungal pathologies, and then they are ineffective.

Therefore, it is first necessary to conduct a thorough interview with the parents and a physical examination of the child. Additionally, the following examinations are prescribed:

  • general blood test (for bacterial pathology - leukocytosis, neutrophilia, increased number of young cell forms and erythrocyte sedimentation rate, monocytosis is possible);
  • general urine analysis;
  • biochemical blood test (appearance of inflammatory proteins);
  • X-ray examination of the chest cavity and skull (if sinusitis, bronchitis and pneumonia are suspected) and computed tomography.

The key study to determine the cause of the pathological process is bacteriological. To carry it out, it is necessary to collect sputum, pleural fluid, blood or a smear from the posterior wall of the nasopharynx.

It allows you to reliably determine which microorganism caused the disease, as well as what drugs it is sensitive to. This research method is the gold standard for diagnosis.

Its only drawback is the fact that the results of the bacteriological analysis are received by the doctor only on the 3-4th day. Therefore, initial antibiotic therapy should be empirical and based on the recommendations of domestic and European pediatricians.

How to properly treat with antibiotics

Antibacterial drugs must be taken regularly without skipping to create a therapeutic dose in the body.

It is recommended to take Macropen after meals, as this minimizes the negative effect of the drug on the digestive tract and does not affect the absorption of antibiotic molecules.

If you miss an appointment, there is no need to panic. It is enough to take the missed dose of Macropen as quickly as possible, and then continue therapy as usual.

If side effects occur, you should report them to your doctor. Most of them are not too serious (headache, diarrhea, feeling of heaviness in the stomach), for which treatment can be continued. But the decision about this should be made only by the attending physician.

The effectiveness of therapy is assessed 2-3 days after initiation. For this purpose, repeated analyzes are carried out. If there are good dynamics of their results, as well as the clinical picture of the disease, therapy continues.

If there is no effect, then it is necessary to change the antibacterial drug, based on the results of a bacteriological study.

Contraindications for taking Macropen

Macropen should not be prescribed if the child has the following conditions:

  • allergic reactions in the past when using macrolide antibiotics;
  • chronic or acute liver pathologies, which are accompanied by dysfunction of organs;
  • acute or chronic renal failure;
  • if there is evidence of the presence of a pathogen that is not sensitive to the action of this antibiotic;
  • congenital cardiac conduction disorder (risk of developing reciprocal tachycardia).

It is necessary to use the medicine "Macropen" with caution in the first months of a child's life, since there is not enough information about the safety of the drug's composition during this period.

Side effects of the drug

Macrolide preparations are among the safest antibacterial agents.

But since the Macropen composition has a systemic effect, side effects sometimes develop when taking it.

Among them, the most common are the following:

  • functional disorders of the digestive tract (feeling of heaviness in the abdomen, nausea, vomiting, diarrhea, flatulence);
  • hypersensitivity reactions (allergic rash, redness of the skin with severe itching, anaphylactic shock, Quincke's edema);
  • pseudomembranous colitis of varying severity;
  • addition of superinfection;
  • transient increase in liver enzyme levels;
  • jaundice (if the child has congenital disorders of bilirubin metabolism);
  • general weakness and/or headache.

Indications for taking Macropen

Macropen can be taken for bacterial pathologies of the respiratory, genitourinary and digestive systems:

  • bronchitis;
  • community-acquired pneumonia without complications;
  • sinusitis;
  • pharyngitis and tonsillitis (including those caused by diphtheria or meningococcus);
  • otitis;
  • urethritis;
  • cystitis;
  • acute or chronic pyelonephritis;
  • nonspecific enteritis;
  • gonorrhea;
  • brucellosis;
  • inflammation of the soft tissues of the body.

Macropen is often prescribed in situations where the patient has hypersensitivity to beta-lactam antibiotics, as well as when protected penicillins are ineffective.

Principles of using Macropen

Macropen is available for children in the form of 400 mg tablets and powder for preparing a suspension with a special spoon for the exact dosage of the drug. Usually she is given priority when the child is under 8 years old.

When determining the daily dose of the drug, it is necessary to proceed from the calculation of 50 mg per 1 kg. It should be borne in mind that after preparing the syrup (for which you need to add 100 ml of water), 1 ml of it contains 35 mg of midecamycin.

For children weighing more than 30 kg, you need to take 1 tablet (400 mg) 3 times a day. The duration of therapy for respiratory infections is 3-7 days. For pathologies of the genitourinary system and intestines, the course of taking Macropen can reach 7-14 days.

Most antibiotics, while suppressing the development of infectious agents, in parallel. 5 Roxithromycin. 6 Erythromycin. 7 Macropen. 8 Josamycin.

Macropen. The active substance of the medical product is the antibiotic Midecamycin. Macropen is taken orally, before eating; is derived from.

Antibiotics have contraindications, so they must be used wisely. . Macropen. The active ingredient is midecamycin.

This mechanism of action of the antibiotic is called bacteriostatic. Azithromycin, macropen, and clarithromycin are most often prescribed for tracheitis.

5 Rules for antibiotic therapy. 6 Side effects of amikacin. . Indications for the use of the antibiotic Macropen.

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Most antibiotics, while suppressing the development of infectious agents, in parallel. 5 Roxithromycin. 6 Erythromycin. 7 Macropen. 8 Josamycin.

Macropen. The active substance of the medical product is the antibiotic Midecamycin. Macropen is taken orally, before eating; is derived from.

Source: http://med-antibiotiki.ru/instrukcii/pokazaniya-k-primeneniyu-antibiotika-makropen/

Macropen

Description current as of 12/27/2014

  • Latin name: Macropen
  • ATX code: J01FA03
  • Active ingredient: Midecamycin (Midecamycin)
  • Manufacturer: KRKA (Slovenia)

Compound

Tablets: midecamycin 400 mg, magnesium stearate, potassium polacriline, talc and MCC as excipients.

Granules: midecamycin acetate 175 mg and excipients.

Release form

Granules in a bottle for the preparation of a suspension of 175 mg/5 ml.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

The antibiotic Macropen belongs to the group of macrolides. By inhibiting the synthesis of proteins in microbial cells, it has a bacteriostatic effect in small doses, and a bactericidal effect in large doses. Its effectiveness has been noted against gram-positive (clostridium, streptococcus, listeria, staphylococcus, corynobacteria), gram-negative (campylobacter, moraxella, hemophilus influenzae, helicobacter, bacteroides) bacteria, as well as intracellular microorganisms (mycoplasma, chlamydia, ureaplasma).

After administration, it is quickly and completely absorbed from the gastrointestinal tract. The maximum concentration of the drug in the serum is after 1–2 hours. At this level, the concentration remains for up to 6 hours. Eating slightly reduces the concentration of the drug in the blood, so it is recommended to take it before meals. The highest concentrations are created in the lungs, parotid gland and skin.

The drug is metabolized in the liver and excreted in the bile and kidneys (to a lesser extent).

Indications for use

Infections caused by microorganisms sensitive to the drug:

  • respiratory tract infections (tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia);
  • infections of the urinary system, caused, among other things, by mycoplasma, ureaplasma, chlamydia;
  • infections of mucous membranes and skin;
  • enteritis caused by Campylobacter;
  • diphtheria and whooping cough;
  • treatment of patients who cannot tolerate penicillin antibiotics.

Contraindications

  • sensitivity to midecamycin;
  • severe liver failure;
  • age up to 3 years (for taking tablets).

Side effects

  • epigastric pain, nausea, vomiting, loss of appetite, diarrhea, jaundice;
  • pseudomembranous colitis;
  • skin rash, urticaria, skin itching;
  • eosinophilia;
  • bronchospasm;
  • weakness.

Instructions for use Macropen (Method and dosage)

Macropen has two forms of release - tablets and suspension, which is prepared from granules by adding water.

Macropen tablets, instructions for use

Macropen is prescribed every 8 hours.

Adults and children (body weight 30 kg or more) - 400 mg 3 times. For adults, the daily dose (maximum) is 1600 mg.

Children weighing less than 30 kg - 20–40 mg/kg, dividing the daily dose into 3 times. The daily dose for severe infections can be 50 mg/kg, also divided by 3 times.

Macropen suspension, instructions for use

This form of release is used in childhood. Depending on the child’s body weight, the dosage is calculated and taken 2 times a day:

  • from 0 to 5 kg -3.75 ml of suspension 2 r/s;
  • from 5 to 10 kg -7.5 ml of suspension 2 r/s;
  • from 10 to 15 kg - 10 ml of suspension 2 r/s;
  • from 15 to 20 kg - 15 ml of suspension 2 r/s;
  • from 20 to 25 kg—22.5 ml of suspension 2 r/s.

To prepare the suspension, add 100 ml of water to the granules in the bottle. The course of treatment with Macropen is 7-10 days, and in the case of chlamydial infection, 14 days.

The answer to the question of what Macropen tablets are for is that this antibiotic is prescribed for any infections, but most often for respiratory tract infections. It is effective in 90% of patients with tonsillopharyngitis, acute otitis media and sinusitis, chronic bronchitis and pneumonia. Due to its low toxicity and high efficiency, Macropen is used in newborns in the treatment of chlamydial respiratory tract infection.

There is a high effectiveness of using this drug for angina. Since the antibiotic is broad-spectrum, the infection of the nasopharynx is quickly suppressed, and the symptoms of the disease are stopped. Macropen for angina is prescribed 400 mg 3 times a day.

Macropen is also widely used for sinusitis. And depending on the severity of this disease, the dose in adults can be 1200 mg - 1600 mg per day. With timely administration of Macropen for sinusitis, the likelihood of complications is reduced and in many cases, therapeutic puncture of the maxillary sinus can be avoided.

Macropen for children

In pediatric practice, this drug is considered the most effective and safest antibiotic. Pediatricians encounter virtually no side effects.

Macropen does not cause dysbiosis, which is often encountered when prescribing other antibiotics. Antifungal agents are not prescribed when using this drug (only in weakened infants). Macropen for children is available in a form convenient for administration - the prepared suspension has a pleasant taste, so there are no problems during treatment. This is also evidenced by reviews from parents who note the effect of treatment in cases where penicillin antibiotics are no longer effective.

Overdose

There are no reports of cases of overdose. Possible symptoms are nausea, vomiting.

Interaction

When using the drug with carbamazepine, its transformation in the liver decreases and, accordingly, the concentration in the serum increases, which increases the risk of the toxic effects of the latter: urinary retention, ataxia, convulsions.

Terms of sale

Dispensed by prescription.

Storage conditions

Tablets and granules in a bottle are stored in a dry place, the temperature should not exceed 25°C. The finished suspension is stored for 7 days at room temperature and 14 days in the refrigerator.

Best before date

Shelf life: 3 years.

Macropen's analogs

There are no analogues for the active substance. Analogues of Macropen belonging to the same pharmacological group (second generation macrolides): Clarithromycin, Azithromycin, Josamycin.

The price of analogues Clarithromycin 500 mg No. 14 is 311 – 456 rubles. (manufactured by Pliva), designed for a 7-day course of treatment.

Azithromycin capsules 500 mg No. 3 — rub. (Obolenskoye FP Russia), designed for a 3-day course of treatment.

Reviews about Macropen

Reviews about Macropen are mostly positive. Most of them are about the use of the drug for sinusitis. High efficiency is noted - in many cases, with timely administration of the drug, the patient's condition quickly improves, and puncture can be dispensed with. Duration of treatment is from 7 to 14 days. It is important to complete the course of treatment, otherwise the “hidden” infection may become chronic.

A large number of reviews about the use of the suspension for children. Parents are satisfied with the results of the treatment: it quickly and effectively helps with coughs, especially prolonged ones. Since the treatment lasted up to 10 days, the child was given probiotics (Linex, Bactisubtil) in parallel. Some noted the appearance of adverse reactions in children: nausea, lethargy, vomiting. In such cases, Macropen was canceled. In any case, there is no point in drawing conclusions that the drug is not effective. It depends on the individual characteristics of the organism.

Macropen price, where to buy

This drug can be found in any pharmacy. When purchasing Macropen tablets, the price of which in Moscow pharmacies varies and amounts to rub. for 16 capsules, you can make a request on the Internet and choose a more acceptable option. The price of Macropen suspension is from 270 rubles. up to 306 rub.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

WER.RU

ZdravZone

Pharmacy IFC

Pharmacy24

PaniPharmacy

BIOSPHERE

Education: Graduated from the Sverdlovsk Medical School (1968 - 1971) with a degree in Paramedic. He graduated from the Donetsk Medical Institute (1975 - 1981) with a degree in epidemiologist and hygienist. He completed his postgraduate studies at the Central Research Institute of Epidemiology in Moscow (1986 - 1989). Academic degree - Candidate of Medical Sciences (degree awarded in 1989, defense - Central Research Institute of Epidemiology, Moscow). Completed numerous advanced training courses in epidemiology and infectious diseases.

Work experience: Work as head of the disinfection and sterilization department 1981 - 1992. Work as head of the department of especially dangerous infections 1992 - 2010. Teaching activity at the Medical Institute 2010 - 2013

It treats tracheitis in children well. Dysbacteriosis and allergies are possible. It is inconvenient to give to a child at night.

good antibiotic! I give it 5+

A good drug, it has saved me many times! I use it to treat a severe cough. And before that I tried another drug - zero effect. And then after a couple of days there was improvement.

A friend told me about him and also praised him!

My husband was treated for pneumonia and was prescribed Macropen. He was cured in 2 weeks. We were afraid that there would be consequences from taking antibiotics, but everything worked out! I think it's an excellent medicine!

Sivaya: I started taking ginkum before the session because I was very worried that I wouldn’t have time to do everything.

Igor: it helps, try it, I wanted de-nol, but it’s easier

Konstantin: What I liked about the drug Prostanorm: reasonable price, pronounced effect of taking it.

Valentina: I, too, am all about diet and exercise. I hoped for loads, I thought that my healthy lifestyle.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/makropen

Macropen - instructions for use, analogs, reviews and release forms (granules for preparing a suspension, 400 mg tablets) of a drug for the treatment of sore throat, sinusitis and other infections in adults, children and pregnancy. Compound

In this article you can read the instructions for use of the drug Macropen. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Macropen in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Macropen in the presence of existing structural analogues. Use for the treatment of sore throat, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Macropen is an antibiotic of the macrolide group. Inhibits protein synthesis in bacterial cells. Reversibly binds to the 50S subunit of the bacterial ribosomal membrane. In low doses the drug has a bacteriostatic effect, in high doses it has a bactericidal effect.

Active against intracellular microorganisms: Mycoplasma spp., Chlamydia spp., Legionella spp., Ureaplasma urealyticum; gram-positive and gram-negative bacteria.

Midecamycin + excipients.

After oral administration, Macropen is quickly and fairly completely absorbed from the gastrointestinal tract. High concentrations of midecamycin and midecamycin acetate are created in internal organs (especially in lung tissue, parotid and submandibular glands) and skin. Midecamycin is excreted in bile and to a lesser extent (about 5%) in urine.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

  • respiratory tract infections: tonsillopharyngitis, acute otitis media, sinusitis, exacerbation of chronic bronchitis, community-acquired pneumonia (including those caused by atypical pathogens Mycoplasma spp., Chlamydia spp., Legionella spp. and Ureaplasma urealyticum);
  • infections of the genitourinary system caused by Mycoplasma spp., Chlamydia spp., Legionella spp. and Ureaplasma urealyticum;
  • infections of the skin and subcutaneous tissue;
  • treatment of enteritis caused by Campylobacter spp.;
  • treatment and prevention of diphtheria and whooping cough.

Film-coated tablets 400 mg.

Granules for the preparation of suspension for oral administration (ideal children's form).

Instructions for use and dosage

The drug should be taken before meals.

For adults and children weighing more than 30 kg, Macropen is prescribed 400 mg (1 tablet) 3 times a day. The maximum daily dose for adults is 1.6 g.

For children weighing less than 30 kg, the daily dose is mg/kg body weight in 3 divided doses or 50 mg/kg body weight in 2 divided doses, for severe infections - 50 mg/kg body weight in 3 divided doses.

The prescription regimen for Macropen in the form of a suspension for children (daily dose of 50 mg/kg body weight in 2 doses) is presented below:

  • up to 5 kg (approx. 2 months) - 3.75 ml (131.25 mg) 2 times a day;
  • up to 10 kg (approx. 1-2 years) - 7.5 ml (262.5 mg) 2 times a day;
  • up to 15 kg (approx. 4 years) - 10 ml (350 mg) 2 times a day;
  • up to 20 kg (approx. 6 years) - 15 ml (525 mg) 2 times a day;
  • up to 30 kg (approx. 10 years) - 22.5 ml (787.5 mg) 2 times a day.

The duration of treatment is from 7 to 14 days, for the treatment of chlamydial infections - 14 days.

To prevent diphtheria, the drug is prescribed at a dose of 50 mg/kg per day, divided into 2 doses, for 7 days. A control bacteriological study after completion of therapy is recommended.

To prevent whooping cough, the drug is prescribed at a dose of 50 mg/kg per day for 7-14 days in the first 14 days from the moment of contact.

To prepare the suspension, add 100 ml of boiled or distilled water to the contents of the bottle and shake well. It is recommended to shake the prepared suspension before use.

  • decreased appetite;
  • stomatitis;
  • nausea, vomiting;
  • diarrhea;
  • feeling of heaviness in the epigastrium;
  • increased activity of liver transaminases and jaundice;
  • severe and prolonged diarrhea, which may indicate the development of pseudomembranous colitis;
  • skin rash;
  • hives;
  • skin itching;
  • eosinophilia;
  • bronchospasm;
  • weakness.
  • severe liver failure;
  • children under 3 years of age (for tablets);
  • hypersensitivity to midecamycin/midecamycin acetate and other components of the drug.

Use during pregnancy and breastfeeding

The use of Macropen during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Midecamycin is excreted in breast milk. When using Macropen during lactation, breastfeeding should be stopped.

Use in children under 12 years of age

The drug is used according to indications, in the recommended dosage form and in doses taking into account the age of the patients.

As with the use of any other antimicrobial drugs, overgrowth of resistant bacteria is possible with long-term therapy with Macropen. Prolonged diarrhea may indicate the development of pseudomembranous colitis.

During long-term therapy, liver enzyme activity should be monitored, especially in patients with impaired liver function.

Mannitol contained in suspension granules may cause diarrhea.

If you have a history of an allergic reaction to acetylsalicylic acid, azo dye E110 (sunset yellow dye) can cause an allergic reaction, including bronchospasm.

Impact on the ability to drive vehicles and operate machinery

The effect of Macropen on the speed of psychomotor reactions and the ability to drive a car and other mechanisms has not been reported.

With the simultaneous use of Macropen with ergot alkaloids and carbamazepine, their metabolism in the liver decreases and their concentration in the serum increases. Therefore, caution should be exercised when prescribing these drugs simultaneously.

When Macropen is used simultaneously with cyclosporine and anticoagulants (warfarin), the elimination of the latter is slowed down.

Macropen does not affect the pharmacokinetic parameters of theophylline.

Analogues of the drug Macropen

The drug Macropen has no structural analogues for the active substance.

Analogs by pharmacological group (Macrolides and azalides):

Source: http://instrukciya-otzyvy.ru/259-makropen-po-primeneniyu-analogi-granuly-dlya-prigotovleniya-suspenzii-tabletki-angina-gaymorit.html

Macropen - purpose, dosage and antibiotic analogues

The drug Macropen belongs to the group of antibiotics - macrolides. It is used to treat various infectious and inflammatory diseases and is a relatively safe treatment.

However, often due to intolerance to the active substance of any drug, it is necessary to replace antibiotics with other drugs. How does Macropen work and what analogues can be used instead of this medication?

Composition and properties of Macropen

Macropen is an antibacterial drug that has a wide spectrum of action

One antibiotic tablet contains 400 mg of the active substance - midecamycin. The auxiliary components of Macropen include:

  • Microcrystalline cellulose
  • Magnesium stearate
  • Potassium polacriline
  • Talc
  • Macrogol
  • Titanium dioxide

The composition of the granules for the preparation of the suspension includes 175 mg of midecamycin acetate. Excipients include citric acid, propyl parahydroxybenzoate, sodium hydrogen phosphate, banana flavor, methyl parahydroxybenzoate, sodium saccharinate, yellow dye, hypromellose.

When Macropen is used in low dosages, a bacteriostatic effect occurs, and at higher doses the active substance has a bactericidal effect.

The drug inhibits the growth and reproduction of gram-positive and gram-negative microorganisms:

The drug is absorbed quickly and excreted in bile and urine.

When is an antibiotic prescribed?

Macropen is an effective drug for the treatment of diseases of the ENT organs and respiratory tract

Macropen is prescribed for infectious diseases, the pathogens of which are sensitive to the active component of the antibiotic.

The remedy is effective for respiratory infections and otolaryngological diseases:

The drug is prescribed for infectious and inflammatory diseases of the genitourinary system, skin, subcutaneous tissue, and gastrointestinal tract. This antibiotic is also used to treat patients who have an allergic reaction to penicillin antibiotics.

Rules for using the drug and its dosage

Macropen tablets and suspension are taken orally before eating

It is important to remember that only a specialist can prescribe the dosage and course of treatment. When determining the dose of the drug, the patient’s body weight is taken into account. For those weighing more than 30 kilograms, take one tablet three times a day.

For children, the drug is given in suspension or the dose of the drug is calculated up to forty milligrams per kilogram of weight, dividing this amount into three doses or up to fifty milligrams in two doses.

The course of treatment with Macropen ranges from one to two weeks. To prevent whooping cough and diphtheria, I take an antibiotic at a dosage of 50 mg per 1 kg per day, divided into two doses over seven days. Since the drug affects the liver, with long-term use of Macropen the activity of the organ’s enzymes is controlled.

To prepare a suspension, macropen, like its analogues, is dissolved in ordinary water. It is used to treat children. The dosage is as follows:

  • 20-25 kg – up to 22.5 milliliters
  • Up to 20 kg – 15 ml
  • Up to 15 kg – 10 ml
  • Up to 10 kg – 7.5 ml
  • For children weighing up to 5 kg, about 3.75 ml of suspension is given.

If you take other antimicrobial drugs simultaneously with Macropen, you can provoke the development of resistance of pathogenic microorganisms to the components of the drug. When prolonged diarrhea occurs after taking an antibiotic, this may indicate the presence of pseudomembranous colitis.

It is important to remember that during antibacterial therapy you should take drugs to prevent dysbiosis - probiotics, for example, Laktovit, Linex, Normobakt, Baktisubtil.

Contraindications and side effects

Misuse or overdose of Macropen may cause side effects

Macropen, among other antibiotics, has a small list of restrictions. The main contraindications are:

  • Liver pathologies.
  • Hypersensitivity to the components of the antibiotic, namely midecamycin.
  • Ages up to three years (use tablet form).
  • Allergy to acetylsalicylic acid.

Macropen is prescribed to pregnant women with caution. It is not allowed to use the antibiotic during lactation, since some of it passes into breast milk. In such cases, breastfeeding women are advised to stop breastfeeding.

The advantage of macrolide antibiotics is not only their effect on various types of microorganisms, but also minimal side effects.

In rare cases, reactions from the digestive system are possible:

  • Diarrhea.
  • Decreased appetite.
  • Nausea.
  • Vomiting.
  • Discomfort in the epigastric zone.
  • Jaundice.
  • Tests may indicate increased bilirubin in the blood.
  • If you are prone to allergies, skin rashes, hives, and itching are sometimes observed.
  • If you are allergic to acetylsalicylic acid, bronchospasm may occur.
  • Lethargy and general weakness may occur.

If such reactions occur, it is necessary to stop using the drug and select another antibiotic.

Drug analogues: types and uses

In terms of their composition and mechanism of action, the following drugs are completely identical to Macropen:

They belong to the macrolide group of antibiotics. The active substance in these drugs is midecamycin. Indications for their use include infections of the respiratory tract, genitourinary system, skin and mucous membranes.

You can replace Macropen with other drugs of the macrolide group. The second generation of such drugs, which are more effective and safe, include:

You can use an antibiotic with another active component as analogues:

These drugs have an affordable price. They can be used in childhood, also in the presence of penicillin intolerance.

Useful video - Antibiotics: meaning and rules of use

  • A popular analogue is Azitral. Effective against infections such as whooping cough, scarlet fever, diphtheria. Prescribed for otolaryngological diseases, diseases of the respiratory and genitourinary systems, damage to soft tissues and skin.
  • You can also replace Macropen with the drug Sumamed, which contains azithromycin. For children, a suspension is prescribed; for the treatment of adult patients, a tablet form of the drug is available. The drug is taken to treat diseases for which Macropen is also used. However, the course of treatment with Sumamed lasts three days. The dosage of the antibiotic is determined by the doctor.
  • Erythromycin is also considered an inexpensive analogue. It is a first generation antibiotic. Copes well with pathogenic microorganisms in respiratory diseases. Like Macropen, Erythromycin helps suppress the synthesis of proteins of pathogenic bacteria.

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Source: http://tvojlor.com/lekarstva/makropen-analog.html

Macropen - official instructions for use

Registration number:

Trade name:

International nonproprietary name:

Dosage form:

granules for the preparation of suspension for oral administration

Compound

1 g of granules contains:

Active substance: midecamycin acetate 200.00 mg (corresponding to 175 mg of midecamycin acetate in 5 ml suspension)

Excipients: methyl parahydroxybenzoate 1.00 mg, propyl parahydroxybenzoate 0.20 mg, citric acid 0.25 mg, sodium hydrogen phosphate, anhydrous 16.75 mg, banana flavor, powder 14.00 mg, sunset yellow dye FCF, E110 1.50 mg, hypromellose 30.00 mg, silicone defoamer 0.17 mg, sodium saccharinate 0.70 mg, mannitol qs up to 1000.00 mg.

Description

Small orange granules with a slight banana aroma without visible impurities.

Description of the suspension: an aqueous suspension prepared in 100 ml of water, orange in color with a slight banana aroma.

Pharmacotherapeutic group:

Pharmacological properties

Macropen is a macrolide antibiotic that inhibits the synthesis of proteins in bacterial cells; it has a bacteriostatic effect in low doses and a bactericidal effect in large doses. Reversibly binds to the 50S subunit of the bacterial ribosomal membrane. It is effective against intracellular microorganisms: Mycoplasma spp., Chlamydia spp., Legionella spp., Ureaplasma urealyticum; gram-positive bacteria: Stretococcus spp., Staphylococcus spp., Corynebacterium diphtheriae, Listeria monocytogenes, Clostridium spp. and some gram-negative bacteria: Neisseria spp., Moraxella catarrhalis, Bordetella pertussis, Helicobacter spp., Campylobacter spp., Bacteroides spp.

After oral administration, the drug is quickly and fairly completely absorbed from the gastrointestinal tract (GIT). Maximum serum concentrations of midecamycin and midecamycin acetate are 0.5-2.5 mcg/L and 1.31-3.3 mcg/L, respectively, and are achieved 1-2 hours after oral administration.

High concentrations of midecamycin and midecamycin acetate are created in internal organs (especially in lung tissue, parotid and submandibular glands) and skin. The minimum inhibitory concentration (MIC) persists for 6 hours. The half-life is approximately 1 hour. Protein binding - 47% midecamycin and 3-29% metabolites.

The drug is metabolized in the liver to form 2 active metabolites with antimicrobial activity. It is excreted in the bile and to a lesser extent (about 5%) by the kidneys.

In liver cirrhosis: plasma concentrations, area under the concentration-time curve and half-life increase significantly.

Indications

Contraindications

  • Hypersensitivity to midecamycin/midecamycin acetate and any other components of the drug;
  • severe liver failure.

Pregnancy and lactation

The use of the drug during pregnancy is indicated only in cases where the potential benefit to the mother outweighs the risk to the fetus.

Nursing mothers should stop breastfeeding during treatment with Macropen, as the drug is excreted into breast milk.

Directions for use and doses

Orally, should be taken before meals.

Children weighing less than 30 kg: the daily dose of midecamycin is mg/kg body weight, divided into 3 doses, or 50 mg/kg body weight, divided into 2 doses.

1 dosing spoon has measuring divisions of 1.25 ml, 2.5 ml and 5 ml.

Side effects

From the gastrointestinal tract: loss of appetite, stomatitis, nausea, vomiting and diarrhea, feeling of heaviness in the epigastrium, increased activity of “liver” transaminases and hyperbilirubinemia, jaundice.

In rare cases, severe and prolonged diarrhea may occur, which may indicate the development of pseudomembranous colitis.

Allergic reactions: skin rash, urticaria, itching, eosinophilia, bronchospasm.

Overdose

There are no reports of cases of serious overdose caused by Macropen.

Possible symptoms: nausea, vomiting. Treatment: symptomatic.

Interaction with other drugs

When ergot alkaloids or carbamazepine are taken simultaneously with Macropen, their metabolism in the liver decreases and serum concentration increases. Therefore, caution should be used when taking these drugs together.

Does not affect the pharmacokinetic parameters of theophylline.

When Macropen is used simultaneously with cyclosporine or anticoagulants (warfarin), the elimination of the latter slows down.

special instructions

During long-term therapy, the activity of liver enzymes should be monitored, especially in patients with impaired liver function.

As with any antimicrobial drug, long-term treatment may result in overgrowth of resistant bacteria. Prolonged diarrhea may indicate the development of pseudomembranous colitis.

Mannitol contained in Macropen (granules for oral suspension) may cause diarrhea.

If there is an allergic reaction to acetylsalicylic acid, azo dye E PO (sunset yellow dye, E110) can cause an allergic reaction, including bronchospasm.

Effect on the ability to drive a car or use other machinery

The effect of Macropen on psychophysiological reactions and the ability to drive a car and other mechanisms has not been reported.

Release form

Storage conditions

Best before date

Do not use the drug after the expiration date.

Vacation conditions

Dispensed by prescription.

Manufacturer:

JSC Krka d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia

Representative office of JSC "KRKA, d.d., Novo Mesto" in the Russian Federation / Organization accepting consumer complaints:

125212, Moscow, Golovinskoe highway, building 5, building 1

Source: http://medi.ru/instrukciya/makropen_3264/

DocVita

Active substance: midecamycin

ATX code: J01FA03

KFG: Macrolide antibiotic

Reg. number: P No. 015069/

Registration date: 06/23/03

Owner reg. ID: KRKA dd

DOSAGE FORM, COMPOSITION AND PACKAGING

Film-coated tablets are round, slightly biconvex, scored on one side and beveled edge, white.

Excipients: microcrystalline cellulose, potassium polacrillin, magnesium stearate, talc, methacrylic acid copolymer, macrogol, titanium dioxide.

8 pcs. — contour cell packaging (2) — cardboard packs.

The granules for preparing a suspension for oral administration are small, orange in color, with a slight banana odor and sweet taste; the prepared suspension is orange in color, with a slight banana smell.

Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium saccharin, mannitol, dispersive yellow dye (E110), citric acid, hypromellose, disodium phosphate (anhydrous), banana flavor, silicone defoamer.

Dark glass bottles with a volume of 115 ml (1) complete with a dosing spoon - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Antibiotic of the macrolide group. Inhibits protein synthesis in bacterial cells. Reversibly binds to the 50S subunit of the bacterial ribosomal membrane. In low doses the drug has a bacteriostatic effect, in high doses it has a bactericidal effect.

Active against intracellular microorganisms: Mycoplasma spp., Chlamydia spp., Legionella spp., Ureaplasma urealyticum; gram-positive bacteria: Streptococcus spp., Staphylococcus spp., Corynebacterium diphtheriae, Listeria monocytogenes, Erysipelothrix spp., Clostridium spp.; gram-negative bacteria: Neisseria spp., Moraxella catarrhalis, Bordetella pertussis, Helicobacter spp., Campylobacter spp., Bacteroides spp.

After oral administration, midecamycin is quickly and fairly completely absorbed from the gastrointestinal tract.

C max in the serum of midecamycin and myocamycin (midecamycin acetate) are 2.5 mg/l and 1.31-3.3 mg/l, respectively, and are achieved 1-2 hours after oral administration.

High concentrations of midecamycin and myocamycin are created in internal organs (especially in lung tissue, parotid and submandibular glands) and skin. MIC is maintained for 6 hours.

Midecamycin is metabolized in the liver to form 2 metabolites with antimicrobial activity.

T1 /2 is approximately 1 hour. Midecamycin is excreted in bile and to a lesser extent (about 5%) in urine.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

— infections of the respiratory tract, urinary system, genital organs caused by Mycoplasma spp., Chlamydia spp., Legionella spp. and Ureaplasma urealyticum;

- infections of the respiratory tract, skin and subcutaneous tissue caused by microorganisms sensitive to penicillin;

- treatment of infections in patients with hypersensitivity to penicillin antibiotics;

- treatment of enteritis caused by Campylobacter spp.;

- treatment and prevention of diphtheria and whooping cough.

The drug should be taken before meals.

For adults and children weighing more than 30 kg, Macropen is prescribed 400 mg (1 tablet) 3 times a day. The maximum daily dose for adults is 1.6 g.

For children weighing less than 30 kg, the daily dose is mg/kg body weight in 3 divided doses or 50 mg/kg body weight in 2 divided doses, for severe infections - 50 mg/kg body weight in 3 divided doses.

The prescription regimen for Macropen in the form of a suspension for children (daily dose 50 mg/kg body weight) is presented in the table.

The duration of treatment is from 7 to 14 days, for the treatment of chlamydial infections - 14 days.

To prepare the suspension, add 100 ml of boiled or distilled water to the contents of the bottle and shake well. It is recommended to shake the prepared suspension before use.

From the digestive system: possible loss of appetite, stomatitis, nausea, vomiting, diarrhea, increased activity of liver transaminases and jaundice; rarely - a feeling of heaviness in the epigastrium; in some cases, severe and prolonged diarrhea, which may indicate the development of pseudomembranous colitis.

Allergic reactions: possible skin rash, urticaria, itching, eosinophilia.

- severe liver failure;

- hypersensitivity to midecamycin/myocamycin and other components of the drug.

The use of Macropen during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Midecamycin is excreted in breast milk. When using Macropen during lactation, breastfeeding should be stopped.

As with the use of any other antimicrobial drugs, overgrowth of resistant bacteria is possible with long-term therapy with Macropen. Prolonged diarrhea may indicate the development of pseudomembranous colitis.

During long-term therapy, liver enzyme activity should be monitored, especially in patients with impaired liver function.

Impact on the ability to drive vehicles and operate machinery

The effect of Macropen on the speed of psychomotor reactions and the ability to drive a car and other mechanisms has not been reported.

There are no reports of cases of serious intoxication caused by the drug Macropen.

Symptoms: possible nausea, vomiting.

Treatment: symptomatic therapy.

With the simultaneous use of Macropen with ergot alkaloids and carbamazepine, their metabolism in the liver decreases and their concentration in the serum increases. The simultaneous administration of these drugs with Macropen is not recommended.

When Macropen is used simultaneously with cyclosporine and warfarin, the elimination of the latter is slowed down.

The drug is available with a prescription.

Tablets should be stored in a place protected from moisture, out of the reach of children, at a temperature not exceeding 25°C. Granules for preparing the suspension should be stored at a temperature not exceeding 25°C. Shelf life: 3 years.

The prepared suspension can be used within 14 days if stored in the refrigerator.

Source: http://docvita.ru/Details/MAKROPEN.html

Macropen for children: instructions for use

The group of macrolides is considered one of the most popular and effective among modern antibacterial agents. A representative of this group of drugs is Macropen for children. If you are interested in when it is prescribed to children, as well as instructions for use, read this article.

Release form

Macropen is produced in two different forms:

  • A bottle with granules from which a suspension is made. These granules are small in size, have a banana smell and are orange in color. After combining with water, they form an orange-colored liquid that has a not very strong banana smell. The bottle comes with a dosage spoon containing 5 ml of the drug.
  • Tablets that have a coating. Their characteristics are round (slightly convex) shape and white color. One pack contains 16 tablets.

Compound

The main ingredient of Macropen, thanks to which the medicine acts on harmful bacteria, is midecamycin in the form of acetate. Its dosage in 5 ml of suspension is 175 mg, and in one tablet – 400 mg.

Additionally, the composition of the granules includes propyl and methyl parahydroxybenzoate, citric acid, yellow dye, mannitol, hypromellose, banana flavor and some other substances. In tablets, midecamycin is combined with talc, MCC, macrogol, potassium polacrilin and other components that create the core and shell of this form of the drug.

Operating principle

Midecamycin has the ability to inhibit the synthesis of protein molecules inside microbial cells. This action is called bacteriostatic. If you use children's Macropen in a high dose, it will destroy harmful microorganisms (act bactericidal). The drug has activity against:

Indications

The reason for prescribing Macropen to a child may be an infectious disease caused by any of the microorganisms sensitive to such a drug. The medication is used:

  • For pneumonia, otitis media, sore throat, sinusitis, bronchitis and other bacterial infections of the respiratory system.
  • For infections of the subcutaneous tissue or skin.
  • When infected with mycoplasmas, chlamydia or other pathogens of the genitourinary system.
  • For whooping cough and for its prevention.
  • With enteritis caused by Campylobacter.
  • For diphtheria and for its prevention.

At what age is it allowed to take it?

The medication in granules is prescribed from birth, and the tablet form is prescribed to children over three years of age. Macropen tablets are usually given to small patients weighing more than 30 kg. If the child is already 3 years old, but his weight has not yet reached 30 kg, it is more convenient for him to give the suspension, since it is easier to dose and swallow.

Contraindications

  • With severe liver pathologies.
  • With intolerance to midecamycin or any other ingredient of the medicine.

If the child has previously had an allergic reaction to acetylsalicylic acid, the use of the medicine requires caution.

Side effects

Sometimes a small patient, when treated with Macropen, experiences an allergy, as well as weakness or a negative reaction from the digestive tract. In addition, long-term therapy with such an antibacterial agent can provoke bacterial resistance, which will make the treatment ineffective.

If a child experiences vomiting after taking Macropen, as well as a feeling of heaviness in the abdomen, loose stools and other negative symptoms, you should consult a doctor and choose an equally effective medicine instead of this antibiotic. When prescribing the drug for a long period, it is important to monitor liver function.

The pharmacist also talks about the drug Macropen, the active ingredients included in its composition, method of use, side effects and contraindications in this video.

Instructions for use and dosage

To make a suspension, add 100 ml of boiled, non-hot water to the bottle with granules. Shake the closed bottle well so that all the medicine is evenly dissolved. It is also recommended to shake the medication before each use.

Macropen is given to the child before meals. For body weights above 30 kg, the medication is prescribed 1 tablet (400 mg) three times a day. For a child weighing up to 30 kg, the daily dose of the drug is calculated by multiplying the patient’s body weight in kilograms by (if the drug is prescribed three times) or by 50 (if twice a day is prescribed).

The annotation for the granules contains a scheme for taking the suspension depending on the weight of the children.

  • With a weight of up to 5000 g, children are given 3.75 ml per dose (half a measuring spoon and another 1/4).
  • For a child weighing 5-10 kg, a single dose is 7.5 ml (one and a half dosing spoons).
  • For a patient who weighs kg, 10 ml of suspension (2 measuring spoons) is required at a time.
  • For a child weighing 1 kg, the medication is given 15 ml per dose (this amount fits in three dosing spoons).
  • For children weighing one kilogram, a single dose of the medicine is 22.5 ml (four and a half spoons).

At this dosage, the suspension is taken twice a day. The duration of treatment is determined by the doctor, but usually the course lasts 7-14 days. Preventive treatment against diphtheria lasts 1 week, and after contact with a patient with whooping cough, the medication is prescribed for a course of 7 to 14 days.

Overdose

If you accidentally give a child Macropen at a higher dose, it may cause nausea or vomiting. The manufacturer does not mention toxic effects when the dosage of the drug is exceeded.

Interaction with other drugs

Macropen is often prescribed in combination with other medications in order not only to influence the cause of the disease, but also to alleviate the symptoms. When coughing, the antibiotic is supplemented with expectorant medications (for example, Lazolvan syrup), and for severe pain, antipyretic drugs (Ibuprofen and others) are prescribed. However, there are some medications that should not be given together with Macropen. They are noted in the instructions for this antibiotic.

Terms of sale

To buy granules or tablets from a pharmacy, you must first consult your doctor and get a prescription from him.

The average price of Macropen in suspension is rubles per bottle, and a package of tablets costs about rubles.

Storage conditions and shelf life

To preserve the healing properties of Macropen, you need to keep it at home in a dry place, at a temperature below 25 degrees Celsius. It is important to ensure that young children do not have access to such a place. The shelf life of both forms of the drug is 3 years. After mixing the granules with water, the suspension can be stored for no longer than 7 days at room temperature - and up to 14 days if the bottle is placed in the refrigerator.

Reviews

There are usually good reviews about the treatment of children with Macropen - both from pediatricians and from parents. They confirm the high effectiveness of this antibiotic for sinusitis, otitis and other infections. One of the main advantages of the medicine for mothers is the presence of a liquid form. They say that giving the suspension to babies is easy, and the sweet banana taste does not cause any complaints from most children. As for the disadvantages, these include the side effects of the drug and the short shelf life of the prepared suspension.

Analogs

You can replace Macropen with one of the antibiotics of the same drug group. The following options are possible:

  • "Sumamed." The basis of this medicine is azithromycin. The drug is available in suspension (it is given to children over 6 months old) and dispersible tablets (they can be given from three years of age).
  • "Vilprafen Solutab". The effect of such soluble tablets is ensured by josamycin. The medication is used to treat children weighing more than 10 kg.
  • "AzitRus". This medicine based on azithromycin is available in portioned sachets containing the active substance in different doses (50, 100 or 200 mg). The drug is prescribed from 6 months of age.
  • "Klacid." This suspension containing clarithromycin is used for children over six months of age. Tablets "Klacid" are prescribed from 3 years of age.

mother of two children with medical education

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Source: http://www.o-krohe.ru/antibiotiki/makropen/