Coldact medicine instructions

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Koldakt - instructions for use, analogs, reviews and release forms (Flu plus capsules, Broncho syrup, Lorpils lozenges) of a medicinal product for the treatment of cold symptoms in adults, children and pregnancy.

Table of contents:

Composition and alcohol

In this article you can read the instructions for use of the drug Koldakt. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Koldakt in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Koldakt analogues in the presence of existing structural analogues. Use for the treatment of cold symptoms (pain, fever, runny nose) in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Koldakt is a long-acting combination drug.

Chlorphenamine has an antiallergic effect, eliminates lacrimation, itching in the eyes and nose.

Paracetamol has an antipyretic and analgesic effect: it reduces the pain syndrome observed during colds - sore throat, headache, muscle and joint pain, and reduces high fever.

Phenylephrine has a vasoconstrictor effect - reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

Phenylephrine hydrochloride + Chlorphenamine (chlorpheniramine) maleate + Paracetamol + excipients (Coldact Flu Plus).

Ambroxol hydrochloride + Chlorphenamine maleate + Guaifenesin + Phenylephrine hydrochloride + excipients (Coldact Broncho).

2,4-dichlorobenzyl alcohol + Amylmetacresol + excipients (Koldakt Lorpils).

  • symptomatic treatment of colds, flu, acute respiratory viral infections (fever, pain, rhinorrhea).
  • symptomatic treatment of colds, flu, acute respiratory viral infections, accompanied by a cough with difficult-to-discharge viscous sputum.

Infectious and inflammatory diseases of the mouth, throat, larynx:

  • tonsillitis;
  • pharyngitis;
  • laryngitis (including of a professional nature - in teachers, announcers, workers in the chemical and coal industries);
  • hoarseness;
  • inflammation of the oral mucosa and gums (aphthous stomatitis, gingivitis, thrush).

Long-acting capsules (Coldact Flu plus).

Syrup (Koldakt Broncho).

Lozenges (Koldakt Lorpils).

Instructions for use and dosage regimen

Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days.

Duration of use as an antipyretic is no more than 3 days; as a pain reliever - no more than 5 days.

Shake before use.

Recommended dose for adults and children over 12 years of age: 20 ml (4 teaspoons) 3 times a day.

Recommended dose for children 6-12 years old: 10 ml (2 teaspoons) 2-3 times a day.

The drug should be taken evenly throughout the day.

Lozenges

Adults: dissolve 1 tablet or lozenge every 2 hours (until complete dissolution). The maximum daily dose is 8 tablets or lozenges.

Children over 5 years old: 1 tablet or lozenge every 4 hours.

  • increased blood pressure;
  • tachycardia;
  • drowsiness;
  • sleep disturbance;
  • dizziness;
  • increased excitability;
  • dry mucous membranes;
  • increased intraocular pressure;
  • loss of appetite;
  • nausea;
  • epigastric pain;
  • urinary retention;
  • allergic reactions (skin rash, itching, urticaria, angioedema);
  • anemia, thrombocytopenia, leukemia, agranulocytosis.
  • hypersensitivity to any of the components included in the composition;
  • severe atherosclerosis of the coronary arteries;
  • arterial hypertension;
  • diabetes;
  • thyrotoxicosis;
  • angle-closure glaucoma;
  • severe diseases of the liver, kidneys, heart, bladder;
  • peptic ulcer of the stomach and duodenum;
  • pancreatic diseases;
  • difficulty urinating with prostate adenoma;
  • diseases of the blood system;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • pregnancy;
  • lactation period;
  • children up to 12 years old (Flu Plus), up to 6 years old (Broncho), up to 5 years old (Lorpils).

Use during pregnancy and breastfeeding

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindicated in children under 12 years of age (Flu Plus), under 6 years of age (Broncho), and under 5 years of age (Lorpils).

Without a doctor's instructions, the drug should not be used by patients undergoing treatment with other medications, in particular MAO inhibitors. If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor. Do not take with alcohol or combine with other drugs containing paracetamol. When using Coldact Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.

Does not contain antibiotics.

Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The risk of developing hematotoxic effects of paracetamol increases with simultaneous use of barbiturates, diphenine, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.

Enhances the effects of sedatives, ethanol (alcohol), and MAO inhibitors.

Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs increase the risk of developing urinary retention, dry mouth, and constipation.

Glucocorticosteroids (GCS) increase the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric drugs.

Chlorphenamine combined with furazolidone can lead to hypertensive crisis, agitation, and hyperrexia.

Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia.

Reduces the hypotensive effect of guanethidine, which in turn enhances the alpha-adrenergic stimulating activity of phenylephrine.

Analogs of the drug Koldakt (all its forms)

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/495-koldakt-po-primeneniyu-analogi-kapsuly-flyu-plyus-sirop-bronho-tabletki-lorpils-prostuda.html

Coldact® Flu Plus - official instructions for use

Trade name of the drug: Coldact ® Flu Plus

International nonproprietary name or generic name paracetamol + phenylephrine + chlorphenamine

Extended release capsules

Compound

Each capsule contains:

Chlorphenamine maleate 8 mg

Paracetamol 200 mg

Phenylephrine hydrochloride 25 mg

Excipients: talc 68.25 mg, hypromellose 4.5 mg, ethylcellulose 29 mg, diethyl phthalate 5.8 mg, microcrystalline cellulose 28.01 mg, povidone (PVP K 30) 6.41 mg, sodium disulfite 0.16 mg, disodium edetate 0.32 mg, crimson dye (Ponceau 4R) 0.35 mg, sunset yellow dye 0.01 mg, quinoline yellow dye 0.08 mg, Non Pareil Seeds 18/22 granules (sugar granules: sucrose, starch molasses) 124.11 mg.

Capsule shell: gelatin qs up to 100%, purified water 14‒15%, methyl parahydroxybenzoate 0.8%, propyl parahydroxybenzoate 0.2%, azorubine dye 0.35%, crimson dye (Ponceau 4R) 0.47%.

Description

Hard gelatin capsules with a red cap and a transparent body, size “0”, containing white or almost white, yellow and orange to red pellets.

Pharmacotherapeutic group

Acute respiratory infections and “cold” symptoms are eliminated (non-narcotic analgesic + alpha-adrenergic agonist + H1-histamine receptor blocker).

Pharmacological properties

Combined drug with prolonged action.

Paracetamol has analgesic and antipyretic effects.

Phenylephrine hydrochloride is an alpha adrenomimetic and has a vasoconstrictor effect, reduces swelling and hyperemia of the nasal mucosa and paranasal sinuses.

Chlorphenamine maleate - a blocker of H1-histamine receptors - has an antiallergic effect, reduces the severity of local exudative manifestations, eliminates lacrimation, itching in the eyes and nose.

Indications for use

Symptomatic treatment of ARVI, including influenza and “colds”, accompanied by high fever, chills, headache and muscle pain, runny nose and nasal congestion, sore throat, body aches, sneezing.

Contraindications

Hypersensitivity to any of the components included in the composition.

Taking monoamine oxidase inhibitors (MAO) (simultaneously or in the previous 14 days), simultaneous use of tricyclic antidepressants, beta-blockers or other sympathomimetic drugs.

Severe cardiovascular diseases, severe atherosclerosis of the coronary arteries, arterial hypertension, hyperthyroidism, diabetes mellitus, thyrotoxicosis, angle-closure glaucoma, pheochromocytoma, deficiency of the enzyme glucose-6-phosphate dehydrogenase. Severe diseases of the liver, kidneys, bladder, peptic ulcer of the stomach and duodenum, diseases of the pancreas, difficulty urinating with prostate adenoma, diseases of the blood system.

Pregnancy, breastfeeding period.

Children's age up to 12 years.

Carefully

Congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), bronchial asthma and chronic obstructive pulmonary disease, viral hepatitis. Should be taken with caution in patients with alcohol dependence.

There is a risk of liver damage in patients with glutathione deficiency (eg, fasting).

Use during pregnancy and breastfeeding

Coldact ® Flu Plus capsules are not recommended for use during pregnancy and breastfeeding.

Directions for use and doses

Orally, adults and children over 12 years old, 1 capsule every 12 hours for 3-5 days. Duration of use as an antipyretic is no more than 3 days; as a pain reliever – no more than 5 days.

If there is no sufficient therapeutic effect, there is a high temperature that persists during treatment for more than 3 days, or if new symptoms appear, consult a doctor immediately.

Side effect

Allergic reactions: skin rash, itching, urticaria, toxic epidermal necrolysis (Lyell's syndrome), polymorphobullous erythema (Stevens-Johnson syndrome), acute generalized exanthematous pustulosis, angioedema, anaphylactic shock.

From the central nervous system: dizziness, increased excitability (especially in children), sleep disturbance, drowsiness, decreased speed of psychomotor reactions, feeling tired.

From the hematopoietic system: anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, hemolytic anemia, methemoglobinemia, pancytopenia.

From the digestive system: nausea, vomiting, stomach pain, dry mouth, diarrhea.

From the liver and biliary tract: liver damage (increased activity of liver enzymes), hepatitis, as well as dose-dependent liver failure, liver necrosis (including fatal outcomes). Long-term unjustified use can lead to liver fibrosis, liver cirrhosis, including death.

From the respiratory system: bronchospasm or exacerbation of bronchial asthma, including in patients sensitive to acetylsalicylic acid or other NSAIDs.

From the cardiovascular system: palpitations, increased blood pressure.

From the urinary system: urinary retention, with long-term use of high doses nephrotoxic effect.

Other: mydriasis, accommodation paresis, increased intraocular pressure.

Overdose

Symptoms of overdose are caused mainly by paracetamol and appear after taking more than 10–15 g.

In acute overdose, paracetamol has a hepatotoxic effect, including causing liver necrosis.

Overdose may cause nephropathy with irreversible liver failure. The severity of an overdose depends on the dose, so patients should be warned not to take drugs containing paracetamol at the same time. The risk of poisoning is pronounced especially in elderly patients, in children, in patients with liver disease, in cases of chronic alcoholism, in patients with chronic malnutrition (calorie deficiency) and in patients taking inducers of microsomal oxidation in the liver. Overdose of paracetamol can lead to impaired glucose metabolism, hypoglycemia, bleeding, pancreatitis, liver failure, encephalopathy, coma and death.

Symptoms of paracetamol overdose in the first 24 hours: pale skin, nausea, vomiting, anorexia, convulsions. Abdominal pain may be the first sign of liver damage and usually does not appear for 24 to 48 hours and may sometimes appear later, after 4 to 6 days, on average 72 to 96 hours after taking the drug. Impaired glucose metabolism and metabolic acidosis may also occur. Even in the absence of liver damage, acute renal failure and acute tubular necrosis can develop. Cases of cardiac arrhythmia and pancreatitis have been reported.

Treatment: Acetylcysteine ​​administered intravenously or orally as an antidote, gastric lavage, and oral methionine may have a beneficial effect for at least 48 hours after an overdose. It is recommended to take activated carbon and monitor breathing and circulation. If seizures develop, diazepam may be prescribed.

Symptoms of overdose include: drowsiness, which is subsequently accompanied by anxiety (especially in children), visual disturbances, rash, nausea, vomiting, headache, increased excitability, dizziness, insomnia, circulatory disorders (thrombocytopenia, agranulocytosis, leukopenia, pancytopenia), coma , convulsions, increased or decreased blood pressure, bradycardia.

Treatment includes surgical gastric lavage, symptomatic and supportive therapy. The hypertensive effect can be reversed by intravenous administration of an alpha-receptor blocker. In case of seizures, diazepam may be used.

Symptoms of chlorphenamine maleate overdose include drowsiness, respiratory arrest, seizures, anticholinergic effects, dystonic reactions, and cardiovascular collapse including arrhythmia.

In children, symptoms of overdose may include incoordination, agitation, tremors, behavioral changes, hallucinations, seizures, and anticholinergic effects.

Treatment includes gastric lavage in case of massive overdose, or induction of vomiting. After this, it is possible to prescribe activated charcoal and a laxative to slow down absorption. In case of seizures, sedation should be performed with intravenous diazepam or phenytoin. In severe cases, hemoperfusion may be performed.

Interaction with other drugs

Enhances the effects of MAO inhibitors, sedatives, ethanol. The risk of hepatotoxic action of paracetamol increases with simultaneous use of barbiturates, phenytoin, phenobarbital, carbamazepine, rifampicin, isoniazid, zidovudine and other inducers of microsomal liver enzymes. The anticoagulant properties of warfarin and other coumarins may be enhanced by long-term regular use of paracetamol, increasing the risk of bleeding. A single dose of paracetamol does not have this effect. Metoclopramide increases the rate of absorption of paracetamol and increases the level of paracetamol concentration in the blood plasma to the maximum. Likewise, domperidone may increase the rate of absorption of paracetamol.

When chloramphenicol and paracetamol are used together, the half-life of chloramphenicol may increase.

Paracetamol may reduce the bioavailability of lamotrigine, with a possible decrease in its effect due to induction of its hepatic metabolism. The absorption of paracetamol may be reduced when taken concomitantly with cholestyramine, but this can be avoided if cholestyramine is taken one hour after paracetamol. Regular use of paracetamol concomitantly with zidovudine may cause neutropenia and increase the risk of liver damage. Probenecid affects the metabolism of paracetamol. In patients taking probenecid concomitantly, the dose of paracetamol should be reduced. The hepatotoxicity of paracetamol may be increased by chronic or excessive alcohol consumption. Paracetamol may interfere with the results of the uric acid test using the phosphotungstate precipitating reagent.

Contraindicated in patients who are taking or have taken MAOIs within the past two weeks. Phenylephrine can enhance the effect of MAO inhibitors and cause a hypertensive crisis.

Concomitant use of phenylephrine with other sympathomimetic drugs or tricyclic antidepressants (eg, amitriptyline) may increase the risk of cardiovascular side effects. Phenylephrine may reduce the effectiveness of beta blockers and other antihypertensive drugs (eg, debrisoquine, guanethidine, reserpine, methyldopa); The risk of increased blood pressure and other cardiovascular side effects may be increased. Concomitant use of phenylephrine with digoxin and other cardiac glycosides may increase the risk of arrhythmia or myocardial infarction. Concomitant use of phenylephrine with ergot alkaloids (ergotamine and methysergide) may increase the risk of ergotism.

Antihistamines, such as chlorphenamine, may enhance the effects of opioid analgesics, anticonvulsants, antidepressants (tricyclics and monoamine oxidase inhibitors), other antihistamines, antiemetics and antipsychotics, anxiolytics, hypnotics, ethanol (alcohol) and other central nervous system depressants.

Because chlorphenamine has some anticholinergic activity, the effects of anticholinergic drugs (eg, some psychotropic drugs, atropine, and urinary incontinence drugs) may be increased by this drug. This can lead to tachycardia, dry mouth, gastrointestinal disorders (eg, colic), urinary retention and headache.

The metabolism of phenytoin may be inhibited by chlorphenamine, and phenytoin toxicity may develop.

special instructions

If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor. Do not take with alcohol or combine with other drugs containing paracetamol. When using Coldact ® Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.

Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma.

In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.

Impact on the ability to drive vehicles and machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

Long-acting capsules.

10 capsules in a blister made of aluminum foil and PVC/PVdC film; 1 or 10 blisters with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than 25°C.

Keep out of the reach of children.

Best before date

Do not use after expiration date.

Vacation conditions

Registration Certificate Holder

Sun Pharmaceutical Industries Ltd., Sun House, Raft No. 201 B/1, Western Express Highway, Goregaon (East), Mumbai -, Maharashtra, India

Sun Pharmaceutical Industries Ltd., Sun House, Plot No. 201 B/1, Western Express Highway, Goregaon (East), Mumbai -, Maharashtra, India.

Manufacturer

Natco Pharma Limited, Kothur, Mahabubnagar District, Telangana, India.

Natco Pharma Limited, Kothur, Mahaboobnagar District, Telangana, India.

Consumer complaints should be sent to the representative office of Sun Pharmaceutical Industries Ltd. by the address:

129223, Moscow, Mira Ave., building. 119, pp. 537/2.

Source: http://medi.ru/instrukciya/koldakt-flyu-plyus_9844/

Coldact Flu Plus: instructions for use

The drug Coldact Flu Plus is used for the symptomatic treatment of acute respiratory viral pathology. Its effect is due to the complex effect on the body of the main active ingredients of the drug.

Release form and composition

The drug Coldact Flu Plus is available in two dosage forms - capsules for oral administration of prolonged action and syrup for oral (inside) administration. The drug contains several active ingredients:

  • Chlorphenamine maleate – 8 mg in 1 capsule or 2 mg in 5 ml of suspension for oral administration.
  • Phenylephrine hydrochloride – 25 mg in 1 capsule or 5 mg in 5 ml of suspension.
  • Paracetamol – 200 mg per capsule or 125 mg per 5 ml suspension.

Coldact Flu Plus capsules have a solid consistency and a red cap, they are packaged in blister packs of 10 pieces, a cardboard pack contains 1 or 10 blisters and instructions for use of the drug. The suspension has an orange color and a characteristic odor; it is contained in a 60 ml bottle. The cardboard pack contains one bottle, a measuring spoon and instructions for use of the drug.

pharmachologic effect

The clinical and therapeutic effect of the drug Coldact Flu Plus is realized due to the complex effect of its active ingredients:

  • Chlorphenamine – has an antiallergic, antihistamine effect, reduces the intensity of lacrimation, itching, burning in the eyes and nose.
  • Paracetamol is a representative of the pharmacological group of non-steroidal anti-inflammatory drugs; it has an antipyretic and analgesic effect, reduces the severity of headache, muscle and joint pain, and reduces the manifestations of fever.
  • Phenylephrine has a vasoconstrictor effect - it reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

After oral administration, regardless of the dosage form, the active substances are quickly absorbed from the intestinal lumen into the systemic bloodstream. They are almost evenly distributed in the tissues of the body. They are metabolized in the liver to form inactive breakdown products, which are excreted primarily in the urine. The half-life (the time during which half of the entire dose of the drug is eliminated from the body) is slightly higher for the dosage form of the drug Coldact Flu Plus in the form of capsules for oral administration.

Indications for use

Taking tablets or suspension Coldact Flu Plus is indicated for symptomatic therapy (treatment aimed at reducing the intensity of manifestations of the pathological process) of acute respiratory viral pathology with manifestations in the form of headache, fever, swelling of the mucous membranes of the upper respiratory tract and paranasal sinuses, rhinorrhea (abundant mucous discharge from the nose).

Contraindications for use

Taking Coldact Flu Plus capsules or suspension is contraindicated in a number of pathological and physiological conditions of the human body, which include:

  • Individual intolerance to any of the components of the drug.
  • Severe atherosclerosis (formation of atherosclerotic plaques due to the deposition of cholesterol in the walls of the arteries).
  • Arterial hypertension is an increase in the level of systemic blood pressure.
  • Angle-closure glaucoma – increased intraocular pressure.
  • Diabetes mellitus is a disorder of carbohydrate metabolism in the body, which causes an increase in blood glucose levels.
  • Peptic ulcer of the stomach or duodenum with the formation of a defect in the mucous membrane and a high probability of developing gastrointestinal bleeding.
  • Deficiency of the enzyme glucose-6-phosphate dehydrogenase in the body, in which the properties of the cell membrane of red blood cells are disrupted.
  • Difficulty urinating, which is a result of prostate adenoma.
  • Pathology of the pancreas.
  • Thyrotoxicosis is a significant increase in the functional activity of the thyroid gland.
  • Pathology of the blood system.
  • Severe pathological conditions of the liver, heart, kidneys and bladder.
  • Pregnancy at any stage of its course and breastfeeding.
  • Children's age up to 12 (for capsules) or up to 6 (for suspension) years.

The drug is used with caution in congenital hyperbilirubinemia (increased levels of bilirubin in the blood), chronic obstructive bronchial pathology or bronchial asthma (specific allergic inflammation of the bronchi with attacks of spasm).

Directions for use and doses

Coldact Flu Plus capsules and suspension are taken orally; the suspension must be shaken before use. Adults and children over 12 years of age take 1 capsule every 12 hours. The dosage of the suspension for adults and children over 12 years of age is 10 ml (2 teaspoons) 3-4 times a day, for children aged 6 to 12 years - 5 ml (1 teaspoon) 3-4 times a day. The duration of taking the drug ranges from 3 (decrease in temperature) to 5 (reduce the severity of pain) days.

Side effects

Taking Coldact Flu Plus capsules or suspension can lead to the development of undesirable reactions from various organs and systems:

  • Digestive system – loss of appetite, nausea, pain in the stomach.
  • Nervous system – dizziness, sleep disturbances such as insomnia, increased excitability.
  • Sense organs – mydriasis (dilation of the pupils), accommodation paresis (impaired contraction of the muscle that regulates the curvature of the eye lens), increased intraocular pressure.
  • Cardiovascular system – tachycardia (increased heart rate), increased systemic blood pressure.
  • Blood and red bone marrow - anemia (anemia), thrombocytopenia (decreased number of platelets per unit volume of blood), leukopenia (decreased number of leukocytes in the blood).

If adverse reactions develop, you should stop taking the drug and consult a doctor.

special instructions

Before you start taking Coldact Flu Plus tablets or suspension, you must carefully read the instructions for the drug; you should pay attention to special instructions regarding the use of the drug, which include:

  • The active ingredients of the drug may interact with drugs from other pharmacological groups, so if you take them, you should warn your doctor about this.
  • Taking the drug together with barbiturates can lead to the development of liver failure.
  • When using Coldact Flu Plus capsules or suspension, you should avoid taking hypnotics and tranquilizers in parallel.
  • The drug may distort the results of laboratory tests of blood glucose levels and plasma uric acid levels.
  • With long-term use of the drug, it is necessary to carry out laboratory monitoring of indicators of the functional activity of the liver and blood.
  • During treatment with the drug, it is recommended to refuse work that requires increased functional activity of the cerebral cortex, speed of psychomotor reactions and concentration.

In the pharmacy chain, Coldact Flu Plus capsules and oral suspensions are available without a doctor’s prescription. If you have questions or doubts about taking them, you should consult your doctor for advice.

Overdose

If the recommended therapeutic dose of Coldact Flu Plus is significantly exceeded, overdose symptoms develop, which are characterized by abdominal pain, pale skin, nausea, vomiting, hepatonecrosis (partial death of liver tissue). Treatment of overdose consists of washing the stomach, intestines, and taking intestinal sorbents (activated carbon). SH-group donor compounds, N-acetylcysteine ​​and methionine are also used, which reduce the negative effects of high doses of paracetamol.

Coldact Flu Plus analogues

In terms of active substance and therapeutic effect, Coldact Flu Plus tablets and suspensions are AntiFlu and TeraFlu.

Terms and conditions of storage

The shelf life of Coldact Flu Plus tablets and suspension is 2 years from the date of their manufacture. The drug, regardless of its dosage form, must be stored in a dry place, out of reach of children, at an air temperature no higher than +25º C.

Coldact Flu Plus price

The average cost of 10 Coldact Flu Plus tablets in Moscow pharmacies varies within 136 rubles.

Source: http://bezboleznej.ru/koldakt-flyu-plyus

Koldakt: brief instructions, analogues

Koldakt is a powerful combination drug for colds and allergies. It is intended to relieve or reduce the severity of clinical symptoms, and does not in any way affect the cause of the pathology. The components of this medicine have vasoconstrictor (vasoconstrictor), anticongestive (decongestant) and antihistamine (antiallergic) properties.

Active ingredients and dosage forms

This pharmacological agent is produced in the form of capsules (long-acting), suspension, powder for preparing a solution and syrup for children.

Coldact capsules contain 50 mg of phenylpropanolamine hydrochloride and 8 g of chlorpheniramine maleate.

Each Coldact Flu Plus capsule additionally contains 200 mg of paracetamol, and the dose of phenylephrine hydrochloride is half as much (25 mg).

In 5 ml of Koldakt syrup for children (1 scoop) - 10 mg of phenylpropanolamine hydrochloride and 2 mg of chlorpheniramine.

Capsules are supplied in blisters (10 pieces each), and syrup - in bottles (60 ml).

Note! Due to the fact that the granular contents of Coldact Flu Plus capsules dissolve and are absorbed in the gastrointestinal tract gradually, the medicine acts within hours.

What does Koldakt help with?

The drug helps relieve symptoms of inflammation of the paranasal sinuses, as well as acute, chronic and allergic rhinitis.

Coldact is prescribed for the following diseases:

The product eliminates swelling, sore throat, nasal congestion, rhinorrhea, and lacrimation.

Contraindications

Please note: the drug in capsules is not prescribed to children and adolescents under 12 years of age.

An absolute contraindication is individual hypersensitivity to the active or auxiliary ingredients of the drug.

Coldact should not be taken in severe cases of coronary heart disease and severe hypertension.

Dosage regimen and recommended dosages

A single dose is 1 capsule, and the frequency of administration is 2 times a day, observing a 12-hour time period. It is recommended to drink the drug after meals.

For influenza and ARVI, symptomatic treatment according to indications is continued for 1 to 3 days. Allergic rhinitis requires taking Coldact capsules for 3-6, and chronic rhinitis – up to 30 days. For sinusitis, the medicine is taken on average from one to one and a half weeks.

Coldact syrup is given to children every 4-6 hours.

Single dosages (by age):

  • 2-6 years – half a teaspoon (2.5 ml);
  • 6-12 – 5 ml;
  • 12 or more – 5-10 ml per dose.

pharmachologic effect

Chlorpheniramine is able to block specific receptors of the main allergy mediator - histamine. The substance is characterized by moderately expressed sedative (calming) and antimuscarinic properties. It reduces the permeability of vascular walls, which helps reduce inflammatory exudation.

Another active substance, phenylpropanolamine, is an indirect-acting sympathomimetic. Its action is similar to that of ephedrine, but it affects the central nervous system to a lesser extent. The compound helps reduce congestion in the mucous membranes of the upper respiratory system.

Coldact stimulates α-adrenergic receptors and constricts blood vessels, thereby reducing hyperemia and swelling of the mucous membranes of the respiratory tract and nasal sinuses.

Paracetamol inhibits the enzyme cyclooxygenase and affects the hypothalamic centers of thermoregulation and pain. This compound helps reduce high fever and relieve headaches and muscle pain during colds and acute respiratory viral infections (including influenza).

After oral administration of Coldact capsules, the active components are absorbed gradually in the digestive tract. The maximum serum concentration of chlorpheniramine is recorded after 2-6 hours. Its biotransformation occurs in the liver, and the unchanged substance and its metabolites are excreted mainly by the kidneys. The peak concentration of phenylpropanolamine in plasma is reached after 1-2 hours. The substance leaves the body mainly unchanged in the urine.

Side effects

If the components are intolerant, there is a possibility of developing allergic reactions - skin itching and rashes (urticaria), angioedema and bronchospasm. In severe cases, anaphylactic shock cannot be ruled out.

Most patients tolerate Koldakt well.

In rare cases, the following side effects have been reported:

Overdose

There have been no cases of overdose of Koldakt. If single and daily doses of Kodakt FluPlus are significantly exceeded, paracetamol poisoning cannot be ruled out.

Interaction with other drugs

Koldakt is capable of potentiating the effect of sedative (sedative) and hypnotic pharmacological agents.

During treatment, you should refrain from taking pharmaceutical alcohol tinctures and alcoholic beverages.

Parallel use of furazolidone and monoamine oxidase inhibitors increases the likelihood of a sharp rise in blood pressure (up to a hypertensive crisis). With simultaneous use of Halothane, ventricular arrhythmia cannot be excluded. Guanethidine increases the activity of phenylpropanolamine.

Coldact during pregnancy

During pregnancy and breastfeeding, it is not recommended to take this remedy for colds and flu. This is especially true for Coldact FluPlus, which contains paracetamol.

A doctor may recommend a drug if the benefit to the mother outweighs the likely risk to the fetus. If symptomatic treatment is necessary during lactation, it is advisable to temporarily transfer the child to breastfeeding.

Additionally

Coldact should be taken with caution in case of the following diseases and pathological conditions:

The combined use of antibiotics (according to indications for diseases of bacterial origin), mucolytics and expectorants helps to speed up the healing process.

During treatment, it is recommended to refrain from activities that require increased concentration, including driving vehicles and working with potentially dangerous mechanisms.

Conditions for storage and release from pharmacies

To purchase Koldakt in pharmacy chains you do not need a prescription.

The medicine should be kept in places with low humidity at a temperature not exceeding +25°C.

The shelf life of capsules is 3 years from the date of release (it is marked on the packaging).

Keep away from children!

Koldakt's analogues

Analogues of the drug are:

Plisov Vladimir, medical observer

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The information is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor. There are contraindications, a doctor's consultation is required. The site may contain content prohibited for viewing by persons under 18 years of age.

Source: http://okeydoc.ru/koldakt-kratkaya-instrukciya-analogi/

Coldact Flu Plus

Description current as of 06/04/2014

  • Latin name: Coldact Flu Plus
  • ATX code: N02BE51
  • Active ingredient: Paracetamol + Phenylephrine + Chlorphenamine (Paracetamol + Phenylephrine + Chlorphenamine)
  • Manufacturer: Natco Pharma (India)

Composition of Koldakt

The composition of the drug Koldakt includes the active ingredients phenylpropanolamine hydrochloride - 0.5 g + chlorpheniramine maleate - 0.08 g and additional substances that make up the gelatin shell.

Coldact Flu Plus contains capsules of active ingredients: paracetamol – 0.2 g; chlorphenamine maleate – 8 mg; phenylephrine hydrochloride – 25 mg and excipients (hypromellose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, isopropanol, dyes, sucrose, water, sodium disulfite, starch syrup, disodium edetate, granulated sugar).

Flu Plus suspension contains active ingredients: chlorphenamine maleate – 2 mg; paracetamol – 0.125 g; phenylephrine hydrochloride - 5 mg + sodium carmellose, propyl parahydroxybenzoate, disodium edetate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanthan gum, silicon dioxide, flavorings, polysorbate 20, sodium citrate, water, citric acid.

Release form

Koldakt is produced in long-acting capsules in a gelatin shell, packs of 10 pieces.

Coldact Flu Plus - in two forms:

  • capsules in a gelatin shell, half red, half transparent, inside - yellow, red and white pellets, in packs of pieces;
  • suspension for internal use, viscous, orange, with a specific odor, in a 60 ml bottle.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Chlorpheniramine, which is part of the Coldact and Coldact Plus tablets, is the most effective antihistamine that reduces the effect on H1 receptors. It also has a slight sedative and antimuscarinic effect. The substance has the ability to reduce the permeability of mucosal cells in the nose, thereby reducing unpleasant symptoms (itching and swelling).

The process of interaction with blood plasma occurs slowly. The maximum concentration is after 2-6 hours, metabolized in the body. However, a small part of it is excreted by the kidneys.

Another active ingredient, phenylpropanolamine, is a symptomatomimetic. It affects alpha-adrenergic receptors, but to a lesser extent than, for example, ephedrine. It has a vasoconstrictor, anti-edematous effect on the mucous membrane of the nose and paranasal sinuses.

Reaches maximum concentration within 2 hours. Excretion is carried out through the kidneys.

Paracetamol reduces body temperature and relieves pain. Helps eliminate cold symptoms - headaches, pain in joints and muscles, discomfort in the throat.

It binds poorly to blood proteins, less than 10%, is metabolized in the liver, maximum concentration is after 3 hours. Excretion occurs in the urine within 24 hours after administration.

Indications for use

  • rhinitis (vasomotor or allergic);
  • elimination of cold symptoms such as allergies, swelling, runny nose, stuffy nose.

Contraindications

Taking the drug in capsules is not recommended for children under 12 years of age if they have a drug allergy to any of the components.

The suspension can be taken by children from 6 years of age.

Flu Plus has a number of additional contraindications:

Side effects

Doesn't happen often:

Instructions for Koldakt (Method and dosage)

The duration of administration and dosage should be prescribed by a doctor.

According to the instructions for use of Koldakt, adults are prescribed 2 capsules per day, divided into 2 doses.

Instructions for use Coldact Flu Plus

According to the instructions for Coldact Flu Plus, two capsules are prescribed per day, at regular intervals.

The syrup should be shaken well before use.

Adults are prescribed poml per day, in 3-4 doses. Children from six years old – ml, in 3-4 doses.

The course of treatment, as a rule, is no more than five days.

Overdose

No cases have been reported. Therapy - according to symptoms.

For the form that contains paracetamol, the symptoms are: nausea, hepatonecrosis, pallor and weakness, loss of appetite. Consult a doctor as soon as possible and rinse the stomach, administer SH-group donors, methionine (first 8 hours) or N-acetylcysteine ​​(12 hours).

Interaction

Use with caution in combination with MAO inhibitors, tricyclic antidepressants, halothane, guanethidine, furazolidone.

Terms of sale

Storage conditions

Dry, cool place.

Best before date

Coldact Flu Plus – 2 years.

Analogs

During pregnancy and lactation

Reviews about Koldakt

There are not many reviews about Koldakt. But of those that exist, the positive ones predominate. Colds and flu are easier to bear with the drug; runny nose and other unpleasant symptoms go away faster. The most common side effect is drowsiness.

Reviews of Koldakt Flu Plus are good. The drug quickly reduces fever, relieves nasal congestion, and is relatively inexpensive. In reviews of Koldakt Flu Plus, side effects, mainly drowsiness, are considered a disadvantage.

Koldakt price (where to buy)

The approximate price of Koldakt is about 98 rubles for 10 pieces.

Price Coldact Flu Plus for 10 capsules rubles.

The price of Coldact Flu Plus syrup is 100 rubles.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Kazakhstan Kazakhstan

ZdravZone

Pharmacy IFC

BIOSPHERE

jreview excellent product. I have one question - I was prescribed this drug along with another drug that I forgot, you can’t tell me. The fact is that when used together, the effect was stunning.

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/koldakt-flyu-plyus

Coldact

Koldakt, which you advertise (composition: chlorpheniramine

maleate - 8 mg., phenylpropanolamine - 50 mg.). This is the medicine

for some reason it completely disappeared from pharmacies, but it’s so good

helps with nasal congestion and runny nose. Previously, only they

was saved. Now there is only Kodakt-plus, which causes

severe drowsiness and lethargy. I am a singer, and for me

this is contraindicated, since substances with similar effects

reduce the tone of the larynx. Please help me find these

pills. Or maybe you can recommend something in return

minimum side effects for the voice? Thank you in advance.

The composition you specified is not currently registered.

All these are Chlorphenamine + Phenylpropanolamine preparations, not counting the triple action syrup “Our Choice” that you already mentioned.

I started having a typical cold: sore throat, cough, runny nose and a runny nose. Every day I have to be in important meetings with clients, during which it is very inconvenient to look sick. Please, advise whether there is any powerful drug that “removes” a runny nose for several minutes. hours. Thank you

My diagnosis is encephalopathy of mixed origin.

Help me find a cure for spasticity.

I was already taking medications: Medokalm, sirdalud, phenazapam.

The information provided is intended for medical and pharmaceutical professionals, should not be used for treatment and cannot be considered as official. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Please pay attention to the specified dates for entering information; information may become outdated.

Source: http://www.webapteka.ru/drugbase/name6881.html

Coldact

Instructions for use:

Price in online pharmacies:

The drug Koldakt is a long-acting combined anti-cold drug with a pronounced anticongestive, antihistamine and vasoconstrictor effect.

The mechanism of action of Koldakt and Koldakt Plus is determined by the components included in its composition. This drug is not intended to eliminate the underlying cause of the disease, but effectively eliminates the main symptoms of viral inflammation of the respiratory tract.

The combination of this symptomatic remedy with antibiotics and expectorants will speed up the healing process and prevent the development of bacterial complications.

Release form

The following dosage forms of the drug are available: long-acting capsules, tablets, powders for solution, suspension.

Koldakt capsules contain two active ingredients - phenylpropanolamine hydrochloride (50 mg) and chlorphenylaraine maleate (8 mg).

Chlorphenylaramine is one of the most powerful histamine H1 receptor blockers. It has a moderate antimuscarinic and sedative effect.

An indirect action symptom mimetic, phenylpropanolamine, is used to eliminate congestion in the mucous membrane of the respiratory tract. According to the mechanism of action, this substance is similar to ephedrine, but has less effect on the central nervous system.

Coldact Flu Plus capsules contain three active components - chlorphenamine maleate (8 mg), paracetamol (200 mg) and phenylephrine hydrochloride (25 mg), and excipients - ethylcellulose, talc, sucrose, starch, sodium disulfite.

The uniqueness of Coldact Flu Plus capsules lies in the fact that each drug in the form of granules dissolves in the intestines gradually and the effect of the medicinal substance is extended up to 24 hours.

pharmachologic effect

The drug has a stimulating effect on alpha-adrenergic receptors, has a vasoconstrictor effect, reduces hyperemia and swelling of the mucous membrane of the paranasal sinuses and respiratory tract. Coldact Flu Plus actively blocks histamine receptors, which prevents the development of allergic reactions, reduces the permeability of blood vessels in the mucous membrane, eliminates itching in the nose and eyes, and eliminates lacrimation.

Paracetamol, acting on the thermoregulation center in the hypothalamus, has a pronounced antipyretic effect and eliminates pain.

When taken orally, the drug is absorbed relatively slowly from the intestine, with maximum plasma concentrations achieved 1-2 hours after oral administration. Widely distributed in the body, metabolized and excreted in urine almost unchanged.

Indications

The instructions for Koldakt recommend prescribing the drug for the symptomatic treatment of various colds, which are accompanied by swelling of the mucous membrane of the respiratory tract, lacrimation, runny nose, and sore throat.

The use of Koldakt is indicated for colds, which are characterized by allergization of the body, as well as for sinusitis, ARVI, and influenza.

Reviews of Koldakt confirm that it is extremely effective for the treatment of allergic and vasomotor rhinitis.

Coldact Flu Plus is indicated for use to eliminate symptoms of inflammation in the following respiratory tract diseases - tracheitis, pharyngitis, rhinitis, sinusitis, sinusitis. The drug also significantly reduces the severity of clinical manifestations of hay fever, allergic rhinitis, various colds, and flu.

Instructions for use (method and dosage)

Coldact and Coldact Flu Plus are prescribed to adults and children over 12 years of age, 1 capsule every 12 hours.

In complex therapy for influenza and ARVI, the drug is used for 1-3 days; for the treatment of sinusitis, Coldact Plus must be taken for 6-12 days. For allergic rhinitis, the drug is recommended to be used for 3-6 days, and for the treatment of chronic rhinitis for a month.

Coldakt Plus is prescribed as an antipyretic for no longer than 3 days. To relieve pain, the drug should be used for no more than 5 days. Numerous reviews of Koldakt indicate that the drug effectively eliminates pain in the throat, joints, muscles, and headaches.

Koldakt Broncho syrup is prescribed to children for colds that are accompanied by a cough with hard-to-clear sputum for five days in the following dosages:

  • children from 2 to five years old, 5 ml per day;
  • from 6 to 12 years, 10 ml/day;
  • over 12 years old and adults – 20 ml/day.

Contraindications

The instructions for Koldakt prohibit prescribing the drug to people with individual intolerance to any component in its composition. Also, the drug is not prescribed to patients with pheochromocytoma, thyrotoxicosis, closed-angle glaucoma, or prostatic hyperplasia. It is strictly prohibited to use the drug in children under one year of age and in patients with severe hypertension or coronary artery disease.

Koldakt should not be taken if you have arterial hypertension, diabetes mellitus or chronic heart failure.

Use during pregnancy and breastfeeding

The use of Koldakt by pregnant women and during lactation is not recommended.

special instructions

Children under 12 years of age are prohibited from prescribing the drug in capsule form; the use of suspension, powder and syrup is indicated.

Coldact Plus is also prohibited from being prescribed to patients with severe atherosclerosis of the coronary arteries, recent myocardial infarction, aortic aneurysm, unstable angina, as well as people taking MAO inhibitors or tricyclic antidepressants.

Reviews of Koldakt from specialists and patients are positive and confirm that the drug is well tolerated. In very rare cases, the following side effects have been reported:

  • dry mucous membranes;
  • dyspepsia;
  • allergic reactions;
  • cardialgia, increased blood pressure;
  • loss of appetite, nausea, vomiting;
  • tremor, headache.

During treatment, care should be taken when driving a vehicle, since the drug has a mild sedative effect and reduces concentration and reaction time.

Overdose

Long-term use of high doses of Coldact can lead to liver and kidney damage. Consumption of more than 15 g of the drug per day can lead to acute poisoning of the body. Symptoms of overdose are pale skin, nausea, vomiting, liver failure. If such clinical manifestations occur, it is necessary to rinse the stomach; treatment is symptomatic.

Storage conditions and shelf life

Koldakt must be stored at room temperature, out of reach of children, in a cool, dry place. The shelf life of the drug is 3 years from the date of production.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Coldact flu plus No. 10 capsules

Coldact flu plus caps N10

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Source: http://dolgojit.net/koldakt.php