Desrinite drops

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Desrinitis is a hormonal drug that you should not be afraid of. Composition, contraindications, side effects, analogues...

There are many medications available today to treat allergies. Some of them are effective, others not so much.

Table of contents:

This article will discuss the drug Dezrinit, which is often prescribed for allergic rhinitis and bronchial asthma.

Some patients, upon hearing the word “hormones,” refuse treatment prescribed by their doctor. And they make a big mistake. Sometimes hormones and only they can completely eliminate the manifestations of the disease and put a person back on his feet. This is explained by the fact that.

>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <

What are glucocorticoids and should you be afraid of them?

This is explained by the fact that glucocorticoids act on different cells and have a wide spectrum of action. Steroids are indispensable in the treatment of allergic diseases. They have no equal in their ability to relieve unpleasant symptoms.

Glucocorticoids have antitoxic, anti-inflammatory, antishock, desensitizing and antiallergic effects.

The antiallergic effect is due to a decrease in the synthesis of allergic mediators (substances that cause an allergic reaction), inhibition of the process of release of mast cells and the formation of antibodies, a decrease in the number of basophils, and suppression of the release of cytokines.

In simple words, glucocorticoids do everything possible to stop the spread of pathology and return a person to the usual rhythm of life. So why are they so afraid? There are several reasons for this. The main ones are side effects, addiction, weight gain. In fact, everything is not as scary as it seems. If you follow medical recommendations regarding the use and withdrawal of hormones, you can easily avoid “terrible” side effects and withdrawal syndrome.

In addition, the fears listed are valid exclusively for tablet and injection forms. Intranasal forms of hormones are safe when used correctly.

Desrinit: composition and pharmacological action

Desrinit belongs to the group of GCS (glucocorticosteroids) for intranasal and inhalation use. Available in spray form. It is characterized by a pronounced anti-allergic and anti-inflammatory effect.

The main active ingredient is mometasone. And to be as precise as possible, it is mometasone furoate monohydrate. Additional - Avicel, glycerol, citric acid monohydrate, benzalkonium chloride, sodium citrate dihydrate, water. It is necessary to know about the constituent components. Especially for those who are “sensitive” to certain medications.

When is Desrinit prescribed?

Desrinit spray is used in the treatment of:

  • allergic rhinitis;
  • acute sinusitis and rhinosinusitis;
  • bronchial asthma;
  • chronic obstructive pulmonary disease (COPD).

For sinusitis and rhinitis, Dezrinit is used directly in the nose, for asthma and COPD - inhalation.

As a result of complex treatment, lacrimation, burning sensation in the nose, sneezing and runny nose disappear. Shortness of breath and cough - the main troubles of patients with obstructive disease - become less pronounced. Desrinitis is necessary to normalize breathing and prevent the occurrence of respiratory failure.

Desrinit: instructions for use

The dosage and duration of the therapeutic course is determined individually. Only a doctor can correctly determine how long to use the drug. Self-medication in this case is unacceptable, because the risk of side effects is too great.

Contraindications

Desrinit should not be prescribed for:

  • hypersensitivity to the constituent components;
  • local infectious processes with damage to the nasal mucosa;
  • the presence of an untreated fungal, bacterial or viral infection;
  • ophthalmoherpes.

It is not recommended to inject the spray into patients who have recently undergone surgery or trauma to the nasal cavity.

There are no data on use during pregnancy and lactation, so it is better for women to refrain from taking it during this period. Please note that the solution is prescribed only to adults and adolescents over 12 years of age. Desrinitis is not used to treat young children.

Side effects

If, during intranasal use, itching, dryness, irritation of the mucous membrane, nosebleeds or candidiasis occur, you should stop taking it and consult a doctor.

Do not ignore discomfort that indicates that Dezrinite is not suitable for you.

This is important to know!

With long-term use, it is necessary to monitor the functioning of the adrenal glands, monitor the condition of the skeletal system and gastrointestinal tract, conduct control ophthalmological examinations, ECG, and take a detailed blood test.

Among other things, regular examination by an ENT doctor is necessary. If signs of mucosal atrophy, infection of the nose or pharynx are detected, Desrinit is canceled.

Desrinitis is not intended for short-term relief of clinical manifestations, but for treatment in courses. Otherwise, it is unlikely that a positive result will be achieved. The drug is discontinued slowly - gradually reducing the dosage. You can’t stop taking it suddenly!

Sometimes signs of adrenal insufficiency occur during withdrawal. In such a situation, the dosage is increased for a while, and then decreased more gradually.

When treating adolescents, growth should be monitored. When it slows down, the dose is gradually reduced to the lowest, but effectively suppressing the symptoms of the disease.

Reviews of the drug Dezrinit

So, what do patients say about the drug? How effectively does Desrinit=mometasone cope with the tasks assigned to it? Reviews about the drug are mostly positive. Experts and patients note an improvement in their general condition within a few hours after use. Swelling of the mucous membrane, runny nose and cough disappear, breathing is fully restored and the person returns to normal activities.

The drug is well tolerated. Rarely, irritation of the mucous membrane and minor nosebleeds occur. If you follow the dosage regimen, drug withdrawal is easy and “painless”.

Dezrinit's analogs

The main analogue of Desrinit, which is available in the form of a spray and contains mometasone, is Nasonex. Are you wondering which is better: Desrinit or Nasonex? The answer is simple - these medications are the same. They have identical pharmacological effects, indications, contraindications and side effects.

There are other drugs, but in a different dosage form (ointment, cream, lotion) - Uniderm, Elokom, Gistan-N, Avecort. They are prescribed for dermatoses of various origins.

Asmanex and Asmanex Twisthaler are available in the form of powder for inhalation. Prescribed for bronchial asthma.

Conclusion: Desrinit is a hormonal drug widely used in ENT practice. Highly effective and, subject to certain rules, relatively safe.

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Good articles to follow:

I used to spray Nasonex in my nose, it opens my breathing well. But there is a huge side effect - it causes dry nose. Now I have switched to Dezrinit, according to subjective feelings, in this regard it acts more gently. But I still can’t get away from the dryness.

Dezrinit, unlike Nasonex, contains 2 times more preservative, but at the same time it is stored less, Nasonex has more indications, the spout is more convenient, it contains glycerin, which softens the mucous membrane. So these are completely different drugs, although they seem to have the same active ingredient.

The doctor prescribed Desrinit, although they had previously used Nasonex.

I opened the instructions, the indications were the same as in Nasonex.

The only downside to Nasonex was bleeding for my daughter.

in the case of Dezrinit, we’ve been using it for 2 weeks now, there’s nothing.

We are very pleased, and it is also more affordable. Now all medicines are quite expensive, and the quality leaves much to be desired. For me as a mother, the main thing is not to harm the child.

We used Nasonex and was also bothered by dryness; the doctor advised us to point the bottle spout to the side - the pinching stopped.

This year, the pharmacy offered desrinit - we bought it in advance, started using it before the season - we didn’t notice much of a difference, I was pleased with the savings, but as soon as flowering began, I had to return to Nasonex (fortunately, there was a little left from last year) - expensive, but at least endless the snot stopped. Desinitis did not help us during the aggravation.

The doctor prescribed Dezrinit for my daughter, we’ve been using it for 10 days, it helps great, the effect is noticeable, we haven’t noticed any side effects yet.

The allergist prescribed desrinitis, please tell me, is it hormonal or not? Before that I used it on my own. Of course, it didn’t help either, but for some reason the doctor prescribed desrinitis once again. I have bronchial asthma and allergic rhinitis.

I used different nasal sprays. Only Nasonex helped. The pharmacy recommended desrinitis. God, why did I do this! Wasted money. It doesn’t help at all, and even when I sprayed it, it seemed to be running down my throat! I asked my ENT doctor (he treats our whole family), they scolded me))). Don’t listen to pharmacists, they just want to sell stale goods!

After a month of use, my 5-year-old daughter began to experience daily heavy nosebleeds. Not right away, but I read in the instructions that this could be a side effect. The drug was discontinued immediately, a third of the bottle was thrown into the trash. This is such a bad drug. Attention parents!

“Please note that the solution is prescribed only to adults and adolescents over 12 years of age. Desrinitis is not used to treat young children.”

We read the instructions better.

That's how it is. From 12 years old for children. But what to do if a doctor prescribed it to a child at an earlier age. We are 4 years old, we were also prescribed Desrinit - I found out that it is also hormonal, I still think whether it is worth giving it to my child?

A new ENT specialist prescribed Desrinitis, although before that I had been using Nazonex for many years. The drug did not help at all, and the life of the open bottle is only two months, while Nasonex has two years. It turns out I didn’t throw away my money, it would be better to buy a proven drug that is always effective.

A new ENT specialist prescribed Desrinitis, although before that I had been using Nazonex for many years. The drug did not help at all, and the life of the open bottle is only two months, while Nasonex has two years. It turns out I didn’t throw away my money, it would be better to buy a proven drug that is always effective.

I went to the ENT specialist with acute perennial allergic rhinitis (with snot, congestion, headaches, etc. The doctor prescribed Nazanex (or Dezrinit) and Nixar (allergy tablets👍🏻). Nazanex helped perfectly (2 bottles), the third bottle was Dezrinit ( in order to save money) and turned out to be very “evil". Gradually, against the background of Dezrinitis, terrible sinusitis developed (it came to antibiotics), pharyngitis and accompanying symptoms. So, if the doctor said: “Nasonex,” it means Nasonex! Still, these are different drugs, despite the same active ingredient, and the body’s reaction to them is different.No “less expensive analogues” imposed by pharmacy workers and recommended by neighbors.

Nozanex sucks. I have been suffering with my nose for 15 years now. Specific allergy. The ENT specialist does not know anything other than washing and piercing. I haven’t tried any medications, expensive or cheap, complete crap. It's just a matter of getting used to it and that's all. I found inexpensive drops in Russia and they only provide support and relief. After honey it became a little easier, but the problem still remains.

and about polyps. write - who did this drug help?

Source: http://gaimoriti.ru/medicamenty/dezrinit.html

Nasal drops "Derinat" for children

One of the drugs in demand for runny nose, sinusitis, adenoiditis and other diseases of the ENT organs is Derinat. It in the form of drops is often used by adults to treat viral infections of the nasopharynx and to prevent colds or flu. But is it possible to treat children with such a medication, does it harm the child’s body, and what can it be replaced with if necessary?

Release form

Derinat in the form of nasal drops is a dropper bottle containing 10 ml of a colorless transparent solution. There should be no visible suspended matter in it. This drug has no smell or taste.

Compound

The active ingredient in Derinat drops is sodium deoxyribonucleinate. Since the solution has a concentration of 0.25%, each milliliter contains 0.0025 g of deoxyribonucleinate (2.5 mg). Sodium chloride is added to it, and the remainder of the drug is water for injection. There are no other substances in such a liquid.

Operating principle

The active component Derinat has an immunomodulatory effect, since it has the ability to activate both humoral and cellular immunity. Thanks to this, immune reactions in response to infection by bacteria, fungi and viruses become more pronounced. And although the medication does not directly affect the infectious agent, it helps the immune system cope with the pathological agent faster and easier.

In addition, Derinat is classified as a reparative, since this remedy stimulates the processes of healing and tissue regeneration. The solution is especially helpful for trophic ulcers and deep burns. Its use accelerates the epithelization of such lesions both on the skin and on the mucous membrane. This determines the popularity of the drug in surgical practice and ophthalmology.

Indications

It is recommended to drip Derinat into the nose for acute respiratory viral infections, as well as for their prevention. In this case, the medication can be used as monotherapy. For chronic or acute diseases of the upper respiratory tract such as sinusitis, pharyngitis, otitis media, laryngitis, inflammation of the adenoids or rhinitis, Derinat can also be used as an additional remedy to the main treatment (antibacterial, antiviral).

In addition, the solution is in demand for inflammation of the oral mucosa and for ophthalmological pathologies in which there is inflammation or dystrophy. Local use of the medicine is possible for infected wounds, trophic ulcers, frostbite, burns and other injuries.

At what age is it acceptable to use?

Derinat in the form of nasal drops does not have any age restrictions for use. This product is safe for babies from the first days of their life.

Contraindications

The only reason to refuse to use Derinat drops is intolerance to the components of the drug. There are no other contraindications for this drug.

Side effects

The medication is generally well tolerated and is considered safe for children. It does not cause vasoconstriction and does not provoke negative reactions from the digestive or nervous system. Addiction to such a medicine does not develop. If a child has a burn or an open wound, the drug will have an analgesic effect.

Instructions for use and dosage

  • Before dripping Derinat into a child’s nose, it is important to clean the nasal passages of crusts or pathological secretions. To do this, it is convenient to use a nasal aspirator or cotton wool flagella.
  • When storing a bottle of medicine in the refrigerator, you first need to hold it in your hands for a while, and then inject the medicine into the baby’s nasal cavity. After laying the child down, the medication is carefully dripped into each nostril, after which the child is told to lie down for a while.
  • If a child is sick with the flu or a cold, in the first two days from the onset of the illness he needs to drip 2 drops of the drug into his nose every 1.5-2 hours. From the third day they switch to 3-4 times application. The medicine is administered 2 drops at a time, and treatment is continued until complete recovery.
  • If Derinat is used as part of a set of measures against sinusitis, sinusitis, sinusitis or rhinitis, the medicine is dripped 4 to 6 times a day, and a single dose is 3-5 drops. The duration of use for such pathologies ranges from 7 to 15 days.
  • For preventive purposes, Derinat is recommended to drop 2 drops into each nasal passage three or four times a day. This use of the drug is possible throughout the season of colds and acute respiratory viral infections, but most often the solution is prescribed in a course lasting one or two weeks.
  • If a child has inflammation of the oral mucosa, the drops can be used for rinsing. One bottle of medicine is enough for 1-2 rinses. The procedure should be carried out up to four to six times a day for 5-10 days.
  • Ophthalmologists prescribe liquid Derinat for dystrophic or inflammatory eye diseases, 1-2 drops. The medication is dripped in this dosage into each eye two or three times a day. The drug is prescribed for a course of two weeks to 1.5 months.
  • If drops are used for local treatment of skin lesions, gauze is moistened with the solution and an application bandage is made. Then a new portion of the medication is applied to the bandage 3-4 times during the day.
  • For prolonged rhinitis, tonsillitis, adenoids, hay fever, bronchial asthma and other pathologies, inhalations with Derinat may be used. For the procedure, the drug is diluted 1 to 1 with saline solution - take 1-2 ml of saline solution for 1-2 ml of medication. Using a nebulizer, inhalation is done twice a day for 5-10 days.

Practical video lesson on how to properly apply nose drops to children.

Overdose

There were no cases of negative effects of high doses of the solution.

Interaction with other drugs

The drug is often prescribed not independently, but as an additional remedy in the treatment of viral or bacterial infections. Derinat can be combined with antibacterial drugs and anti-inflammatory drugs with antipyretic effects. The medication is only incompatible with hydrogen peroxide and ointments containing fat - this is important to consider when using local treatment with Derinat.

Terms of sale

Since Derinat is an over-the-counter drug, it is available in most pharmacies for anyone. The average price of a bottle of drops is rubles.

Storage Features

It is recommended to keep the drops at home out of the reach of small children and away from direct sunlight. The sealed bottle should be stored at a temperature of +4+20 degrees Celsius throughout the shelf life of 5 years. Once the bottle is opened, the contents can only be used for 2 weeks. 14 days after the first use of the drops, the bottle with unused medicine must be thrown away.

Reviews

Many mothers speak positively about the use of Derinat in children. They say that such a medicine really helps not to get colds and flu, and if the child does become infected, then ARVI is easier and complications do not arise. The advantages of the drops include the ability to use them from birth, as well as convenient packaging.

The disadvantages of the drug are the short shelf life and the need to keep the drops in the refrigerator. In addition, many mothers complain that one bottle is not enough for the full course of treatment. There are also reviews that mention the lack of therapeutic effect in a particular child.

Doctors treat the medication differently. Some doctors prescribe it to children and note that Derinat is able to enhance the effectiveness of other drugs, for example, antibiotics. Others are suspicious of this drug and compare it to a placebo.

Analogs

For ARVI with a runny nose in a child, instead of Derinat, you can use:

  • Aqua Maris. The basis of such nasal drops is sea water, thanks to which the product perfectly moisturizes the nasal mucosa and helps reduce the inflammatory process. This medicine is allowed from birth even in prematurity. It is also produced in the form of a spray, but this form is recommended to be used only in children over the age of 1 year.
  • IRS-19. This nasal spray has an immunostimulating effect due to the presence of several types of bacteria in the lysates. It is prescribed for prevention, as well as for the treatment of rhinitis, pharyngitis, tonsillitis and other diseases from 3 months of age.
  • Viferon. For a runny nose, this medication is in demand in the form of a gel (can be used from birth) or ointment (approved for children over one year old). The basis of the drug is interferon, so this drug helps the child’s immune system in the fight against viral diseases.
  • Grippferon. This drug also contains interferon and is available in spray and nasal drops. If necessary, this medication can be used to treat babies from birth.
  • Vibrocil. The active ingredients in this drug are phenylephrine and dimethinidene. The product is in demand for rhinitis, including allergic rhinitis. It is used in drops for children over one year of age, and in a spray for children over 6 years of age.
  • Nazol Baby. This medication contains phenylephrine and has a vasoconstrictor effect. Pediatricians prescribe it for rhinitis in children of any age if there are indications for such treatment.

It is important to remember that any of these medications should be selected as a replacement for Derinat together with your pediatrician. When looking for a cheaper drug, you should not take any of these medications and administer it to your child yourself, because a small patient may have contraindications to the chosen remedy. In addition, when self-medicating, the mother may be mistaken about the cause of the disease and the drops will not have any beneficial effect, and time will be lost and the pathology will become chronic.

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Source: http://www.o-krohe.ru/immunomodeliruyushchie-preparaty/kapli-v-nos-derinat/

Complete instructions for Derinat nasal drops

Compound

The main active ingredient in the composition is an extract from the milt of sturgeon fish - a highly purified sodium salt of deoxyribonucleic acid. It is an immunomodulator that stimulates hematopoiesis and tissue healing processes. The drops contain purified water.

Manufacturer

The drug was created and produced in Russia by the pharmaceutical company JSC TECHNOMEDSERVICE.

Release form, cost

Drops are available without a doctor's prescription. Release form: 0.25% colorless transparent solution in a dark glass bottle.

Available for sale:

  • Dropper bottle – 10 ml;
  • Bottle with spray cap – 10 ml;
  • Glass bottles without sprayers, 10 and 20 ml.
  • The medicine bottle and instructions for use are packaged in a cardboard box.
  • Estimated cost for 10 ml – 310 – 390 rubles.

Where can I buy

The drug is sold in almost any city pharmacy. For convenience, it can be ordered on the official Derinat website.

How it works

The manufacturer claims that the drug Derinat triggers a reaction to strengthen the immune system at the level of cells and blood. Increases the nonspecific resistance of the human body against the penetration and reproduction of viruses, bacteria and various fungi.

Stimulates the healing processes of the epithelium, restores the mucous membrane of the nose and paranasal sinuses, activates the drainage and detoxification function of the entire lymph of the human body.

Nasal drops increase local immunity, activate the production of secretory immunoglobulin and young cells, which activates the healing of microcracks. The drug relieves inflammation well and normalizes vascular tissue nutritional disorders. If there are areas of necrosis and suppuration in the nose, Derinat promotes easy separation of pus and healing of this tissue area.

Derinat has no toxic or teratogenic effects and does not lead to the development of serious diseases.

Interesting to know!

Based on studies carried out at the Mordovian Medical University, the successful use of the immunomodulator Derinat in children with congenital heart defects has been proven. When using Derinat, the incidence of arrhythmia and conduction disorders in children decreases by 20%, clinical manifestations of the disease and syncope disappear.

The drug may have antioxidant and anti-ischemic effects.

Metabolism

The drug is well absorbed and distributed throughout the body through the lymph, concentrated in the bone and brain, lymphatic tract, spleen, liver and kidneys. During metabolism, the active substance is excreted through the kidneys and intestines with urine and feces.

How to store

Derinat is stored in a dark, dry and cool place, away from children. The optimal temperature is 5–15 degrees. The shelf life is 5 years; it is strictly prohibited to use expired medicine.

An open bottle of solution should be used up within 2 weeks.

Indications

Derinat increases the body's protective properties, therefore it is actively used as a single drug and as part of a complex treatment. The instructions for use contain indications with disease codes according to ICD-10; we offer a list in accessible language.

Main areas of application:
  • Treatment of inflammation in ARVI. Derinat helps stop a cold or reduce it to a lighter form;
  • Prevention of colds and ARVI. Studies on the use of the drug against swine and bird flu have not been conducted, so it cannot be stated about its anti-influenza effectiveness;
  • The drops reduce the influence of harmful environmental factors and strengthen the protective barrier of the mucous membrane, therefore they can be used to protect people living in cities with high air pollution, working in production, indoors, in frosty winter air, with injuries to the nasal mucosa, smokers and alcohol drinkers of people;
  • Treatment of inflammation of the oral cavity;
  • Elimination of acute inflammation of the respiratory system - sinusitis, sinusitis, ethmoiditis, sphenoiditis, runny nose. Indicated when ARVI is combined with influenza, bronchitis, community-acquired pneumonia;
  • Prescribed as part of complex therapy and prevention of exacerbations and relapses of chronic diseases - chronic rhinosinusitis, chronic obstructive, mucous and purulent bronchitis, bronchial asthma;
  • To protect the mucosa in autoimmune disorders;
  • Treatment of the throat with pharyngitis and sore throat - the remedy relieves inflammation and pain, moisturizes the mucous membrane and protects it from the aggressive effects of bacterial toxins. To treat pharyngitis in infants, drops are instilled into the nose. As they flow down, they end up on the back wall of the pharynx;
  • Treatment of burns and frostbite of the skin;
  • Drops are used to treat trophic ulcers, gangrene, post-traumatic infected wounds, inflammation of the eyes, mouth, vagina, rectum, Raynaud's syndrome, intermittent claudication (vascular disease of the legs), varicose veins with trophic ulcers;
  • Derinat drops are also used to treat necrosis of the skin and mucous membrane that appears as a result of complications of radiation therapy.

How to use

The drug is approved for children and newborns.

If you have a cold, you can put nasal drops in the first day of the disease every hour to an hour and a half. From the second day, continue to drip 3 drops into the nose four times a day. The total duration of treatment ranges from 5 to 30 days. The pediatrician determines how many days to put drops into the child’s nose.

To prevent ARVI, you need to drip a couple of drops into each nasal passage 2-4 times a day for one to two weeks. The instructions for use indicate that prevention of ARVI is allowed for newborn children and infants.

For the treatment of bacterial inflammation of the paranasal sinuses - sinusitis, sinusitis - the scheme is slightly different. It is necessary to drip 2 drops into the nose in each nostril 3–6 times a day or insert tampons soaked in the solution into the nose for 10–15 minutes. The duration of treatment sometimes exceeds a month.

To treat inflammation and ulcers in the mouth, rinse with a solution 4–6 times a day for 5–10 days. One bottle should be used for 2-3 rinses.

For obliterating disease of the lower extremities, Derinat is instilled into the nose, 2 drops up to 6 times a day. The course of treatment is about 6 months.

For frostbite, ulcers and skin necrosis, burns, poorly healing ulcers, gangrene, dirty wounds and other damage to the integrity of the skin, lotions are applied to the affected areas. Derinat is moistened with gauze folded in several layers and applied to the affected area up to 4 times a day, or the entire bottle is sprayed over the affected area in 4 doses over the course of 24 hours.

Duration of treatment is 1–3 months. When used on open wounds and lesions, the medicine has a mild analgesic effect.

In proctology and gynecology, intravaginal administration of cotton swabs moistened with drops or external irrigation with the drug is used. Prescribe 1-2 procedures per day for 5-10 days. One procedure should require half a bottle of medication.

In ophthalmology, for dystrophic and inflammatory eye diseases, it is allowed to drip 2 drops twice or thrice a day. Duration of treatment is 15–45 days.

A detailed treatment and prevention regimen is described in the official instructions for use.

During pregnancy

In the instructions for use, pregnancy and lactation are not indicated as contraindications to the use of the drug, but this does not exclude increased alertness. Therefore, if there are indications for treatment with Derinat and clear contraindications to the use of other drugs, the doctor may decide to treat a pregnant or lactating woman, taking into account that the expected benefit to the mother is higher than the risk to the child.

Use in pediatrics

Based on data obtained from various clinical and laboratory tests, it has been proven that Derinat has an extremely beneficial effect on growing children's bodies, so it can be used to treat and prevent colds in children.

It is ideal for strengthening the immune system in the treatment of bronchitis, pneumonia and sore throat. It is justified to add the drug to complex therapy for the treatment of myocarditis, inflammation of the kidneys and joints in children. For young children, Derinat can be added to inhalations when treating infections of the upper and lower respiratory tract, to relieve attacks of allergic rhinitis and sneezing, and to relieve and prevent attacks of bronchial asthma.

Children are more susceptible to allergic reactions, hypersensitivity and intolerance. Therefore, before using Derinat or any other new medicine, we recommend trying a small dose on the first day to monitor for a possible negative reaction.

For children, the medicine is prescribed only by a pediatrician.

Why is it recommended for children?

When children enter a group environment, they become infected with viral and bacterial infections several times a month, which must be treated with antibiotics and antiviral drugs. In turn, the internal organs and immunity of children suffer from them.

To protect the child, it is necessary to stimulate the immune system with the help, for example, of Derinat. It is convenient to use and is not contraindicated for children. Derinat is allowed for newborns and infants, although for the first 6 months of life the child is protected by innate immunity transmitted from the mother.

Side effects

The drug has undergone numerous experimental, laboratory and clinical tests, during which no mutagenic, teratogenic, carcinogenic, toxic, embryotoxic, cytogenetic or allergenic properties were identified.

However, as when using any medicine, you should not exceed the dosage or use Derinat for other purposes. Exceeding the dosage can enhance the therapeutic effect and recovery, but at the same time lead to undesirable reactions.

Increased caution and vigilance should be taken when treating people with intolerance to certain medications, young children, and people with allergies. To do this, in the first days of use, it is recommended to carefully monitor the body’s reactions.

When using injections, a sharp drop in blood glucose is observed. This effect is not described in the instructions for use of the drops, however, we recommend that people suffering from diabetes mellitus take this drug with caution.

Contraindications

You should not take Derinat if you experience intolerance or allergic reactions in response to its use.

Interaction with other drugs

The instructions for use indicate the inadmissibility of simultaneous use of the drug with hydrogen peroxide and other drugs prepared on the basis of fats and oils. Therefore, when treating a runny nose and sinusitis, you should not combine Derinat with Pinosol, intranasal use of oils and folk remedies prepared on an oil and fat basis.

Derinat should not be used simultaneously with anticoagulants; it can increase their therapeutic effect.

If you are taking any medication, tell your doctor before using Derinat drops, read the instructions about interactions with other medications for special instructions.

Reviews on the Internet

The use of Derinat drops, judging by the numerous reviews left on various forums on the Internet, has a positive effect. After prevention, colds do not occur for several weeks, and often sick children, after using the drops, recover faster and catch colds less often.

Most users write that it is enough to cure a cold with Derinat once, and then use it sometimes for prevention.

Children do not refuse these drops; unlike vasoconstrictors and antibiotics, they do not have an unpleasant foreign odor or bitter taste.

The proposed description of the drug is presented in a free style and is intended for informational purposes only. Before using the drops, carefully read the official instructions for use and consult your doctor.

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Desrinitis - instructions for use, reviews, analogs and release forms (dosed nasal spray, nasal drops) of a medicinal product for the treatment of runny nose, sinusitis, polyps or adenoids in adults, children and pregnancy. Compound

In this article you can read the instructions for use of the drug Dezrinit. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Dezrinit in their practice are presented. We kindly ask you to actively add your reviews about the hormonal drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Dezrinit in the presence of existing structural analogues. Use for the treatment of runny nose, sinusitis, polyps or adenoids in adults, children, as well as during pregnancy and breastfeeding. Composition of the drug.

Desrinit is a synthetic glucocorticosteroid (GCS) for topical use. Mometasone (the active ingredient of the drug Dezrinit) has anti-inflammatory and antiallergic effects. The local anti-inflammatory effect of the drug is manifested when it is used in doses at which systemic effects do not occur.

Inhibits the release of inflammatory mediators. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, which causes a decrease in the release of arachidonic acid and, accordingly, inhibition of the synthesis of arachidonic acid metabolic products - cyclic endoperoxides, prostaglandins. Prevents the marginal accumulation of neutrophils, which reduces inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, and leads to a decrease in the processes of infiltration and granulation. Reduces inflammation by reducing the formation of a chemotaxis substance (impact on late allergy reactions), inhibits the development of an immediate allergic reaction (by inhibiting the formation of arachidonic acid metabolites and reducing the release of inflammatory mediators from mast cells).

In studies with provocative tests with the application of antigens to the nasal mucosa, high anti-inflammatory activity of the drug was demonstrated, both in the early and late stages of the allergic reaction. When compared with placebo, a decrease in the level of histamine and eosinophil activity was found, as well as a decrease (compared to the baseline) in the number of eosinophils, neutrophils and epithelial cell proteins.

Mometasone furoate monohydrate + excipients.

When administered intranasally, the systemic bioavailability of mometasone fuorate is less than 1%. A small amount of the active substance, which can enter the gastrointestinal tract during intranasal use, is absorbed to a small extent and is actively biotransformed during the first passage through the liver.

  • treatment of seasonal and year-round allergic rhinitis in adults and children over 2 years of age;
  • acute sinusitis or exacerbation of chronic sinusitis in adults (including the elderly) and children over 12 years of age - as an adjuvant in treatment with antibiotics;
  • prevention of moderate and severe seasonal allergic rhinitis in adults and children over 12 years of age (recommended 4 weeks before the start of the dusting season);
  • treatment of nasal polyposis or adenoids in adults over 18 years of age.

Dosed nasal spray, 140 doses in one bottle.

There was no dosage form in the form of nasal drops at the time of publication of the drug in the Directory.

Instructions for use and method of use

The drug is used intranasally. The spray contained in the bottle is injected into the nasal cavity using a special dispensing device.

Before using the spray for the first time, it is necessary to make about 10 “calibration” clicks on the dosing device. After “calibration,” a stereotypical supply of the drug is established, in which with each click on the dosing device, 100 mg of suspension is released, which corresponds to 50 mcg of mometasone. If the drug has not been used for 14 days or more, then “calibration” must be repeated before new use.

Before each use of the spray, shake the bottle vigorously.

Seasonal and year-round allergic rhinitis

Adults (including the elderly) and children over 12 years of age are prescribed 2 injections (50 mcg each) into each nasal passage 1 time per day (total daily dose). After achieving the desired effect, the dose of the drug for maintenance therapy is 1 injection (50 mcg) into each nasal passage 1 time per day (total daily dose mkg). If necessary, the dose of the drug can be increased to 4 injections (50 mcg each) into each nasal passage 1 time per day (total daily dose kg).

Children aged 2 to 11 years are prescribed 1 injection (50 mcg) into each nasal passage 1 time per day (total daily dose mkg).

Positive dynamics of clinical symptoms are observed, as a rule, within the first 12 hours after the first use of the drug.

Acute sinusitis or exacerbation of chronic sinusitis

Adults (including the elderly) and children over 12 years of age - 2 injections (50 mcg each) into each nasal passage 2 times a day (total daily dose kg). If necessary, the dose of the drug can be increased to 4 injections (50 mcg each) into each nasal passage 2 times a day (total daily dose kg). After symptoms decrease, a dose reduction is recommended.

Adults (including elderly people) over 18 years of age are prescribed 2 injections (50 mcg each) into each nasal passage 2 times a day (total daily dosage mg). After the symptoms of the disease have reduced, it is recommended to reduce the dose to 2 injections (50 mcg each) in each nasal passage 1 time per day (total daily dose kg).

  • hypersensitivity reactions, incl. bronchospasm, shortness of breath;
  • anaphylaxis;
  • angioedema;
  • headache (in adults and children);
  • children experienced growth retardation, psychomotor hyperactivity, sleep disturbance, anxiety, depression, and aggressive behavior;
  • nose bleed;
  • burning in the nasal cavity;
  • ulceration of the nasal mucosa;
  • feeling of irritation of the nasal mucosa;
  • pharyngitis;
  • upper respiratory tract infections;
  • perforation of the nasal septum;
  • sneezing;
  • feeling of irritation of the pharyngeal mucosa;
  • impaired sense of smell;
  • taste disturbance;
  • glaucoma;
  • increased intraocular pressure;
  • cataract.
  • recent surgery or trauma to the nose - before the wound heals (due to the inhibitory effect of GCS on the healing process);
  • children's age (for seasonal and year-round allergic rhinitis - up to 2 years; for acute sinusitis or exacerbations of chronic sinusitis - up to 12 years; for nasal polyposis - up to 18 years);
  • hypersensitivity to mometasone or any of the components of the drug.

Use during pregnancy and breastfeeding

No special studies have been conducted on the safety of using Dezrinit during pregnancy and breastfeeding.

As with the use of other nasal corticosteroids, Dezrinit should be prescribed during pregnancy and lactation only if the expected benefit to the mother outweighs the potential risk to the fetus and child. Newborns whose mothers used corticosteroids during pregnancy should be carefully examined to identify possible adrenal hypofunction.

The use of the drug in children is contraindicated (for seasonal and year-round allergic rhinitis - up to 2 years; for acute sinusitis or exacerbations of chronic sinusitis - up to 12 years; for nasal polyposis or adenoids - up to 18 years).

When using Dezrinit for 12 months, there were no signs of atrophy of the nasal mucosa. A study of biopsy samples of the nasal mucosa revealed that mometasone tended to normalize the histological picture. When using the drug for a long time (as with any long-term treatment), periodic examination of the nasal mucosa by an otolaryngologist is necessary.

The drug should be prescribed with caution for tuberculosis (active or latent) of the respiratory tract; fungal, bacterial or systemic viral infection (including Herpes simplex or herpes affecting the eyes); long-term therapy with GCS; the presence of an untreated local infection involving the nasal mucosa; pregnancy and during breastfeeding.

If a local fungal infection of the nose or pharynx develops, it is recommended to stop treatment with the drug and begin specific therapy.

Irritation of the mucous membrane of the nasal cavity and pharynx that persists for a long time is an indication for discontinuation of the drug.

With long-term use of the drug, no signs of suppression of the function of the hypothalamic-pituitary-adrenal system were observed.

Patients who switch to mometasone therapy after long-term treatment with systemic GCS require special attention. Withdrawal of systemic corticosteroids in such patients may lead to adrenal insufficiency, which may require appropriate measures.

During the transition from treatment with systemic corticosteroids to mometasone therapy, some patients may experience withdrawal symptoms of systemic corticosteroids (for example, joint and/or muscle pain, fatigue, depression), despite a decrease in the severity of symptoms associated with mucosal damage nose, such patients must be specifically convinced of the advisability of continuing treatment with Desrinit. The transition from systemic corticosteroids to local corticosteroids may also reveal pre-existing allergic diseases, such as allergic conjunctivitis and eczema, that were masked by systemic corticosteroid therapy.

The effectiveness and safety of Desrinit has not been studied in the treatment of unilateral polyps, polyps associated with cystic fibrosis and polyps that completely cover the nasal cavity. Unilateral polyps that are irregular in shape or bleeding should be further examined.

Patients undergoing GCS therapy have a reduced immune reactivity, so they should be warned about the increased risk of infection when contacting patients with certain infectious diseases (for example, chickenpox, measles), as well as the need for medical advice if such contact occurs.

With long-term use of nasal corticosteroids in high doses, systemic side effects may develop. The likelihood of developing these effects is much less than with the use of systemic corticosteroids and may vary in individual patients, as well as between different corticosteroids. Potential systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and, less commonly, a range of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbance, anxiety, depression, or aggression (especially in children).

It is recommended to regularly monitor the growth of children receiving long-term therapy with Desrinit. If growth slows, therapy should be reconsidered in order to reduce the dose of mometasone to the minimum effective to control the symptoms of the disease. In addition, the patient should be referred to a pediatrician for consultation.

Treatment with corticosteroids in doses higher than recommended may lead to clinically significant suppression of adrenal function. If it is known that GCS are used in high doses, it is necessary to consider the possibility of additional use of systemic GCS during periods of stress or planned surgery.

Impact on the ability to drive vehicles and operate machinery

No studies have been conducted to study the effect on the ability to drive vehicles and machinery.

The simultaneous use of Dezrinit with loratadine did not lead to a change in the concentration of loratadine or its main metabolite in the blood plasma, and the presence of mometasone in the plasma was not detected even in minimal concentrations.

Drug interaction studies of mometasone with other drugs have not been conducted.

Analogs of the drug Dezrinit

Structural analogues of the active substance:

Analogs for therapeutic effect (medicines for the treatment of vasomotor and allergic rhinitis):

  • Avamis;
  • Aqua Maris;
  • Aqualor baby Means for irrigation and rinsing of the nasal cavity for children;
  • Aqualor norms Means for irrigation and rinsing of the nasal cavity for children and adults;
  • AquaMaster;
  • Allergodil;
  • Allergoferon;
  • Afrin;
  • Vibrocil;
  • Galazolin;
  • Histaglobin;
  • Histaphen;
  • Dexamethasone;
  • Derinat;
  • Diprospan;
  • Zaditen;
  • Zyrtec;
  • Zodak;
  • Intal;
  • IRS 19;
  • Kenalog;
  • Ketotifen;
  • Claritin;
  • Clemastine;
  • Codipront;
  • Coldact;
  • Cromolyn;
  • Xylene;
  • Xylometazoline;
  • Loratadine;
  • Marimer;
  • Momat Rhino Advance;
  • Montelar;
  • Morenasal;
  • Nazivin;
  • Nazol;
  • Nasonex;
  • Nasobek;
  • Naphthyzin;
  • Nosolin;
  • Otrivin;
  • Pinosol;
  • Polyoxidonium;
  • Polcortolon;
  • Prednisolone;
  • Rinza;
  • Rhinonorm;
  • Sanorin;
  • Snoop;
  • Suprastin;
  • Tavegil;
  • Telfast;
  • Tizin;
  • Tizin Xylo;
  • Farmazolin;
  • Fenistil;
  • Fenkarol;
  • Physiomer nasal spray;
  • Flixonase;
  • Celeston;
  • Cetrin;
  • Erbisol;
  • Erius;
  • Erolyn.

Source: http://instrukciya-otzyvy.ru/1419-dezrinit-po-primeneniyu-analogi-sprey-nazalnyy-dozirovannyy-kapli-v-nos-adenoidy.html

Derinat nasal drops: instructions for use

The drug Derinat is an immunomodulatory agent that increases the body's protective functions, restores the mucous membranes of the nasopharynx after illnesses, accelerates the recovery process and prevents the spread of viral infection to the lower respiratory tract.

Release form and composition of the drug

The drug Derinat is available in the form of a solution for instillation into the nasal passages, in dark glass bottles with a convenient rubber dropper tip at the end. Bottle volume 10 ml. The drug is packaged in a cardboard box with detailed instructions in the middle.

Derinat 0.25% drops contain sodium deoxyribonucleate, as well as physiological sodium chloride solution and purified water. The solution for instillation into the nose is a clear, colorless liquid, without any odor or impurities.

Pharmacological properties of the drug

The drug Derinat in the form of nasal drops is a powerful immunomodulatory agent that affects cellular and humoral immunity. The active components of the drug have a pronounced anti-inflammatory effect, relieve swelling of the nasal mucosa, form local immunity and prevent the spread of viral, bacterial and fungal infections to the lower respiratory tract, oropharynx and middle ear.

The drug restores the mucous membrane of the nasal cavity after surgical interventions, removal of polyps, and degenerative changes of vascular origin.

Indications

The drug Derinat in the form of a nasal solution is prescribed to patients when the following pathologies are detected:

  • Complex treatment of viral infections at the initial stage of their development;
  • Rhinitis of viral, bacterial and fungal nature;
  • Sinusitis;
  • Adenoiditis;
  • Sinusitis;
  • Atrophy of the nasal mucosa;
  • Weak immunity, frequent colds;
  • Upper respiratory tract infections;
  • Tonsillitis;
  • Otitis;
  • Eustachitis as part of complex therapy;
  • Tracheitis;
  • Laryngitis;
  • Inflammatory processes in the nasal cavity that develop against the background of previous surgical interventions or manipulations of the ENT organs.

Contraindications for use

Before starting therapy with Derinat, the patient should carefully read the instructions, since nasal drops have some contraindications and limitations. An absolute contraindication to the use of the nasal solution is individual intolerance to the components of the drug. Otherwise, the drug does not have any strict restrictions and can be used for treatment from the first days of life in children.

Method of administration and dosage of the drug

Derinat solution 0.25% for instillation into the nasal passages can be used to treat children from the first days of life. According to the instructions, for the prevention of acute respiratory infections when in contact with a sick person, the patient instills 2 drops of the drug into each nasal passage 2-3 times a day. The duration of the course of preventive treatment is from 5 to 14 days.

When the first symptoms of a cold and rhinitis appear, the drug is instilled into each nasal passage, 1-2 drops every 2 hours on the first day; starting from the second day of therapy, the drug can be instilled up to 4 times a day at regular intervals. The duration of the course of drug therapy is 2 weeks.

When inflammatory processes are detected in the paranasal sinuses or when infection spreads to the middle ear, Derinat nasal drops are soaked in a cotton swab and carefully introduced into the nasal or ear canals for 1-2 hours 3-5 times a day. The duration of the course of therapy is 1 month. All this time, the patient should be regularly monitored by an otolaryngologist in order not to miss the progression of the disease and to take adequate measures in time.

Use of the drug during pregnancy and lactation

The drug Derinat in the form of nasal drops can be used for the treatment and prevention of nasopharyngeal disease in women during pregnancy. The studies conducted did not reveal any negative effect of the active component of the drug on the intrauterine development of the fetus and the course of pregnancy itself.

The use of the drug in the form of nasal drops during breastfeeding is possible according to indications and for preventive purposes. In this case, the woman does not need to interrupt lactation.

Side effects

As a rule, Derinat nasal drops are well tolerated even by the smallest patients, however, in case of hypersensitivity to the components included in the drug, the following side effects may develop:

All these symptoms are not dangerous, go away on their own and do not require discontinuation of drug treatment.

Overdose

No cases of overdose with Derinat in the form of nasal drops have been reported in medicine.

Interaction with other drugs

When using the drug Derinat in the form of nasal drops simultaneously with other drugs, an increase in their therapeutic effect is observed. This is especially true for antibiotics, antivirals, and immunostimulants.

Derinat may enhance the therapeutic effect of anticoagulants, so you should be especially careful with this drug interaction.

special instructions

The drug Derinat in the form of nasal drops does not affect the functioning of the central nervous system and does not inhibit the speed of psychomotor reactions.

The substances included in the product do not have a mutagenic, embryotoxic or teratogenic effect, even when the drug is used in large doses for a long time.

Analogs of Derinat nasal drops

The following drugs are similar in their therapeutic effect to the drug Derinat:

  • Vibrocil drops;
  • Aqua-Maris solution for rinsing the nasal passages;
  • Sinuforte;
  • Sinupret.

Before starting to use an analogue, the patient should consult a doctor, since the above drugs have contraindications and limitations.

Conditions for storing and dispensing the drug

Derinat in the form of nasal drops is available in pharmacies without a doctor's prescription. It is recommended to store the product out of the reach of children, at a temperature of no more than 20 degrees, avoiding direct sunlight on the bottle.

The shelf life of the drops is 5 years from the date of production, subject to storage rules. Do not use after expiration date.

Drops Derinat price

The average cost of Derinat nasal solution in Moscow pharmacies is rubles.

Source: http://bezboleznej.ru/derinat