Ergoferon tablets

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Ergoferon - instructions for use, reviews, analogs and release forms (lozenges) of the drug for the treatment and prevention of infectious diseases in adults, children and pregnancy. Compound

In this article you can read the instructions for use of the drug Ergoferon.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Ergoferon in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Ergoferon in the presence of existing structural analogues. Use for the treatment and prevention of infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Ergoferon is used in the complex treatment of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including atypical pathogens (Mycoplasma pneumoniae, Chlamydophila (Chlamydia) pneumoniae, Legionella spp.), is used to prevent bacterial complications of viral infections, and prevents the development of superinfections. Application the drug in the pre- and post-vaccination period increases the effectiveness of vaccination, provides nonspecific prevention of ARVI and influenza at the time of formation of post-vaccination immunity.Ergoferon has preventive effectiveness against ARVI of non-influenza etiology, prevents the development of intercurrent diseases in the post-vaccination period.

The components included in the drug have a single mechanism of action in the form of increasing the functional activity of the CD4 receptor, receptors for interferon (IFN)-gamma and histamine, which is accompanied by a pronounced immunotropic effect.

It has been experimentally proven that:

1. Antibodies to interferon-gamma increase the expression of IFN-gamma, IFN alpha/beta, as well as interleukins associated with them (IL-2, IL-4, IL-10, etc.), improve the ligand-receptor interaction of IFN, restore cytokine status ; normalize the concentration and functional activity of natural antibodies to IFN-gamma, which are an important factor in the body’s natural antiviral tolerance; stimulate interferon-dependent biological processes: induction of expression of major histocompatibility complex type 1 and 2 antigens and Fc receptors, activation of monocytes, stimulation of the functional activity of NK cells, regulation of immunoglobulin synthesis, activating a mixed Th1 and Th2 immune response.

2. Antibodies to CD4, probably being allosteric modulators of this receptor, regulate the functional activity of the CD4 receptor, which leads to an increase in the functional activity of CD4 lymphocytes, normalization of the CD4/CD8 immunoregulatory index, as well as the subpopulation composition of immunocompetent cells (CD3, CD4, CD8, CD16, CD20).

3. Antibodies to histamine modify histamine-dependent activation of peripheral and central H1 receptors and thus reduce the tone of bronchial smooth muscles, reduce capillary permeability, which leads to a reduction in the duration and severity of rhinorrhea, swelling of the nasal mucosa, coughing and sneezing, as well as a decrease in the severity of associated the infectious process of allergic reactions by suppressing the release of histamine from mast cells and basophils, the production of leukotrienes, the synthesis of adhesion molecules, reducing the chemotaxis of eosinophils and platelet aggregation in reactions to contact with an allergen.

The combined use of the components of a complex drug is accompanied by an increase in the antiviral activity of its components.

Antibodies to human interferon gamma, affinity purified + Antibodies to histamine, affinity purified + Antibodies to CD4, affinity purified + excipients.

Antibodies are applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted respectively 100 to the 12th power, 100 to the 30th power, 100 to the 200th power, therefore it is permissible to call Ergoferon a homeopathic remedy.

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Ergoferon.

  • prevention and treatment of influenza A and B (including avian influenza A/H5N1 and swine influenza A/H1N1);
  • prevention and treatment of acute respiratory viral infections caused by parainfluenza virus, adenovirus, respiratory syncytial virus, coronavirus;
  • prevention and treatment of herpes viral infections (labial herpes, ophthalmic herpes, genital herpes, chicken pox, herpes zoster, infectious mononucleosis);
  • prevention and treatment of acute intestinal infections of viral etiology (caused by calicivirus, adenovirus, coronavirus, rotavirus, enteroviruses);
  • prevention and treatment of enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis;
  • complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including those caused by atypical pathogens (Mycoplasma pneumoniae, Chlamydophila (Chlamydia) pneumoniae, Legionella spp.);
  • prevention of bacterial complications of viral infections, prevention of superinfections.

Lozenges No. 20.

Instructions for use and dosage regimen

Inside. The tablet should be kept in the mouth without swallowing until completely dissolved. For one dose - 1 tablet (not during meals).

Children from 6 months. When prescribing the drug to young children (from 6 months to 3 years), it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

Treatment should be started as early as possible, when the first signs of acute infection appear, according to the following scheme: in the first 2 hours, the drug is taken every 30 minutes, then during the first 24 hours, 3 more doses are taken at equal intervals. From the 2nd day onwards, take 1 tablet 3 times a day until complete recovery.

For the prevention of viral infectious diseases - 1-2 tablets per day. The recommended duration of the preventive course is determined individually and can be 1-6 months.

If necessary, the drug can be combined with other antiviral and symptomatic agents.

  • reactions of increased individual sensitivity to the components of the drug.
  • increased individual sensitivity to the components of the drug;
  • galactosemia;
  • malabsorption syndrome.

Use during pregnancy and breastfeeding

The safety of Ergoferon during pregnancy and lactation has not been studied. If it is necessary to prescribe a drug, the risk/benefit ratio should be taken into account.

The use of the drug is allowed for children from 6 months of age.

The drug contains lactose, and therefore it is not recommended for use in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or congenital lactase deficiency.

Impact on the ability to drive vehicles and operate machinery

Has no effect.

No cases of incompatibility with other drugs have been reported to date.

Analogues of the drug Ergoferon

The drug Ergoferon has no structural analogues of the active substance.

Analogs in the pharmacological group of immunomodulators:

Similar medications:

Other medicines:

News edited by: admin16, 15:54

Source: http://instrukciya-otzyvy.ru/515-ergoferon-po-primeneniyu-analogi-tabletki-dlya-rassasyvaniya-infekciya-u-vzroslyh-detey.html

Ergoferon

Ergoferon: instructions for use and reviews

Latin name: Ergoferon

ATX code: J05AX, R06A

Active ingredient: affinity purified antibodies to human interferon gamma, histamine and CD4 gene

Manufacturer: Materia Medica Holding NPF LLC (Russia)

Update of description and photo: 01/11/2018

Prices in pharmacies: from 305 rubles.

Ergoferon is a homeopathic combined immunomodulatory drug; has antiviral, antihistamine, anti-inflammatory activity.

Release form and composition

  • lozenges: from almost white to white, flat-cylindrical, with a chamfer, on one side there is the inscription ERGOFERON, on the other there is a line mark and the inscription MATERIA MEDICA (20 pcs. in blister packs, in a cardboard pack of 1, 2 or 5 packs);
  • oral solution: transparent, almost colorless or colorless liquid (100 ml in an orange glass bottle with a dropper, 1 bottle in a cardboard box).
1 tablet contains:
  • active ingredients: affinity-purified antibodies to human gamma interferon - 0.006 g (in aqueous-alcoholic dilution), affinity-purified antibodies to histamine - 0.006 g (in aqueous-alcoholic dilution), affinity-purified antibodies to the CD4 gene - 0.006 g (in aqueous -alcohol dilution);
  • auxiliary components: microcrystalline cellulose, lactose monohydrate, magnesium stearate.

100 ml of oral solution contains:

  • active ingredients: affinity purified antibodies to human interferon gamma – 0.12 g (in aqueous-alcoholic dilution); affinity purified antibodies to histamine – 0.12 g (in aqueous-alcoholic dilution), affinity-purified antibodies to the CD4 gene – 0.12 g (in aqueous-alcoholic dilution);
  • auxiliary components: potassium sorbate, maltitol, anhydrous citric acid, glycerol, purified water.

Pharmacological properties

Pharmacodynamics

Ergoferon is an immunomodulating drug with antiviral, anti-inflammatory and antihistamine activity. A wide range of pharmacological effects is due to its combined composition. All active components of the drug have the same mechanism of action, which is to increase the functional activity of the CD4 receptor, receptors for interferon gamma and histamine. This contributes to the pronounced immunotropic effect of Ergoferon.

Thanks to the combination of three active components, their immunomodulatory activity is enhanced:

  • antibodies to interferon gamma: increasing the expression of alpha, beta and gamma interferon and related interleukins (IL) - IL-2, IL-4, IL-10, normalize the level and functional activity of natural antibodies to interferon gamma, which are an essential factor in the natural antiviral resistance of the body. The presence of antibodies to interferon gamma in Ergoferon helps improve the ligand-receptor interaction of interferons and restore cytokine status. Potentiates the induction of the expression of major histocompatibility complex antigens of types I and II, Fc receptors, monocytes, stimulates the regulation of immunoglobulin synthesis, the functional activity of NK cells (natural killer cells), activates the immune response of T-helpers type 1 and 2 (Th1 and Th2);
  • Antibodies to histamine: by modifying histamine-dependent activation of H1 receptors, they help reduce the tone of bronchial smooth muscles and capillary permeability. This effect reduces the duration and severity of swelling of the nasal mucosa, rhinorrhea, coughing and sneezing. At the same time, the severity of concomitant allergic reactions decreases, the chemotaxis of eosinophils and platelet aggregation in reactions to contact with an allergen decreases;
  • antibodies to CD4: by regulating the functional activity of the CD4 receptor, they cause an increase in the functional activity of CD4 lymphocytes, normalization of the immunoregulatory index CD4/CD8, the composition of subpopulations of immunocompetent cells - CD3, CD4, CD8, CD16 and CD20.

The experimentally established effectiveness of the drug components is confirmed by data from clinical studies obtained in the treatment of the following infectious diseases: acute respiratory pathologies (caused by adenoviruses, parainfluenza viruses, respiratory syncytial viruses and coronaviruses), influenza A and B viruses, chickenpox, labial herpes, ophthalmoherpes, shingles herpes, genital herpes, infectious mononucleosis, meningitis (enteroviral, meningococcal), tick-borne encephalitis, acute intestinal infections (caused by rotaviruses, enteroviruses, caliciviruses and coronaviruses), hemorrhagic fever with renal syndrome.

The use of bacterial infections (including pneumonia of various etiologies, including those caused by atypical pathogens - Chlamydophila pneumoniae, Mycoplasma pneumoniae, Legionella speciales), pseudotuberculosis, yersiniosis, whooping cough, in addition to the therapeutic effect, helps prevent the development of superinfections as part of complex therapy. The drug is effective in preventing bacterial complications of viral lesions; increases the effectiveness of vaccination when taken in the pre- and post-vaccination period. At the stage of formation of post-vaccination immunity, it provides nonspecific prevention of influenza and acute respiratory viral infections (ARVI). It has a preventive effect against acute respiratory viral infections of non-influenza etiology and prevents the development of intercurrent diseases after vaccination.

Pharmacokinetics

It is technically impossible to study the pharmacokinetics of Ergoferon due to the insufficient sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry), which does not allow a reliable assessment of the content of the active components of the drug in human tissues, organs and biological fluids.

Indications for use

According to the instructions, Ergoferon is recommended for the prevention and treatment of the following diseases:

  • influenza virus types A and B;
  • acute respiratory viral infections caused by adenovirus, parainfluenza virus, coronavirus, respiratory syncytial virus;
  • herpesvirus infections (varicella, ophthalmic herpes, labial herpes, herpes zoster, genital herpes, infectious mononucleosis);
  • acute intestinal infections caused by adenovirus, calicivirus, coronavirus, enteroviruses, rotavirus;
  • meningitis (enteroviral and meningococcal);
  • hemorrhagic fever with renal syndrome;
  • tick-borne viral encephalitis.

In addition, the drug is prescribed as part of complex therapy for whooping cough, pseudotuberculosis, pneumonia of various etiologies (including Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella speciales), yersiniosis of bacterial origin. And also to prevent superinfections and prevent bacterial complications of viral infections.

Contraindications

The use of Ergoferon is contraindicated in patients with hypersensitivity to its components.

The drug should be prescribed with caution during pregnancy and breastfeeding.

  • tablets: congenital galactosemia or lactase deficiency, glucose-galactose malabsorption syndrome;
  • solution: hereditary fructose intolerance, age up to 3 years.

The solution should be taken with caution in patients with diabetes.

Instructions for use of Ergoferon: method and dosage

Lozenges

The tablets are taken orally, not swallowed immediately, but held in the mouth until completely dissolved. The drug should be taken some time after eating.

It is recommended to first dissolve the Ergoferon tablet for children aged six months to three years in 1 tablespoon of boiled water, cooled to room temperature.

Recommended dosage of Ergoferon:

  • acute infections: 7 pcs. during the first day according to the scheme - 1 pc. every 0.5 hour for the first 2 hours, then 1 pc. at intervals of 7 hours. Treatment is continued at a dose of 1 pc. 3 times a day. The drug should be used until complete recovery;
  • prevention of viral infectious diseases: 1–2 pcs. in a day. The duration of the course is determined by the doctor individually; it can range from 30 to 180 days.

Oral solution

The solution is taken orally, not swallowed immediately, but kept in the mouth for a while, this will ensure the maximum effect of the drug. Taking the solution should not be combined with meals.

Recommended dosage of Ergoferon:

  • acute infections: during the first day according to the regimen - 5 ml (1 teaspoon) 4 times every 0.5 hour, then 5 ml every 7 hours (3 times). From the second day onwards, treatment is continued at a dose of 5 ml 3 times a day. The solution should be used until complete recovery;
  • prevention of viral infectious diseases: 5–10 ml per day, the duration of the course is determined by the doctor individually, it can range from 30 to 180 days.

It is necessary to begin treatment of an acute infection from the moment its first symptoms appear.

Side effects

Taking Ergoferon may cause the development of hypersensitivity reactions.

Overdose

Symptoms of an overdose of Ergoferon are dyspeptic symptoms in the form of nausea, vomiting and/or diarrhea. When they appear, symptomatic therapy is recommended.

special instructions

If signs of Ergoferon side effects appear, you should consult a doctor.

The content of maltitol in 5 ml of solution is 0.3 g, which corresponds to 0.02 XE (bread unit). To metabolize maltitol in diabetes mellitus, it is necessary to consider adjusting the insulin dose. When prescribing a dose of insulin, one should take into account the slow hydrolysis and absorption of the drug in the gastrointestinal tract. The energy value of 5 ml of solution is 1.37 kcal. The energy value of maltitol is much lower than that of sucrose and is 2.4 kcal/g.

Impact on the ability to drive vehicles and complex mechanisms

Taking Ergoferon tablets does not affect the patient’s ability to drive vehicles and machinery. The effect of the solution on the psychophysical state of patients has not been studied.

Use during pregnancy and lactation

There is no information on the safety of using Ergoferon during pregnancy and lactation.

It is recommended to resort to prescribing the drug during pregnancy and breastfeeding only in cases where, in the opinion of the attending physician, the expected effect of therapy for the mother outweighs the potential threat to the fetus or child.

Use in childhood

Ergoferon is contraindicated for children under six months of age - in the form of tablets, for children under three years of age - in the form of a solution.

Drug interactions

Taking Ergoferon can be combined with medications for symptomatic therapy and other antiviral drugs; cases of incompatibility have not been established.

Analogs

Analogs of Ergoferon are: Alpizarin, Allokin-alpha, Arbidol, Viferon, Giporamin, Oscillococcinum, Celsentri, Ingavirin, Viracept, Kagocel, Fuzeon, Nikavir, Tiloron, etc.

Terms and conditions of storage

Keep away from children.

Store at temperatures up to 25 °C, protected from light.

Shelf life – 3 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Ergoferon

Reviews about Ergoferon are quite contradictory. Patients who started taking the drug when the first symptoms of influenza appeared, in strict accordance with the regimen specified in the instructions, noted a noticeable improvement in their condition already on the second day of therapy. Prophylactic use of a homeopathic remedy by family members who have a patient with a viral infectious disease allows them to avoid infection. Many patients, after repeated use of the drug for diseases of viral etiology, report that the therapy allows them to more easily endure the acute period of the disease and helps speed up the recovery process.

Reviews with a negative assessment of Ergoferon indicate a complete lack of therapeutic effect, and in some cases even a worsening of the disease.

Price for Ergoferon in pharmacies

The price of Ergoferon for a package containing 20 tablets can range from 319 rubles.

Ergoferon tablets 20 pcs.

Ergoferon No. 20 tablets

Ergoferon tab. d/rassas n20

Ergoferon N20 lozenge tablet

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

Smiling just twice a day can lower your blood pressure and reduce the risk of heart attacks and strokes.

74-year-old Australian resident James Harrison has donated blood about 1,000 times. He has a rare blood type whose antibodies help newborns with severe anemia survive. Thus, the Australian saved about two million children.

Scientists from Oxford University conducted a series of studies in which they came to the conclusion that vegetarianism can be harmful to the human brain, as it leads to a decrease in its mass. Therefore, scientists recommend not completely excluding fish and meat from your diet.

The highest body temperature was recorded in Willie Jones (USA), who was admitted to the hospital with a temperature of 46.5°C.

In an effort to get the patient out, doctors often go too far. For example, a certain Charles Jensen in the period from 1954 to 1994. survived more than 900 operations to remove tumors.

The liver is the heaviest organ in our body. Its average weight is 1.5 kg.

When we sneeze, our body stops working completely. Even the heart stops.

Tooth decay is the most common infectious disease in the world, which even the flu cannot compete with.

When lovers kiss, each of them loses 6.4 calories per minute, but at the same time they exchange almost 300 types of different bacteria.

Our kidneys are capable of purifying three liters of blood in one minute.

In the UK there is a law according to which a surgeon can refuse to perform an operation on a patient if he smokes or is overweight. A person must give up bad habits, and then, perhaps, he will not need surgical intervention.

An educated person is less susceptible to brain diseases. Intellectual activity promotes the formation of additional tissue that compensates for the disease.

According to statistics, on Mondays the risk of back injuries increases by 25%, and the risk of a heart attack by 33%. Be careful.

Over the course of a lifetime, the average person produces no less than two large pools of saliva.

The rarest disease is Kuru disease. Only members of the For tribe in New Guinea suffer from it. The patient dies of laughter. The disease is believed to be caused by eating human brains.

Every time a child has a fever, a sore throat, a runny nose and a cough, parents are worried about the question - is it a common cold or the flu? In this

Source: http://www.neboleem.net/jergoferon.php

Ergoferon - official instructions for use

Registration number

Tradename

Dosage form

Composition (per 1 tablet)

affinity purified antibodies to human interferon gamma – 0.006 g*

affinity purified antibodies to histamine – 0.006 g*

affinity purified antibodies to CD4 – 0.006 g*

Excipients: lactose monohydrate 0267 g, microcrystalline cellulose 0.03 g, magnesium stearate 0.003 g.

* applied to lactose monohydrate in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted accordingly by a factor of .

Flat-cylindrical tablets with a score and a bevel, from white to almost white. On the flat side with a mark there is the inscription MATERIA MEDICA, on the other flat side there is the inscription ERGOFERON.

Pharmacotherapeutic group

Pharmacological properties

The spectrum of pharmacological activity of Ergoferon includes antiviral, immunomodulatory, antihistamine, and anti-inflammatory.

The effectiveness of the use of Ergoferon components in viral infectious diseases has been experimentally and clinically proven: influenza A and influenza B, acute respiratory viral infections (caused by parainfluenza viruses, adenoviruses, respiratory syncytial viruses, coronaviruses), herpes viral infections (labial herpes, ophthalmic herpes, genital herpes, shingles herpes, chicken pox, infectious mononucleosis), acute intestinal infections of viral etiology (caused by caliciviruses, coronaviruses, rotaviruses, enteroviruses), enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis.

The drug is used in the complex treatment of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including atypical pathogens (M.pneumoniae, C.Pneumoniae, Legionella spp.), is used to prevent bacterial complications of viral infections, prevents the development of superinfections. Use of the drug in pre- and post-vaccination period increases the effectiveness of vaccination, provides nonspecific prevention of ARVI and influenza at the time of formation of post-vaccination immunity.Ergoferon has preventive effectiveness against ARVI of non-influenza etiology, prevents the development of intercurrent diseases in the post-vaccination period.

The components included in the drug have a single mechanism of action in the form of increasing the functional activity of the CD4 receptor, receptors for interferon gamma (IFN-γ) and histamine, respectively; which is accompanied by a pronounced immunotropic effect.

It has been experimentally proven that antibodies to interferon gamma: increase the expression of IFN-γ, IFN α/β, as well as interleukins associated with them (IL-2, IL-4, IL-10, etc.), improve the ligand-receptor interaction of IFN, restore cytokine status; normalize the concentration and functional activity of natural antibodies to IFN-γ, which are an important factor in the body’s natural antiviral tolerance; stimulate interferon-dependent biological processes: induction of expression of major histocompatibility complex type I, II antigens and Fc receptors, activation of monocytes, stimulation of the functional activity of NK cells, regulation of immunoglobulin synthesis, activating a mixed Th1 and Th2 immune response.

Antibodies to CD4, probably being allosteric modulators of this receptor, regulate the functional activity of the CD4 receptor, which leads to an increase in the functional activity of CD4 lymphocytes, normalization of the CD4/CD8 immunoregulatory index, as well as the subpopulation composition of immunocompetent cells (CD3, CD4, CD8, CD16, CD20) .

Antibodies to histamine modify histamine-dependent activation of peripheral and central H1 receptors and thus reduce the tone of bronchial smooth muscles, reduce capillary permeability, which leads to a reduction in the duration and severity of rhinorrhea, swelling of the nasal mucosa, coughing and sneezing, as well as a decrease in the severity of associated the infectious process of allergic reactions by suppressing the release of histamine from mast cells and basophils, the production of leukotrienes, the synthesis of adhesion molecules, reducing the chemotaxis of eosinophils and platelet aggregation in reactions to contact with an allergen.

The combined use of the components of a complex drug is accompanied by an increase in the antiviral activity of its components.

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Ergoferon.

Indications for use

  • Prevention and treatment of influenza A and B. Prevention and treatment of acute respiratory viral infections caused by parainfluenza virus, adenovirus, respiratory syncytial virus, coronavirus.
  • Prevention and treatment of herpes virus infections (labial herpes, ophthalmic herpes, genital herpes, chicken pox, herpes zoster, infectious mononucleosis).
  • Prevention and treatment of acute intestinal infections of viral etiology (caused by calicivirus, adenovirus, coronavirus, rotavirus, enteroviruses).
  • Prevention and treatment of enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis.
  • Use in complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including those caused by atypical pathogens (M.pneumoniae, C.Pneumoniae, Legionella spp)); prevention of bacterial complications of viral infections, prevention of superinfections.

Contraindications

Pregnancy and lactation

Directions for use and doses

Children from 6 months. When prescribing the drug to young children (from 6 months to 3 years), it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

Treatment should be started as early as possible, when the first signs of acute infection appear, according to the following scheme: in the first 2 hours the drug is taken every 30 minutes, then during the first 24 hours three more doses are taken at regular intervals. From the second day onwards, take 1 tablet 3 times a day until complete recovery.

For the prevention of viral infectious diseases - 1-2 tablets per day. The recommended duration of the preventive course is determined individually and can be months.

If necessary, the drug can be combined with other antiviral and symptomatic agents

Side effect

Overdose

In case of accidental overdose, dyspepsia may occur due to the excipients included in the drug.

Interaction with other drugs

No cases of incompatibility with other drugs have been reported to date.

special instructions

The drug contains lactose monohydrate, and therefore is not recommended for use in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or congenital lactase deficiency.

Ergoferon does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

Release form

Lozenges. 20 tablets each in a blister pack made of polyvinyl chloride film and aluminum foil.

1, 2 or 5 blister packs along with instructions for medical use are placed in a cardboard pack

Storage conditions

Keep out of the reach of children.

Shelf life

Do not use after the expiration date.

Conditions for dispensing from pharmacies

Name, address of the manufacturer of the medicinal product/organization accepting the claims

LLC "NPF "MATERIA MEDICA HOLDING";,

Russia, Moscow, 3rd Samotechny lane, no.9.

Address of the place of production of the medicinal product.

Russia, Chelyabinsk, st. Buguruslanskaya, 54

Source: http://medi.ru/instrukciya/ergoferon_2472/

ERGOFERON

◊ Lozenges from white to almost white, flat-cylindrical in shape, scored and chamfered; on the flat side with a mark there is the inscription MATERIA MEDICA, on the other flat side there is the inscription ERGOFERON.

* applied to lactose monohydrate in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted accordingly by a factor of .

Excipients: lactose monohydrate - 0.267 g, microcrystalline cellulose - 0.03 g, magnesium stearate - 0.003 g.

20 pcs. — cellular contour packages (1) — cardboard packs.

20 pcs. — contour cell packaging (2) — cardboard packs.

20 pcs. — contour cell packaging (5) — cardboard packs.

The spectrum of pharmacological activity of Ergoferon includes antiviral, immunomodulatory, antihistamine, and anti-inflammatory.

The effectiveness of the use of Ergoferon components in viral infectious diseases has been experimentally and clinically proven: influenza A and influenza B, acute respiratory viral infections (caused by parainfluenza viruses, adenoviruses, respiratory syncytial viruses, coronaviruses), herpes viral infections (labial herpes, ophthalmic herpes, genital herpes, shingles herpes, chicken pox, infectious mononucleosis), acute intestinal infections of viral etiology (caused by caliciviruses, coronaviruses, rotaviruses, enteroviruses), enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis.

The drug is used in the complex treatment of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including atypical pathogens (Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella spp.), is used to prevent bacterial complications of viral infections, prevents the development of superinfections. The use of the drug in pre- and in the post-vaccination period increases the effectiveness of vaccination, provides nonspecific prevention of ARVI and influenza at the time of formation of post-vaccination immunity.Ergoferon has preventive effectiveness against ARVI of non-influenza etiology, prevents the development of intercurrent diseases in the post-vaccination period.

The components included in the drug have a single mechanism of action in the form of increasing the functional activity of the CD 4 receptor, interferon gamma (IFN γ) and histamine receptors, respectively, which is accompanied by a pronounced immunotropic effect.

It has been experimentally proven that antibodies to interferon gamma increase the expression of IFN γ, IFN α/β, as well as interleukins associated with them (IL-2, IL-4, IL-10 and others), improve the ligand-receptor interaction of IFN, and restore cytokine status ; normalize the concentration and functional activity of natural antibodies to IFN γ, which are an important factor in the body’s natural antiviral tolerance; stimulate interferon-dependent biological processes (induction of expression of major histocompatibility complex antigens of types I, II and F c receptors, activation of monocytes, stimulation of the functional activity of NK cells, regulation of immunoglobulin synthesis, activating a mixed Th1 and Th2 immune response).

Antibodies to CD 4 , probably being allosteric modulators of this receptor, regulate the functional activity of the CD 4 receptor, which leads to an increase in the functional activity of CD 4 lymphocytes, normalization of the immunoregulatory index CD 4 / CD 8 , as well as the subpopulation composition of immunocompetent cells (CD 3 , CD 4 , CD 8 , CD 16 , CD 20 ).

Antibodies to histamine modify histamine-dependent activation of peripheral and central H1 receptors and, thus, reduce the tone of bronchial smooth muscles, reduce capillary permeability, which leads to a reduction in the duration and severity of rhinorrhea, swelling of the nasal mucosa, coughing and sneezing, as well as reducing the severity of allergic reactions accompanying the infectious process by suppressing the release of histamine from mast cells and basophils, the production of leukotrienes, the synthesis of adhesion molecules, reducing the chemotaxis of eosinophils and platelet aggregation in reactions to contact with an allergen.

The combined use of the components of a complex drug is accompanied by an increase in the antiviral activity of its components.

— prevention and treatment of influenza A and B;

— prevention and treatment of acute respiratory viral infections caused by parainfluenza virus, adenovirus, respiratory syncytial virus, coronavirus;

- prevention and treatment of herpes virus infections (labial herpes, ophthalmic herpes, genital herpes, chicken pox, herpes zoster, infectious mononucleosis);

— prevention and treatment of acute intestinal infections of viral etiology (caused by calicivirus, adenovirus, coronavirus, rotavirus, enteroviruses);

— prevention and treatment of enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis;

— use in complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including those caused by atypical pathogens (Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella spp.));

- prevention of bacterial complications of viral infections, prevention of superinfections.

The drug is taken orally, not during meals. The tablet should be kept in the mouth without swallowing until completely dissolved.

When prescribing the drug to young children (from 6 months to 3 years), it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

On the 1st day of treatment, take 8 tablets. according to the following scheme: 1 tab. every 30 minutes in the first 2 hours (total 5 tablets in 2 hours), then during the same day take another 1 tablet. 3 times at equal intervals. On the 2nd day and further, take 1 tablet. 3 times a day until complete recovery.

For the prevention of viral infectious diseases - 1-2 tablets/day. The recommended duration of the preventive course is determined individually and can be 1-6 months.

If necessary, the drug can be combined with other antiviral and symptomatic agents.

The drug contains lactose monohydrate, and therefore is not recommended for use in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or congenital lactase deficiency.

Impact on the ability to drive vehicles and operate machinery

Ergoferon does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

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Source: http://health.mail.ru/drug/ergoferon/

Ergoferon - instructions for use (tablets, solution), analogues, reviews, price of the drug. Can a child take Ergoferon, and at what age? Which is better: Ergoferon or Kagocel?

Release forms, varieties and composition

Currently, Ergoferon is available in two dosage forms:

  • Dissolving tablets for oral administration;
  • Oral solution.

Regarding the types of the drug, there is currently a widespread opinion at the household level that there are two types of Ergoferon - children's and adults. However, this is not true.

Both solution and Ergoferon tablets contain the same active substances:

  • Antibodies to interferon gamma, affinity purified – 0.12 g per 100 ml of solution or 0.006 g per tablet;
  • Antibodies to histamine, affinity purified – 0.12 g per 100 ml of solution or 0.006 g per tablet;
  • Affinity purified antibodies to CD4 - 0.12 g per 100 ml of solution or 0.006 g per tablet.

These active substances are antibodies obtained using biotechnological methods to substances (to histamine, to interferon gamma) and cells (to CD4), which support the inflammatory reaction in all organs and tissues of the human body. Once antibodies are obtained, impurities are removed from their bulk using biotechnological methods, resulting in them becoming affinity purified.

  • Microcrystalline cellulose;
  • Lactose monohydrate;
  • Magnesium stearate.

Ergoferon solution contains the following substances as auxiliary components:

  • Glycerol;
  • Anhydrous citric acid;
  • Maltitol;
  • Potassium sorbate;
  • Purified water (deionized and distilled).

Therapeutic effect

Ergoferon has antiviral, immunomodulatory, anti-inflammatory and antihistamine effects. The antiviral effect is to ensure effective elimination and suppression of the activity of viruses in the body, which leads to the cure of viral infections. The anti-inflammatory effect is to suppress inflammation in various organs and tissues, which ensures the cure of chronic low-grade inflammatory diseases. The antihistamine effect is to suppress the activity of histamine, which causes swelling, redness, dysfunction and pain in the inflamed area. Accordingly, suppression of histamine activity helps to reduce pain, swelling, redness and normalize the functioning of the inflamed organ or tissue. The immunomodulatory effect is to provide a more intense response of the immune system aimed at destroying pathogenic microbes that have entered the body.

  • Antibodies to interferon gamma cause an increase in the production of gamma, alpha and beta interferons, as well as interleukins 2, 4 and 10. In addition, antibodies improve the interaction of various cells with the produced interferon and normalize the ratio of cytokines (interleukins, interferons, etc.). Also, antibodies to gamma interferon increase the number of molecules of the major histocompatibility complex on the surface of immune cells, activate monocytes and natural killer cells (NK cells). All these effects activate natural antiviral immunity, due to which the immune system successfully destroys viruses. And due to the destruction of viruses, any viral infections are easier, recovery occurs faster, and the risk of complications is reduced.
  • Antibodies to the CD4 receptor increase its activity, which causes an increase in the functional activity of CD4 lymphocytes (lymphocytes belonging to the CD4 cluster), and also normalizes the ratio of various populations of immune system cells (such as CD3, CD4, CD8, CD16, CD20). All these effects increase the efficiency of the immune system, due to which recovery from infectious diseases occurs faster, and the body’s overall resistance to various pathologies increases.
  • Antibodies to histamine reduce the activation of histamine receptors in various tissues and organs under the influence of histamine. As a result, the tone and tension of the smooth muscles of the bronchi decreases, and the permeability of capillaries decreases, due to which the duration and severity of rhinorrhea (snot), swelling of the nasal mucosa, coughing and sneezing is reduced. In addition, the severity of allergic reactions accompanying infectious diseases is reduced.

Due to its therapeutic effects, Ergoferon is effective in the treatment and prevention of a wide range of different viral infections (for example, influenza, parainfluenza, ARVI, adenovirus, coronavirus infections, intestinal infections, herpes infections, tick-borne encephalitis, etc.). In addition, Ergoferon increases the effectiveness of the treatment of bacterial infections if used in combination with antibiotics.

Indications for use

Ergoferon tablets and solution are indicated for use in the same following cases:

  • Prevention and treatment of influenza A and B;
  • Prevention and treatment of acute respiratory viral infections (ARVI) caused by a variety of viruses, such as adenovirus, coronavirus, respiratory syncytial virus, parainfluenza virus;
  • Prevention and treatment of infections caused by various types of herpes virus (labial and genital herpes, ophthalmic herpes, herpes zoster, chicken pox, infectious mononucleosis);
  • Prevention and treatment of acute intestinal infections caused by various viruses, such as calicivirus, adenovirus, coronavirus, rotavirus, enterovirus;
  • Prevention and treatment of meningitis caused by enteroviruses or meningococci;
  • Prevention and treatment of tick-borne encephalitis and hemorrhagic fever with renal syndrome;
  • As part of complex therapy for various bacterial infections, such as pseudotuberculosis, whooping cough, yersiniosis, pneumonia (including those caused by atypical pathogenic microbes Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella spp.);
  • Prevention of bacterial complications in various viral infections;
  • Prevention of superinfections (re-infection with an infection against the background of incomplete recovery from a previous infectious disease).

Instructions for use

Instructions for use of Ergoferon tablets

Tablets can be given to children from the age of six months.

Instructions for use of Ergoferon solution

The solution is intended for adults and children over three years of age.

How to take Ergoferon for prevention?

For the prevention of any diseases for which the use of Ergoferon is indicated, it is recommended to take the drug one tablet or one teaspoon (5 ml) of solution 1 - 2 times a day for 1 - 6 months, without breaks.

Use during pregnancy and breastfeeding

The effect of Ergoferon solution and tablets on the course of pregnancy and the condition of the fetus has not been studied for obvious ethical reasons. Therefore, it is currently not known for sure whether the drug Ergoferon has a negative effect on the fetus and the course of pregnancy. However, theoretically, the drug should not adversely affect the fetus and the course of pregnancy. Considering this, the drug in any form (solution and tablets) is not recommended for use during pregnancy and breastfeeding, so as not to encounter any (albeit very unlikely) negative consequences for the fetus.

special instructions

Ergoferon solution contains maltitol in the amount of 0.09 bread units (XE) per teaspoon (5 ml). And although the processing of maltitol in the amount of 0.09 XE requires a small amount of insulin (less than for the processing of 0.09 XE of sucrose), nevertheless, this circumstance should be known and taken into account by people suffering from diabetes when taking Ergoferon solution.

Impact on the ability to operate machinery

Ergoferon tablets and solution do not affect the ability to control mechanisms, since they do not have any effect on the central nervous system. Therefore, while using Ergoferon in one or another dosage form (tablets, solution), you can engage in any type of activity that requires a high speed of reactions and concentration.

Overdose

In case of an accidental overdose of Ergoferon tablets or solution, dyspepsia (nausea, vomiting, diarrhea, etc.) may develop due to the excipients included in the drug. In case of overdose, symptomatic medications should be used to eliminate the manifestations of dyspepsia (for diarrhea - Loperamide, for nausea and vomiting - Cerucal).

Interaction with other drugs

Ergoferon tablets and solution do not significantly interact with other drugs. This means that both tablets and Ergoferon solution can be used in combination with any other drugs.

Ergoferon for children

General provisions

Ergoferon tablets in Russia are approved for use in children from the age of six months, and in Belarus - only from six years. Ergoferon solution is approved for use in Russia for children from the age of three years, and in Belarus - from the age of six years. More stringent restrictions on the use of the drug for children in the Republic of Belarus are due to the peculiarities of the legislation, which allows the use of any homeopathic medicines for children only from the age of six.

Instructions for use of Ergoferon for children

Children under three years of age should be given Ergoferon only in tablet form. From the age of three, Ergoferon can be given to children both in the form of tablets and as a solution.

Side effects

As side effects, both solution and Ergoferon tablets can only provoke allergic reactions or intolerance reactions to any component of the drug. If a person experiences an allergic reaction or any other manifestations of intolerance, they should immediately stop taking Ergoferon and consult a doctor.

Contraindications for use

Ergoferon tablets are contraindicated for use only in children under six months of age and if a person has individual hypersensitivity or allergic reactions to any component.

  • Age under 3 years;
  • Individual hypersensitivity or allergic reactions to any components of the drug;
  • Fructose intolerance.

In addition, both Ergoferon solution and tablets should be used with caution by people with diabetes, since both dosage forms contain small amounts of sugars.

Analogs

On the domestic pharmaceutical market, the drug Ergoferon has analogue drugs only in terms of therapeutic action, and has no analogues in terms of the active substance. That is, there are no drugs that contain the same active ingredients as Ergoferon on the pharmaceutical market of the countries of the former USSR. But there are analogues of Ergoferon for therapeutic action. This means that Ergoferon analogues are drugs that contain different active substances, but have similar therapeutic effects.

  • Alpizarin tablets;
  • Amizon tablets;
  • Amiksin tablets;
  • Anaferon and Anaferon for children lozenges;
  • Arbidol capsules, tablets, powder for the preparation of suspension for oral administration;
  • Arbidol Maximum capsules;
  • Arpetolide tablets;
  • Arpeflu tablets;
  • Viburcol suppositories;
  • Hyporamine tablets, suppositories, lyophilisate for the preparation of solutions for inhalation and intranasal administration;
  • Groprinosin tablets;
  • Isoprinosine tablets;
  • Immunal tablets and drops for oral administration;
  • Immunex syrup;
  • Ingavirin capsules;
  • Yodantipyrine tablets;
  • Kagocel tablets;
  • Lavomax tablets;
  • Oksolin ointment;
  • ORVItol NP capsules;
  • Panavir gel for local and external use, suppositories, capsules and solution for intravenous administration;
  • Tilaxin tablets;
  • Tiloram tablets;
  • Tiloron capsules and tablets;
  • Triazavirin capsules;
  • Engystol absorbable tablets;
  • Echinacea tablets, granules, drops, lozenges.

Ergoferon - cheaper analogues

The following analogue drugs are cheaper than Ergoferon:

  • Alpizarin – 170 – 260 rubles for 20 tablets;
  • Anaferon and Anaferon for children – 180 – 230 rubles for 20 tablets;
  • Arpeflu – 100 – 180 rubles for 20 tablets;
  • Hyporamine – 140 – 180 rubles for 20 tablets;
  • Yodantipyrine – 180 – 220 rubles for 20 tablets;
  • Oksolin ointment – ​​40 – 70 rubles per tube;
  • Echinacea – 50 – 150 rubles.

Reviews

Approximately 2/3 of the reviews about Ergoferon are positive, which is due to a noticeable effect in the treatment of acute respiratory viral infections. Unfortunately, there are practically no reviews about the treatment of other viral diseases with Ergoferon, they are literally isolated, so it is not possible to obtain any objective picture in this case.

Ergoferon for children - reviews

Most of the reviews on the use of Ergoferon for children are positive (about 85%). It should be noted that all reviews of the use of Ergoferon relate to the treatment and prevention of various acute respiratory viral infections in children. There are no reviews on the use of the drug for children for other indications.

Ergoferon - reviews from doctors

Reviews from doctors about Ergoferon are in almost all cases positive, which is due to a number of reasons. Firstly, the drug speeds up recovery and alleviates the course of ARVI in many sick children and adults, that is, it turns out to be effective and suitable for a wide range of patients. Secondly, Ergoferon practically does not cause side effects, which is also a significant advantage of the drug in the eyes of doctors. Thirdly, Ergoferon is a homeopathic and, therefore, a safe drug that is suitable for both adults and children. And even if the medicine turns out to be ineffective in a particular case, it will not cause harm, which is very important in the case of treating young children.

What is better than Ergoferon?

In medical practice, there is no clear answer to the question “What is better than Ergoferon?”, since it is impossible to find a remedy that in different situations and in different people would be better in all respects than another, similar, comparable in quality and range of therapeutic effect. Therefore, the doctor, instead of determining “what is better?” use the term “what is optimal?”

Ergoferon or Kagocel?

Both drugs have immunomodulatory and antiviral effects, and also promote the production of interferon. However, Ergoferon is a homeopathic drug, while Kagocel is not. Therefore, Ergoferon is effective only when used in the initial stages of the disease, and if you start taking it on the 2nd - 4th day of ARVI, it will be useless. Kagocel, unlike Ergoferon, is effective at any stage of the disease.

Currently, the cost of a package of 20 tablets of Ergoferon in pharmacies in Russian cities is 265 – 353 rubles.

Author: Nasedkina A.K. Specialist in research of biomedical problems.

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