Erespal syrup side effects

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Erespal instructions

Erespal is a bronchodilator and anti-inflammatory drug intended for the treatment of inflammatory diseases of the upper and lower respiratory tract, accompanied by severe inflammation, edema and bronchospasm.

Table of contents:

It contains an active substance - fenspiride hydrochloride, which belongs to the pharmacological group - H1-antihistamines and is therefore an anti-inflammatory agent, with an antihistamine, myotropic antispasmodic and antiexudative mechanism of action and has a bronchodilator effect. Therefore, this drug is one of the drugs included in regimens for the complex treatment of bronchial asthma.

Phakmacodynamics of Erespal

The mechanism of action of erespal is its pronounced anti-inflammatory, anti-edematous and antispasmodic effect on the mucous membrane of the upper and lower respiratory tract, as well as its anticonstrictor effect on the bronchial tree. Its action is based on active blockade of H1-histamine receptors, inhibition of arachidonic acid metabolism and blockade of alpha-adrenergic receptors. The effect of fenspiride on arachidonic acid metabolism occurs indirectly through calcium metabolism, which is a regulator of the activity of phospholipase A, which promotes the formation of arachidonic acid. Thus, it antagonizes the mediators of allergy and inflammation - histamine, serotonin and bradykinin, reduces the production of leukotrienes and prostaglandins, which are also stimulated by histamine, and reduces the secretion of bronchial glands and has a chemotactic effect. When used in high doses, fenspiride significantly inhibits the production of inflammatory agents in the mucous membranes: free radicals, cytokines, tumor necrosis factor alpha and arachidonic acid metabolites. Some of these inflammatory factors have a bronchoconstrictor effect, so a decrease in their production causes an antiasthmatic and bronchodilator effect. In this regard, the activity and release of a number of factors that contribute to the development of inflammation, hypersecretion of inflammatory agents and bronchial obstruction decreases. It also has a paperrine-like myotropic antispasmodic effect.

Fenspiride in its mechanism of action differs from all anti-inflammatory drugs (non-steroidal and steroidal anti-inflammatory drugs), since it has an original effect on the inflammatory process and affects all inflammatory mediators.

Pharmacokinetics of Erespal

Erespal has good absorption from the gastrointestinal tract. Its maximum concentration in the blood plasma after taking the syrup is achieved after 2.3 hours, and when taken in tablet form - after 6 hours, on average from 0.5 to 8 hours and depends on the absorption capacity of the intestine. Erespal is excreted from the body 90% by the kidneys, and 10% through the intestines. The half-life of the drug from the body is 12 hours.

Instructions for use of Erespal

Due to its high efficiency, excellent anti-inflammatory and bronchodilator effects, this drug is used for most diseases of the upper and lower respiratory tract as an anti-inflammatory, bronchodilator, anti-edematous, antispasmodic agent.

Indications:

  1. Acute nasopharyngitis, acute laryngitis, acute laryngotracheitis;
  2. Acute nasotracheobronchitis, acute bronchitis, acute obstructive bronchitis;
  3. Acute otitis media, acute sinusitis of various etiologies;
  4. Bronchospastic syndrome in acute respiratory infections, acute respiratory viral infections;
  5. Bronchial asthma;
  6. Measles, whooping cough (to eliminate respiratory disorders and bronchospasm);
  7. Infectious diseases of the respiratory tract, complicated by spastic cough syndrome and bronchial obstruction;
  8. Chronic nasopharyngitis, chronic laryngitis and chronic laryngotracheitis;
  9. Chronic bronchitis (against the background of respiratory failure or its absence);
  10. Chronic rhinitis;
  11. Chronic otitis media, chronic sinusitis
  12. Allergic rhinitis.

Instructions for using erespal

This drug has two forms of release: in the form of syrup and tablets and is produced by Servier Laboratories in France.

The syrup is available in 150 ml dark plastic bottles containing 2 mg of the active substance fenspiride per 1 ml of syrup.

The tablet form of erespal is tablets of 15 pieces in a blister, film-coated and containing 80 mg of fenspiride.

The syrup is an orange transparent liquid, taken orally before meals, it is advisable to shake it before use.

The dose for adults and adolescents is: three to six tablespoons per day, which is ml. One tablespoon of syrup contains 30 mg of fenspiride.

For adults, Erespal tablets are prescribed 1 tablet (80 mg) two to three times a day.

For children under fourteen years of age, erespal is prescribed only in the form of syrup.

The recommended dosage is 4 mg/kg per day, which is:

For body weights up to ten kilograms - ml per day, from two to four teaspoons daily, the drug can be added to a bottle of baby food;

from two to sixteen years, with a weight of more than ten kilograms, the recommended dose is 2-4 tablespoons of syrup, which corresponds to 1 ml daily.

Contraindications

Contraindications for use are individual hypersensitivity to the active substance of the drug - fenspiride hydrochloride or another component included in the drug (most often to Sunset Yellow CFC dye or propylarbenam).

Taking the tablet form of the drug is also contraindicated for children under 14 years of age.

Special instructions and interactions with other drugs

This drug should be taken with caution in patients with fructose intolerance, with glucose-galactose maladsorption, in patients with diabetes mellitus and with isomaltose deficiency (due to the presence of sucrose in the drug).

It is not recommended to take the drug together with acetylsalicylic acid and other non-steroidal anti-inflammatory drugs due to the possibility of developing allergic reactions, including bronchospasm.

It is also not recommended to prescribe erespal together with a sedative group of drugs, since their interaction can lead to potentiation of the sedative effect and cause severe weakness and drowsiness (histamine H1 receptor blockers have their own sedative effect).

For the same reason, it is not advisable to combine the use of erespal and alcohol.

For inflammatory diseases of infectious origin, complicated by bacterial infection, erespal is prescribed in combination with antibacterial drugs.

Side effects of Erespal

Side effects of erespal include changes in the central nervous system in the form of drowsiness and dizziness;

from the cardiovascular system - palpitations and moderate tachycardia, which decreases with decreasing dose of the drug;

from the digestive system - gastrointestinal disorders, nausea, epigastric pain, sometimes vomiting and diarrhea;

Allergic reactions may also occur in case of individual sensitivity to the drug in the form of erythema, urticaria, angioedema, as well as asthenia, fatigue, and fixed erythema pigmentosa.

If any of these symptoms occur, you should immediately stop using Erespal and consult your doctor.

Overdose

An overdose of a drug occurs when the drug is taken in dosages exceeding the average daily allowable dose, when the drug accumulates in the body, which occurs when it is taken for a long time or when excretion is impaired.

Symptoms of an overdose of erespal are agitation or drowsiness, nausea, vomiting, and sinus tachycardia.

Sometimes situations arise when a small child drinks a large amount of the drug. In the case of erespal, this can be extremely dangerous due to its adrenergic blocking and histamine blocking effects, which can provoke an attack of sinus tachycardia, accompanied by severe weakness, drowsiness or overexcitation.

All organs and systems of the child’s body are characterized by ongoing differentiation, and therefore insufficient stability and a paradoxical reaction to a large simultaneous administration of the drug, and the delicate gastric mucosa contributes to faster absorption of the drug into the bloodstream. Therefore, if a situation arises where a child, out of ignorance or out of curiosity, takes a large dose of erespal, it is necessary to immediately contact a medical institution for medical help for gastric lavage and, if necessary, symptomatic drug therapy, detoxification measures and ECG monitoring.

Also no less dangerous when taking a large amount of the drug, both in children and adults, especially in old age, is the occurrence of allergic reactions in the form of angioedema or Quincke's edema, which are immediate-type allergic reactions and are characterized by a rapid course. Therefore, if they occur, you must immediately contact a medical facility.

Instructions for using erespal during lactation and pregnancy

Taking this medicine during pregnancy is not recommended, as there is always a risk of adverse effects of the medicine on the embryo (if used in the early stages) or on the developing fetus (in later stages of pregnancy). Some sources contain data on the teratogenic effect of fenspiride hydrochloride with the development of an anomaly of the upper palate in the form of a “cleft palate”. But therapy with erespal is not a basis for termination of pregnancy, since in general there is no clinical data on its teratogenic effect, and in this case the protective properties of the fetoplacental barrier and the individual characteristics of the course of pregnancy and the activity of the mother’s excretory systems should not be excluded.

Also, when breastfeeding a child, taking Erespal is not recommended, since the active components of the drug that enter breast milk can enter the child’s body and adversely affect its organs and systems, in particular causing increased drowsiness or overexcitation, as well as sinus tachycardia. Taking this drug is possible only if you stop breastfeeding for a while, due to the fact that studies on the concentration of the active substance in breast milk have not been conducted and for a child, especially a newborn, they may exceed the maximum permissible dose of the drug for his weight.

Practice of using erespal and reviews

Erespal is an excellent development of the pharmacological company Servier Laboratories, introduced in Russia back in 1998 and today is a very effective and popular drug that is widely used in medical practice - therapy, otolaryngology and pediatrics, as an anti-inflammatory and bronchodilator drug. It is prescribed for inflammatory diseases of the upper and lower respiratory tract of infectious and allergic origin, which are accompanied by spasm and severe cough - acute and chronic laryngitis, pharyngitis, laryngotracheitis, acute, chronic and obstructive bronchitis. It is also effective as a symptomatic remedy used in complex therapy for severe cough and spasm of the larynx and bronchi with whooping cough and parawhooping cough, spasmodic cough with measles and parainfluenza infection. Erespal has a potentiating anti-inflammatory effect when used together with antibacterial drugs for infectious and colds of the upper and lower respiratory tract, complicated by bacterial infection.

This drug is very effective in complex and maintenance therapy regimens for bronchial asthma, which is due to its dual mechanism of action at all stages of the development of the pathological process in this disease - bronchodilation, inhibition of mucus production, anti-edematous and anti-inflammatory effect, as well as inhibition of the production of histamine and serotonin, which potentiates its antiallergic effect.

Erespal is used in otolaryngology for the treatment of acute and chronic inflammatory processes of the paranasal sinuses and nasal cavity - sinusitis and rhinitis. It is used in combination with other drugs: antibacterial, desensitizing and local anti-inflammatory drugs. In this case, erespal, which has an anti-inflammatory effect on the mucous membrane of the paranasal sinuses and a stimulating effect on mucociliary transport, has proven itself in the treatment of purulent and pollipous sinusitis and rhinosinusitis.

Its effective practical use in combination with desensitizing drugs allows us to recommend erespal for the treatment of patients with combined chronic inflammation in the upper and lower respiratory tract, including bronchial asthma, subacute laryngotracheitis and exacerbations of chronic laryngitis.

In clinical use, the drug has excellent tolerability, even with long-term use.

Erespal storage conditions

Like all medications, erespal must be used only before its expiration date. It can be stored for no more than three years in a sealed form.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/116-erespal-instruktsiya

Erespal

Prices in online pharmacies:

Erespal is an anti-inflammatory drug used to treat bronchopulmonary diseases.

Release form and composition of Erespal

Erespal is available in the form of white round tablets and in the form of an orange transparent syrup, the main active ingredient of which is fenspiride hydrochloride.

The following are used as excipients:

  • in tablets - calcium hydrogen phosphate, povidone, hypromellose, anhydrous colloidal silicon dioxide, magnesium stearate;
  • in syrup – licorice root extract, flavoring composition, vanilla tincture, sunset yellow dye, glycerol, saccharin, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sucrose, potassium sorbate, purified water.

Pharmacological action of Erespal

Fenspiride, which is the main active ingredient of Erespal, has antibronchoconstrictor and anti-inflammatory effects, the mechanism of which is based on a decrease in the production of biologically active substances such as cytokines, including tumor necrosis factor α, free radicals, arachidonic acid derivatives, which are active participants in bronchospasm and the process inflammation.

Fenspiride inhibits the metabolism of arachidonic acid by blocking histamine H1 receptors . Fenspiride also blocks α-adrenergic receptors, which, when stimulated, increase the secretion of the bronchial glands. Thus, fenspiride reduces the effect of factors contributing to bronchial obstruction and the development of inflammation.

Fenspiride also has an antispasmodic effect.

Indications for use of Erespal

According to the instructions, Erespal can be prescribed in the presence of diseases of the upper and lower respiratory tract, such as:

  • bronchial asthma (in complex therapy);
  • bronchitis;
  • tracheobronchitis;
  • laryngitis and rhinopharyngitis;
  • influenza, measles, whooping cough, which are accompanied by hoarseness, cough, sore throat;
  • respiratory tract infections accompanied by cough, when patients are prescribed standard antibiotic therapy;

as well as for sinusitis and otitis of various etiologies.

Contraindications to the use of Erespal

According to the instructions, Erespal is not used:

  • up to 2 years of age (syrup);
  • under 18 years of age (tablets);
  • if the patient is hypersensitive to the main substance of the drug and its other components.

Erespal syrup, due to the presence of sucrose in it, is cautiously prescribed to persons with diabetes mellitus, glucose/galactose malabsorption syndrome, fructose intolerance, and sucrase/isomaltase deficiency.

Directions for use and dosage of Erespal

The drug is intended for oral administration.

  • Tablets – 2-3 times a day, 80 mg. In this case, the daily dose of the drug should not exceed 240 mg. Erespal tablets are intended only for patients over 18 years of age. Before reaching this age, syrup is prescribed.
  • Children weighing up to 10 kg – one ml per day (possibly adding syrup to a bottle of baby food);
  • Children weighing more than 10 kg – one ml per day;
  • Children over 2 years old - at the rate of 4 mg per kg of body weight per day;
  • For teenagers and adults – one ml per day.

The syrup is taken before meals.

Erespal syrup must be shaken before use.

15 ml of syrup contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.

The duration of use of the drug is determined by the doctor.

Side effects of Erespal

According to reviews, Erespal may cause side effects.

Digestive system: nausea, gastrointestinal disorders, epigastric pain, vomiting, diarrhea.

Cardiovascular system: moderate tachycardia.

Nervous system: drowsiness, dizziness.

Skin: erythema, urticaria, rash, fixed erythema pigmentosa, angioedema, skin itching, hypersensitivity reactions to the yellow dye included in Erespal.

Other: increased fatigue, asthenia.

If any side effects occur while taking the drug, the patient should inform the doctor.

Overdose

According to reviews of Erespal, an overdose of the drug manifests itself in the form of: nausea, vomiting, agitation or drowsiness, sinus tachycardia.

Treatment of overdose is limited to performing gastric lavage and maintaining vital functions.

In case of an overdose of Erespal, you should urgently seek medical help.

Use during pregnancy and lactation

During the period of bearing a child, taking the drug is not recommended.

Treatment with this drug is not a reason to terminate an existing pregnancy.

Due to the fact that there is no information about the penetration of fenspiride into breast milk, Erespal is not recommended for use during breastfeeding.

Interaction with other drugs

According to reviews of Erespal, special studies aimed at identifying the interaction of this drug with other drugs have not been conducted.

It is not recommended to use Erespal simultaneously with sedatives or ethanol due to their increased sedative effect.

special instructions

When prescribing Erespal to people with diabetes, it should be taken into account that one teaspoon of syrup contains 3 g of sucrose, and one tablespoon contains 9 g.

Erespal syrup contains parabens, so the use of this form of the drug can cause allergic reactions, including delayed ones.

When treating patients under 18 years of age, the drug is used only in syrup form.

Special studies aimed at studying the effect of taking Erespal on the ability to drive a car and operate various mechanisms have not been carried out. But, nevertheless, patients should be aware of the likely development of drowsiness when using this drug (this applies to a greater extent to the initiation of treatment and the simultaneous use of Erespal with alcohol).

Erespal's analogs

Analogs of Erespal are drugs such as Fenspiride and Fenspiride hydrochloride.

Erespal storage conditions

Erespal is stored in places with limited access to children at a temperature not exceeding 25º.

Erespal syrup 2 mg/ml 150 ml

Erespal syrup 150ml

Erespal syrup 2mg/ml 150ml n1

Erespal syrup 150 ml

Erespal tablets 80 mg 30 pcs.

Erespal tab. p.p.o. 80mg n30

Erespal 80mg No. 30 tablets

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Source: http://zdorovi.net/preparaty/jerespal.html

Erespal

Content

Pharmacological properties of the drug Erespal

fenspiride (8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4,5]decan-2-one hydrochloride) has an anti-inflammatory and antibronchoconstrictor effect, which is due to the complex mechanism of action of the drug: blocking H1-histamine receptors, what causes antihistamine and antispasmodic effects; anti-inflammatory effect due to a decrease in the production of various inflammatory factors (cytokines, TNF-α, arachidonic acid derivatives, free radicals), some of which can cause bronchospasm; blocking α1-adrenergic receptors responsible for the secretion of viscous mucus.

The maximum concentration in blood plasma is achieved on average 6 hours after oral administration in the form of tablets and 2.3 ± 2.5 hours (range of fluctuations from 0.5 to 8 hours) in the form of syrup. The half-life is 12 hours. It is excreted mainly in the urine.

Indications for use of the drug Erespal

Acute and chronic inflammatory diseases of the ENT organs and respiratory tract (otitis, sinusitis, rhinitis, nasopharyngitis, tracheitis, rhinotracheobronchitis, bronchitis), COPD with or without respiratory failure, as part of complex therapy for BA; seasonal or year-round allergic rhinitis and other allergy symptoms from the ENT organs and respiratory system; respiratory manifestations of measles, influenza; symptomatic treatment of whooping cough.

Use of the drug Erespal

For children from 0 to 14 years old, the daily dose of syrup is 4 mg/kg. The daily dose should be divided into 2-3 doses.

Children weighing up to 10 kg: the daily dose is 2 to 4 teaspoons of syrup (10–20 ml). The daily dose should be divided into 2-3 doses. Erespal syrup can be added to baby food bottles. 1 teaspoon of syrup (5 ml) contains 10 mg of fenspiride hydrochloride.

Children weighing from 10 kg to 45 kg: the daily dose is 2–6 tablespoons (30–90 ml) of syrup per day, apply before meals.

For ease of use, children over 14 years of age and adults are recommended to use Erespal in tablets.

Tablets are used before meals.

Typically, the recommended therapeutic dose for the treatment of chronic inflammatory processes is 2 tablets per day (morning and evening). To enhance the effect and/or in case of acute illness - 3 tablets per day (morning, afternoon and evening).

The duration of treatment depends on the indications for use and the course of the disease. The minimum course of treatment for acute conditions is 7–10 days. The duration of treatment for chronic conditions is from 2 to 6 months.

Contraindications to the use of the drug Erespal

Hypersensitivity to fenspiride or other components of the drug.

Side effects of the drug Erespal

Nausea, gastralgia, drowsiness are possible, rarely - moderate sinus tachycardia, which disappears when the dose is reduced, urticaria, erythema, rashes, Quincke's edema.

Special instructions for the use of the drug Erespal

It is not recommended to take during pregnancy and breastfeeding.

The use of Erespal does not replace the prescription of antibiotics.

Erespal drug overdose, symptoms and treatment

Manifested by drowsiness, agitation, nausea, vomiting, sinus tachycardia. Gastric lavage, ECG monitoring, and symptomatic therapy are recommended.

Source: http://www.minclinic.ru/drugs/E/erespal.html

Medical card

A bad doctor treats a disease, a good doctor treats the cause of the disease.

Erespal

"Erespal" is a medical product for the prevention and treatment of diseases of the respiratory system and ENT organs. The therapeutic effect is provided by the active substance - fenspiride hydrochloride. Erespal belongs to the group of anti-inflammatory antibronchoconstrictor drugs. In pharmacies, the price of this medicine, depending on different dosages and forms, ranges, on average, from 210 to 430 rubles.

Indications and contraindications for use

Indications

"Erespal" is prescribed for the following diseases:

  • Lung diseases: chronic bronchitis (with and without respiratory failure), bronchospasm, bronchial asthma (including for the purpose of maintenance therapy).
  • Diseases of the ENT organs: pharyngitis, rhinopharyngitis, sinusitis, rhinitis, otitis media, laryngitis.

Indications for the use of the drug are also rhinitis of allergic origin, which is seasonal or permanent. Erespal is also prescribed to reduce respiratory syndromes in infectious diseases (acute respiratory infections, influenza, measles, whooping cough).

Contraindications

Erespal is contraindicated in case of hypersensitivity to fenspiride hydrochloride and in case of individual intolerance to certain components of the drug. Erespal in tablet form is also contraindicated in children under 14 years of age.

"Erespal" during pregnancy and breastfeeding

You should also refrain from using the drug during pregnancy due to insufficient data on clinical trials. At the same time, treatment with fenspiride in the event of pregnancy is not a basis for its termination. During breastfeeding, it is recommended to stop taking Erespal. In case of urgent need to take the drug, it is advisable to interrupt breastfeeding for a while - due to the lack of data on the excretion of Erespal together with breast milk.

pharmachologic effect

The active ingredient of the drug "Erespal" - fenspiride hydrochloride - has an anti-inflammatory effect, suppresses exudation and prevents bronchoconstriction. Fenspiride inhibits the metabolism of arachidonic acid, resulting in an anti-inflammatory effect of the drug. The antibronchoconstrictor effect is due to a decrease in the production of biologically active substances (histamine, serotonin, bradykinin). Fenspiride also has a blocking effect on α-adrenergic receptors (due to their stimulation, the secretion of bronchial secretions increases).

Release form

  • Tablets in a white coating, one tablet contains 80 mg of fenspiride hydrochloride. The cardboard packaging contains 2 blisters of 15 tablets each (total quantity - 30 pieces).
  • Syrup 200 mg fenspiride hydrochloride for every 100 ml. Each 150 ml bottle is placed in a cardboard package.

"Erespal" in the form of syrup can be stored for 3 years, in the form of tablets - 2 years. It is recommended to store the medicine at room temperature.

Dosage and method of administration

The required dosage of Erespal depends on the form of the medicine:

  1. Tablets: adults and children from 14 years of age and above - one tablet in the morning and evening (2 times a day). Total daily dose of drugs mg. If necessary, the daily dose can be increased to 320 mg - it should be divided into 2-3 doses.
  2. Syrup: children over 14 years old, adults - from 3 to 6 tablespoons of the drug 2 times a day (45-90 ml). One tablespoon of the drug contains: active ingredient fenspiride hydrochloride - 30 mg, sucrose - 9 g.

For children who have not yet reached the age of 14 years, Erespal is prescribed only in the form of syrup. The required dosage depends on the body weight and age of the patient:

  • up to 1 year (up to 10 kg weighing): 1-2 teaspoons of syrup 2 times a day; 4 mg per kilogram of weight.
  • over 1 year (weight more than 10 kg): 2 times a day, 1-2 tablespoons.

Erespal is taken before meals. The maximum course of treatment with fenspiride varies from 20 days to 1 month. Repeating the course is possible only after preliminary consultation with the treating doctor. Treatment with Erespal is not an alternative to antibacterial therapy and does not serve as a basis for postponing the prescription of antibacterial drugs.

Side effects

Erespal can cause the following side effects:

  • CNS: dizziness, drowsiness.
  • Cardiovascular system: tachycardia (with decreasing dosage its severity decreases).
  • Digestive system: nausea, diarrhea, vomiting, gastrointestinal disorders, discomfort (pain) in the epigastric region.
  • Skin: rash, erythema, urticaria, itching, angioedema.
  • General: asthenic disorder, increased fatigue.

Overdose

An overdose of Erespal can be judged by the following symptoms: nausea and vomiting, sinus tachycardia, agitation or drowsiness. In case of overdose, gastric lavage, ECG monitoring, and symptomatic treatment are prescribed.

Total score: 5 Votes: 7

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I suffer from chronic sinusitis and if a cough starts, it may not go away for a very long time and quite often turns into bronchitis. (And there it’s not far from pneumonia) Therefore, there is always an erespal in the home medicine cabinet. A truly effective medicine, although I would not recommend taking it to people who have problems with the stomach and pancreas (read side effects).

I was prescribed this drug for severe ARVI, to treat a persistent cough and runny nose. When all sorts of Lazolvans and Ambrobenes did not help. The drug helped quite quickly, by the third day of treatment, the cough became much less, and the swelling of the nasal mucosa subsided. At first I was scared that the instructions for the drug contained a huge list of side effects. But I didn’t have them at all, apparently everything is individual. But despite the synthetic composition, the drug is excellent.

the drug is excellent! The cough went away instantly!

Source: http://www.goagetaway.com/page/erespal

Erespal syrup for children: instructions for use

Erespal syrup for children represents a clinical and pharmacological group of drugs with antiallergic, anti-inflammatory, and antispasmodic effects. It is used for children and adults to treat inflammatory pathologies mainly of the respiratory system, which is accompanied by spasm of hollow structures.

Compound

Erespal syrup for children is a transparent (slight opalescence is allowed) yellow-brown liquid. The main active ingredient of the drug is fenspiride hydrochloride, its content in 1 ml of syrup is 2 mg. Excipients include:

  • Licorice root extract.
  • Sucrose.
  • Vanilla tincture.
  • Glycerol.
  • Potassium sorbate.
  • Glycerol.
  • Methyl parahydroxybenzoate.
  • Propyl parahydroxybenzoate.
  • Flavoring composition.
  • Purified water.

Erespal syrup for children is in a dark plastic bottle of 150 ml. The cardboard pack contains 1 bottle of syrup and annotation.

Action

The main active component of Erespal syrup for children, fenspiride, suppresses the activity of a number of biologically active compounds that are produced at the site of the pathological process (cytokines, tumor necrosis factor, prostaglandins, which are a chemical derivative of arachidonic acid). Due to the suppression of biologically active compounds, several therapeutic effects of the drug are realized, which include:

  • Anti-inflammatory effect – reducing the severity of inflammation, namely pain, tissue swelling and hyperemia (increased blood supply to tissue vessels in the area of ​​the pathological process).
  • Antihistamine effect - blocking H-histamine receptors, which are responsible for the development of an allergic reaction with the appearance of discomfort in the form of itching, burning, bronchospasm, tissue swelling.
  • The antispasmodic effect is a decrease in the tone of the smooth muscles of the respiratory tract, namely the bronchi of various sizes with the expansion of their lumen.

After taking Erespal syrup for children orally, the active substance is well absorbed into the systemic bloodstream. It is processed in the liver, and breakdown products are excreted primarily in the urine. The half-life (the time it takes to eliminate half of the entire dose of the drug) is about 12 hours.

Indications

The main medical indication for taking Erespal syrup in children is the presence of inflammatory pathology of the respiratory system, which includes:

  • Acute or chronic bronchitis is inflammation of the bronchial mucosa caused by various reasons.
  • Tracheobronchitis is a combined inflammation of the trachea and bronchi.
  • Rhinopharyngitis is a lesion of the nasal and pharyngeal mucosa.
  • Laryngitis is an inflammatory lesion of the larynx.
  • Otitis and sinusitis are diseases of the middle ear and paranasal sinuses.

Taking the drug is also indicated during combination therapy for infectious pathologies localized in the respiratory organs.

Contraindications

Taking Erespal syrup for children is contraindicated in the presence of individual intolerance to any of the components of the drug, as well as in children under 2 years of age. The drug is used with caution against the background of concomitant disturbances in the digestion and absorption of carbohydrates (glucose-galactose malabsorption, deficiency of the digestive enzyme lactase), as well as in patients with diabetes mellitus. Before starting to use the drug, it is important to ensure that there are no contraindications.

Dosage

Erespal syrup for children is taken orally. The bottle should be shaken well before use. The average therapeutic dosage for children over 2 years of age is 4 mg of the active ingredient per 1 kg of body weight. For a child weighing up to 10 kg, the average dose is 2-4 teaspoons per day before meals. For body weight more than 10 kg - 2-4 tablespoons. For children over 12 years of age and adults, the therapeutic dose varies from 3 to 6 tablespoons per day. The duration of therapy using Erespal syrup is determined individually by the attending physician.

Side effects

With the use of Erespal syrup, the development of negative reactions from various organs and systems is possible:

  • Digestive system - nausea, pain in the stomach, less often vomiting and diarrhea (diarrhea) may develop.
  • Nervous system – drowsiness, periodic dizziness.
  • Cardiovascular system - a moderate increase in heart rate (tachycardia), a decrease in systemic blood pressure, and the appearance of an unpleasant sensation of palpitations.
  • Skin and subcutaneous tissue - redness, less often rash, itching of the skin, necrotizing dermatitis with the death of a significant number of skin cells.

If signs of negative reactions develop while taking Erespal syrup, you should contact a medical specialist.

Peculiarities

Before you start using Erespal syrup, it is important to carefully read the instructions for it, and also pay attention to several special instructions:

  • The drug contains parabens, which can cause delayed allergic reactions.
  • Erespal syrup contains sucrose, which should be taken into account when using it in patients with concomitant diabetes mellitus.
  • The drug is not recommended for pregnant women, as its safety remains unclear.
  • After taking the drug, it is not recommended to engage in activities that require increased concentration of attention and speed of psychomotor reactions.

In the pharmacy chain, Erespal syrup for children is available with a prescription. Self-administration of the drug without a doctor's prescription is not recommended.

Overdose

If the recommended therapeutic dosage of Erespal syrup is significantly exceeded, drowsiness or agitation, nausea, periodic vomiting, and increased heart rate develop. Treatment of overdose consists of gastric lavage, taking enterosorbents (activated carbon), as well as prescribing symptomatic therapy. There is no specific antidote for the drug today.

Analogs of syrup for children Erespal

For the drug Erespal, similar ones are Fenspiride, Eladon, Epistat.

Storage

The shelf life of Erespal syrup for children is 3 years. It should be stored in its original packaging, in a dark, dry place, out of reach of children, at an air temperature not exceeding +25° C.

The average cost of a package of Erespal syrup for children in Moscow pharmacies varies within rubles.

Source: http://bezboleznej.ru/erespal-sirop-dlya-detey

Erespal

— CLD: bronchial asthma, chronic bronchitis, including symptoms of bronchial obstruction;

- diseases of ENT organs: rhinitis, nasopharyngitis, otitis, sinusitis;

— reduction of respiratory syndromes during acute respiratory infections, whooping cough, measles;

Erespal - has an anti-inflammatory effect, inhibits exudation, prevents bronchoconstriction. The anti-inflammatory effect of fenspiride is due to inhibition of arachidonic acid metabolism, and the antibronchoconstrictor effect is achieved by reducing the production of biologically active substances: serotonin, histamine (at the level of blockade of H1 receptors), bradykinin. It also blocks α-adrenergic receptors, the stimulation of which causes an increase in the production of bronchial secretions.

Adults and children over 14 years old: 1 tablet (80 mg) morning and evening or 3-6 tablespoons (45-90 ml) of syrup. If necessary, the daily dose can be increased to 320 mg, dividing it into 2-3 doses.

Intolerance to any of the components of the product.

From the gastrointestinal tract: nausea, vomiting, discomfort in the epigastric region.

Allergic reactions: more often urticaria, less often Quincke's edema. Usually associated with taking syrup, due to the presence of para-hydroxybenzoate in it.

Other side effects: drowsiness, slight tachycardia. In cases of tachycardia, it is necessary to reduce the dose of the product.

During pregnancy, Erespal is not prescribed, since there is no convincing clinical evidence of the absence of terratogenic and fetotoxic effects. At the same time, taking fenspiride is not an indication for terminating a pregnancy that occurs while taking it.

During Erespal therapy, it is necessary to interrupt breastfeeding, due to the lack of data on the excretion of fenspiride in breast milk.

Symptoms of overdose: nausea, vomiting, agitation, tachycardia, drowsiness. There are no special antidotes; in cases of overdose, gastric lavage, symptomatic therapy, and ECG monitoring are recommended.

The interaction of Erespal with other medicinal products has not been described.

Film-coated tablets, white No. 30.

Syrup 150 ml, 200 mg/100 ml, No. 1.

The drug should be stored at room temperature. The shelf life of Erespal in syrup form is 3 years, in tablet form - 2 years.

Each tablet contains 80 mg of fenspiride hydrochloride and excipients: calcium hydrogen phosphate, hypromellose, povidone, silicon dioxide, magnesium stearate, titanium dioxide, glycerol, macrogol 6000.

The use of Erespal does not replace antibiotic therapy.

For patients with diabetes, the product is prescribed mainly in tablet form, since the syrup contains sucrose.

The drug belongs to the prescription group, so you should consult a doctor before using it.

Before using Erespal, you should consult your doctor.

The instructions are provided solely for familiarization with Erespal.

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ALPHABETIC INDEX

Medprep.info is a leading reference book for medications and diseases with detailed instructions and photos.

This material is for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Source: http://medprep.info/drug/medicament/2721

Erespal instructions for use, contraindications, side effects, reviews

Erespal - a new description of the drug, you can read the contraindications, indications for use, dosage of the drug Erespal. Reviews about Erespal -

A drug with anti-inflammatory and antibronchoconstrictor activity.

Active ingredient of the drug: fenspiride

ATX encoding: R03DX03

KFG: A drug with anti-inflammatory and antibronchoconstrictor activity

Reg. number: P No. 012547/02

Registration date: 08.26.05

Owner reg. Credit: Les Laboratoires SERVIER

Erespal release form, drug packaging and composition.

White film-coated tablets, round, biconvex.

Excipients: calcium hydrogen phosphate, hypromellose, povidone, colloidal anhydrous silicon dioxide, magnesium stearate, titanium dioxide, glycerol, macrogol 6000.

15 pcs. - blisters (2) - cardboard packs.

The syrup is transparent, orange in color, sometimes with a small sediment that disappears when shaken.

Excipients: flavoring composition with hints of honey scent, natural condensed licorice extract, vanilla tincture, glycerol, Sunset Yellow CFC, methyl parahydroxybenzoate, propyl parahydroxybenzoate, saccharin, sucrose, potassium sorbate, water.

150 ml - dark plastic bottles (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

The anti-inflammatory and anti-bronchoconstrictor activity of the drug Erespal is due to the fact that fenspiride reduces the production of a number of biologically active substances (cytokines, especially tumor necrosis factor (TNF-), arachidonic acid derivatives, free radicals), which play an important role in the development of inflammation and bronchospasm. Inhibition of arachidonic acid metabolism by fenspiride is potentiated by blockade of histamine H1 receptors, because histamine stimulates the formation of its products (prostaglandins and leukotrienes). Fenspiride blocks β-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of the bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of proinflammatory factors, the development of inflammation and bronchial obstruction. Fenspiride is also characterized by the presence of antispasmodic activity.

Pharmacokinetics of the drug.

Absorbed from the gastrointestinal tract relatively slowly. After oral administration of tablets, Cmax is achieved after 6 hours, after taking syrup - after 2.3±2.5 hours (from 0.5 to 8 hours).

T1/2 is 12 hours. It is excreted mainly in the urine.

Indications for use:

Diseases of the upper and lower respiratory tract:

- nasopharyngitis and laryngitis;

- otitis and sinusitis of various etiologies, including allergic (both seasonal and permanent);

- bronchitis (with or without chronic respiratory failure);

- complicated or isolated bronchial asthma (maintenance therapy);

- respiratory phenomena with measles, whooping cough, influenza.

Dosage and method of administration of the drug.

For adults, the drug is prescribed 80 mg (1 tablet) 2-3 times a day or 3-6 tablespoons (45-90 ml) of syrup per day. 1 tablespoon contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.

Erespal in tablet form is not intended for the treatment of children under 14 years of age. For use of the drug in children under 14 years of age, Erespal in the form of syrup is recommended.

For children and adolescents under the age of 14 years, the drug is prescribed at the rate of 4 mg/kg body weight/day. Children aged 0 to 2 years (body weight up to 10 kg) - 2-4 teaspoons of syrup (10-20 ml)/day, can be added to a bottle with food (1 teaspoon contains 10 mg of fenspiride hydrochloride and 3 g of sucrose ). Children aged 2 to 16 years (body weight more than 10 kg) - 2-4 tablespoons of syrup (30-60 ml)/day.

Course of treatment days. A repeated course is possible after consultation with a doctor.

The drug should be taken before meals. The syrup should be shaken before use.

Side effects of Erespal:

From the digestive system: nausea, stomach pain, vomiting.

Allergic reactions: very rarely - erythema, angioedema, fixed erythema pigmentosa, rash; Due to the presence of para-hydroxybenzoate in the syrup, urticaria may develop.

Other: drowsiness; rarely - moderate tachycardia, disappearing after discontinuation of the drug.

Contraindications to the drug:

- children under 14 years of age (for tablets);

- hypersensitivity to the active substance and/or any of the components of the drug, especially to the Sunset yellow CFC dye, methyl and propylparabens (for syrup).

Use during pregnancy and lactation.

It is not recommended to use Erespal during pregnancy due to the lack of sufficient clinical data. Fenspiride therapy is not a reason to terminate an ongoing pregnancy.

While taking Erespal during lactation, you should stop breastfeeding, because There is no data on the excretion of fenspiride in breast milk.

Special instructions for the use of Erespal.

If the disease is infectious, treatment with Erespal is carried out in combination with standard antibiotic therapy.

Erespal in the form of syrup is prescribed with caution to patients with hypersensitivity to acetylsalicylic acid and other NSAIDs due to the risk of allergic reactions (including bronchospasm) in this category of patients due to the fact that the syrup contains Sunset Yellow CFC dye .

Since the syrup contains sucrose, it should be administered to patients with diabetes mellitus with caution, because Dosage adjustment of hypoglycemic drugs may be required.

Due to the presence of sucrose, Erespal in syrup form should not be administered to patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrazoisomaltase deficiency (a rare metabolic disorder).

Drug overdose:

Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.

Treatment: gastric lavage, ECG monitoring.

Interaction of Erespal with other drugs.

Drug interactions with Erespal have not been described.

Terms of sale in pharmacies.

The drug is available with a doctor's prescription.

Terms of storage conditions for the drug Erespal.

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C. The shelf life of tablets is 2 years, syrup - 3 years. Do not use after the expiration date indicated on the package.

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Egilok instructions for use, contraindications, side effects, reviews

Egilok - a new description of the drug, you can read the pharmacological action, indications for use, Egilok. .

The material is published for informational purposes only and under no circumstances can it be considered a substitute for medical consultation with a specialist in a medical institution. The site administration is not responsible for the results of using the posted information. For questions of diagnosis and treatment, as well as prescribing medications and determining their dosage regimen, we recommend that you consult a doctor.

Source: http://medistok.ru/je/2992-jerespal-instrukcija-po-primeneniju.html

Instructions for use of Erespal syrup for children: dosage for children aged 1 year and older, analogues of the drug

Cough is a fairly common problem in children who have recently had an acute respiratory viral infection. It can begin quite harmlessly, but over time develop into a serious complication.

There are a number of medications for the treatment of upper respiratory tract diseases that will help get rid of an annoying cough. Today we will look at an unusual drug to eliminate this symptom called Erespal. When it is shown what type of cough it can handle, as well as side effects - all this can be found in our publication.

Erespal syrup 2 mg/ml 150 ml

Release form, composition of the drug and action

Erespal for children is available in the form of syrup, for adolescents and adults - in tablets. The drug contains an active substance - fenspiride hydrochloride, which has several beneficial properties:

  • anti-inflammatory;
  • antiallergic;
  • antispasmodic;
  • prevents the development of the process of narrowing of the bronchi - bronchoconstriction;
  • reduces the production of bronchial secretions.

1 ml of syrup contains 2 mg of the active substance, and the bottle contains 150 (250) ml of the product. One tablet contains 80 mg of fenspiride hydrochloride. Next, let's look at the auxiliary components included in the syrup. There are quite a lot of them, since fenspiride has a not very pleasant bitter taste and the manufacturer is forced to use components to improve it:

  • licorice root extract;
  • glycerol;
  • orange yellow food coloring S;
  • methylparaben (E-218);
  • para-hydroxybenzoic acid ester;
  • sweeteners;
  • potassium salt of sorbic acid;
  • water;
  • flavoring additive "honey".
  • calcium phosphate disubstituted dihydrate;
  • methyloxypropylcellulose;
  • crospovidone;
  • silica;
  • colloidal silicon dioxide anhydrous;
  • magnesium salt and stearic acid;
  • titanium white;
  • glycerol;
  • macrogol 6000.

The drug begins to act within an hour after administration (this is quite normal for syrup). The tablets begin to work in two hours.

Indications for use of syrup

Erespal is prescribed to children and adults to relieve cough. However, the instructions indicate much more indications. Let's look at them in more detail:

  1. Treatment of inflammation of the ENT organs and respiratory tract caused by infection. These include various types of bronchitis, otitis, laryngitis, tracheitis.
  2. Pulmonary obstruction, pneumonia. In this case, Erespal is prescribed in combination with other drugs.
  3. Allergic rhinitis, which appears seasonally or does not go away throughout the year.
  4. Respiratory symptoms of ARVI, influenza, childhood infectious diseases.
  5. Whooping cough.

What type of cough does the remedy help with?

According to experts, Erespal is effective in combating any type of childhood cough. This distinguishes it from the mass of drugs with similar effects, including cough suppressants, expectorants, and mucolytics. Erespal does not belong to the listed groups, since it has several beneficial properties.

The drug Erespal effectively relieves the symptoms of severe cough and reduces sputum production

The instructions for use indicate that Erespal will relieve the symptoms of allergic cough and rhinitis, reduce the formation of sputum and at the same time expand the airways to facilitate its discharge. That is, the drug will help to quickly cope with dry, wet, as well as lingering cough that plagues the patient for many months.

Due to the listed advantages, the syrup can replace several medications that are prescribed for children when coughing - antiallergic drops, mucolytics, expectorants. Moreover, taking it allows you to reduce the list of prescribed medications, especially when it comes to long-term cough.

Erespal dosage for children

Let's consider the dosage of Erespal for children (see also: use of Prospan syrup for children over one year old). The syrup is indicated for children from 24 months. When prescribing it, the doctor is guided by the child’s body weight at the rate of 4 mcg (2 ml of syrup) per 1 kg of the child’s weight. This is the daily dose of the medicine - it should be divided into the number of doses per day, which can be 2 or 3.

Example: a child weighing 9 kg can receive 18 ml of Erespal syrup per day. This means that parents can give the baby 6 ml of syrup 3 times a day.

For children over 12 years of age and adults, the daily dose is prescribed within ml of syrup. However, in this case, it is advisable to use Erespal tablets, which should be taken two pieces a day - morning and evening. In acute cases of the disease, it is allowed to increase the intake - drink 3 tablets per day.

The course of therapy depends on many factors - the dynamics of the disease, individual sensitivity to the drug, the nature of the cough (dry or productive). The doctor prescribes Erespal’s appointment and he also monitors the effectiveness of the treatment. On average, it is recommended to take the medication for a month or until a stable effect appears.

Erespal can be used in combination with antibiotics and other drugs. Syrup is often prescribed as an adjuvant during the treatment of bronchitis and pneumonia. It is only important to correctly distribute the medications. Erespal should be taken before meals, and antibiotics after.

Contraindications for use

If the patient knows that he has an intolerance to one of the components of the drug, then the drug is not prescribed to him. In addition, the instructions for use indicate other contraindications. The tablets are not given to children under 12 years of age, and the syrup is not recommended:

  • children under 2 years old;
  • people with chronic hypertension, heart failure, cirrhosis of the liver, since the composition contains licorice root;
  • during pregnancy and breastfeeding, since research in this direction has not been conducted.

Possible side effects

According to studies, side effects when taking Erespal do not occur often. In children, undesirable consequences were recorded in 2.4% of cases, in adults - a little more (about 8%). According to statistics, gastrointestinal disorders most often occur as side effects while taking Erespal. Abdominal pain, loose stools, nausea, and vomiting are possible. In addition, it is noted:

  • drowsiness;
  • dizziness;
  • increased heart rate;
  • skin manifestations - urticaria, small rash, redness of the skin, itching;
  • asthenic syndrome, general weakness, severe fatigue.

Erespal is not recommended to be taken with antihistamines, since this drug already has an antiallergic effect. Antihistamines can make you drowsy, and cough syrup will make the problem worse.

Cost of the drug and its analogues

Syrup can be bought in pharmacies at prices ranging from 250 to 600 rubles per bottle. The cost does not depend on the manufacturer (domestic medicines are not cheaper than imported ones), but on the volume. The drug is available in bottles of 150 and 250 ml. A package of tablets (30 pieces) costs about 400 rubles.

Analogs of Erespal containing the same active substance are presented in our table. In addition, we indicated the cost of the drugs and the age at which they can be taken.

When purchasing an analogue, you should take into account the auxiliary components, as well as the concentration of the active substance. There is no significant difference in price between Erespal and its analogues, so the choice should be made based on personal preferences.

The pediatrician prescribed Erespal for my child when we couldn’t get rid of a cough for a long time. It helped a lot - the cough began to “fade away” already on the second day, so we didn’t drink it for long. The disadvantages include the not very pleasant taste.

We tried it once, but didn't try again. The syrup helped the child, the cough quickly went away. But still, I try to use herbal products - they are safer for the child. Well, all sorts of rubbing, compresses, baths.

Attention! All information on the site is provided for informational purposes only and is for informational purposes only. For all questions regarding the diagnosis and treatment of diseases, you must consult a doctor for an in-person consultation.

Source: http://vseprorebenka.ru/zdorove/preparaty/erespal-sirop-instrukciya-po-primeneniyu-dlya-detej.html