Fluimucil for cough instructions for use

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Fluimucil powder 200 mg for cough: instructions and reviews of use in children and adults

Respiratory diseases are often accompanied by such an unpleasant symptom as coughing. I want to get rid of it as quickly as possible, regardless of its etiology and type.

Table of contents:

Modern pharmacology provides a wide selection of cough medicines. One of them is Fluimucil powder. Instructions for use contain complete information about the drug. From it we learn that this medicine belongs to the class of mucolytics and has expectorant properties.

Composition (active ingredient)

Fluimucil powder is packaged in multilayer bags in cardboard boxes of 20 or 60 pcs. Each package must contain instructions for use. White granules of the drug Fluimucil with orange splashes have a pronounced citrus aroma with a slight smell of sulfur.

According to the instructions, the active ingredient of Fluimucil powder is acetylcysteine, 200 mg per 1 gram of the drug. In addition to acetylcysteine, the medication also contains aspartame, orange flavor and other excipients.

Is Fluimucil a cough medicine?

Instructions for use state that Fluimucil 200 mg granules help to liquefy secretions, facilitating the release of mucus from the respiratory system.

Acetylcysteine ​​has a destructive effect on the sulfide bonds of the secretion, thereby reducing its viscosity. The medication is also effective in the presence of a purulent component.

According to the instructions for use, Fluimucil powder 200 mg is prescribed in the following cases:

  1. Disturbances in the separation and removal of mucus due to:
  • bronchitis;
  • tracheitis;
  • laryngotracheitis;
  • bronchiolitis;
  • pneumonia;
  • cystic fibrosis;
  • lung abscess.
  1. Sinusitis or sinusitis to facilitate the removal of mucus from the respiratory system.
  2. Post-traumatic or post-operative cases to remove sticky sputum.

Instructions for use of granules 200 mg

Fluimucil powder is a pharmaceutical product for making a solution. According to the instructions for use, the highest concentration of acetylcysteine ​​in plasma occurs 60–180 minutes after consumption. It is excreted unchanged from the body through the kidneys and intestines.

How to breed?

Based on the information in the instructions for use, clean glass or porcelain containers should be used to dilute the powder, avoiding interaction with objects made of metal or rubber. The finished mixture cannot be stored.

What water to dissolve in?

Fluimucil granules are dissolved in 100 ml of clean water. According to the instructions for use, it is recommended to use warm boiled water.

How to use?

The powder is taken orally between meals. For adult patients and children over 6 years of age, the medication is prescribed in the amount of 200 mg in the morning, lunch and evening.

The instructions for use do not recommend taking Fluimucil granules together with other cough medications. This combination promotes mucus retention by inhibiting the cough reflex.

How long can you drink?

According to the instructions, the period of use of the powder is prescribed by a specialist, based on the individual characteristics of the disease in each patient.

In the case of an acute form of the disease, therapy continues for an average of 5–10 days. If the disease is chronic, treatment can be carried out over several months.

Special Notes

Acetylcysteine-based medications are prescribed with caution for bronchial asthma and obstructive bronchitis.

The use of the drug is not recommended for:

  • lactation;
  • hypersensitivity to acetylcysteine ​​or other additional ingredients of the powder;
  • individual fructose intolerance;
  • exacerbation of peptic ulcer of the stomach and duodenum.

Can the powder be used for children?

According to the instructions for use, Fluimucil powder for children under the first 2 years of life is allowed to be used exclusively under the supervision of a pediatrician.

For newborn babies, the solution is prescribed only in case of vital indications, based on the patient’s body weight. For each kg of weight, a dose of 10 mg is indicated. Children from 2 to 6 years old are prescribed 200 mg of powder in the morning and evening.

What kind of reviews does the drug receive?

Fluimucil 200 mg powder receives excellent reviews from patients due to its effectiveness and quick relief from cough. Consumers note its relatively short course of treatment. In the vast majority of cases, the medicine is not addictive, which allows it to be used every time a cough appears for the whole family.

Patients are not satisfied with the high cost of the medication and the presence of the smell of sulfur. This feature of the drug is due to the presence of acetylcysteine ​​in the composition.

Analogs

According to the active substance, there are the following analogues of Fluimucil cough powder:

By pharmacological group, the following similar drugs can be noted:

Useful video

Useful information about the treatment of pneumonia can be found in this video:

Conclusion

  1. According to the instructions, Fluimucil powder is an effective medicine for reducing the viscosity of sputum and facilitating its removal from the respiratory system.
  2. A small number of contraindications and a high rate of achieving a therapeutic effect allow the drug to remain popular, despite its high cost.
  3. Under the strict supervision of a pediatrician, the use of Fluimucil powder in children from birth is allowed.

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Source: http://www.pulmonologiya.com/preparaty/kashel/poroshok-fluimutsil-200.html

Cough syrup "Fluimucil": taking the drug, contraindications

Fluimucil cough syrup is recommended for oral administration to children. The manufacturer offers a solution of 20 mg/ml for children from 2 to 5 years old. It is a clear, colorless liquid with a raspberry odor.

For older children, a 40 mg/ml form is available that has a strawberry or pomegranate scent. The drug is manufactured in Switzerland by the pharmaceutical company Zambon Switzerland Ltd.

Fluimucil is the trade name of a drug that uses the active substance acetylcysteine. It is known to consumers from the drug ACC. Cough syrup is recommended by doctors for the treatment of dry cough in children and adolescents. It is also prescribed for inflammation of the middle ear in children to dilute and remove secretory fluid.

Why does the product help?

Fluimucil cough syrup is called a mucolytic agent by the instructions for use. It thins sputum, increasing its quantity and facilitating the removal of secretions from the lungs. The drug is useful in the formation of viscous mucus, which needs to be evacuated from infected respiratory organs.

Fluimucil for children in the form of syrup has the ability to transform a dry cough into a productive form, remove signs of the inflammatory process and increase local immunity. Acetylcysteine ​​in liquid form is well absorbed in the intestines. Together with the blood, it is evenly distributed in the liver, kidneys, lungs and secretions produced by the bronchi.

Fluimucil for children in syrup form has the ability to transform dry cough into a productive form

The active substance easily penetrates into the cell, where, under the influence of biochemical reactions, it is first synthesized into a tripeptide, which is responsible for the health of the human body. It is then transformed into the amino acid cysteine, which is a proteinogenic amino acid. This biochemical compound can effectively cleanse the body of toxic substances, free radicals, and pathogenic agents. Cysteine ​​is involved in the regeneration of tissues and organs, maintaining the body in functional balance.

Acetylcysteine ​​metabolites are excreted from the body 3 hours after ingestion by the kidneys. If there are diseases of the urinary system, the excretion of the active substance in the form of inactive metabolites is delayed for up to 8 hours. This feature of the elimination mechanism requires reducing the number of single doses per day in children with diseased kidneys.

On a note! Acetylcysteine ​​helps detoxify harmful substances formed in cells during viral infection.

This allows you to achieve a quick recovery when treating colds in a child. A positive therapeutic effect is achieved when traditional drugs do not give the desired result.

Fluimucil is used for bronchitis

When does the drug help?

Preparations with acetylcysteine ​​are recommended in pulmonology. The effectiveness and safety of their use in patients of all ages has been confirmed by numerous studies in many countries.

Fluimucil in the form of cough syrup for children is prescribed for diseases when there are disturbances in the discharge of secretory fluid. It could be:

These diseases require mucolytic therapy, and acetylcysteine ​​performs its functions well. It actively dissolves mucus that is excessively formed when an infection enters the respiratory system. After this, the respiratory organs can evacuate excess secretory fluid by activating the cough center. The processes of cleansing the respiratory system begin an hour after taking the medicine and actively continue for about 3 hours, bringing significant relief to the sick child.

On a note! The medicine works especially well for inflammation of the trachea.

The drug is used for pneumonia

With this disease, a dry, tearing cough is observed, which is accompanied by chest pain. Tracheitis is often complicated by shortness of breath. Then small children suffer from lack of oxygen. Dry cough with this disease worsens at night and is difficult to stop. It is not always possible to cure it with traditional means. Acetylcysteine ​​allows you to quickly remove the unpleasant symptoms of this acute disease.

The drug is recommended after surgery on the respiratory system. It is taken to perform diagnostics before tracheotomy.

When to give it up

The drug is well tolerated by patients, and no overdose is observed at a dose of 500 mg/kg/day. The medicine is discontinued if symptoms of individual intolerance to the active substance or other components included in the syrup appear.

The drug cannot be used for treatment if there is hereditary fructose intolerance.

For varicose veins of the esophagus, the medicine should be taken under medical supervision

The syrup is not given to children under 2 years of age because the effect of the medicine has not been studied in this group of patients. The medicine should not be used during exacerbation of gastric ulcer. Since the active substance passes the placental barrier, it cannot be used without a doctor’s recommendation during pregnancy and lactation.

The medicine is used under medical supervision if there is a history of:

  • varicose veins of the esophagus;
  • bleeding;
  • kidney and liver failure;
  • low pressure;
  • adrenal gland diseases.

The medicine may cause heartburn

While taking the drug, side effects and signs of individual intolerance may appear. It could be:

If such signs appear, refuse the drug and inform the attending physician. Further treatment against the background of such symptoms can lead to collapse.

Important! For treatment to be effective, acetylcysteine ​​should not be mixed with antitussive drugs.

Some antibiotics, when mixed with cysteine, reduce their effect on pathogenic microflora. They, in turn, worsen the effectiveness of Fluimucil. If you use nitroglycerin during treatment with this drug, its activity increases, which will cause severe headaches due to a sharp dilation of blood vessels.

Some antibiotics, when mixed with cysteine, reduce their effect on pathogenic microflora

How do consumers respond to the drug?

The drug is usually prescribed by a pediatrician, who first determines the cause of the cough and makes a diagnosis. When prescribed correctly, cough syrup performs its functions well. When self-medicated, the drug may be ineffective.

Fluimucil cough syrup for children has different reviews. The remedy was not suitable for a small number of small patients due to individual intolerance. Some mothers found that drugs with other active substances had a better effect on their children than acetylcysteine.

When prescribed correctly, cough syrup performs its functions well

But mostly parents responded positively to Fluimucil. They note that the syrup works well as a mucolytic agent. The cough after several single doses becomes moist and unobtrusive. If the functioning of the vocal cords is disrupted, the voice is restored. Night attacks stop bothering children during sleep. Parents claim that taking the last dose 2 hours before bedtime allows the child to sleep peacefully throughout the night.

Mothers, comparing the effects of Fluimucil cough syrup, reviews of which are posted on many sites, with other drugs, indicate that the product helps in the most difficult cases. The effect of the drug is especially clearly visible when treatment of dry cough with conventional methods does not bring results.

Parents get a quick positive result after taking the syrup when mucaltin and bromhexine cannot transform the cough into a productive form. Improvement after taking this form of Fluimucil occurs after the 2nd dose, and after three days the symptoms of dry cough disappear completely. The residual effects of a wet cough disappear on their own after a few days.

Most reviews about the medicine are positive

The syrup tastes pleasant, and children take the medicine voluntarily. Even small children, who are often capricious when sick, take the drug without fail, because they like its taste.

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Source: http://antirodinka.ru/sirop-ot-kashlya-fluimutsil-priem-preparata-protivopokazaniya

FLUIMUCIL

◊ Effervescent tablets , white, round, with a rough surface; with a lemony, slightly sulfuric odor; the solution prepared by reconstituting the tablets in water should be slightly opalescent, with a characteristic odor and taste of lemon flavor.

Excipients: citric acid, sodium bicarbonate, aspartame, lemon flavor.

2 pcs. - blisters (5) - cardboard packs.

2 pcs. - blisters (10) - cardboard packs.

10 pieces. - blisters (1) - cardboard packs.

10 pieces. - blisters (2) - cardboard packs.

◊ Granules for the preparation of a solution for oral administration are white-yellow in color, with orange inclusions, with a characteristic orange, slightly sulfurous odor.

Excipients: aspartame, betacarotene, orange flavor, sorbitol.

Multilayer bags (20) - cardboard packs.

Multilayer bags (60) - cardboard packs.

Mucolytic drug. Liquefies mucus, increases its volume and facilitates its separation. The action of acetylcysteine ​​is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

When taken orally, it is well absorbed from the gastrointestinal tract. After oral administration, Cmax in plasma is reached within 1-3 hours and is 15 mmol/l. Bioavailability is 10% due to the pronounced “first pass” effect through the liver.

Penetrates into the intercellular space, predominantly distributed in the liver, kidneys, lungs, and bronchial secretions. Penetrates through the placental barrier. Binding to blood plasma proteins is 50%.

Rapidly deacetylated to cysteine ​​in the liver. In the plasma, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcystine) is observed, free and bound to plasma proteins.

T1 /2 when taken orally is 1 hour, with cirrhosis of the liver it increases to 8 hours. It is excreted in the urine in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines.

- diseases of the respiratory system, accompanied by impaired sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung diseases, pulmonary atelectasis /due to blockage of the bronchi by mucus plug/) ;

- catarrhal and purulent otitis media, sinusitis, incl. sinusitis (to facilitate the passage of secretions);

- to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

- peptic ulcer of the stomach and duodenum in the acute phase;

- children under 2 years of age (for granules for the preparation of a solution for oral administration);

- children and adolescents up to 18 years of age (for effervescent tablets);

- hypersensitivity to acetylcysteine.

The use of the drug in the form of granules for the preparation of a solution for oral administration in children under 2 years of age is possible only if there are vital indications and under strict medical supervision.

with caution for peptic ulcers of the stomach and duodenum, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time/day. Before use, the effervescent tablet is dissolved in 1/3 glass of water.

Granules for the preparation of a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day; children aged 1 to 2 years - 100 mg 2 times a day.

In newborns, the drug is used only for health reasons at a dose of 10 mg/kg body weight under the strict supervision of a physician.

Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle.

The duration of the course of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

From the digestive system: rarely - heartburn, nausea, feeling of fullness in the stomach, vomiting, diarrhea; Cases of the development of stomatitis have been described.

Allergic reactions: rarely - skin rash, itching, urticaria; Cases of bronchospasm have been described.

Other: rarely - nosebleeds, tinnitus; Cases of collapse and decreased platelet aggregation have been described.

The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs, so the interval between taking acetylcysteine ​​and antibiotics should be at least 2 hours.

The simultaneous use of Fluimucil and nitroglycerin can lead to an increase in the vasodilatory and antiplatelet effects of the latter.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

For patients with bronchial asthma and obstructive bronchitis, Fluimucil can be prescribed with caution under systematic monitoring of bronchial conduction.

The drug contains aspartame, so it should not be prescribed to patients with phenylketonuria.

When dissolving the drug, you must use glass containers and avoid contact with metal and rubber surfaces. When opening a bag of granules, there may be a smell of sulfur, which is the smell of the active substance.

During pregnancy, the use of Fluimucil is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Contraindicated in children under 2 years of age (for granules for the preparation of solution for oral administration); in childhood and adolescence up to 18 years (for effervescent tablets).

The drug should be prescribed with caution to patients with kidney disease.

The drug should be prescribed with caution to patients with liver disease.

The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life: 3 years.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/fluimutsil_1/

Fluimucil solution - official instructions for use

Registration number: LP1011

Trade name of the drug: Fluimucil®

International nonproprietary name: Acetylcysteine

Chemical name: (R)-2-acetamido-3-mercaptopropionic acid.

Dosage form: solution for oral administration.

Oral solution 20 mg/ml:

active substance - acetylcysteine ​​20.0 mg;

excipients: methyl parahydroxybenzoate 1.0 mg; sodium benzoate 1.5 mg; disodium edetate 1.0 mg; carmellose sodium 4.0 mg; sodium saccharinate 0.4 mg; raspberry flavor 2.5 mg; sodium hydroxide to pH 6.5; purified water to 1.0 ml.

Oral solution 40 mg/ml:

active substance - acetylcysteine ​​40.0 mg;

Excipients: methyl parahydroxybenzoate 1.8 mg;

propyl parahydroxybenzoate 0.2 g; disodium edetate 1.0 mg; carmellose sodium 4.0 mg; sorbitol 70% 120.0 mg; sodium saccharinate 0.4 mg; strawberry flavor 10.0 mg; pomegranate flavor 2.0 mg; sodium hydroxide to pH 6.5; purified water to 1.0 ml.

Oral solution 20 mg/ml: Clear or slightly opalescent colorless solution with a characteristic raspberry odor and a faint sulfuric odor. Oral solution 40 mg/ml: A clear, colorless or slightly yellow solution with a characteristic odor of strawberry and pomegranate and a faint sulfuric odor.

Pharmacotherapeutic group. mucolytic expectorant.

A mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum. The action is associated with the ability of free sulfhydryl groups of acetylcysteine ​​to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity. Remains active against purulent sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOC1, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Fluimucil® is well absorbed when taken orally. It is immediately deacetylated to cysteine ​​in the liver. In the blood, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Due to the high “first pass” effect through the liver, the bioavailability of acetylcysteine ​​is about 10%. Acetylcysteine ​​penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions.

The maximum concentration in plasma is reached 1-3 hours after oral administration and is 15 mmol/l, binding to plasma proteins is 50%. Half-life is about 1 hour, with liver cirrhosis it increases to 8 hours. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. Penetrates through the placental barrier.

Indications for use

Impaired sputum discharge: bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, interstitial lung diseases, pulmonary atelectasis (due to blockage of the bronchi by mucus plug). Catarrhal and purulent otitis media, sinusitis, sinusitis (facilitation of secretion discharge). Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Contraindications

Hypersensitivity to acetylcysteine ​​and other components of the drug, children under 2 years of age; peptic ulcer of the stomach and duodenum in the acute stage, lactation period.

With caution: peptic ulcer of the stomach and duodenum, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

Use of the drug during pregnancy and lactation.

The drug is prescribed during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Directions for use and doses

The maximum daily dose of acetylcysteine ​​is 600 mg/day.

Adults: 15 ml of oral solution 40 mg/ml 1 time per day (corresponds to 600 mg acetylcysteine ​​per day).

- children from 2 to 5 years: 5 ml of oral solution 20 mg/ml 2-3 times a day (corresponds to mg acetylcysteine ​​per day)

- children from 6 to 14 years old: 5 ml of oral solution 20 mg/ml 3-4 times a day or 4 ml of oral solution 40 mg/ml 2 times a day (corresponds to mg acetylcysteine ​​per day)

- children over 14 years of age: 15 ml of oral solution 40 mg/ml 1 time per day (corresponds to 600 mg acetylcysteine ​​per day).

Side effect

In rare cases, possible: nausea, heartburn, feeling of fullness in the stomach, vomiting, diarrhea, skin rash, itching, urticaria, nosebleeds, tinnitus. When taking acetylcysteine, cases of bronchospasm, collapse, stomatitis, and decreased platelet aggregation have been described.

Acetylcysteine ​​when taken at a dose of 500 mg/kg/day does not cause signs and symptoms of overdose.

Interaction with other drugs

The combined use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs. Therefore, the interval between doses of these drugs should be at least 2 hours.

The simultaneous use of acetylcysteine ​​and nitroglycerin can lead to an increase in the vasodilating and disaggregating effects of the latter. Acetylcysteine ​​eliminates the toxic effects of paracetamol.

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

Fluimucil® oral solution 40 mg/ml contains sorbitol; patients with hereditary fructose intolerance should not take this drug.

Impact on the ability to drive vehicles and machinery

There are no data confirming the effect of acetylcysteine ​​on the ability to drive vehicles or mechanisms.

Oral solution 20 mg/ml: 100 ml, 150 ml, 200 ml solution in a dark glass bottle type III, sealed with a plastic screw cap with chlorobutyl elastomer coating. 1 bottle complete with a measuring cap and instructions for use in a cardboard box.

Oral solution 40 mg/ml: 150 ml, 200 ml solution in a dark glass bottle type III, sealed with a plastic screw cap with chlorobutyl elastomer coating. 1 bottle complete with a measuring cap and instructions for use in a cardboard box.

2 years. Do not use after the expiration date stated on the packaging.

After opening the bottle for the first time, the drug should be used within 15 days.

At a temperature not higher than 25 °C. Keep out of the reach of children.

Conditions for dispensing from pharmacies

Manufacturer company

Via della Chimica, Vicenza, Italy.

Complaints regarding the quality of the drug should be sent to:

Representative office of JSC "Zambon S.P.A." (Italy):

Russia, Moscow, Glazovsky lane, 7, office 17.

Source: http://medi.ru/instrukciya/fluimutsil-rastvor_2770/

Fluimucil

Instructions for use:

Prices in online pharmacies:

Fluimucil is an expectorant mucolytic drug.

Release form and composition

Dosage forms of Fluimucil:

  • oral solution: 20 mg/ml – transparent or slightly opalescent, colorless, with a characteristic raspberry odor and a slight sulfuric odor; 40 mg/ml – transparent, colorless or slightly yellow, with a characteristic odor of pomegranate and strawberries and a faint sulfuric odor (in dark glass bottles of 100, 150 or 200 ml, 1 bottle in a cardboard box);
  • solution for injection and inhalation: transparent, colorless, with a slight sulfuric odor; with prolonged contact with air after opening the ampoule, a slight pink-violet tint may appear (in dark glass ampoules of 3 ml, 5 ampoules in contour plastic packages, 1 package in a cardboard box);
  • granules for preparing a solution for oral administration: white-yellow with orange inclusions, have a characteristic orange, slightly sulfurous odor (1 g in multi-layer laminated bags, 20 or 60 bags in a cardboard box);
  • effervescent tablets: round, white, have a rough surface and a lemony, slightly sulfuric odor; the solution after reconstitution in water should be somewhat opalescent, have a characteristic smell and taste of lemon flavor (2 or 10 tablets in strip packs, 1, 2, 5 or 10 packs in a cardboard box).

Composition of 1 ml oral solution:

  • active substance: acetylcysteine ​​– 20 or 40 mg;
  • auxiliary components (20/40 mg): methyl parahydroxybenzoate – 1/1.8 mg; sodium benzoate – 1.5/0 mg; edetate disodium – 1/1 mg; carmellose sodium – 4/4 mg; sodium saccharinate – 0.4/0.4 mg; propyl parahydroxybenzoate – 0/0.2 g; 70% sorbitol – 0/120 mg; raspberry flavor – 2.5/0 mg; strawberry flavor – 0/10 mg; pomegranate flavor – 0/2 mg; sodium hydroxide – up to pH 6.5/6.5; purified water – up to 1/1 ml.

Composition of 1 ampoule of solution for injection and inhalation:

  • active substance: acetylcysteine ​​– 300 mg;
  • auxiliary components: sodium hydroxide – up to pH 6.5 (about 74 mg); edetate disodium – 3 mg; water for injection – up to 3 ml.

Composition of 1 sachet for oral solution:

  • active substance: acetylcysteine ​​– 200 mg;
  • auxiliary components: sorbitol – 662.7 mg; aspartame – 25 mg; orange flavor – 100 mg; betacarotene – 12.3 mg.

Composition of 1 effervescent tablet:

  • active substance: acetylcysteine ​​– 600 mg;
  • auxiliary components: sodium bicarbonate – 500 mg; aspartame – 20 mg; citric acid – 680 mg; lemon flavor – 100 mg.

Indications for use

  • impaired sputum discharge associated with blockage of the bronchi by a mucus plug, in diseases such as pulmonary atelectasis, pneumonia, bronchitis, bronchiolitis, tracheitis, cystic fibrosis, bronchiectasis, lung abscess, laryngotracheitis, pulmonary emphysema, interstitial lung diseases;
  • otitis (purulent and catarrhal), sinusitis, sinusitis (to facilitate the discharge of secretions);
  • viscous secretion in the respiratory tract during postoperative/post-traumatic conditions (for removal).

Additional indications for Fluimucil solution for injection and inhalation:

  • preparation for bronchoscopy, bronchography, aspiration drainage;
  • treatment of fistulas, the surgical field during operations on the mastoid process and the nasal cavity;
  • washing the middle ear, nasal passages, abscesses, maxillary sinuses.

Contraindications

  • exacerbation of peptic ulcer of the stomach and duodenum;
  • fructose intolerance (for oral solution 40 mg/ml);
  • age up to 2 years (for oral solution and granules for the preparation of oral solution), up to 6 years (for solution for injection and inhalation) and up to 18 years (for effervescent tablets);
  • lactation period;
  • individual intolerance to the components of the drug.

Relative (Fluimucil is prescribed with caution in the presence of the following diseases/conditions):

  • adrenal diseases;
  • pulmonary hemorrhage;
  • arterial hypertension;
  • peptic ulcer of the stomach and duodenum;
  • hemoptysis;
  • varicose veins of the esophagus;
  • bronchial asthma (for intravenous administration of Fluimucil solution for injection, since there is a high probability of bronchospasm);
  • renal/liver failure;
  • phenylketonuria (for granules for the preparation of oral solution and effervescent tablets; due to the presence of aspartame in the composition of the drug);
  • age up to 1 year (for intravenous administration of Fluimucil solution for injection, use of the drug is possible only in hospital settings in cases of vital indications);
  • pregnancy (the use of Fluimucil is possible only after assessing the ratio of benefits to possible risks).

Directions for use and dosage

Oral solution

Fluimucil is taken orally.

Recommended regimen for use of the drug (the daily dose of acetylcysteine ​​is indicated in parentheses):

  • children 2–5 years old: 2–3 times a day, 5 ml of a 20 mg/ml solution (200–300 mg);
  • children 6–14 years old: 3–4 times a day, 5 ml of a 20 mg/ml solution or 2 times a day, 4 ml of a 40 mg/ml solution (300–400 mg);
  • children over 14 years of age and adults: 15 ml of a 40 mg/ml solution (600 mg) once a day.

Maximum per day – 600 mg of acetylcysteine.

Solution for injection and inhalation

How to use Fluimucil:

  • parenterally: route of administration – intramuscular and intravenous (preferably drip or slow stream over 5 minutes); dosage regimen – 1–2 times a day, 3 ml (adults), 1–2 times a day, 1.5 ml (children 6–14 years old) or 10 mg/kg per day (children under 6 years old; it is preferable to prescribe the drug in oral forms; intravenous administration to children under 1 year of age is possible only if there are vital indications in a hospital setting);
  • inhalation (aerosol therapy): a 10% solution of 3–9 ml (in ultrasound devices) or 6 ml (in devices with a distribution valve) is used. The duration of inhalation is from 15 to 20 minutes, the frequency of use is 2–4 times a day. The average course duration for acute conditions is 5–10 days, for chronic conditions – up to 6 months. Depending on the therapeutic effect and the patient's condition, the doctor may make changes to the dosage regimen. For children, the drug is prescribed in adult doses. With a strong secretolytic effect, the secretion is sucked out, and the frequency of inhalations and the daily dose are reduced;
  • locally (instillation into the nasal passages and external auditory canal): 1.5–3 ml per 1 procedure;
  • intratracheal (during therapeutic bronchoscopy for washing the bronchial tree): 1–2 ampoules or more per day (depending on clinical indications).

The duration of the course is determined by the results of treatment. Fluimucil has high general and local tolerability, so its long-term use is possible.

Before intravenous administration, the solution should be further diluted with 5% dextrose solution or 0.9% NaCl solution (ratio 1:1).

For patients over 65 years of age, Fluimucil is usually prescribed in minimally effective doses.

Granules for the preparation of solution for oral administration

Fluimucil is taken orally, after dissolving a single dose in 1/3 glass of water.

Recommended dosage regimen:

  • newborns (only if there are vital indications and under medical supervision) and children under 1 year: 10 mg/kg (from a feeding bottle or spoon);
  • children 1–2 years old: 2 times a day, 100 mg;
  • children 2–6 years old: 3 times a day, 100 mg or 2 times a day, 200 mg;
  • children over 6 years old and adults: 2-3 times a day, 200 mg.

The duration of the therapeutic course is determined individually:

  • acute course of the disease: 5–10 days;
  • chronic course of the disease: up to several months.

Effervescent tablets

Fluimucil is taken orally (solution – 1 tablet in 1/3 glass of water).

Recommended dosage regimen for adults: 1 tablet once a day.

The duration of the therapeutic course is determined individually:

  • acute course of the disease: 5–10 days;
  • chronic course of the disease: up to several months.

Side effects

Oral solution, granules for solution, effervescent tablets

In rare cases, the development of the following adverse reactions may occur: nosebleeds, tinnitus, disorders of the digestive system (in the form of nausea, heartburn, feeling of fullness in the stomach, skin rash, vomiting, diarrhea), urticaria, itching.

There is also evidence of the development of collapse, bronchospasm, decreased platelet aggregation, and stomatitis.

Solution for injection and inhalation

  • inhalation administration: rhinorrhea, respiratory tract irritation, reflex cough; rarely – bronchospasm, stomatitis;
  • intramuscular administration: skin rash, burning at the injection site, urticaria; with long-term therapy – functional disorders of the kidneys/liver.

special instructions

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

A light sulfuric odor is characteristic of the active substance Fluimucil.

The ampoule with solution for injection and inhalation must be opened before use. After opening, the drug can be used for 24 hours only for inhalation, provided it is stored in the refrigerator.

With shallow intramuscular injection of Fluimucil and in the presence of hypersensitivity, the development of a slight and quickly passing burning sensation may be observed, so it is recommended to inject the drug deep into the muscle.

Fluimucil solution (ready-made or obtained by dissolving tablets or granules) should not come into contact with metal/rubber surfaces.

Drug interactions

When Fluimucil is used in combination with certain drugs/substances, the following effects may develop:

  • antitussive drugs: increased stagnation of sputum, which is associated with suppression of the cough reflex;
  • antibacterial drugs - ampicillin, tetracyclines (except doxycycline), amphotericin B: decreased effectiveness of both drugs (recommended interval between doses is at least 2 hours);
  • nitroglycerin: enhancing its disaggregant and vasodilator effects;
  • paracetamol: eliminating its toxic effects.

Fluimucil solution is pharmaceutically incompatible with other drug solutions.

Terms and conditions of storage

Store at temperatures up to 25 °C. Keep away from children.

  • solution for oral administration – 2 years (after the first opening of the package – 15 days);
  • solution for injections and inhalations – 5 years;
  • granules for the preparation of solution for oral administration, effervescent tablets – 3 years.

Fluimucil tablets 600 mg 10 pcs.

Fluimucil 600 mg No. 10 effervescent tablets

Fluimucil tab. thorn. 600mg n10

Fluimucil effervescent tablets 600 mg n10

Fluimucil granules 200 mg orange 20 pcs.

Fluimucil gran. d/r-ra internal 200mg n20 (orange)

Fluimucil granules 200 mg No. 20 sachets

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

The cough medicine “Terpinkod” is one of the top sellers, not at all because of its medicinal properties.

In the UK there is a law according to which a surgeon can refuse to perform an operation on a patient if he smokes or is overweight. A person must give up bad habits, and then, perhaps, he will not need surgical intervention.

The first vibrator was invented in the 19th century. It was powered by a steam engine and was intended to treat female hysteria.

Scientists from Oxford University conducted a series of studies in which they came to the conclusion that vegetarianism can be harmful to the human brain, as it leads to a decrease in its mass. Therefore, scientists recommend not completely excluding fish and meat from your diet.

If your liver stopped working, death would occur within 24 hours.

There are very interesting medical syndromes, for example, compulsive swallowing of objects. One patient suffering from this mania had 2,500 foreign objects in her stomach.

Research shows that women who drink several glasses of beer or wine per week have an increased risk of developing breast cancer.

Most women are able to derive more pleasure from contemplating their beautiful body in the mirror than from sex. So, women, strive to be slim.

Many drugs were initially marketed as medicines. Heroin, for example, was originally brought to market as a cure for children's coughs. And cocaine was recommended by doctors as an anesthesia and as a means of increasing endurance.

Human bones are four times stronger than concrete.

During operation, our brain expends an amount of energy equal to a 10-watt light bulb. So the image of a light bulb above your head at the moment an interesting thought arises is not so far from the truth.

The human stomach copes well with foreign objects without medical intervention. It is known that gastric juice can even dissolve coins.

The liver is the heaviest organ in our body. Its average weight is 1.5 kg.

In order to say even the shortest and simplest words, we use 72 muscles.

The rarest disease is Kuru disease. Only members of the For tribe in New Guinea suffer from it. The patient dies of laughter. The disease is believed to be caused by eating human brains.

An infectious inflammatory process in the kidneys associated with the development of bacteria in the urinary system is called pyelonephritis. This serious illness is observed in...

Source: http://www.neboleem.net/fluimucil.php

Fluimucil - instructions for use, analogs, reviews and release forms (granules 200 mg, powder, solution for inhalation antibiotic IT in ampoules, effervescent tablets 600 mg) of a drug for the treatment of cough in adults, children and pregnancy

In this article you can read the instructions for use of the drug Fluimucil. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Fluimucil in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Fluimucil in the presence of existing structural analogues. Use for the treatment of cough and thinning of sputum in adults, children, as well as during pregnancy and breastfeeding.

Fluimucil is a mucolytic drug. Liquefies mucus, increases its volume and facilitates its separation. The effect of acetylcysteine ​​(the active ingredient of the drug Fluimucil) is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Acetylcysteine ​​+ excipients.

Thiamphenicol glycinate acetylcysteinate + excipients (Fluimucil antibiotic IT).

When taken orally, it is well absorbed from the gastrointestinal tract. Penetrates into the intercellular space, predominantly distributed in the liver, kidneys, lungs, and bronchial secretions. Penetrates through the placental barrier. Rapidly deacetylated to cysteine ​​in the liver. In the plasma, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcystine) is observed, free and bound to plasma proteins. It is excreted in the urine in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines.

  • respiratory diseases accompanied by impaired sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung diseases, pulmonary atelectasis (due to blockage of the bronchi by mucus plug));
  • catarrhal and purulent otitis, sinusitis, incl. sinusitis (to facilitate the passage of secretions);
  • to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions;
  • preparation for bronchoscopy, bronchography, aspiration drainage;
  • for washing abscesses, nasal passages, maxillary sinuses, middle ear, treatment of fistulas, surgical field during operations on the nasal cavity and mastoid process;
  • with concomitant nonspecific forms of respiratory infections to improve drainage, including cavernous lesions, with mycobacterial infections.

Solution for injection and inhalation (sometimes mistakenly called syrup).

Effervescent tablets 600 mg.

Granules for the preparation of a solution for oral administration 200 mg (sometimes mistakenly called powder).

Lyophilisate for the preparation of solution for injection and inhalation in ampoules (Fluimucil antibiotic IT).

Instructions for use and method of use

For aerosol therapy, 3-9 ml of a 10% solution is sprayed in ultrasound devices, and 6 ml of a 10% solution is sprayed in devices with a distribution valve. Duration of inhalation min; frequency: once a day. When treating acute conditions, the average duration of therapy is days; for long-term therapy of chronic conditions, the course of treatment is up to 6 months.

Due to the high safety of the drug, the frequency of administration and the relative dose can be changed by the doctor within acceptable limits, depending on the patient’s condition and the therapeutic effect. There is no need to change the adult dose when using the drug to treat children. In the case of a strong secretolytic effect, the secretion is sucked out, and the frequency of inhalations and the daily dose are reduced.

The therapeutic mixture cannot be placed in an ultrasonic nebulizer, because it quickly destroys the active substance Fluimucil. It is advisable to use a compressor device for inhalation, which provides an ideal setting for the size of the inhaled particles of the drug.

To wash the bronchial tree during therapeutic bronchoscopy, use 1-2 ampoules or more per day, depending on clinical indications.

Instill in the external auditory canal and nasal passages (in the nose) mg (1.5-3 ml) for 1 procedure.

Administer intravenously (preferably drip or slow stream over 5 minutes) or intramuscularly. Adults - 300 mg (3 ml) 1-2 times a day; children from 6 to 14 years old - 150 mg (1.5 ml) 1-2 times a day. The daily dose for children under 6 years of age is 10 mg/kg body weight; for children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting. The duration of treatment should be determined based on changes in the patient's condition.

It should be taken into account that oral administration of the drug is preferable for children under 6 years of age.

High local and general tolerability of the drug allows for long courses of treatment.

For intravenous administration, the solution is further diluted with 0.9% sodium chloride solution or 5% dextrose solution in a 1:1 ratio. The duration of therapy is determined individually (no more than 10 days).

In patients over 65 years of age, the minimum effective dose is used.

The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time per day. Before use, the effervescent tablet is dissolved in 1/3 glass of water.

Granules for preparing a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times a day or 100 mg 3 times a day; children aged 1 to 2 years - 100 mg 2 times a day.

In newborns, the drug is used only for health reasons at a dose of 10 mg/kg body weight under the strict supervision of a physician.

Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle.

The duration of the course of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

  • reflex cough;
  • respiratory tract irritation;
  • rhinorrhea;
  • stomatitis;
  • bronchospasm;
  • burning at the injection site;
  • skin rash;
  • hives;
  • impaired liver and/or kidney function (with long-term use).
  • peptic ulcer of the stomach and duodenum in the acute phase;
  • lactation period;
  • children under 2 years of age (for granules for the preparation of a solution for oral administration);
  • children and adolescents up to 18 years of age (for effervescent tablets);
  • anemia;
  • leukopenia;
  • thrombocytopenia;
  • hypersensitivity to acetylcysteine.

Use during pregnancy and breastfeeding

During pregnancy, the use of Fluimucil is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

With shallow intramuscular injection of the drug and in the presence of increased sensitivity, a slight and quickly passing burning sensation may appear, and therefore it is recommended to inject the drug deep into the muscle.

The Fluimucil ampoule is opened before use. An opened ampoule can be stored in the refrigerator for 24 hours, during which time the drug can only be used for inhalation.

Fluimucil solution should not come into contact with rubber and metal surfaces.

Prescribed with caution for peptic ulcers of the stomach and duodenum in remission, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, bronchial asthma (with intravenous administration the risk of developing bronchospasm increases), diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension, and also for children under 6 years of age.

For children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting.

The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs, so the interval between taking acetylcysteine ​​and antibiotics should be at least 2 hours.

The simultaneous use of Fluimucil and nitroglycerin can lead to an increase in the vasodilatory effect of the latter.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Pharmaceutically incompatible with other drug solutions.

Analogues of the drug Fluimucil

Structural analogues of the active substance:

  • N-AC-ratiopharm;
  • N-acetylcysteine;
  • Acestine;
  • Acetylcysteine;
  • Acetylcysteine ​​solution for inhalation 20%;
  • Acetylcysteine ​​solution for injection 10%;
  • ACC;
  • ACC 100;
  • ACC 200;
  • ACC injection;
  • ACC Long;
  • Vicks Active ExpectoMed;
  • Mukobene;
  • Mucomist;
  • Mukonex;
  • Fluimucil;
  • Exomyuk 200.

Similar medications:

Other medicines:

News edited by: admin017, 12:37

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