What is the difference between Flemoclav and Flemoxin?

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Flemoxin and Flemoklav - is there a difference between the two drugs?

It is important to treat diseases of bacterial etiology efficiently and in a timely manner. Antibacterial drugs based on amoxicillin are excellent for this purpose.

Table of contents:

They not only help in a short time to stop the adverse effects of microflora on the body, but also completely destroy it.

Today, the antibiotic market is filled with a huge number of drugs that differ in potency and other characteristics. In today's material, our resource decided to take a closer look at such popular medications as Flemoxin and Flemoklav, and also highlight the most significant differences between them.

Flemoxin Solutab - composition, properties and release form

Flemoxin Solutab is a broad-spectrum antibacterial agent

Before analyzing the effects of drugs on the human body and highlighting the differences between them, it would be a good idea to consider each antibiotic separately. Let's start looking at medications with Flemoxin.

So, the trade name of this antibiotic looks like “Flemoxin Solutab”. The drug belongs to the group of antibacterials based on the active substance “amoxicillin” (the pharmacological group of the drug is penicillin, semi-synthetic antibiotics). Flemoxin is produced in white or slightly yellow tablets, which have an oval shape and an image of the manufacturer’s logo, as well as a digital designation. The latter is identification and indicates how much active substance the tablet contains.

Digital identification has the following grouping:

The tablets are sorted into rectangular packages and similar blisters, which contain 5 tablets each and are presented in 2 or 4 copies.

The active ingredient in the drug "Flemoxin Solutab" is represented by amoxicillin, which is contained in the drug in the dosages mentioned above.

In addition, the drug contains dispersible cellulose, microcrystalline cellulose, crospovidone, vanillin, saccharin, magnesium stearate and some flavorings.

The properties of Flemoxin Solutab are standard for its pharmacological group. In simple terms, this drug stops the development of the bacterial microflora that caused the disease, and over time reduces its adverse effects on the patient’s body to a minimum. Thanks to this, the antibiotic is accepted for its excellent bactericidal properties all over the world.

More information about the drug Flemoxin Solutab can be found in the video:

You can take Flemoxin Solutab for pathologies of bacterial etiology in such human organs as:

  • respiratory system organs
  • genitourinary system organs
  • organs of the gastrointestinal tract
  • leather and other soft tissues

It is important to take the drug taking into account the recommendations of the treating specialist and the background information provided in the instructions for the antibiotic. It is in the latter that you can learn in more detail about contraindications, dosages and other things related to Flemoxin Solutab.

Flemoklav Solutab - composition, properties and release form

Flemoxin Solutab effectively treats respiratory diseases caused by bacterial infection

Flemoklav Solutab, in turn, is not much different from its opponent in terms of release form. This antibiotic is also available in tablets similar in size to Flemoxin. However, the tablets are divided into 4 per blister, which can be from 4 to 8 in one package. At the same time, Flemoklav contains slightly less active substance (the same amoxicillin) than in the previously considered drug.

Depending on the form of release, the antibiotic may contain from 125 to 875 mg of active substance, supplemented by an appropriate dose of a special substance - clavulanic acid.

The composition of Flemoklav Solutab includes:

  • active substance – amoxicillin trihydrate
  • clavulanic acid
  • microcrystalline cellulose
  • vanillin
  • saccharin
  • magnesium stearate
  • flavorings

Similar to Flemoxin, Flemoklav has antibacterial properties with a wide spectrum of effects, since both drugs belong to the same pharmacological group - penicillin, semi-synthetic antibiotics.

Despite this similarity, the medication is taken in fewer situations.

Thus, Flemoklav is widely used in the treatment of the following pathologies:

  • respiratory diseases
  • diseases of the genitourinary system
  • lesions of the skin and soft tissues
  • rarely – gastrointestinal pathologies

The dosage for use is determined solely by the doctor based on the severity of the disease and the age of the patient. It is worth understanding that correct use is a fundamental factor in successful therapy, therefore it is necessary to take Flemoklav taking into account the recommendations of the treating specialist and the manufacturer of the drug. You can find out about contraindications, expiration dates and similar things about a medication by carefully reading the instructions for it.

Flemoxin and Flemoklav - what is the difference?

It would seem that after receiving general information about both Flemoxin and Flemoklav, it is extremely difficult to identify any differences between the drugs. However, this is a rather erroneous judgment, since, delving into the study of antibiotics more deeply, a number of differences can be identified between them. Our resource has carried out this procedure and is ready to present you with its results.

First of all, we note that Flemoclav Solutab contains clavulanic acid, but its opponent does not. This difference makes the first antibiotic more resistant in the fight against bacterial microflora, since it is clavulanic acid that binds to bacterial beta-lactamases, which helps protect the antibiotic from the adverse effects of particularly strong microorganisms and their enzymes that can destroy the drug and neutralize its effects. Such a minor nuance puts Flemoklav Solutab in a more honorable position relative to his today's opponent.

In addition, the combined use of clavulanic acid and amoxicillin allows Flemoclav to provide additional benefits:

  • increase the versatility of the drug, that is, this antibiotic is able to fight a larger list of bacteria than its opponent - Flemoxin
  • reduce the dose of the antibiotic taken, since amoxicillin is supplemented with an appropriate dose of clavulanic acid (for example, 250 + 62.5 Mg or 875 + 125 Mg)

Despite the smaller list of pathologies for the treatment of which Flemoklav is used, it is more universal, especially in the treatment of respiratory tract pathologies. It is worth noting that both drugs we are considering are produced by the same pharmacological company from Holland. In fact, they are close analogues with slight differences in composition, which modify the method and effect of the drugs.

Comparing the statistical data collected by specialists regarding treatment with Flemoxin and Flemoclav, the following can be highlighted:

  • When using the first antibiotic, about 50% of people notice a noticeable effect from the drug
  • when using a medication containing clavulanic acid, this effect is noted by more than 60% of patients

There are no other differences between the drugs, except for their cost. On average, Flemoklav costs % more than its opponent when used in similar situations.

Do not forget that both antibiotics are quite potent and should not be prescribed for self-medication by the patient himself or his relatives.

Which of them is most optimal for use in a particular case can only be determined by the attending physician who has the necessary information about the pathology and clinical picture of the patient’s illness. Improper organization of antibacterial therapy is a dangerous practice that can cause some complications in the patient, remember this.

Summarizing today's material, we note that Flemoxin and Flemoklav are highly soluble and very similar antibiotics, but they still have differences between themselves. The most significant of these is the general principle of influencing unfavorable microflora. It can be stated that Flemoclav is a more universal antibiotic that will perform slightly better than its opponent. Despite this, the final choice between two drugs should be made only by the treating specialist, taking into account all the characteristics of the patient’s disease. We hope that the previously presented material was useful to you. Good luck in treating your illnesses!

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The medical information published on this page is strictly not recommended for self-medication. If you feel negative changes in your health, immediately contact an ENT specialist. All articles published on our resource are for informational purposes only. If you use this material or a fragment of it on your website, an active link to the source is required.

Source: http://tvojlor.com/lekarstva/flemoksin-i-flemoklav-otlichie.html

What is the difference between Flemoklav and Flemoxin

Timely prescription of medications and a well-designed drug therapy regimen are an important condition for the treatment of bacterial infections. Modern pharmacology offers a huge list of means to suppress the activity of pathogenic microflora. They all have different properties and characteristics. But today we decided to focus our attention on the drugs Flemoxin and Flemoklav. Is there a difference between these two drugs?

Composition of drugs

According to pharmaceutical data, Flemoxin is an analogue of Flemoklav. Many pharmacists offer it as an alternative to their customers if the prescribed medicine is out of stock. In fact, this is not entirely correct. And now we will explain why.

The active ingredient of one and the second drug is amoxicillin. It is an antibiotic of the penicillin series, known for its broad spectrum of action and effectiveness against a large number of pathogenic microorganisms. At the same time, Flemoclav also contains clavulanic acid, which not only protects antibiotic cells in the internal environment of the body, but also exhibits its own antibacterial activity, enhancing the effect of amoxicillin.

Here is the first difference - different pharmacological groups. Flemoxin is a penicillin antibiotic, and Flemoklav is a combination drug, penicillins with beta-lactamase inhibitors.

Release form and dosage

Flemoxin Solutab and Flemoklav Solutab are produced by Astellas Pharma Europe B.V. (Netherlands). Release form: dispersed tablets, easily soluble in water.

If for some reason the patient cannot take the medicine in solid tablet form, both products are suitable for preparing a pleasant-tasting suspension.

As for the dosage, some differences are already found here. Thus, Flemoxin is available in the following dosages:

Where mg is the amount of active ingredient amoxicillin in 1 tablet. Each tablet has an engraving corresponding to the dosage. For convenience, we have indicated it in parentheses.

The dosage for the drug Flemoklav indicates the amount of amoxicillin and clavulanic acid:

The tablets also have markings corresponding to the amount of active substance.

Pharmacological properties

Now let's move on to the question of what is the main difference between Flemoxin and Flemoclav. From a chemical point of view, amoxicillin is similar in structure to ampicillin. Both antibiotics have the same spectrum of action against pathogenic microorganisms. At the same time, amoxicillin is absorbed 50-60% better when taken orally. Thanks to this, a higher concentration of the active substance in the blood is achieved and, as a result, higher efficiency in the treatment of bacterial infections.

Amoxicillin, like other penicillin antibiotics, is called beta-lactam. The principle of operation of antibiotic molecules on the cells of pathogenic microorganisms is very simple. Due to its chemical structure, its structural components have the ability to bind to the center of the enzyme responsible for accelerating the production of peptidoglycan.

Peptidoglycan is an important component of the cell wall of pathogenic bacteria. Violation of the synthesis process of this important element interferes with the process of division of cellular structures.

The mechanism of development of bacterial inflammation is active cell proliferation, in which two daughter units are formed from each parent unit. Inhibition of the process of peptidoglycan production leads to a failure of the well-functioning mechanism and, as a consequence, the death of these cells.

But, unfortunately, not only humanity has evolved in our world, but also bacteria. Many of them have managed to develop a kind of protection against antibacterial drugs - beta-lactamase enzymes, which have the property of breaking down antibiotic molecules. This concept is better known to us as antibiotic resistance or resistance of pathogenic microflora to the action of a drug.

It is for such cases that combination drugs were developed, one of which is Flemoklav. Unlike Flemoxin, it contains clavulanic acid. When ingested, clavulanic acid molecules bind to bacterial enzymes and block their work. This allows you to preserve the integrity of the antibiotic cells and, as a result, achieve the maximum therapeutic effect.

Which drug to choose: effectiveness assessment

Considering the difference in pharmacological properties due to the composition of the drugs, their therapeutic effect will also differ. And where Flemoxin cannot effectively resist microorganisms that produce beta-lactamases, Flemoklav will cope with this task perfectly.

The main advantages of the combination antibiotic:
  • a wide range of applications due to the expansion of the list of bacteria sensitive to the action of the drug;
  • higher clinical effectiveness of the drug;
  • reducing the dose required to achieve a therapeutic effect.

Based on all of the above, we can draw the right conclusions that Flemoxin or Flemoklav is better. Thus, Flemoclav becomes the first choice drug for infectious diseases caused by bacteria that have already developed resistance to antibiotics. Among them:

  • otitis;
  • sinusitis;
  • bronchitis;
  • urinary tract infections;
  • skin and soft tissue infections;
  • abscesses of the oral cavity (including for the prevention of complications after surgery, tooth extraction).

Some facts in favor of Flemoclav indicate the following:

  1. Patients diagnosed with reactive arthritis (children). For a month, one group of patients was treated with amoxicillin, and the second was treated with a combination drug with clavulanic acid. The results of antibacterial therapy of the first group - 48% of children showed an improvement in their condition. The results of treatment with amoxicillin in combination with clavulanic acid were higher - 58% of young patients showed positive dynamics.
  2. Surgical dentistry. According to the observations of dentists, taking combined antibacterial agents can not only shorten the rehabilitation period after surgery (tooth extraction), but also significantly alleviate the patient’s condition.
  3. Complex treatment of gastric ulcer caused by Helicobacter pylori. Treatment with a combination antibiotic and clavulanate helps achieve complete recovery in 92% of cases. At the same time, a single dose of amoxicillin gives indicators not exceeding 85%.

Safety of Flemoxin and Flemoklav: is there a difference?

And after all this, a completely logical question arises: if combined antibiotics are so effective in fighting bacterial infections, then why produce single drugs at all? But, as we found out, Flemoxin differs from Flemoklav in its level of safety. Moreover, he is the leader in this category.

We all know about the side effects of taking amoxicillin. But clavulanic acid itself can cause unwanted reactions. Therefore, when taking combination drugs, the risks of developing these side effects significantly increase, and the list of contraindications expands.

According to statistics, when taking antibiotics in combination with clavulanic acid, complaints of gastric side effects are much more common. And the risk of developing liver disease increases sixfold!

Therefore, you should not self-medicate and choose medications at your own discretion. Without wanting to, you risk seriously undermining your health by not getting rid of the first problem - a bacterial infection.

Flemoxin and Flemoklav in pediatrics

Both drugs are used to treat bacterial infections in children. The daily dose of Flemoklav for children weighing up to 40 kg is calculated based on 30 mg of amoxicillin per kg of body weight. For Flemoxin, the formula is used to calculate mg of amoxicillin per kg of body weight.

More precise recommendations regarding the duration of the course and dosage regimen can be obtained from your doctor. When selecting a medicine, not only the type of infection will be taken into account, but also the age of the child, as well as the presence of concomitant diseases.

Cost of drugs

In conclusion, it is necessary to mention one more difference between these antibiotics - price. The standard treatment regimen for infection involves a weekly course provided that the drug is taken 2-3 times a day. Since the tablets are available in packs of 20, a full course will require 1 package of the drug. Prices for Flemoxin Solutab, depending on the dosage, fluctuate within rubles per package, for Flemoklav Solutab – rubles. That is, the difference is about 17-30%; the combined antibiotic with clavulanic acid is more expensive.

Antibiotics are not a harmless vitamin. Therefore, you cannot decide on your own which drug will be better in your case. Entrust this choice to a professional.

Source: http://pulmono.ru/lekarstva/dlya-legkih/raznitsa-mezhdu-flemoklavom-i-flemoksinom

Flemoxin and Flemoklav - what is the difference?

When the cold season begins, every person thinks about choosing an effective medicine.

The complex of treatment for colds always includes an antibacterial drug. Some of the most common drugs in this group are Flemoklav solutab and Flemoxin solutab. These drugs are in great demand in medicine; you can buy them at any pharmacy and the packaging is very similar in appearance. Now he’ll try to figure out whether Flemoxin Solutab or Flemoklav - which is better?

To make a choice in someone’s favor, let’s consider how Flemoxin Solutab differs from Flemoklav Solutab.

Flemoklav Solutab

The drug is aimed at treating the respiratory system, which is caused by a bacterial infection. Flemoxin comes in the form of tablets. The active substance is amoxicillin. The dosage of the active ingredient depends on the form of release. The antibacterial agent may contain from 125 to 875 mg of the active component. The active substance is supplemented with a special component. It's called clavulanic acid.

Flemoklav is an antibiotic with a broad spectrum of action. Like Flemoxin, Flemoklav is part of the same pharmacological group - penicillin, semi-synthetic antibiotics.

Flemoklav is prescribed for:

  • respiratory tract diseases;
  • ailments of the genitourinary system;
  • lesions of the gastrointestinal tract.

Only the doctor who is seeing the patient can determine the required dosage, based on the severity of the disease and age.

Amoxicillin and clavulanic acid can develop a number of adverse reactions. Often, patients complain of stomach pain, vomiting, diarrhea, dyspepsia, flatulence and dryness of the oral mucosa. This drug can be prescribed to pregnant women. Clavulanic acid and Amoxicillin do not adversely affect intrauterine development. But in any case, in the first months, doctors try to replace Flemoklav with a more gentle drug. If, according to indications, a woman needs to undergo a course of treatment during breastfeeding, then it would be good to temporarily transfer the child to artificial feeding.

If you take Flemoklav according to all the rules, you can achieve quick positive results. To do this, you need to listen to all the doctor’s recommendations and carefully study the description of use.

Flemoxin contains amoxicillin. It is the active ingredient and exhibits resistance to trihydrate compounds. Amoxicillin is part of the group of semisynthetic penicillins. Their chemical spectrum and active structure are similar to Ampicillin.

Flemoxin consists of additional components, namely a chemical substance that ensures solubility in minimal volumes. Chemical substances include cellulose and microcrystalline cellulose.

To remove the bitterness in the tablets, pharmacists added special flavorings. Thanks to them, the tablets became pleasant in taste, reminiscent of the taste of tangerine and lemon.

This drug is also available in tablet form. Their color can be white or light yellow. Color may vary due to cellulose dosage.

Doctors can prescribe Flemoxin for children. Therefore, pharmacists have created special children's tablets with a lower dosage of the active substance. But it is very difficult to give a tablet to a small child, and Flemoxin is not available in powder form. Although, all oral antibiotics are produced in this form.

The attending physician can prescribe a drug to a woman during pregnancy, but only if the positive results outweigh the risk of adverse reactions.

The active substance flemoxin easily penetrates the placental barrier and is excreted in breast milk during lactation. This may cause sensitization in the newborn.

Side effects may include nausea, vomiting, and loss of taste buds. Also, due to individual intolerance to the active substance, the patient begins to experience allergic reactions in the form of skin rashes.

Release form of Flemoxin:

  • Flemoxin Solutab - dosage 125 mg;
  • Flemoxin Solutab - dosage 250 mg;
  • Flemoxin Solutab - dosage 500 mg;
  • Flemoxin Solutab - dosage 1000 mg.

What is the difference between Flemoxin and Flemoklav?

The chemical structure of amoxicillin is almost the same as ampicillin. It has the same spectrum of antibacterial actions. But there is one main difference - amoxicillin is more easily absorbed, thereby ensuring a higher level of the active component in the blood.

Penicillins, ampicillins, oxacillins, amoxicillins are beta-lactam antibiotics, that is, the structure of their molecules contains a beta-lactam ring. Because of this, they act identically on bacterial cells. The mechanism of action lies in the chemical structure: the antibiotic binds to the active center of the enzyme. A kind of catalytic exchange of peptidoglycan occurs. Peptidoglycan is an important component of bacterial cell walls. If the body produces it, then the division process is completed. When bacteria reproduce, one parent cell divides into two daughter cells. But, if peptidoglycan synthesis is inhibited, then the new cell does not receive its own separate place and is not separated from the parent. Because of this, two cells die.

Why then invent a combination drug if everything is so easy? Every pathogenic microorganism has a natural protective barrier. The process of evolution has developed special enzyme substances in them, these are beta lactamases.

So, what is the difference between these two drugs? Flemoclav contains not only amoxicillin, but also clavulanic acid. Beta-lactamases bind to clavulanic acid and inactivation begins. Therefore, the active component is not damaged by enzymes and exerts its antibacterial effect.

What is better Flemoxin or Flemoklav?

Above, we examined the compositions of these two drugs and determined that Flemoklav better fights pathogenic microorganisms that produce beta-lactamases. Meanwhile, Flemoxin does not resist these bacteria. But, more often, Flemoxin copes with infectious diseases.

If doctors have not diagnosed the disease, namely its causative agent, then it is better to take Flemoklav. The drug has a great chance of coping with infectious diseases of an inflammatory nature. In addition, clavulanic acid in some situations reduces the concentration of the antibiotic and increases effectiveness.

Although antibiotics have become popular, they have one negative effect - they negatively affect the microflora of the human body.

Therefore, doctors do not recommend taking antibiotics on your own. It is better to leave the choice to your doctor.

Also, the doctor will help you choose one of the two medications under consideration.

What is the difference between Flemoklav Solutab and Flemoxin Solutab?

Flemoxin Solutab contains one active ingredient - amoxicillin, and Flemoklav consists of two active ingredients - amoxicillin and clavulanic acid.

Due to the fact that Flemoklav contains clavulanic acid, the drug is considered more active.

If you compare the price, then Flemoklav is two times cheaper than Flemoxin.

If you decide to choose one of the medications that are not particularly different from each other, then first consult with your doctor. Self-medication can negatively affect your health.

Source: http://wmedik.ru/zabolevaniya/urologiya/flemoksin-i-flemoklav-v-chem-raznica.html

What is the difference between Flemoklav and Flemoxin?

Often, with the beginning of the cold season, people need to take antibacterial drugs that suppress the activity of pathogens. The most common medications are considered to be the group of penicillins, prominent representatives of which are Flemoklav with Flemoxin. This article will help you understand the difference between Flemoxin and Flemoklav.

Indications for use

Both Flemoklav Solutab and Flemoxin Solutab have fairly high effectiveness against pathogens, against which Amoxicillin is effective.

These medications are effective in eliminating the following pathologies:

  • infectious pathologies of the respiratory system;
  • genitourinary system infections;
  • inflammatory processes of the skin;
  • diseases of bone tissue;
  • ENT diseases.

Flemoxin Solutab differs from Flemoklav Solutab in the absence of a broad composition, due to which Flemoklav has an increased ability to eliminate bacteria from the lactamase environment.

This is the best drug to combat the following microorganisms:

  • staphylococcus;
  • Pseudomonas aeruginosa;
  • hydrophilic aeromonas.

Important! Taking medications together is strictly prohibited.

In addition, Flemoklav is distinguished by its effectiveness in treating gastrointestinal diseases; it is effective against the Helicobacter bacterium. This advantage is achieved by the drug due to the presence of clavulanic acid, which does not allow pathogens to resist drug exposure. If a patient takes Flemoxin Solutab and it turns out that the disease is caused by the above representatives, then the drug should be replaced with another, stronger drug.

Active substance

Based on pharmaceutical data, Flemoxin is an analogue of the drug Flemoklav. Sometimes in the pharmacy, if the original has run out, they offer this particular substitute. In fact, this alternative is not always correct. The active ingredient of both drugs is amoxicillin. It belongs to the penicillin series, which has a fairly wide spectrum of action and is effective against a large number of pathogens.

However, Flemoklav has a wider composition. Along with amoxicillin, it contains clavulanic acid, known as a blocker of enzymes of the causative agent of the disease, which also has antibacterial activity. This intensity further expands the range of antimicrobial actions. Due to this, Flemoklav is able to block the enzymes of pathogenic bacteria that destroy amoxicillin.

Important! Clavulanic acid, which is part of Flemoklav, enhances the effect of amoxicillin.

When describing comparisons between Flemoxin and Flemoclav, it should be noted that they are similar in their active component. Based on this, the principle of influencing pathogenic microorganisms is approximately similar. However, Flemoklav is a combination drug, and Flemoxin is a single drug. This is the main difference between these medications.

Compound

Flemoklav and Flemoxin were released in the Netherlands. On the pharmaceutical market they are presented as dispersed tablets that easily dissolve in water. The tablets are in a blister of 4 pieces. in everyone. Moreover, 1 package can contain 4-8 blisters. These medications have different dosages. For example, Flemoxin is issued in the following dose, which is indicated in mg:

Moreover, the amount of mg. shows the content of the active ingredient in 1 tablet form. Each tablet is engraved with the exact amount of active ingredient indicated. The exact content of clavulanic acid is added to the dosage of amoxicillin in Flemoclav. The tablets are also labeled with the amount of active ingredients listed in mg.

Advice: when the patient cannot take the medicine in tablets, it can be prepared in the form of a suspension, which will have a rather pleasant taste.

When is Flemoklav prescribed?

Many people cannot decide which is better, between Flemoxin or Flemoklav, or how to make a choice in favor of one drug or another. First of all, the combination drug is prescribed when pathogenic bacteria have developed resistance to amoxicillin. This often happens when using Flemoxin Solutab on your own or stopping the drug too early. Most often this situation occurs with the following diseases:

In medicine, an experiment was carried out in which children were treated for reactive arthritis for 30 days with Flemoxin and Flemoclav. In the group taking Flemoxin, complete cure occurred in 48% of cases. Those who were treated with the combination drug were cured in 58%. The same results were observed in the treatment of gastric ulcers caused by the Helicobacter bacterium. Therapy with Flemoklav gave complete recovery in 92%, and with a single dose of amoxicillin, a positive result occurred in 85% of cases.

In addition, operative surgery notes that the combination of amoxicillin with clavulanic acid leads to a reduction in the period of complete recovery. Typically, during recovery, patients taking this drug experience faster relief from swelling and less pain than those treated with Flemoxin.

Advantages of Flemoclav

Having considered the effect of both drugs, we can say that you can take both drugs if you have an infectious disease. Flemoxin can successfully cope with a number of pathogenic microorganisms. If the causative agent of the disease is not known in the patient, then it would be good to opt for Flemoklav. Since it gives a better chance of a speedy recovery due to the presence of clavulanic acid. Its introduction gives the combination drug the following advantages:

  • Expanded number of drug-sensitive microorganisms;
  • Reduced antibiotic dosage;
  • Increased effectiveness of the product.

Side effects

Mentioning the difference between Flemoxin and Flemoclav, it should be said that the single drug is safer to use. Everyone knows about adverse reactions of antibiotics. However, clavulanic acid, which is part of the combined product, also has a number of side effects. It turns out that while taking Flemoclav, a number of undesirable effects increase significantly and, accordingly, the number of contraindications increases.

Based on reviews of people who have taken this drug, it can be argued that the combination of clavulanic acid with an antibiotic increases complaints from the gastrointestinal tract several times. When taken regularly, the risk of liver pathologies increases 6 times.

Treatment of children

Both of these drugs can be prescribed in pediatrics for the treatment of bacterial infections. Moreover, the instructions say that they can be given to a child from 3 months of age. There is a difference in dosage between Flemoxin and Flemoklav for the treatment of children. When treating with the first drug, the calculation is made using the following formula: per 1 kg. The child’s weight is taken from 40 to 60 mg. amoxicillin. In severe cases of the disease, a large dosage of antibiotic is prescribed.

The daily dosage of Flemoclav should not exceed mg. per 1 kg. child's weight. A more precise recommendation for admission is given by the attending physician, based on the condition of the baby and his individual characteristics. When selecting a drug and its quantity, the child’s weight, type of pathogen, and the presence of chronic diseases are taken into account.

Cost of medicines

In addition, you should indicate the difference in price between Flemoxin and Flemoklav. Doctors usually prescribe treating the infection for a week, taking an antibiotic twice or three times a day. Since a standard package usually contains 20 tablets, you will need to purchase one package to complete the full course.

The cost of Flemoxin Solutab in pharmacies varies from 230 to 470 rubles. This difference in price depends on the dosage of the drug. Flemoklav Solutab can be purchased in exchange. per package. It follows from this that a combination antibiotic usually costs 20% more than a single drug.

Flemoxin and Flemoklav are quite serious drugs, treatment of which should be started only after a doctor’s prescription.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Source: http://pillsman.org/24566-flemoksin-i-flemoklav.html

Flemoxin and Flemoklav - what is the difference?

Thanks to the discovery of antibiotics, many diseases have ceased to be deadly. Over the last century, many antibacterial agents have been synthesized, but amoxicillin, first introduced into clinical practice in the 70s, is still one of the widely used antibiotics. Its importance is so great that the drug has been listed by the WHO as an essential medicinal substance needed in the basic health care system of all countries. Let's compare modern antibiotics based on amoxicillin, which can be found in our pharmacies.

What is the difference between Flemoklav and Flemoxin?

There are contraindications, use only after consulting a doctor

The antibiotics contain the same active ingredient - amoxicillin . However, Flemoklav contains an additional active agent - clavulanic acid . Therefore, the pharmacological groups to which the drugs belong are different. Thus, the usual one belongs to the pharmaceutical group of penicillins, and Flemoklav belongs to penicillins in combination with beta-lactamase inhibitors.

Both drugs are products of Astellas Pharma Inc. (Netherlands) and are available in the form of easily dissolving tablets, as emphasized in their name (“Solutab”). But, if you compare other characteristics of the drugs, there is a difference in the dosage of amoxicillin.

Flemo xin is produced in the following dosages:

  • 125 mg;
  • 250 mg;
  • 500 mg;
  • 1000 mg.

Flemo Clav has the following dosages of amoxicillin plus a proportional amount of clavulanic acid (indicated in parentheses):

  • 125 + (31.25) mg;
  • 250 + (62.5) mg;
  • 500 + (125) mg;
  • 875 + (125) mg.

Difference in Action

In terms of its chemical structure, amoxicillin is closest to ampicillin. It has the same spectrum of antibacterial action, but unlike ampicillin, it is 40-60% better absorbed when taken per os (orally) and thus provides a higher concentration of the active substance in the blood.

Antibiotics of this series (penicillin, ampicillin, oxacillin, amoxicillin, etc.) are also called beta-lactams, because in the structure of their molecule they contain the so-called beta-lactam ring. Therefore, their mechanism of action on a bacterial cell is similar. It lies in the fact that, thanks to this chemical structure, the antibiotic binds to the active center of the enzyme that catalyzes the synthesis of peptidoglycan.

Peptidoglycan is a vital component of the bacterial cell wall. If it is not produced, the bacteria cannot complete the division process. When bacteria multiply, two daughter cells arise from one parent cell. However, when peptidoglycan synthesis is inhibited, the new cell will never receive its own “separate apartment” and will not bud off from the parent. As a result, both cells die.

If the mechanism is so simple and reliable, why come up with combination drugs? This is necessary because bacteria have natural protection. During evolution, they developed beta-lactamase enzymes that hydrolyze beta-lactam antibiotics.

So, Flemoklav, in addition to amoxicillin, contains clavulanic acid. This substance irreversibly binds to beta-lactamases and inactivates them. As a result, the antibiotic is saved from the damaging effects of the enzyme and can achieve its antibacterial effect.

"Solyutab" - packages of 250, 500 and 875 mg

What's better?

According to the differences in composition, the difference will also be observed in their therapeutic effect. Flemoxin cannot effectively fight bacteria that can produce beta-lactamases.

But the introduction of clavulanic acid into the composition of Flemoklav allows you to achieve the following advantages:

  1. expand the list of sensitive microorganisms (and therefore expand the indications for use);
  2. reduce the dose of antibiotic;
  3. increase the clinical effectiveness of the drug.

Thus, a combined antibiotic is the drug of choice in cases where the pathogenesis of the disease is due to the presence of microorganisms that produce beta-lactamases, namely when:

Many studies have been conducted to find the optimal combinations of amoxicillin and clavulanate. Nowadays, the ratios most often used in pharmaceuticals are 14:1, 7:1, 4:1, 2:1. In the drug Flemoklav, the ratio is 4 or 7 parts of antibiotic to 1 part of inhibitor.

A comparative evaluation of the effectiveness made it possible to establish that in the treatment of reactive arthritis in children, after only a month of taking amoxicillin in combination with clavulanate, an improvement was observed in 58% of patients compared to 48% of patients in the group taking only amoxicillin.

Observations in operative dentistry have shown that taking a combination of amoxicillin + clavulanate shortens the recovery period after surgery, relieves swelling faster and reduces the subjective feeling of pain compared to a single antibiotic.

The use of amoxicillin in combination with clavulanate as part of combination therapy for peptic ulcer disease associated with Helicobacter pylori resulted in recovery in 92% of patients, while the rate in the group taking only amoxicillin was 85%.

However, simple and combined antibiotics differ not only in their therapeutic properties, but also in their safety profile. The fact is that clavulanate can cause adverse reactions on its own, regardless of amoxicillin. This increases the list of contraindications and increases the risk of side effects when taking Flemoklav.

Clinical trial data indicate a higher incidence of gastrointestinal symptoms (diarrhea, vomiting, nausea) after taking the combination drug. Retrospective studies show that liver disease is 6 times more common in patients taking clavulanate-based drugs. Therefore, you should not make a decision on your choice without consulting a doctor and testing. Otherwise, you can cause harm to your health, and you will never be cured of pathogenic bacteria.

Can these antibiotics be used for children?

With a doctor's prescription, of course, yes. According to the instructions, Flemoklav Solutab can be prescribed to children starting from 3 months of age. The daily dose for them is 20–30 mg amoxicillin/kg body weight.

The daily dose of Flemoxin for children under 1 year of age is 30–60 mg amoxicillin/kg body weight.

Cost difference

When treating mild/moderate infections, an adult needs to take 1–1.5 g of the drug per day, the duration of use is 7 days. The dose is divided into 2-3 doses. Let's calculate how much a course of treatment with tablets with a dosage of amoxicillin of 500 mg will cost.

The daily dose will be 3 tablets, 21 will be needed per week. 20 tablets of Flemoxin costs from 335 to 380 rubles. The same package of Flemoclav will cost approximately 15% more.

Source: http://www.kliwi.ru/2016/12/flemoksin-i-flemoklav-v-chem-raznica.html

The difference between Flemoxin Solutab and Flemoklav Solutab

Every winter, European residents are greeted with a surge of respiratory infections, and this is not at all surprising. Sledding and skiing, playing in the fresh air - all this, of course, helps improve health, but does not in any way exclude the development of infectious viral diseases as a result of general hypothermia of the body. A trip to the clinic often ends with the prescription of antibiotics, but pharmaceutical chains often offer us to replace one drug with another.

Definition

Flemoxin Solutab is a broad-spectrum antibacterial drug, the active substance in it is amoxicillin trihydrate (a beta-lactam antibacterial agent from the category of semi-synthetic penicillins). The drug is effective against many gram-positive and gram-negative bacteria, and to some extent has bactericidal properties against intestinal infections.

Flemoclav Solutab is also a broad-spectrum antibacterial drug; it is a combination of amoxycycline and clavulanic acid. Amoxicycline, which is part of the drug, has bactericidal activity, and clavulanic acid enhances its effect and expands the range of its actions, forming a stable complex with the enzyme. It is this fact that determines the price of the drug, which can be twice as much as Flemoxin Solutab.

Comparison

Both drugs contain the active ingredient amoxicillin, which belongs to the category of antibiotics with a broad spectrum of action, to the category of penicillins. This drug is actively used in domestic medicine for the treatment of infectious diseases of the upper and lower respiratory tract, as well as many other diseases caused by bacterial infection. The composition of the drug Flemoklav Solutab also includes clavulanic acid, which enhances the effects of amoxicycline and significantly expands the spectrum of its action.

Flemoxin Solutab and Flemoklav Solutab are used for the treatment of infectious and inflammatory diseases of the ENT organs (pharyngitis, otitis, tonsillitis, sinusitis), lower respiratory tract (acute and chronic bronchitis, community-acquired pneumonia), infectious processes of the skin, soft tissues, joints and bones (in including osteomyelitis), gynecological infections and infections of the urinary system.

The dosage form Solutab (soluble tablets) is one of the dosage forms that ensures almost one hundred percent absorption of the drug and instant absorption in the gastrointestinal tract. The active substance in both drugs is contained in acid-resistant microspheres, which allow the zone of maximum absorption to be reached in its original form. This fact guarantees a fairly high effectiveness of the drug.

Conclusions TheDifference.ru

  1. Flemoxin Solutab has one active substance - amoxycycline; Flemoklav Solutab contains two active substances - amoxycycline and clavulanic acid.
  2. Flemoklav Solutab, due to the second active component (clavulanic acid), has greater activity and a wider spectrum of action.
  3. Flemoklav Solutab costs 2-2.5 times more than Flemoxin Solutab.
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Source: http://thedifference.ru/chem-otlichaetsya-flemoksin-solyutab-ot-flemoklav-solyutab/

Flemoxin and Flemoklav - what is the difference?

Thanks to the discovery of antibiotics, many diseases have ceased to be deadly. Over the last century, many antibacterial agents have been synthesized, but amoxicillin, first introduced into clinical practice in the 70s, is still one of the widely used antibiotics. Its importance is so great that the drug has been listed by the WHO as an essential medicinal substance needed in the basic health care system of all countries. Flemoxin Solutab or Flemoklav Solutab are modern amoxicillin-based antibiotics that can be found in our pharmacies. Let's look at their main characteristics and differences.

What is the difference between Flemoxin Solutab and Flemoklav Solutab?

The statement that Flemoxin and Flemoklav are the same thing is not entirely true. Indeed, both drugs contain the same active ingredient - amoxicillin . However, Flemoklav contains an additional active agent - clavulanic acid . Therefore, the pharmacological groups to which the drugs belong are different. Flemoxin belongs to the pharmaceutical group of penicillins, and Flemoklav belongs to penicillins in combination with beta-lactamase inhibitors.

Both drugs are products of Astellas Pharma Inc. (Netherlands) and are available in the form of easily dissolving tablets, which is emphasized in their name (“Solutab”). But, if you compare other characteristics of the drugs Flemoklav and Flemoxin, the difference will be found in the dosage of amoxicillin.

Flemoxin is produced in the following dosages of amoxicillin:

Flemoclav has the following dosages of amoxicillin plus a proportional amount of clavulanic acid (indicated in parentheses):

How does the action of Flemoxin differ from Flemoklav?

In terms of its chemical structure, amoxicillin is closest to ampicillin. It has the same spectrum of antibacterial action, but unlike ampicillin, it is 40-60% better absorbed when taken per os (orally) and thus provides a higher concentration of the active substance in the blood.

Antibiotics of this series (penicillin, ampicillin, oxacillin, amoxicillin, etc.) are also called beta-lactams, because in the structure of their molecule they contain the so-called beta-lactam ring. Therefore, their mechanism of action on a bacterial cell is similar. It lies in the fact that, thanks to this chemical structure, the antibiotic binds to the active center of the enzyme that catalyzes the synthesis of peptidoglycan.

Peptidoglycan is a vital component of the bacterial cell wall. If it is not produced, the bacteria cannot complete the division process. When bacteria multiply, two daughter cells arise from one parent cell. However, when peptidoglycan synthesis is inhibited, the new cell will never receive its own “separate apartment” and will not bud off from the parent. As a result, both cells die.

If the mechanism is so simple and reliable, why come up with combination drugs? This is necessary because bacteria have natural protection. During evolution, they developed beta-lactamase enzymes that hydrolyze beta-lactam antibiotics.

Now we need to remember once again how Flemoxin differs from Flemoclav. So, Flemoklav, in addition to amoxicillin, contains clavulanic acid. This substance irreversibly binds to beta-lactamases and inactivates them. As a result, the antibiotic is saved from the damaging effects of the enzyme and can achieve its antibacterial effect.

"Flemoklav Solutab" - packages of 250, 500 and 875 mg of amoxicillin

Flemoxin or Flemoklav - which is better?

According to the difference that exists in the composition of the active components of the drugs Flemoklav Solutab and Flemoxin Solutab, the difference will also be observed in their therapeutic effect. Flemoxin cannot effectively fight bacteria that can produce beta-lactamases.

But the introduction of clavulanic acid into the composition of Flemoklav allows you to achieve the following advantages:

  1. expand the list of sensitive microorganisms (and therefore expand the indications for use);
  2. reduce the dose of antibiotic;
  3. increase the clinical effectiveness of the drug.

Thus, the combined antibiotic Flemoklav is the drug of choice in cases where the pathogenesis of the disease is due to the presence of microorganisms that produce beta-lactamases, namely when:

Many studies have been conducted to find the optimal combinations of amoxicillin and clavulanate. Nowadays, the ratios most often used in pharmaceuticals are 14:1, 7:1, 4:1, 2:1. In the drug Flemoklav, the ratio is 4 or 7 parts of antibiotic to 1 part of inhibitor.

A comparative assessment of the effectiveness of the two drugs allowed us to establish the following. In the treatment of reactive arthritis in children, after only a month of taking amoxicillin in combination with clavulanate, an improvement was observed in 58% of patients compared to 48% of patients in the group taking amoxicillin alone.

Observations in operative dentistry have shown that taking a combination of amoxicillin/clavulanate shortens the recovery period after surgery, relieves swelling faster and reduces the subjective feeling of pain compared to a single antibiotic.

The use of amoxicillin in combination with clavulanate as part of combination therapy for peptic ulcer disease associated with Helicobacter pylori resulted in recovery in 92% of patients, while the rate in the group taking only amoxicillin was 85%.

However, simple and combined antibiotics, including Flemoxin or Flemoklav, differ not only in their therapeutic properties, but also in their safety profile. The fact is that clavulanate can cause adverse reactions on its own, regardless of amoxicillin. This increases the list of contraindications and increases the risk of side effects when taking Flemoklav compared to Flemoxin.

Clinical trial data indicate a higher incidence of gastrointestinal symptoms (diarrhea, vomiting, nausea) after taking the combination drug. Retrospective studies show that liver disease is 6 times more common in patients taking clavulanate-based drugs.

Thus, without consulting a doctor, you should not decide whether Flemoxin Solutab or Flemoklav Solutab is better to buy. Otherwise, you can cause harm to your health, and you will never be cured of pathogenic bacteria.

Can Flemoxin or Flemoklav be used for children?

Are these antibiotics used in pediatric practice? With a doctor's prescription, of course, yes. According to the instructions, Flemoklav Solutab can be prescribed to children starting from 3 months of age. The daily dose for them is 20–30 mg amoxicillin/kg body weight.

If you compare the instructions for the drugs, you will find a difference between Flemoxin and Flemoklav for children in dosage.

The daily dose of Flemoxin for children under 1 year of age is 30–60 mg amoxicillin/kg body weight.

Difference in drug costs

Let's consider another important aspect: is there a difference between Flemoxin Solutab and Flemoklav Solutab in price?

When treating mild/moderate infections, an adult needs to take 1–1.5 g of the drug per day, duration of administration is 7 days. The dose is divided into 2-3 doses. Let's calculate how much a course of treatment with these antibiotics, taken at a dosage of amoxicillin 500 mg, will cost.

The daily dose is 3 tablets, 21 tablets are required per week. 20 tablets of Flemoxin cost from 335 to 380 rubles. The same package of Flemoclav will cost approximately 15% more.

Source: http://mymednews.ru/flemoksin-i-flemoklav-v-chem-raznica/