Cetirizine tablets composition

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Cetirizine - instructions for use, reviews, analogs and release forms (10 mg tablets, drops, syrup) of the drug for the treatment of urticaria, hay fever and other manifestations of allergies in adults, children and pregnancy.

Table of contents:

Compound

In this article you can read the instructions for use of the drug Cetirizine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Cetirizine in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Cetirizine analogues in the presence of existing structural analogues. Use for the treatment of urticaria, hay fever and other manifestations of allergies in adults, children, as well as during pregnancy and breastfeeding. Composition of the drug.

Cetirizine is a competitive histamine antagonist, a metabolite of hydroxyzine, and blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects. Affects the early stage of allergic reactions, limits the release of inflammatory mediators at the late stage of the allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles.

Eliminates skin reactions to the introduction of histamine, specific allergens, as well as to cooling (with cold urticaria).

It has virtually no anticholinergic and antiserotonin effects. In therapeutic doses it practically does not cause a sedative effect. The onset of action after a single dose of 10 mg of cetirizine is after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), lasting more than 24 hours. During a course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After stopping treatment, the effect lasts up to 3 days.

Cetirizine dihydrochloride + excipients.

Rapidly absorbed from the gastrointestinal tract. Food does not affect the completeness of absorption (AUC), but prolongs the time to reach Cmax by 1 hour and reduces Cmax by 23%. In small quantities, it is metabolized in the liver by O-dealkylation to form a pharmacologically inactive metabolite (unlike other H1-histamine receptor blockers, which are metabolized in the liver with the participation of the cytochrome P450 system). Does not accumulate. 2/3 of the drug is excreted unchanged by the kidneys and about 10% through the intestines. Passes into breast milk.

  • seasonal and year-round allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia);
  • urticaria (including chronic idiopathic urticaria);
  • hay fever (hay fever);
  • itching;
  • angioedema (Quincke's edema);
  • itchy allergic dermatoses (including atopic dermatitis, neurodermatitis).

Film-coated tablets 10 mg.

Drops for oral administration.

Instructions for use and dosage

Adults and adolescents over 12 years of age are recommended to take 10 mg (1 tablet) of cetirizine, preferably in the evening.

Children aged 6 to 12 years and weighing less than 30 kg, 5 mg (1/2 tablet) in the evening; with a body weight of more than 30 kg - 10 mg (1 tablet) in the evening. You can take 5 mg (1/2 tablet) 2 times a day (morning and evening).

Adults and adolescents over 12 years of age are recommended to take 10 mg (10 ml (2 scoops)) of cetirizine, preferably in the evening.

Children aged 2 to 12 years and weighing less than 30 kg are prescribed 5 ml (1 scoop); with a body weight of more than 30 kg - 10 ml (2 scoops) in the evening. You can take 5 ml (1 measuring spoon) 2 times a day (morning and evening).

Adults and adolescents over 12 years of age are recommended to take 10 mg (20 drops) of cetirizine, preferably in the evening.

For children aged 1-2 years, the drug is prescribed 2.5 mg (5 drops) 2 times a day; at the age of 2-6 years - 2.5 mg (5 drops) 2 times a day (morning and evening) or 5 mg (10 drops) in the evening; at the age of 6-12 years - 5 mg (10 drops) 2 times a day (morning and evening) or 10 mg (20 drops) in the evening.

Patients with renal failure should reduce the recommended dose by 2 times.

If liver function is impaired, the dose must be selected individually, especially carefully in case of simultaneous renal failure.

Elderly patients with normal renal function do not require dose adjustment.

For seasonal allergic rhinitis, the duration of therapy for adults is usually from 3 to 6 weeks, and for short-term exposure to the allergen, 1 week is sufficient. The duration of therapy for children over 6 years of age is from 2 to 4 weeks, and for short-term exposure to the allergen, 1 week is sufficient.

The tablets are taken orally, regardless of meals, without chewing and with a sufficient amount of liquid, preferably in the evening.

  • dry mouth;
  • dyspepsia;
  • headache;
  • drowsiness;
  • fatigue;
  • dizziness;
  • excitation;
  • migraine;
  • skin rash;
  • angioedema;
  • hives;
  • skin itching.
  • severe kidney disease;
  • pregnancy;
  • lactation (breastfeeding);
  • hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy. If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.

Use in elderly patients

Use with caution in elderly patients.

The drug in the form of drops for oral administration is intended for children over 1 year of age.

The drug in syrup form is intended for children over 2 years of age.

The drug in tablet form is intended for children over 6 years of age.

The simultaneous use of drugs that depress the central nervous system is not recommended.

While using the drug, you should not drink ethanol (alcohol).

When prescribing the drug to patients with diabetes, it should be taken into account that 1 tablet corresponds to less than 0.01 XE, 10 ml of syrup (2 scoops) contains 3.15 g of sorbitol (800 mg of fructose), which corresponds to 0.026 XE.

Due to the content of glycerol, propylene glycol, methyl 4-hydroxybenzoate, propyl 4-hydroxybenzoate in the syrup, when taking the drug in high doses, headaches, gastrointestinal disorders, bronchospasm, and urticaria are possible.

Impact on the ability to drive vehicles and operate machinery

During the period of use of the drug, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

No clinically significant interactions of cetirizine with other drugs have been established.

Combined use with theophylline (at a dose of 400 mg per day) leads to a decrease in the overall clearance of cetirizine (the kinetics of theophylline does not change).

Analogues of the drug Cetirizine

Structural analogues of the active substance:

Analogs for therapeutic effect (medicines for the treatment of urticaria):

Source: http://instrukciya-otzyvy.ru/861-cetirizin-po-primeneniyu-analogi-tabletki-kapli-sirop-krapivnica-allergiya-sostav.html

Cetirizine - instructions for use of tablets, drops and syrup, what to use, analogues

Cetirizine is a 2nd generation antiallergic (antihistamine) drug with a rapid onset of action and a long duration. The use of the drug is justified in cases where long-term treatment of allergic diseases is necessary: ​​chronic urticaria, year-round rhinitis. The drug prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects. Available in the form of tablets, drops and syrup for oral administration.

Composition and release form

Cetirizine (CETIRIZINE) is an antiallergic drug. Histamine H1 receptor blocker. The medicine is included in the list of necessary medications and is available without a prescription.

Excipients of Cetirizine include:

  • colloidal silicon dioxide;
  • lactose monohydrate;
  • crospovidone;
  • magnesium stearate;
  • microcrystalline cellulose:
  • shell: hypromellose, polydextrose, macrogol, titanium dioxide.
  • White, oblong-shaped Cetirizine tablets
  • Colorless, transparent drops for oral administration
  • Colorless, transparent syrup for oral administration, with the smell of banana

pharmachologic effect

The body's perception of the drug begins already at the stage of its ingestion. Actively absorbed by the upper layer of the epidermis and mucous membrane when it enters the oral cavity and then into the intestines, the active substance causes a decrease in the activity of allergy manifestations.

It has virtually no anticholinergic and antiserotonin effects. In therapeutic doses it practically does not cause a sedative effect. The onset of action after a single dose of 10 mg of cetirizine is after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), lasting more than 24 hours. During a course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After stopping treatment, the effect lasts up to 3 days.

The medicine is able to prevent and reduce the skin reaction that occurs when histamine is released and when specific allergens penetrate the skin.

Indications

What does it help with? According to the instructions, Cetirizine is indicated in the following cases:
  • urticaria, including chronic idiopathic;
  • allergic conjunctivitis;
  • seasonal and year-round allergic rhinitis (as symptomatic treatment);
  • dermatoses that occur with itching, including neurodermatitis, atopic dermatitis.

The drug can also be prescribed to patients who are prone to developing allergic reactions to medications, for example, antibiotics, cough syrups and others.

Cetirizine is prescribed with extreme caution to elderly people and persons suffering from moderate and severe chronic pyelonephritis.

Instructions for use

To achieve maximum effect, you should take Cetirizine tablets correctly. The analogue should also be used after carefully studying the instructions. The drug is taken orally. There is no need to chew the tablets. Wash them down with plenty of water. The medication can be used regardless of meals. On an empty stomach, the rate of absorption of tablets increases.

Cetirizine tablets

The tablets are taken orally, as a whole, preferably in the evening, given the sedative effect. Adults and children over 12 years of age are prescribed 10 mg per day. Children 6-12 years old with a weight over 30 kg - 10 mg once a day, with a weight less than 30 kg - 5 mg once a day.

Cetirizine drops

Take Cetirizine orally, regardless of meals.

Instructions for use for children and adults:

  • Adults and adolescents over 12 years of age are recommended to take 20 drops (10 mg) daily, preferably in the evening.
  • Children aged 6-12 years: 10 drops (5 mg) twice a day in the morning and evening or 20 drops (10 mg) in the evening.
  • Children aged 2-6 years: 10 drops (5 mg) in the evening or 5 drops (2.5 mg) in the morning and evening.
  • Children aged 1-2 years: 5 drops (2.5 mg) twice a day.

Due to the depressant effect of Cetirizine on the central nervous system, this drug in the form of drops should be prescribed with extreme caution to children under one year of age in whom factors have been identified that increase the risk of SIDS - sudden infant death syndrome.

Syrup

Cetirizine syrup in dark glass bottles of 75 or 150 ml, complete with a 5 ml measuring spoon, along with instructions for use in a cardboard box.

Children from two to 12 years old and weighing less than 30 kg are prescribed a dose of 5 ml; if the weight is greater, then 10 ml of the drug per day is needed. Patients over 12 years of age require a daily dosage of 10 ml. You can take 2 times a day (morning and evening) 5 ml (1 measuring spoon).

In case of renal failure, the recommended dose should be reduced by 2 times.

Contraindications

Cetirizine should be prescribed with caution to elderly people, as this category of patients may have a decrease in glomerular filtration. In addition, caution must be exercised when prescribing the drug for moderate and severe chronic pyelonephritis.

The official instructions indicate that the drug is contraindicated during pregnancy.

Side effects for the body

Typically, the drug Cetirizine is well tolerated by patients, but with an incorrectly calculated dose, hypersensitivity to the components of the tablet, or prolonged uncontrolled use of the drug, side effects may develop:

  • dry mouth;
  • dyspepsia;
  • headache;
  • drowsiness;
  • fatigue;
  • dizziness;
  • excitation;
  • migraine;
  • skin rash;
  • angioedema;
  • hives;
  • skin itching.

Cetirizine-Teva should be used with caution in patients with moderate to severe chronic renal failure and in elderly patients (reduced glomerular filtration rate is possible).

In case of severe side effects, it is recommended to stop taking this drug and replace it with analogues of action.

Overdose

Excessive use of the above drug can provoke the development of the following symptoms:

  • drowsiness,
  • lethargy,
  • urinary retention,
  • general weakness,
  • headache,
  • tachycardia,
  • increased fatigue and irritability.

special instructions

Concomitant use with alcohol and drugs that depress the central nervous system is not recommended.

During treatment, experts recommend refraining from engaging in activities that require increased attention. The tablets may cause drowsiness and slight dizziness. It is not advisable to drive a car.

According to the instructions, cetirizine is prohibited for use during pregnancy and lactation.

Interaction with other drugs

No clinically significant interactions of cetirizine with other drugs have been established.

Shelf life of tablets

Store the drug in a dry place, protected from light, at a temperature not exceeding 25°C.

  • Tablets, drops and syrup: store for 3 years. An open bottle can be used for 6 months.

Do not use the medicine after the stated expiration date.

Analogs

The most common and most effective analogues of Cetirizine are:

Before replacing a prescribed drug with its analogue, you should read the attached instructions for contraindications and age restrictions.

Prices in pharmacies

The approximate cost of Cetirizine is shown in the table:

Before using the drug, be sure to consult your doctor.

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Cetirizine

Description current as of 07/02/2016

  • Latin name: Cetirizine
  • ATX code: R06AE07
  • Active ingredient: Cetirizine
  • Manufacturer: Obolenskoye, VERTEX, Ozon LLC, Berezovsky Pharmaceutical Plant (Russia), Glochem Industries (India)

Compound

1 tablet contains cetirizine dihydrochloride 10 mg. MCC, silicon dioxide, lactose monohydrate, magnesium stearate as auxiliary components.

1 ml drops - cetirizine dihydrochloride 10 mg. Benzoic acid, propylene glycol, glycerol, water, sodium acetate, as excipients.

Release form

  • Coated tablets Cetirizine Teva 10 mg.
  • Cetirizine Hexal drops for oral administration in bottles of 10 ml or 20 ml.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

H1-histamine receptor blocker, competitive histamine antagonist. Eliminates manifestations of allergic reactions, having antiexudative and antipruritic effects. Reduces capillary permeability, eliminates muscle spasms and skin reactions (with cold urticaria). Reduces the hyperreactivity of the bronchopulmonary system in patients with asthma in response to the release of histamine.

It has almost no anticholinergic and sedative effects. The effect is observed after 1 hour, the maximum effect is determined after 4 hours, and the duration is 24 hours. The effect lasts 3 days after the end of treatment. During treatment, tolerance to the drug does not develop.

Pharmacokinetics

When taken orally it is well absorbed. Cmax is determined in the blood after 1 hour. It is 93% protein bound. Does not accumulate. Metabolized to an inactive metabolite, 60% is excreted by the kidneys in 96 hours and a small part of the active substance (10%) is excreted through the intestines. T1/2 is 7-10 hours. T1/2 in children 6-12 years old is 6 hours. There is an increase in T1/2 with impaired renal and liver function.

Indications for use

Contraindications

  • increased sensitivity;
  • age up to 6 years (for tablets);
  • pregnancy;
  • lactation;
  • severe renal failure;
  • glucose-galactose malabsorption;
  • lactose intolerance.

Prescribed with caution in severe renal failure, in old age, while taking barbiturates, ethanol, opioid analgesics, benzodiazepine derivatives. Avoid driving during the period of use.

Side effects

Most common adverse reactions:

Rarely encountered adverse reactions:

Instructions for use of Cetirizine (Method and dosage)

Cetirizine Hexal drops, instructions for use

Adults and children over 12 years of age are prescribed 20 drops (equivalent to 10 mg), preferably in the evening. Children - 20 drops in the evening, from 2 to 6 years - 10 drops in the evening, from 1 to 2 years 5 drops 2 times a day.

For elderly patients, the dose is not changed. In case of renal failure, the recommended dose is reduced by 2 times. For liver failure, the dose is selected individually. The duration of treatment for seasonal allergic rhinitis is weeks. If the flowering of plants is not long, and the pollen effect is short-term - one week.

Instructions for use Cetirizine Teva

The tablets are taken orally, as a whole, preferably in the evening, given the sedative effect. Adults and children over 12 years of age are prescribed 10 mg per day. Children 6-12 years old with a weight over 30 kg - 10 mg once a day, with a weight less than 30 kg - 5 mg once a day.

Overdose

An overdose is manifested by drowsiness in adults, anxiety and irritability in children, urinary retention, constipation, dry mouth, dilated pupils, tachycardia.

Treatment consists of gastric lavage and the administration of enterosorbents. Symptomatic treatment is carried out. There is no antidote. Hemodialysis is not effective.

Interaction

The drug enhances the effects of alcohol, so taking it is not permissible during treatment with this drug. The use of Cetirizine should be stopped three days before allergy tests are performed.

Terms of sale

Dispensed without a doctor's prescription.

Storage conditions

Storage temperature up to 25°C.

Best before date

Cetirizine during pregnancy

The official instructions indicate that the drug is contraindicated during pregnancy. This is based on the fact that there have been no adequate studies of women in this category, but animal studies have not revealed any risks of negative effects on the fetus (FDA Fetal Risk Category B). There is also no data on its excretion in breast milk, so it should not be used while breastfeeding.

However, according to the few studies of the drug on the possibility of use in pregnant women in the first trimester, it does not increase the number of birth defects, the frequency of spontaneous abortions and early births. There was no difference in the weight of newborns whose mothers took Cetirizine.

If there is a need to use antiallergic drugs during pregnancy, then, weighing all the risks, preference should be given to Fenkarol, cetirizine and Loratadine, which are best not prescribed in the first trimester.

Cetirizine analogs

Reviews of Cetirizine

What are Cetirizine tablets for? This is a second generation antiallergic (antihistamine) drug with a rapid onset of action and a long duration. The use of the drug is justified in cases where long-term treatment of allergic diseases is necessary: ​​chronic urticaria, year-round rhinitis.

Its characteristic feature is its high ability to penetrate the skin, so it is effective for skin manifestations of allergies - atopic dermatitis, urticaria, rashes of allergic origin. Of all the second generation drugs, only Cetirizine is used in children from 6 months.

High affinity for histamine H1 receptors minimizes side effects. According to patient reviews, even long-term use of the drug did not cause dry mouth, nose, or constipation. A number of drugs in this group have a cardiotoxic effect, but Cetirizine, Ebastine, Loratadine, Akrivastine do not have such an effect.

Reviews of Cetirizine Hexal are positive, patients note its effectiveness, and, importantly, the variety of release forms. Parents note that the drug in the form of drops is more acceptable for children. The pharmacy has a large selection of dosage forms with the same active ingredient. Drops of cetirizine hydrochloride are produced under the names Zyrtec, Zodak, Pralazine, and Zerinal, Cetrin, Zincet are produced in the form of syrup, which further expands the possibilities of their use. With all this, the drug is regarded as a drug with a sedative effect (which cannot be said about Amertil), which limits its use.

Cetirizine price, where to buy

You can purchase this drug at any pharmacy. The cost depends on the manufacturer. Price of Cetirizine Teva bran tablets. For children, the release form is more convenient - drops. Price of Cetirizine Hexalrub drops. The same pharmaceutical company also produces a tablet form.

Russian Cetirizine Vertex is also available in the pharmacy chain, 20 tablets of which can be purchased for foreign purchases. These drugs contain the active ingredient cetirizan hydrochloride.

The pharmacy chain offers drugs containing cetirizine dihydrochloride: Cetrin (RUB) and Amertil, which do not have a sedative effect.

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  • Online pharmacies in Ukraine Ukraine

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Medicine to reduce and prevent negative symptoms of various types of allergies - Cetirizine: instructions for use, price and dosage

Cetirizine is an inexpensive antiallergic medicine, a blocker of H1-histamine receptors. The new generation drug quickly eliminates sneezing, lacrimation, coughing, skin itching, and swelling that accompany various types of allergies.

The medicine is recommended as a single drug and as part of complex therapy for urticaria, atopic bronchial asthma, hay fever, allergic conjunctivitis and rhinitis. Cetirizine in the form of tablets, syrup, drops is successfully used by doctors to treat children and adults. Before taking the product, it is important to read the instructions carefully.

Composition and release form

A modern antiallergic drug contains a new generation active ingredient - cetirizine hydrochloride and additional ingredients. The composition is approved for use in adults and children.

Pharmacy chains receive three types of antihistamines:

  • pills. The content of cetirizine is 10 mg per unit. Tablets are oblong, film-coated, white, in blisters;
  • syrup for oral administration. The weak banana taste makes it easier to use the medicine in preschool children. Transparent liquid is poured into bottles, the volume of medicine is 75 and 150 milligrams;
  • Cetirizine drops for oral use. 1 ml of antihistamine contains 10 ml of active substance. Dropper bottles contain 10 and 20 ml of colorless, transparent liquid.

Action

After taking any form of the drug, patients quickly feel the positive effect:

  • the risk of allergic reactions is reduced;
  • skin itching weakens;
  • swelling decreases;
  • lacrimation and conjunctival irritation are reduced;
  • the volume of liquid mucus in the nasal passages is reduced;
  • Sneezing and allergic cough stops.

Find out the instructions for using the drug Telfast to relieve allergy symptoms in children and adults.

Read about the characteristic symptoms and treatment methods of neurodermatitis in adults at this address.

A noticeable effect is the result of the active influence of cetirizine. Active substance:

  • quickly blocks histamine receptors;
  • actively influences the early stage of development of a negative reaction;
  • prevents the release of inflammatory mediators;
  • relieves acute spasms of smooth muscles;
  • quickly removes signs of skin reactions to histamine release;
  • alleviates the patient's condition with cold urticaria, reactions to strong irritants;
  • antiserotonin and anticholinergic effects are almost absent;
  • reduces the permeability of the capillary wall;
  • reduces and significantly reduces tissue swelling.

After a single use, the effect is noticeable in half of the patients within a third of an hour; in 95% of allergy sufferers, the result appears within an hour. Cetirizine is a drug with a prolonged effect, the effect lasts 24 hours. At the end of therapy, the residual effect lasts up to 72 hours.

Indications for use

The drug is effective in relieving the symptoms of many allergic reactions. When prescribing the composition, the doctor takes into account the patient’s age, selects the optimal form of the drug, and determines the frequency of administration.

Indications for use of syrup, tablets and drops of Cetirizine:

  • complex therapy of atopic bronchial asthma;
  • allergic conjunctivitis and rhinitis (year-round and seasonal form);
  • Quincke's edema;
  • urticaria, including the idiopathic form of a chronic nature;
  • allergic dermatitis;
  • hay fever.

Contraindications

The medicine has few restrictions on its use:

  • pregnancy;
  • age up to 1 year;
  • lactation period;
  • excessive sensitivity of the body to cetirizine (including hydroxyzine);

Negative manifestations

The cetirizine-based drug is well tolerated by many patients, regardless of age. If the dosage is strictly observed in young children and elderly patients, severe reactions to the components of the antihistamine occur infrequently.

In some cases it appears:

  • urticaria, swelling, itching;
  • discomfort in the stomach, intestines;
  • migraine;
  • dizziness.

Instructions for use and dosage

A medicine based on cetirizine is prescribed by the attending physician. The frequency of administration and dosage depend on the patient’s condition, severity of the reaction, and age. Independent adjustment of the admission rules is prohibited.

For adults

The best option is tablets with active antiexudative and antipruritic effects. One of the advantages is its prolonged action. To eliminate allergy symptoms, one tablet per day is enough.

You will need ½ glass of liquid; you should not chew the tablets. To enhance the absorption of the active substance, it is undesirable to combine the drug with food.

For children

The antihistamine drug Cetirizine is approved for the relief of allergy symptoms in young patients aged 12 months and older. For children in this category, doctors prescribe only drops. Upon reaching the age of two, the drug is approved in the form of a syrup with a pleasant banana taste, after 12 years - tablets with prolonged action.

Frequency and dosage (single and daily):

  • children from one to two years – give 5 drops (2.5 mg of the drug) to the patient twice a day;
  • age from two to six years – 2.5 mg twice or once 5 mg;
  • from six years and older - 5 mg twice a day or 10 mg once.

special instructions

The use of the drug Cetirizine in some patients causes a slowdown in psychomotor reactions. Such manifestations most often occur due to exceeding the daily dosage (above 10 mg). During therapy, it is important to exercise caution when engaging in activities that require alertness and caution.

Interaction with various drugs

  • during treatment using any form of the drug Cetirizine, it is prohibited to take medications that depress the central nervous system and ethanol;
  • combination with Theophylline in most patients reduces the overall clearance of cetirizine (the effect of theophylline remains at the same level);
  • the hematotoxic effect of cetirizine increases when taken simultaneously with myelotoxic drugs;
  • The studies did not reveal any negative interaction between the drug Cetirizine and Azithromycin, Ketoconazole, Diazepam, Cimetidine, Glipizide.

What is hay fever and how to treat seasonal allergies in children and adults? We have the answer!

Read about nutrition rules and diet for food allergies in children of different ages on this page.

Follow the link http://allergiinet.com/detskaya/starshije/na-koshek.html and read the information about how allergies to cats manifest themselves and how to treat them.

Price

Domestic pharmaceutical companies offer Cetirizine at a low price, while the imported drug is more expensive, sometimes 2 times. The price range in various pharmacy chains is quite wide.

Approximate price of Cetirizine:

  • tablets No. 10 – from 45 to 90 rubles;
  • tablets No. 20 – from 60 to 140 rubles;
  • drops 20 ml – 250 rubles.

Analogs

Allergists recommend substitutes for the drug Cetirizine:

The purchase of an antihistamine of a similar effect and group is permitted only after consultation with your doctor. Parents should be especially careful when choosing allergy medications for children: many medications cannot be given to children under two years of age.

Reviews

Doctors and patients consider Cetirizine a good drug for treating many types of allergies. Quick action, long-lasting effect allows you to take just one tablet per day or give your child a small amount of antihistamine in the form of syrup or drops.

The medicine almost does not provoke sedative effects; tolerance to the active substance does not develop with long-term use. Another plus is the positive effect on many types of sensitization of the body.

Video - review and rules for using the drug Cetirizine Hexal for various allergy symptoms:

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Cetirizine: composition features, method of application and purpose of the drug

The specific effects and possibilities for using the drug Cetirizine are determined by the specifics of its composition. The manufacturer guarantees a high degree of effectiveness of this product, designed to eliminate the consequences of allergic reactions in the body.

Possessing a balanced multicomponent composition, Cetirizine copes well with both the initial stages of allergic reactions and their more advanced manifestations, which significantly worsen the general well-being of the patient, reducing his quality of life.

Features of the drug

Having the Latin name Cetirizine, the drug can be used independently in monotherapy, as well as in complex therapy, which increases the degree of effectiveness in the treatment of allergic reactions.

Being a blocker of H1-histamine receptors, Cetirizine ensures the normalization of processes in the skin, relieves inflammation and swelling of tissues. Presented on the market in the form of two dosage forms, this drug allows you to choose the option that is most suitable for use and will help you get a pronounced positive result as quickly as possible.

The drug is not hormonal, so its use can be recommended for people with hypersensitive skin. A limitation to the long-term use of Cetirizine should be its ability to accumulate in the body, therefore the period of exposure to the drug should be limited and correspond to the available indications. Monitoring by an allergist makes it possible to prevent the manifestation of negative consequences of using this drug.

Cetirizine Hexal is discussed in this video in review form:

Dosage forms

There are two medicinal versions of Cetirizine on sale: drops and tablets. Both of them have some differences in composition, however, the degree of impact and the percentage of the active substance allows you to equally obtain a clear and long-lasting positive result of use.

  • The tablet form of the drug is presented in the form of oblong-shaped dragees, white in color and coated with a coating that is easily soluble when it enters the gastrointestinal tract. The tablets are placed in an aluminum blister, 10 pieces each. The blister is located in a cardboard package.
  • The drops are intended for oral administration; their packaging may vary - 10 and 20 g in a bottle. This dosage form is almost completely transparent; to use the drops should be dissolved in water: the concentration of the resulting solution corresponds to the diagnosis.

Composition of Cetirizine

The active component of the tablets is cetirizine dihydrochloride, which contains 10 mg per tablet. Excipients of the tablets include:

  • lactose monohydrate;
  • microcrystalline cellulose;
  • silica;
  • magnesium stearate;
  • purified water.

This composition allows the medicinal qualities of cetirizine dihydrochloride to be demonstrated to the maximum extent, which is important for the treatment of advanced forms of allergic reactions in the body.

Presented in the form of drops of the drug, the active substance also contains cetirizine dihydrochloride; auxiliary components include glycerin, benzoic acid, propylene glycol, sodium stearate and distilled water.

Cetirizine drops are offered for sale at a price of rubles per package, while tablets have a slightly reduced price: from 120 to 155 rubles per package.

pharmachologic effect

By acting on H1-histamine receptors, the active substance of the drug reduces the severity of allergic reactions. Eliminating swelling of the skin, reducing hypersensitivity of the skin at the site of the lesion, eliminating redness - all this can be achieved by using Cetirizine in any form.

Having a pronounced antiallergic effect, this drug increases the degree of resistance of the body, relieves spasms of smooth muscles, which is most often observed in allergic reactions of various natures. Also, the active substance of the drug can eliminate the possible exudative process and reduce hyperemia of the skin.

Pharmacodynamics

The body's perception of the drug begins already at the stage of its ingestion. Actively absorbed by the upper layer of the epidermis and mucous membrane when it enters the oral cavity and then into the intestines, the active substance causes a decrease in the activity of allergy manifestations. By eliminating skin manifestations, which is most typical for cold and heat urticaria, Cetirizine reduces the rate of histamine release. This quality of the drug makes it possible to use it to relieve the most unpleasant symptoms of allergic reactions.

The earliest manifestation of the medicinal quality of the drug is observed after 1 hour from the start of its administration. Maximum manifestation is after 4 hours. The therapeutic effect lasts for 24 hours from the moment of taking this drug in any form.

Pharmacokinetics

The breakdown of the drug in question into its individual active components occurs within 2-3 days from the moment of use of Cetirizine. Removal of decay products is carried out by the kidneys, partially by the gall bladder.

The duration of complete cleansing of the body from the breakdown products of the drug is carried out in accordance with the age of the patient, from 2-3 days in the case of treatment of children with this drug and 2-4 days when used by adults.

Indications

The following conditions should be considered indications for the use of Cetirizine:

The listed conditions respond to the greatest extent when using Cetirizine in any of its forms. Allergies to smoking, as well as ordinary skin allergies, as well as allergies to water, respond well to treatment with this drug.

Instructions for use

The use of the drug is determined by the age category of the patient. For children, the duration of exposure and frequency of use of Cetirizine tablets or drops will be slightly less than for eliminating allergic symptoms in adult patients. The method of using the drug also differs depending on the type of medicine.

For adults

For adults, the following rules for using the drug should be followed:

  • drops are used 2-3 times a day before meals, for a total of 20 drops per day, preferably in the evening.
  • Tablets are also prescribed 2-4 times a day; they must be swallowed whole, without chewing, with a sufficient amount of water;
  • The duration of use of drops or tablets is 2-5 days, depending on the body’s sensitivity to the active component of the drug.

Children and newborns

For newborns in the treatment of allergic manifestations of the drug Cetirizine in any dosage form is not prescribed. The drug can be taken in the form of drops starting from the age of 6 years.

During pregnancy and lactation

During pregnancy and lactation, due to the penetration of the active component through the placental barrier and into breast milk, the use of Cetirizine in any form is not recommended.

Contraindications

Contraindications to the use of Cetirizine include:

  • allergy to any component of the drug;
  • renal failure;
  • lactose intolerance;
  • the period of bearing a child and breastfeeding.

Also, glucose-galactose malabsorption is included in the list of contraindications to the use of Cetirizine.

Side effects

  • When using the drug in question, there is a high probability of intensifying existing manifestations of allergies, the appearance of anxiety in children and drowsiness in adults.
  • Manifestations such as asthenia, skin itching, tachycardia and signs of anemia may also occur.

In case of severe side effects, it is recommended to stop taking this drug and replace it with a similar one.

special instructions

  • Old age makes it possible to use the drug Cetirizine in independent and complex use, however, in case of increased sensitivity to its components, the dose of the drug taken should be reduced.
  • The drug should be stored at a constant ambient temperature, without direct sunlight. The shelf life of any dosage form of Cetirizine is 3 years.

Interaction with other drugs and alcohol

  • With complex effects, the degree of effectiveness of Cetirizine does not decrease.
  • Alcoholic drinks, especially in significant quantities, reduce the degree of absorption of the drug and reduce its effectiveness.

Reviews

According to the majority of users, the drug Cetirizine showed excellent results in clinical trials and in the treatment of multiple allergic manifestations: eliminating increased sensitivity of the skin, relieving itching and burning, the drug is also able to eliminate hyperemia of the skin. The possibility of using the product to treat children and the elderly is also considered an advantage of this product.

Affordability of cost for buyers is an important advantage of the drug over most similar ones that are offered for sale today.

Comparison with other drugs in this group

If we compare the drug in question with drugs with antihistamine properties, we can notice the following differences:

  • The drug Loratadine, in comparison with Cetirizine, has a slightly lower cost, but its degree of effectiveness is slightly lower, according to reviews from those who have already used it in the treatment of allergic manifestations. Loratadine has a price of 110 to 135 rubles per pack, but it eliminates advanced stages of allergies with less effectiveness;
  • Cetrin, which belongs to the same group of drugs, also has good effectiveness in eliminating allergic manifestations, relieving increased sensitivity of the skin, restoring its normal functioning;
  • if we compare levocetirizine and cetirizine, we can note the greater effectiveness of levocetirizine in the treatment of advanced and accompanied by concomitant organic changes in the body;
  • Zyrtec is more expensive compared to Cetirizine, but its degree of effectiveness is approximately the same compared to Cetirizine;
  • Deslorotadine is less absorbable by the body, and although it is most often prescribed by a doctor for the treatment of advanced stages of the pathological process, the impossibility of its use in complex therapy due to the high probability of negative side effects reduces the advantages of Deslorotadine over Cetirizine;
  • Zodak can be considered approximately equal in effectiveness to Cetirizine;
  • Claritin may have negative effects on the kidneys and liver due to its more active composition;
  • Erius copes with most allergic manifestations, however, in comparison with Cetirizine, this drug has a greater number of possible side effects on the body.

Analogs

Analogues of Cetirizine include such products as Claritin (the price of a package of the drug is rubles), Zodak (rubles) and Zyrtec (the price of rubles per tube of cream or ointment). An analogue in the group of this drug is Terfenadine. Also drugs with a similar effect include Xyzal, Allertek.

The video below will tell you about good allergy remedies:

Source: http://gidmed.com/dermatologiya/lekarstva-derm/tsetirizin.html

Cetirizine: instructions for use

The drug Cetirizine belongs to the group of histamine H1 receptor blockers and is an antiallergic drug.

Release form and composition of the drug

The drug Cetirizine is available in the form of tablets for oral administration. The tablets are white, coated with a protective film, convex on both sides, round, packaged in blisters of 10 pieces (1-3) in a cardboard box, the drug is accompanied by a detailed annotation describing the characteristics of the tablets.

Each tablet contains 10 mg of the active ingredient - Cetirizine dihydrochloride, as well as a number of additional excipients, including lactose monohydrate.

Indications for use

The drug Cetirizine is prescribed to patients for the relief and prevention of clinical manifestations of an allergic reaction in the following conditions:

  • rhinitis caused by flowering plants, herbs, flowers;
  • allergic conjunctivitis;
  • urticaria, including idiopathic and allergic;
  • hay fever;
  • allergic rhinorrhea;
  • itching of the skin due to dermatitis, including atopic dermatitis;
  • angioedema;
  • allergic reaction to ultraviolet rays;
  • insect bites and swelling of the skin due to the bite.

The drug can also be prescribed to patients who are prone to developing allergic reactions to medications, for example, antibiotics, cough syrups and others.

Contraindications

Cetisirine tablets can be taken orally only after carefully reading the attached leaflet, since the drug has a number of contraindications and restrictions for use:

  • severe kidney disease accompanied by dysfunction of the organ;
  • age up to 6 years;
  • hypersensitivity to Cetisirine;
  • pregnancy and breastfeeding;
  • lactose intolerance, malabsorption syndrome;
  • acute liver failure.
Relative contraindications to prescribing the drug to patients are bradycardia, central nervous system diseases, and age over 65 years.

Directions for use and dosage

Cetirizine tablets have a prolonged (long-lasting) antiallergic effect. The drug is taken in a dosage of 10 mg 1 time per day, preferably at night, the tablet is swallowed immediately, without crushing, with a sufficient amount of water.

For children over 6 years of age, the dose is determined individually, depending on body weight. Therapy begins with 5 mg (1/2 tablet) 1 time per day. The duration of therapy is determined by the doctor for each individual patient.

Use during pregnancy and lactation

Research and clinical trials of the drug Cetirizine and its effect on pregnancy and intrauterine development of the fetus have not been conducted. Given the lack of information on the safety of tablets for mother and fetus, Cetirizine is not prescribed to pregnant women.

The active ingredient of the tablets is excreted in breast milk and can enter the baby’s body, so Cetirizine is not prescribed to nursing mothers. If therapy is necessary for a nursing mother, it is recommended to decide on stopping breastfeeding.

Side effects

Typically, the drug Cetirizine is well tolerated by patients, but with an incorrectly calculated dose, hypersensitivity to the components of the tablet, or prolonged uncontrolled use of the drug, side effects may develop:

  • from the digestive canal - dry mouth, severe thirst, heaviness in the stomach, lack of appetite, sometimes nausea, constipation;
  • from the nervous system - dizziness, drowsiness, lethargy, increased fatigue, headache, irritability, apathy;
  • allergic reactions - skin rash, skin itching, idiopathic urticaria;
  • from the cardiovascular system - increased blood pressure, shortness of breath, chest pain, bradycardia, cardiac arrhythmia.

If one or more side effects occur, treatment with the drug should be stopped immediately and consult a doctor.

Overdose

In case of intentionally exceeding the prescribed dose or prolonged uncontrolled use of the drug in large quantities, the patient develops signs of overdose, which are clinically manifested by an increase in the described side effects, double vision, depression of consciousness, increased blood pressure and intraocular pressure, and the development of renal failure.

Treatment of overdose consists of immediate discontinuation of drug therapy, gastric lavage, administration of entrosorbents and symptomatic therapy.

Interaction of the drug with other drugs

When Cetirizine tablets are prescribed simultaneously with Theophylline, the clearance of Cetirizine is reduced, which should be taken into account and these drugs should not be prescribed at the same time.

It is not recommended to prescribe Cetirizine tablets simultaneously with antacids or enterosorbents, since this drug interaction leads to a decrease in the therapeutic effect of the antihistamine.

Under the influence of the drug Cetirizine, the therapeutic effect of sedatives, antidepressants and psycholeptics is enhanced.

special instructions

Cetirizine tablets should be prescribed with caution to elderly patients due to their decreased glomerular filtration rate and the high risk of developing side effects to the drug.

During treatment with Cetirizine tablets, you should not drink alcohol, as this increases the risk of side effects from the central nervous system.

The drug is not prescribed to children under 6 years of age, since there is no experience with the use of tablets in this age category, and the safety of the drug has not been established.

During drug therapy, you should refrain from driving a car or operating equipment that requires increased concentration. This is due to the likelihood of sudden dizziness and drowsiness under the influence of the tablets.

Analogues of Cetirizine tablets

Analogues of the drug Cetirizine are:

Before replacing a prescribed drug with its analogue, you should read the attached instructions for contraindications and age restrictions.

Conditions of release and storage

Cetirizine tablets are sold from pharmacies without a prescription. It is recommended to store the drug out of the reach of children, at a temperature of no more than 25 degrees. The shelf life of the tablets from the date of manufacture is 2 years; do not take orally after the expiration date.

Cetirizine price

The cost of the drug Cetirizine in Moscow pharmacies averages 75 rubles.

Source: http://bezboleznej.ru/tsetirizin